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Cocooning during this Kansas storm season, I try to avoid the cataclysm outside my window

Cocooning during this Kansas storm season, I try to avoid the cataclysm outside my window

Yahoo31-05-2025

The spring storm season has brought frequent rain and thoughts of self-preservation, writes opinion editor Clay Wirestone. (Max McCoy/Kansas Reflector)
Each day now in Lawrence, where my family and I live, I watch the clouds roll in and the rains come.
The spring storm season thunders and flashes and pours, and the lawns flourish and gutters overflow. I sit here in my home office through the evenings and watch as the lightning casts strange shadows. I hear the rain pelting the roof. Later on, when I take our dog out for a walk, the rains have usually slowed and the neighborhood smells earthy and damp, while the doused roads shine under streetlamps.
During these days, my son hangs around the house. School has ended, and summer activities remain a few weeks distant. He plays video games and dotes on the pets. My husband's work has shifted into its busiest season, so some days I only see him toward the end of the day.
I seem to live now, for a week or two at least, in a small protected bubble. The rains come and the world rumbles and my son and I stay indoors and wait for the storm to pass. Aren't many of us doing that right now, staying in those kind of bubbles, waiting for the skies to clear? We can create those bubbles in different ways. Some of us watch seasons of old situation comedies, following the adventures of Sam and Diane and Cliff and Norm on Cheers (rest in peace, George Wendt). Some of us watch horror movies (I enjoyed Nicholas Roeg's 'Don't Look Now' the other night). Some of us find escape through exercise or alcohol or other activities that change our brain and body chemistry.
It is the season of survival.
We endure the weather. It's different for all of us. Here in Kansas, the weather might be a private prison company pressing to reopen facilities to serve Immigrations and Customs Enforcement. It might be a law that denies critical yet misunderstood health care to teenagers. It might be your immigration status if you study at a university. It might be an uncertain economic climate that threatens small business in towns and cities.
In uncertain times, we search for comparisons. We judge today's storm against the storms of the past. We survived those, we tell ourselves, so surely we must survive these ones. Those storms may have even been worse, we tell ourselves. We should expect spring rains, Discover Magazine explains, as humid summer air collides with dry winter air. The mixture forms clouds, yields precipitation.
We still wait indoors, swaddled in decades-old quilts and drinking hot tea.
The metaphor strains. My correspondents will write me email messages insisting that determined Kansans can weatherproof their homes. We can work together to find community and purpose during these dreary, overcast days. We need not — must not — hide from the work ahead of us.
I understand these things, agree with them, have written them before. We can both endure and act. The stormy season will pass. These times will end. The clouds will clear and the sun will nudge itself above the horizon, and we will pick up the pieces. I will mow the lawn and pick up the random branches that fell from the giant tree in our front yard. Cleanup awaits, and it will take the whole subdivision pitching in.
Yet while spring storm season continues, at least let me have these gloomy evenings. Let me embrace poetry and fiction and imagination leaps. Grant me the time to recharge, to dote on my family, to enjoy distractions for a handful of days. We all deserve time to center ourselves, to feel protected from the inevitable deluge.
These moments of grace will steel us for a long, hot summer.
Clay Wirestone is Kansas Reflector opinion editor. Through its opinion section, Kansas Reflector works to amplify the voices of people who are affected by public policies or excluded from public debate. Find information, including how to submit your own commentary, here.

