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Sample crunch stalls genome sequencing of Covid cases

Sample crunch stalls genome sequencing of Covid cases

Time of India11-06-2025

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Ranchi: The state health department is yet to carry out a genome sequencing of the Covid 19 variant which has led to an uptick in cases in Jharkhand in the recent weeks due to lack of adequate collection of samples.
"The samples necessary for genome sequencing have not yet arrived," Dr Anupa Prasad, of the microbiology department of Rajendra Institute of Medical Sciences (Rims) said.
Health department officials said 27 samples were tested for Covid 19 on Wednesday in the district. Of them, seven returned positive, bringing the total number of active cases in the state to 16. Since May 24, a total of 432 samples were tested, with 31 cumulative positive cases reported.
According to experts, genome sequencing can be conducted with more than 75 samples. However, a match requires 96 samples for optimal processing and matching. Experts highlighted that genome sequencing is essential to track mutations in the virus, assess the nature and speed of transmission, and guide public health strategies, including vaccination and containment measures.
Ranchi civil Surgeon Dr Prabhat Kumar said, "Samples for genome sequencing can be sent to Rims, which is the designated centre for conducting genome analysis in the state.
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Health officials are collecting eligible samples, especially those from positive patients with unusual symptoms or severe illness. However, no plan has been made till now for genome sequencing."
Moreover, all district surveillance officers (DSOs) under the Integrated Disease Surveillance Programme (IDSP) in the state have been directed to ensure daily reporting of Covid 19, influenza-like illness (ILI), and severe acute respiratory illness (SARI) cases on the integrated health information portal.
The directive by the health department mandates both govt and private health facilities to input data on suspected and confirmed Covid 19 cases daily.
In addition to portal entry, districts are required to share the same data by 5 pm daily via the official IDSP Jharkhand WhatsApp group. Additional chief secretary (health) Ajoy Kumar Singh said, "All govt and private hospitals have been asked to enable timely trend analysis and ensure effective surveillance and response to emerging Covid 19 cases across the state."

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Paris climate target ‘will never die', remains world's ultimate goal: Researchers
Paris climate target ‘will never die', remains world's ultimate goal: Researchers

Time of India

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  • Time of India

Paris climate target ‘will never die', remains world's ultimate goal: Researchers

