J&J reports results from antibody combo trial for MM patients

Johnson & Johnson (J&J) has reported new outcomes from the Phase II RedirecTT-1 trial of bispecific antibodies, Talvey (talquetamab-tgvs) and Tecvayli (teclistamab-cqyv) for relapsed/refractory multiple myeloma (r/r MM).
The data showed a high overall response rate (ORR) with durability in those who have triple-class-exposed (TCE) RRMM with true extramedullary disease (EMD).
In the trial, which enrolled 90 subjects, the investigational combo resulted in an ORR of 78.9%, with over half of the subjects achieving a complete response or better, representing a significant improvement over the average ORR of less than 40% for this patient group.
Notably, responses were also found to be high among those previously treated with B-cell maturation antigen (BCMA) CAR-T or anti-FcRH5 bispecific antibodies.
According to the company, subjects in the trial showed deep and durable responses, with 66.2% remaining in response at the data cutoff and a median follow-up of 13.4 months.
At one year, 61% of subjects were progression-free and alive, and 74.5% were alive, with median overall survival not yet reached.
The combo was found to be consistent with prior reports of them as single agents.
Subjects had the option to switch to once-a-month dosing, which might have contributed to better tolerability.
The reports of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were found to be mostly low grade.
The study's findings were featured at the 2025 European Hematology Association Congress.
EMD represents a severe form of MM, where myeloma cells form tumours in soft tissues and organs.
Johnson & Johnson innovative medicine multiple myeloma disease area leader and vice-president Jordan Schecter said: 'Patients with extramedullary myeloma, especially those who have exhausted prior therapies, need more effective treatment options.
'Our first-in-class bispecific antibodies, Talvey and Tecvayli, have transformed treatment for relapsed or refractory multiple myeloma.'
Recently, J&J reported that Tremfya decreased the symptoms and signs of active psoriatic arthritis (PsA) at 24 weeks in individuals against a placebo in the Phase IIIb APEX trial.
"J&J reports results from antibody combo trial for MM patients" was originally created and published by Clinical Trials Arena, a GlobalData owned brand.
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TINs and the Machine: AI-Driven Financial Surveillance Tax agencies and compliance institutions now utilize artificial intelligence to analyze the massive flows of TIN-linked data they receive annually. These systems identify: Duplicate or fraudulent TINs TINs registered to deceased persons TINs linked to multiple high-risk jurisdictions TINs used in accounts with transactional patterns indicative of layering or structuring These alerts lead to proactive audits, coordinated international investigations, and often criminal referrals. Amicus Advisory: The New Landscape of Legal Identity Amicus International Consulting offers strategic compliance services to clients worldwide, ensuring lawful restructuring in light of TIN-related risk. 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Under CARF, TINs are required for: Crypto wallet openings Tokenized asset purchases Staking and lending platforms DeFi (decentralized finance) protocols, if jurisdictionally covered The scope of TIN-linked tracking is now: REGIME SCOPE WHO REPORTS USE OF TIN FATCA U.S. Persons Foreign Banks Required for ID and enforcement CRS Global Participants Local Banks Matches with home tax returns CARF Crypto Platforms Exchanges and Wallets Connects users to tax obligations TINs and Risk Ratings: Why Institutions Monitor the Numbers Financial institutions now integrate TIN data into their client risk rating systems. For example: Clients with TINs from high-risk or sanctioned countries receive enhanced due diligence Clients with multiple TINs must explain overlapping residencies Clients with unrecognized or expired TINs may be denied account access This impacts not only account approvals but also transaction clearance times, credit issuance, and internal reporting to regulators. Legal and Financial Consequences of TIN Mismanagement Misuse, non-disclosure, or manipulation of TINs can lead to: Civil penalties of up to 300% of the tax owed Criminal prosecution for tax evasion or fraud Confiscation of assets linked to undeclared income Cross-border arrests and extradition (in extreme cases) Blocklisting of associated corporate or personal accounts Case Study: The TIN That Triggered a Tax Rebellion A South African executive's TIN, linked to a Panama-based trust, was disclosed in a 2023 CRS exchange. While the executive believed the structure was legally opaque, the TIN used during trust setup provided a direct link to his residency and triggered a significant investigation. Ultimately, the executive entered into a public settlement and became a case study for the risks associated with financial opacity. Amicus Case File: TIN Reconciliation to Avoid Disclosure Fallout A Canadian Israeli entrepreneur approached Amicus after receiving FATCA inquiries linked to a dormant U.S. LLC. Amicus performed a TIN alignment and voluntarily disclosed the entity under Canada's tax amnesty program. Outcome: Avoided criminal charges Paid penalties at a reduced rate Cleared the way for future CRS-compliant investment structures The Path Forward: Strategic Transparency with Legal Shielding True privacy no longer lies in secrecy, but in lawful clarity. TINs will continue to expand their reach as: Biometric TINs are adopted in high-fraud countries are adopted in high-fraud countries Digital wallets become tied to tax identifiers become tied to tax identifiers Residency and citizenship-by-investment programs adopt stricter TIN checks adopt stricter TIN checks TIN-based sanctions systems link individuals to national enforcement regimes Amicus continues to serve clients facing this new paradigm, not to avoid transparency, but to master it strategically and lawfully. 📞 Contact Information Phone: +1 (604) 200-5402 Email: info@ Website: Follow Us: 🔗 LinkedIn 🔗 Twitter/X 🔗 Facebook 🔗 Instagram About Amicus International Consulting Amicus International Consulting provides strategic legal and financial restructuring services for global citizens, corporate entities, and high-net-worth individuals navigating the complexities of FATCA, CRS, CARF, and global transparency regulations. Amicus offers lawful pathways for protecting assets, ensuring compliance, and preserving cross-border mobility. TIME BUSINESS NEWS