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Structure Therapeutics Announces Two Late-Breaking Poster Presentations at the American Diabetes Association 85th Scientific Sessions Including New Preclinical Data for Oral Small Molecule Amylin Agonist, ACCG-2671
Structure Therapeutics Announces Two Late-Breaking Poster Presentations at the American Diabetes Association 85th Scientific Sessions Including New Preclinical Data for Oral Small Molecule Amylin Agonist, ACCG-2671

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Structure Therapeutics Announces Two Late-Breaking Poster Presentations at the American Diabetes Association 85th Scientific Sessions Including New Preclinical Data for Oral Small Molecule Amylin Agonist, ACCG-2671

SAN FRANCISCO, June 20, 2025 (GLOBE NEWSWIRE) -- Structure Therapeutics Inc. (NASDAQ: GPCR), a clinical-stage global biopharmaceutical company developing novel oral small molecule therapeutics for metabolic diseases, today announced two upcoming late-breaking poster presentations at the American Diabetes Association 85th Scientific Sessions, being held from June 20-23 in Chicago, IL. 'The amylin receptor is rapidly gaining clinical validation as a key target in obesity, driven by encouraging data from injectable peptide programs. We believe ACCG-2671 is well-positioned and differentiated as an oral small molecule frontrunner that is expected to enter clinical development by the end of 2025,' said Raymond Stevens, Ph.D., Founder and CEO of Structure Therapeutics. 'The preclinical data being presented at ADA include the robust weight-loss effects of ACCG-2671 alone and in combination with a GLP-1 receptor agonist underscoring ACCG-2671's potential as a future small molecule backbone treatment for obesity. In addition, we will present data demonstrating the neuroprotective effects of GLP-1 receptor agonism in preclinical models of Parkinson's disease, reinforcing the broad role of the GLP-1 receptor across different diseases.' Presentation Details: Title: Novel Oral Small Molecule ACCG-2671: A Dual Amylin and Calcitonin Receptor Agonist Development Candidate for Obesity TherapyPoster #: 2184-LBSession: Late Breaking Poster SessionDate: Sunday, June 22Time: 12:30 p.m. – 1:30 p.m. CT Summary: ACCG-2671 demonstrated high binding affinity and balanced potency in human calcitonin receptor (CTR) and amylin receptor (AMY3R) functional assays. In diet-induced obese rats, oral administration of ACCG-2671 resulted in significant, dose-dependent body weight reductions. Combination therapy with semaglutide (both as add-on and concurrent treatment) resulted in superior weight loss compared to monotherapy. Title: Oral Small Molecule GLP-1 Receptor Agonist Demonstrates Beneficial Effects in Parkinson's Disease–Like Model Using Humanized GLP-1R MicePoster #: 1985-LBSession: Late Breaking Poster SessionDate: Sunday, June 22Time: 12:30 p.m. – 1:30 p.m. CT Summary: In a Parkinson's disease mouse model, oral administration of GSBR-5595, a small molecule GLP-1 receptor agonist distinct from Structure Therapeutics' clinical asset aleniglipron (GSBR-1290), significantly improved motor coordination and movement in both the rotarod and open field tests. Additionally, histopathological analyses revealed a significant increase in dopaminergic neurons. These findings suggest this GLP-1 receptor agonist showed neuroprotective effects by mitigating motor deficits and preserving dopaminergic neurons, highlighting a potential benefit in Parkinson's disease. About Structure TherapeuticsStructure Therapeutics is a science-driven clinical-stage biopharmaceutical company focused on discovering and developing innovative oral small molecule treatments for chronic metabolic and cardiopulmonary conditions with significant unmet medical needs. Utilizing its next generation structure-based drug discovery platform, the Company has established a robust GPCR-targeted pipeline, featuring multiple wholly-owned proprietary clinical-stage oral small molecule compounds designed to surpass the scalability limitations of traditional biologic and peptide therapies and be accessible to more patients around the world. 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"It's The Trifecta Of Bad": Dentists Are Sharing The Things They Would Avoid Doing To Their Teeth At All Costs
"It's The Trifecta Of Bad": Dentists Are Sharing The Things They Would Avoid Doing To Their Teeth At All Costs