BATHINDA: The world's expected passing of the Paris Agreement's 1.5°C limit during this decade raises pressure for countries to submit bold emissions reduction plans before COP30 in November, two researchers have warned. Prof Joeri Rogelj and Lavanya Rajamani, in a paper published in Science, argues that determining precisely when the world crosses 1.5°C is not necessary, because the decisions needed in response – reduce emissions rapidly in the near term – are already clear and do not suddenly change at that point. Instead, getting closer to 1.5°C should be a wake-up call for the world to focus on reducing greenhouse gas emissions this decade to limit the amount of warming the world experiences past 1.5°C to protect vulnerable groups, they say adding in the longer term reversing warming and getting below 1.5°C must be the goal. The paper follows the hottest year ever on record, commentary that the 1.5°C target is 'deader than a doornail' and the fact that only 21 out of 195 countries that signed the Paris Agreement have thus far submitted new five-year emissions reduction plans. Warming above 1.5°C greatly increases climate risks, including dangerous sea level rise, the collapse of coral reefs, the loss of the Greenland ice sheet and the dieback of the Amazon rainforest. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Ductless Air Conditioners Are Selling Like Crazy [See Why] Keep Cool Click Here Undo Key arguments in the paper includes: Approaching or exceeding 1.5°C of warming does not extinguish the Paris Agreement's ambitious goal but makes urgent climate action even more important. The exact timing of when the world crosses 1.5°C is less important than sustained efforts to cut emissions. The Paris Agreement remains vital as a global framework to guide emissions cuts and adaptation efforts, despite geopolitical challenges. Professor Rogelj, Director of Research at the Grantham Institute – Climate Change and the Environment, said: '1.5°C of warming is just around the corner and it will take a herculean effort to avoid it. 'This is deeply concerning, but crossing it makes the target more important because every fraction of warming – whether it is 1.6, 2 or 3°C – creates a more dangerous world and the longer we stay above 1.5°C, the higher the losses and damages for people will be. 'The key message of our paper is that 1.5°C will never die. It will remain our ultimate goal for a safe, livable and just planet. We need to remember that reversing warming is not a new goal, but already a key aim of the Paris Agreement.' The 2015 Paris Agreement aims to keep warming 'well below 2°C' and to pursue efforts to limit it to 1.5°C. Small island states proposed the 1.5°C target in the late 2000s as a matter of survival – '1.5 to stay alive' – and since 2015, it has become the immediate goal in the fight to tackle climate change. However, the world is not currently on track to keeping warming below the Paris Agreement targets. Most countries are still burning large amounts of fossil fuels, which release emissions that cause the climate to warm. Global warming is expected to exceed 1.5°C before the end of the decade, near 2°C by 2050, and rise to between 2.6°C and 3.1°C over the course of the century. These projections have resulted in commentary that 1.5°C is 'dead' and calls from some researchers to determine the precise timing of when 1.5°C is crossed. Professors Rogelj and Rajamani argue that exceeding 1.5°C does not mean abandoning the goal or triggering a specific policy shift for emissions reductions or adaptation needs but working harder to limit overshoot – the amount of warming experienced above 1.5°C . Their paper emphasises the need for countries to act with the highest ambition possible to bring emissions down to zero, achieve net-negative emissions, and get warming back below 1.5°C in the long-term. They note that even in a world that has crossed 1.5°C, countries and businesses can continue to follow emission pathways aligned with the target. The Paris Agreement remains the most important international tool for tackling climate change, particularly due to its requirement that countries submit plans to cut emissions every five years, the researchers say. While the deadline has been extended until September, just 21 of 195 countries signed up to the Paris Agreement have submitted their plan, known as a Nationally Determined Contribution or NDC. NDCs with the highest possible cuts to emissions will reduce the amount of time the world spends above 1.5°C and reduce harm to human life and ecosystems, the researchers say. Professor Lavanya Rajamani, Faculty of Law, University of Oxford, said: 'We want to reframe the way people talk about 1.5°C. Approaching or even surpassing it is a warning signal that states need to redouble their efforts, not to throw up their hands and declare 1.5°C 'over' or 'dead.' 'We need to stay focused on keeping warming below 1.5°C in the long term, and avoiding the worst impacts of climate change for people and the planet.' 'Our position is supported by a growing body of scientific evidence, the terms of the Paris Agreement, and the wider normative environment, including human rights obligations, that states are subject to.' Professor Rogelj, Director of Research at the Grantham Institute – Climate Change and the Environment, said: 'There is no such thing as a safe level of warming. 'Even below 1.5°C we see dangerous climate change. Devastating weather disasters in 2024 really made that clear – just think of the Valencia floods, Hajj heatwave and Hurricane Helene which collectively killed more than 1,500 people. 'Every tonne of carbon emitted and every fraction of a degree counts. That's why we need to see bold NDCs before the COP30 climate summit in November that deliver meaningful emissions reductions before the end of the decade. A focus on near-term reductions is key to limiting the harms that come with warming above 1.5°C.'

Can AI quicken the pace of math discovery?
Can AI quicken the pace of math discovery?

Time of India

timean hour ago

  • Time of India

Can AI quicken the pace of math discovery?