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Brushing, flossing and visiting the dentist regularly — we all know the pillars of good dental hygiene. But knowing them and maintaining them are two different things. Nearly 50% of people above 30 have signs of gum disease and 26% of adults have untreated cavities, according to the Centers for Disease Control and Prevention. It's not uncommon to have issues with your teeth or gums, and dentists say certain lifestyle factors may be behind some of your oral health issues. In fact, common behaviors can negate the benefits of good oral hygiene — and you're probably guilty of some of them. Below, we spoke with dentists about the tooth-damaging habits and behaviors that they advise against and would never, ever do themselves: 1. They don't chew ice. 'The first thing that came to mind for me was chewing ice,' said Dr. Natalie Peterson, a clinical associate professor of dentistry at the University of Minnesota. 'A lot of people don't think about it, but they chew on the ice in their drink and they just don't think about the damage that it can do,' she said. Ice can break your teeth because not only is it hard, but it's cold, too, Peterson noted. It can be particularly damaging for people with fillings. 'The thought of chewing on ice just gives me shivers,' she said. 2. They don't bite their nails. According to Dr. Jennifer Soncini, a clinical associate professor of pediatric dentistry at Boston University, biting your nails can lead to dental issues. Plus, nail-biting is often a habit, which means your teeth have to deal with this action repeatedly. As you bite your nails, you wear down the enamel on the edges of your teeth, Soncini explained. Enamel plays many important roles — it helps protect your teeth from cavities, erosion, infection and sensitivity to cold, hot or sweet foods. 3. They don't open bags or bottles with their teeth. 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'Some people might only need to come in once a year, they might be pretty healthy; a lot of people, twice a year is a good idea; and some people that have risk factors or dental problems, they might need to come in three to four times a year,' Peterson continued. Talk to your dentist and dental hygienist to figure out what the best frequency is for article originally appeared on HuffPost. Also in Goodful: Therapists Are Revealing The Moments That Made Them Break Their "No Judgment" Rule, And I'm Honestly Speechless Also in Goodful: 19 "Garbage" Modern Trends People Refuse To Partake In Despite Their Popularity Also in Goodful: "This Has Taken Me Years And Years And YEARS To Figure Out": This Woman's Clever Way To Tell If Someone Is Your Real Friend Is Being Called The Most Accurate Thing Ever

Everything You Should Know About Hormonal Imbalance
Everything You Should Know About Hormonal Imbalance

Health Line

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Everything You Should Know About Hormonal Imbalance

A hormonal imbalance can have a wide range of symptoms, from weight gain to fatigue. Treatment can help resolve many of the underlying causes. Hormones are your body's chemical messengers. Produced in the endocrine glands, these powerful chemicals travel around your bloodstream, telling tissues and organs what to do. They help control many of your body's major processes, including metabolism and reproduction. When you have a hormonal imbalance, you have too much or too little of a certain hormone. Even tiny changes can have profound effects throughout your body. Some hormone levels fluctuate throughout your lifetime and may result from natural aging. However, other changes occur when your endocrine glands produce too much or not enough of certain hormones. Read on to learn more about hormonal imbalances and how they might affect your health. Symptoms of hormonal imbalance Your hormones play an integral role in your overall health. Specific symptoms could indicate a hormonal imbalance. However, the symptoms you might experience depend on which hormones or glands are responsible. Common hormonal conditions that could cause imbalances may result in symptoms such as: Keep in mind that these symptoms are nonspecific. Having one or a few of them doesn't necessarily mean that you have a hormonal imbalance. Some of these symptoms may also reflect other chronic conditions. So, if you notice any notable changes in your body or energy levels, it's a good idea to talk with your doctor. Symptoms in people who were assigned female at birth (AFAB) In people with ovaries, the most common consequence of hormonal imbalance is polycystic ovary syndrome (PCOS). Your hormonal cycle also changes naturally during these stages: Symptoms of a hormonal imbalance specific to AFAB people include: heavy or irregular periods, including missed periods, stopped periods, or frequent periods hirsutism, or excessive hair on the face, chin, or other parts of the body acne on the face, chest, or upper back hair loss hyperpigmentation (darker patches on the skin), especially along neck creases, in the groin, and underneath the breasts skin tags vaginal dryness vaginal atrophy pain during sex night sweats headaches It's important to note that many of these issues, including hirsutism, can affect people of other sexes, too. Symptoms in people who were assigned male at birth (AMAB) Testosterone plays a vital role in development. If you aren't producing enough testosterone, it can cause a variety of symptoms. Symptoms of hormonal imbalance in AMAB people include: gynecomastia, or enlarged breast tissue breast tenderness erectile dysfunction (ED) decrease in beard growth and body hair growth loss of muscle mass loss of bone mass, otherwise known as osteoporosis difficulty concentrating hot flashes It's important to note that AFAB folks can also experience testosterone imbalances. Symptoms in children Children start producing sex hormones during puberty. Many children with delayed puberty will go on to experience typical puberty, but some have a condition called hypogonadism. Individuals with hypogonadism may experience: lack of development of muscle mass a voice that doesn't deepen body hair that grows sparsely impaired penis and testicular growth excessive growth of the arms and legs in relation to the trunk of the body gynecomastia menstruation that doesn't begin breast tissue that isn't developing the growth rate doesn't increase Causes of a hormonal imbalance A hormonal imbalance has many possible causes. They can differ depending on which hormones or glands are affected. Common causes of hormonal imbalance include: hormone therapy medications cancer treatments such as chemotherapy tumors, whether cancerous or benign pituitary tumors eating disorders chronic stress injury or trauma insulin resistance While hormonal imbalances may initially cause some of the conditions below, having these conditions can also lead to further hormonal imbalances: type 1 and type 2 diabetes diabetes insipidus hypothyroidism, or an underactive thyroid hyperthyroidism, or an overactive thyroid hyperfunctioning thyroid nodules thyroiditis hypogonadism Cushing syndrome, or high levels of cortisol congenital adrenal hyperplasia, which causes low levels of cortisol and aldosterone Addison's disease Causes unique to AFAB people Many causes of hormonal imbalance in AFAB people are related to reproductive hormones. Common causes include: menopause primary ovarian insufficiency, which is also known as premature menopause pregnancy breastfeeding PCOS hormone medications, such as birth control pills Tests for hormonal imbalance There's no single test available to help doctors diagnose a hormonal imbalance. Begin by making an appointment with your doctor for a physical exam. Be prepared to describe your symptoms and the timeline along which they've occurred. Include all medications, vitamins, and supplements you're currently taking. Your doctor may ask you questions such as: How often are you experiencing symptoms? Does anything help relieve your symptoms? Have you lost or gained weight recently? Are you more stressed than usual? When was your last period? Are you planning to get pregnant? Do you have trouble getting or maintaining an erection? Do you have vaginal dryness or pain during sex? Your doctor may suggest one or more diagnostic tests depending on your