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Near a bank of chairs, a glass display shows a prosthetic arm that can be controlled by the wearer's brain signals. "By improving mathematics, we're also understanding how AI works better," said Alondra Nelson, who served as a top science adviser in President Joe Biden's administration and is a faculty member at the Institute for Advanced Study in Princeton, New Jersey. "So I think it's kind of a virtuous cycle of understanding." She suggested that, down the road, math-adept AI could enhance cryptography and aid in space exploration. Live Events Started after World War II to compete with the Soviet Union in the space race, DARPA is most famous for fostering the research that led to the creation of ARPANET, the precursor to the internet we use today. At the agency's small gift store, which is not accessible to the public, one can buy replicas of a cocktail napkin on which someone sketched out the rudimentary state of computer networks in 1969. DARPA later funded the research that gave rise to drones and Apple's digital assistant, Siri. But it is also responsible for the development of Agent Orange, the potent defoliant used to devastating effect during the Vietnam War. Discover the stories of your interest Blockchain 5 Stories Cyber-safety 7 Stories Fintech 9 Stories E-comm 9 Stories ML 8 Stories Edtech 6 Stories "I'm sure this isn't 100% innocent," Andrew Granville, a mathematician at the University of Montreal, said of DARPA's math initiative, although he emphasized that he was only speculating about eventual outcomes. DARPA is, after all, part of the Pentagon , even if it has traditionally operated with enviable independence. The U.S. military is rapidly incorporating AI into its operations, with the aim of not losing out to China and its People's Liberation Army or to Russia, which has been testing out new technologies on the battlefield in Ukraine. At the same time, Granville praised the endeavour, which comes as the Trump administration is cutting funding for scientific research. "We are in disastrous times for U.S. science," Granville said. "I'm very pleased that DARPA is able to funnel money to academia." A surfer and skateboarder in his free time, Shafto, 49, sat in a sparse conference room one recent afternoon, imagining a future when AI would be as good at solving multistep problems as it is at trying to glean meaning from huge troves of texts, which it does through the use of probability theory. Despite the unseasonably raw weather, Shafto seemed dressed for the beach in a blue-and-white Hawaiian-style shirt, white flannel trousers and sandals, with a trilby hat on the table before him. His vibe was, on the whole, decidedly closer to that of Santa Cruz than of Capitol Hill, largely in keeping with DARPA's traditional disregard for the capital's slow, bureaucratic pace. (The agency sets priorities and funds outside scientists but does not do research on its own; academics like Shafto spend an average of four years as program managers.) "There are great mathematicians who work on age-old problems," Shafto said. "That's not the kind of thing that I'm particularly interested in." Instead, he wanted the discipline to move more quickly by using AI to save time. "Problems in mathematics take decades or centuries, sometimes, to solve," he said in a recent presentation at DARPA's headquarters on the Exponentiating Mathematics project, which is accepting applications through mid-July. He then shared a slide showing that, in terms of the number of papers published, math had stagnated during the last century while life and technical sciences had exploded. In case the point wasn't clear, the slide's heading drove it home: "Math is sloooowwww." The kind of pure math Shafto wants to accelerate tends to be "sloooowwww" because it is not seeking numerical solutions to concrete problems, the way applied mathematics does. Instead, pure math is the heady domain of visionary theoreticians who make audacious observations about how the world works, which are promptly scrutinized (and sometimes torn apart) by their peers. "Proof is king," Granville said. Math proofs consist of multiple building blocks called lemmas, minor theorems employed to prove bigger ones. Whether each Jenga tower of lemmas can maintain integrity in the face of intense scrutiny is precisely what makes pure math such a "long and laborious process," acknowledged Bryna R. Kra, a mathematician at Northwestern University. "All of math builds on previous math, so you can't really prove new things if you don't understand how to prove the old things," she said. "To be a research mathematician, the current practice is that you go through every step, you prove every single detail." Lean, a software-based proof assistant, can speed up the process, but Granville said it was "annoying, because it has its own protocols and language," requiring programming expertise. "We need to have a much better way of communication," he added. Could artificial intelligence save the day? That's the hope, according to Shafto. An AI model that could reliably check proofs would save enormous amounts of time, freeing mathematicians to be more creative. "The constancy of math coincides with the fact that we practice math more or less the same: still people standing at a chalkboard," Shafto said. "It's hard not to draw the correlation and say, 'Well, you know, maybe if we had better tools, that would change progress.'" AI would benefit, too, Shafto and others believe. Large language models like ChatGPT can scour the digitized storehouses of human knowledge to produce a half-convincing college essay on the Russian Revolution. But thinking through the many intricate steps of a mathematical problem remains elusive. "I think we'll learn a lot about what the capabilities of various AI protocols are from how well we can get them to generate material that's of interest," said Jordan S. Ellenberg, a mathematician at the University of Wisconsin-Madison who is part of a team applying for an Exponentiating Mathematics grant. "We have no intuition yet about which problems are going to be hard and which problems are easy. We need to learn that." One of the more disconcerting truths about artificial intelligence is that we do not entirely understand how it works. "This lack of understanding is essentially unprecedented in the history of technology," Dario Amodei, CEO of the artificial intelligence company Anthropic, wrote in a recent essay. Ellenberg somewhat downplayed that assertion, pointing out that electricity was widely used before its properties were fully understood. Then again, with some AI experts worrying that artificial intelligence could destroy the world, any clarity into its operations tends to be welcome. Nelson, the former White House adviser, acknowledged "legitimate" concerns about the rapid pace at which artificial intelligence is being integrated into seemingly every sector of society. All the more reason, she argued, to have DARPA on the case. "There's a much higher benchmark that needs to be reached than whether or not your chatbot is hallucinating if you ask it a question about Shakespeare," she said. "The stakes are much higher."