symptoms. You can also request that your doctor perform these tests. A healthcare professional can request a blood test to check your thyroid and estrogen, testosterone, and cortisol levels. Pelvic exam If you have a uterus, a doctor may perform an internal exam to feel for any unusual lumps, cysts, or tumors. If you have testicles, a doctor may check your testicles and scrotum for any lumps or abnormalities. Ultrasound An ultrasound machine uses sound waves to look inside your body. Doctors may request an ultrasound to get images of the: uterus ovaries testicles thyroid pituitary gland Additional tests Sometimes, more advanced tests are required. These can include: biopsy MRI X-ray thyroid scan sperm count test (semen analysis) At-home tests If you're experiencing symptoms of a hormonal imbalance, you may also consider using a home testing kit. These kits are available for a variety of conditions. However, while still best to talk with a doctor as they may recommend additional testing to determine the cause of a hormone imbalance, at-home tests can provide a starting point. Home testing kits for menopause measure follicle-stimulating hormone (FSH) in your urine. FSH levels increase when you enter menopause. Levels also rise and fall during a typical menstrual cycle. Other factors, such as the use of hormonal birth control, can also affect your FSH levels. Note that these kits can indicate that menopause may have started, but they can't tell you conclusively. A healthcare professional's confirmation may be necessary. Other home testing kits typically use saliva or blood from the fingertip to measure your cortisol levels, key thyroid hormones, and sex hormones such as progesterone and testosterone. Some tests may require a urine sample. These kits require you to send the sample off to a lab. Your test results are usually available online within 5 to 9 business days. The company LetsGetChecked provides at-home tests that have been approved by the Food and Drug Administration (FDA). However, many at-home tests have not received FDA approval. Regardless of which at-home test you choose, it is important to discuss your test results with your healthcare professional. Let them know if you're concerned about certain symptoms or a possible diagnosis. Treatment options for a hormonal imbalance Treatment for a hormonal imbalance will depend on what's causing it. Some common treatment options include: Estrogen therapy Be sure to discuss the risks and benefits of hormone replacement therapy (HRT) with your doctor. If you don't already have one, you can browse doctors in your area through the Healthline FindCare tool. Vaginal estrogen If you're experiencing vaginal dryness or pain during sex, a doctor may also recommend an estrogen cream, tablet, or ring. This local therapy helps eliminate many of the risks associated with systemic estrogen, or estrogen that travels throughout the bloodstream to the appropriate organ. Hormonal birth control Hormonal birth control can help regulate your menstrual cycles. Types of hormonal birth control include the: birth control pill birth control patch birth control shot vaginal ring intrauterine device (IUD) Some types of hormonal birth control may also help improve acne on the face and body. Anti-androgen medications Androgens are male sex hormones that are present in people of all genders. High androgen levels can be treated with medication that blocks the effects of androgens. These effects include: hair loss facial hair growth acne One androgen closely tied to hair growth and loss is testosterone. A 2020 study found that when not enough testosterone is produced, hair loss and lack of growth are common. Testosterone therapy Testosterone supplements can reduce the symptoms of low testosterone. In adolescents with delayed puberty, it stimulates the start of puberty. It's available in many forms, including injections, a patch, and gel. Testosterone replacement therapy (TRT) has risks, including to your cardiovascular system. Thyroid hormone therapy If you have hypothyroidism, the synthetic thyroid hormone levothyroxine (Levoxyl, Synthroid, Unithroid) can bring hormone levels back into balance. Metformin Metformin is a type 2 diabetes medication that may help some individuals with PCOS symptoms. The FDA has not approved it to treat PCOS, but it might help lower androgen levels and encourage ovulation. It is often prescribed off-label for this purpose. Flibanserin (Addyi) and bremelanotide (Vyleesi) Flibanserin (Addyi) and bremelanotide (Vyleesi) are the only medications that are FDA-approved for the treatment of low sexual desire in premenopausal people. Addyi is a pill, and Vyleesi is a self-administered injectable medication. These drugs may come with some serious side effects, such as severe nausea and changes in blood pressure. Talk with your doctor to see if either one could be right for you. Eflornithine (Vaniqa) This prescription cream is designed specifically for excessive facial hair. Applied topically to the skin, it helps slow new hair growth but does not eliminate existing hair. Natural remedies and supplements Many nutritional supplements on the market claim to treat menopause and hormonal imbalance. However, few of them are backed by scientific evidence. Many of these supplements contain plant-derived hormones, which are sometimes called 'bioidentical' hormones because they chemically resemble the body's natural hormones. However, there's no evidence to suggest that they work better than regular hormone therapy. They are also not regulated by the FDA to the same degree as prescription hormone medications. Some people find that yoga helps ease symptoms of hormonal imbalance. Yoga is excellent for your strength, flexibility, and balance. It may also aid in weight loss, which can further help regulate your hormones. You can also make the following lifestyle changes: Lose weight: If your doctor has recommended it, a reduction in body weight may help regulate menstrual cycles and increase the chances of getting pregnant. Weight loss may also help improve erectile function. Eat well: A balanced diet is an important part of overall health. Decrease vaginal discomfort: Use lubes or moisturizers free of parabens, glycerin, and petroleum. Avoid hot flash triggers when possible: Identify things that commonly trigger your hot flashes, such as warm temperatures, spicy foods, or hot beverages. Remove unwanted hair: If you have excess facial or body hair, you can use hair removal cream, laser hair removal, or electrolysis. Hormonal imbalance and acne The primary cause of acne is excess oil production, which leads to clogged pores. Acne is most common in areas with many oil glands, including the: face chest upper back shoulders Acne is often associated with the hormonal changes of puberty. But there's a lifelong relationship between acne and hormones. Acne and menstruation The menstrual cycle is one of the most common acne triggers. For many individuals, acne develops the week before they get their period and then clears up. Dermatologists recommend hormonal testing for people who have acne in combination with other symptoms, such as irregular periods and excess facial or body hair. Acne and androgens Androgens contribute to acne by overstimulating the oil glands. Children of all genders have high levels of androgens during puberty, which is why acne is so common at that time. Androgen levels typically settle down in a person's early 20s. Hormonal imbalance and weight gain Hormones play an integral role in metabolism and your body's ability to use energy. The only way to treat weight gain from a hormone disorder is to treat the underlying condition. Some hormone conditions, such as Cushing syndrome, can increase the risk of becoming overweight or developing obesity. Cushing syndrome causes high levels of cortisol in the blood. This leads to an increase in appetite and fat storage. Hypothyroidism, if the condition is severe, can also lead to weight gain. Slight hormone imbalances can happen during menopause. During this transition, many people gain weight because their metabolisms slow down. You may find that you still gain weight even though you're eating and exercising like usual. Hormonal imbalance and pregnancy During a typical pregnancy, your body experiences major hormonal changes, which are different from a hormonal imbalance. Pregnancy and PCOS Hormonal imbalances such as PCOS are among the leading causes of infertility. With PCOS, the hormonal imbalance interferes with ovulation. While you can't become pregnant if you're not ovulating, irregular ovulation in PCOS can still result in pregnancy. If you're trying to become pregnant and have PCOS, your doctor may recommend methods to improve your fertility. This may include losing weight, if a doctor recommends it. Prescription medications are also available that can stimulate ovulation and increase your chances of becoming pregnant. In vitro fertilization (IVF) is also an option if medication doesn't work. As a last resort, surgery can temporarily restore ovulation. PCOS can cause issues during pregnancy for both you and your baby. There are higher rates of: gestational diabetes miscarriage preeclampsia cesarean delivery (C-section) high birth weight admission to and time spent in the neonatal intensive care unit Becoming pregnant while living with PCOS does not mean an individual will experience any of the above problems. Talking with your doctor and following their advice is the best way to have a safe pregnancy and delivery. Pregnancy and hypothyroidism Babies born to parents with untreated hypothyroidism are more likely to have developmental issues. This includes intellectual and developmental disabilities. Managing your hypothyroidism along with your doctor's advice can help lessen these risks. Hormonal imbalance and hair loss Most hair loss, such as male pattern baldness, is hereditary but may be influenced by a hormone imbalance. Hormonal changes and imbalances can also sometimes cause temporary hair loss. In AFAB folks, this is often related to: pregnancy childbirth the onset of menopause An overproduction or underproduction of thyroid hormones can also cause hair loss. Other complications Hormone imbalances are associated with many chronic, or long term, health conditions. Without proper treatment, you could be at risk for several serious medical conditions, including: type 1 and type 2 diabetes diabetes insipidus high blood pressure high cholesterol heart disease neuropathy obesity sleep apnea kidney damage depression and anxiety endometrial cancer breast cancer osteoporosis loss of muscle mass urinary incontinence infertility sexual dysfunction goiter

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