Yoga and Ayurveda are keys to perfect skin and health
Yoga and Ayurveda are keys to perfect skin and health

Time of India

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Yoga and Ayurveda are keys to perfect skin and health

This international yoga day the most essential thing to remember is to reinforce the principles of Yoga & Ayurveda within our daily lives. Both are ancient practices rooted from our Vedas since time immortal. It is important to note that the belief of both these practices is to lead a holistic life for the wellbeing of the body. While physical practices of yoga helps in achieving physical harmony, the practices of ayurveda are all about balancing the internal doshas, dietary and lifestyle changes that also impact the skin health. How Yoga & Ayurveda are keys to perfect skin Leading a life of stress and chaos, trying to strike balance between work / personal life is taking a toll on our wellbeing. With this it becomes essential to set aside some time for self-care and reset your rhythm. A holistic approach that is an amalgamation of yoga and ayurveda enables in addressing your ailments and mental aspects of health as well. Not only your flexibility is enhanced, but you feel more at ease, your gut health improves, you have a better immunity and your skin is free of toxins. Reducing stress requires practicing yoga moves that enables in inducing the feelings of peace. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Scam Exposed: What They Won't Tell You about zero trust! Expertinspector Click Here Undo Mindfulness and meditation help in release of anxiety from the body. When you are at ease, your nervous system relaxes, the skin health improves dramatically. Balancing your bodily functions internally impacts the skin, leading to enhanced skin quality. Benefits of Yoga & Ayurveda on skin health Yoga and Ayurveda when these work in combination the body and mind come into perfect harmony with nature. While you might not be aware that even certain yoga poses offer benefit to the skin health, it is essential to pay attention that principles of ayurveda helps in achieving overall skin health. Yoga helps balance your mind and provides clarity by balancing its three essential qualities, the mind therefore becomes calm. With a calm mind it is easy to achieve in optimum productivity. Ayurveda helps in achieving balance between doshas through the use of certain cleansing and therapeutic practices. The products that are based on ayurveda therefore are more of treatment and therapeutic products. Use of full body massage through the incorporation of ayurveda practices enhances muscular and skin quality. With it your skin is nourished greatly and supplied by ample nutrients to keep it healthy. Use of medicated oil therapy is more of a treatment that enables in achieving better mental health. Using ayurveda based products for skincare and haircare containing herbal and floral extracts directly improves skin health and enhances the quality of the skin. With all the above mentioned reasons, yoga and ayurveda are both important in achieving overall beauty that radiates from inside out with healthy body you will be able to have a healthy and youthful skin. Shahnaz Hussain One step to a healthier you—join Times Health+ Yoga and feel the change

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