AbbVie's migraine drug meets main goal of late-stage study
June 18 (Reuters) - AbbVie (ABBV.N), opens new tab said on Wednesday its migraine drug met the main goal and was superior to a generic drug in a head-to head late-stage trial.
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Daily Mail
12 minutes ago
- Daily Mail
What your TONGUE says about you, according to science
It's the muscle we use every day for speaking, swallowing and tasting. But our tongue could also be an important indicator of our health and provide clues about what's going on within our body, experts say. Different colours, textures, coatings and shapes of the tongue can indicate different conditions. And keeping track of the muscular organ could help us detect issues we may otherwise be oblivious to. 'A healthy tongue is pink in colour with a slightly rough surface,' Sarah Ramage, clinical director at Bupa, said. 'What gives it this texture are the tiny bumps on top, called papillae.' Any shift from this may signal an issue or a sign that you need to work on your oral health. So, have you noticed any of these changes? RED OR WHITE PATCHES Abnormal looking patches, lumps or spots could be a sign of mouth cancer, Ms Ramage warned. Red patches could signal a condition called erythroplakia and white or grey patches may be leukoplakia, which could lead to cancer if untreated. Your dentist will look out for these when you go for a check-up, she said, and refer you to a GP or specialist if they have any concerns. 'Mouth cancer rates have increased by almost 60 per cent in the last decade, so it's important to be aware of any changes,' she added. WHITE SPOTS (LESIONS) Creamy white spots or lesions on the tongue could indicate a fungal infection, such as oral thrush. While it's usually harmless it may spread to other parts of your mouth if left untreated, causing an unpleasant taste or pain or difficulty eating and drinking. Dr Leslie Anthony is a dentist who runs her own practice in Montana. 'A red tongue may indicate heat in the body like a fever or a hormonal imbalance,' she said. 'A reddish purple tongue is a sign that there may be inflammation or an infection in the body. 'Meanwhile a pale pink tongue may be a sign of a vitamin deficiency, a weak immune system or a lack of energy.' COATING A thick coating reflects poor intestinal health or digestive issues, Dr Anthony explained. A yellowish coating indicates there may be an infection in the body, while a grey or blackish coating suggests a long-term digestive disorder or that 'something may be very wrong with your body's health'. And a thick white coating means there may be poor circulation to the extremities or possibly a yeast infection. SHAPE 'If the tongue is puffy with scalloped edges or indented teeth marks it may indicate malabsorption of nutrients,' she added. Meanwhile, a very thin tongue may be a sign of dehydration. A BLOTCHY 'GEOGRAPHIC' TONGUE A map-like pattern on the tongue's surface – with normal patches and smooth red patches – occurs when the 'old' surface of the tongue replaces itself and the top layer doesn't come off properly. It can leave a red, sore area like a scratch, but is normally harmless. The experts said it is good practice to look at young tongue in the mirror and notice the colours, textures, bumps and coating. It is best to inspect your tongue before brushing your teeth, they added. HOW TO CLEAN YOUR TONGUE Experts recommend brushing your tongue regularly to help prevent a build-up of bacteria. Tongue brushing is simple enough to do using the bristles of your toothbrush. 'The tongue harbours bacteria and food debris trapped under a thin layer of mucus,' Colgate's website reads. 'Remove this odour-causing build-up by using a small dab of toothpaste and carefully brushing the top of the tongue. 'Start by reaching to the back of the tongue, and then work forwards towards the opening of the mouth. Brush the entire top surface of the tongue using gentle pressure, and then rinse your mouth with mouthwash or water.' For those wanting a more thorough cleaning, a tongue scraper gently peels the thin mucus-based layer of debris from the tongue. WHAT IS MOUTH CANCER? Mouth cancer, also known as oral cancer, is where a tumour develops in the lining of the mouth. It may be on the surface of the tongue, the insides of the cheeks, the roof of the mouth (palate), or the lips or gums. Tumours can also develop in the glands that produce saliva, the tonsils at the back of the mouth, and the part of the throat connecting your mouth to your windpipe (pharynx). However, these are less common. Symptoms of mouth cancer include: sore mouth ulcers that don't heal within several weeks unexplained, persistent lumps in the mouth that don't go away unexplained, persistent lumps in the neck that don't go away unexplained looseness of teeth, or sockets that don't heal after extractions unexplained, persistent numbness or an odd feeling on the lip or tongue sometimes, white or red patches on the lining of the mouth or tongue – these can be early signs of cancer, so they should also be investigated changes in speech, such as a lisp See your GP or dentist if these symptoms don't heal within three weeks, particularly if you drink or smoke heavily.
The Independent
20 minutes ago
- The Independent
Would you hail a 'robotaxi'? Musk bets cabs will give Tesla a lift after boycotts and sales plunge
Elon Musk promised in 2019 that driverless Tesla 'robotaxis' would be on the road 'next year,' but it didn't happen. A year later, he promised to deliver them the next year, but that didn't happen either. Despite the empty pledges the promises kept coming. Last year in January, Musk said, 'Next year for sure, we'll have over a million robotaxis.' Would you settle for 10 or 12? Musk appears to be on the verge of making his robotaxi vision a reality with a test run of a small squad of self-driving cabs in Austin, Texas, starting Sunday. Reaching a million may take a year or more, however, although the billionaire should be able to expand the service this year if the Austin demo is a success. The stakes couldn't be higher, nor the challenges. While Musk was making those 'next year' promises, rival Waymo was busy deploying driverless taxis in Los Angeles, San Diego, Austin and other cities by using a different technology that allowed it to get to market faster. It just completed its 10 millionth paid ride. Boycotts related to Musk's politics have tanked Tesla's sales. Rival electric vehicle makers with newly competitive models have stolen market share. And investors are on edge after a $150 billion stock wipeout when Musk picked a social media fight with a U.S. president overseeing federal car regulators who could make the robotaxi rollout much more difficult. The stock has recovered somewhat after Musk said he regretted some of his remarks. Tesla shareholders have stood by Musk over the years because he's defied the odds by building a successful standalone electric vehicle company — self-driving car promises aside — and making them a lot of money in the process. A decade ago, Tesla shares traded for around $18. The shares closed Friday at $322. Musk says the Austin test will begin modestly enough, with just 10 or 12 vehicles picking up passengers in a limited area. But then it will quickly ramp up and spread to other cities, eventually reaching hundreds of thousands if not a million vehicles next year. Some Musk watchers on Wall Street are skeptical. 'How quickly can he expand the fleet?' asks Garrett Nelson, an analyst at CFRA. 'We're talking maybe a dozen vehicles initially. It's very small." Morningstar 's Seth Goldstein says Musk is being classic Musk: Promising too much, too quickly. 'When anyone in Austin can download the app and use a robotaxi, that will be a success, but I don't think that will happen until 2028," he says. 'Testing is going to take a while.' Musk's tendency to push up the stock high with a bit of hyperbole is well known among investors. In 2018, he told Tesla stockholders he had 'funding secured' to buy all their shares at a massive premium and take the company private. But he not only lacked a written commitment from financiers, according to federal stock regulators who fined him, he hadn't discussed the loan amount or other details with them. More recently, Musk told CNBC in May that Tesla was experiencing a 'major rebound' in demand. A week later an auto trade group in Europe announced sales had plunged by half. Musk has come under fire for allegedly exaggerating the ability of the system used for its cars to drive themselves, starting with the name. Full Self-Driving is a misnomer. The system still requires drivers to keep their eyes on the road because they may need to intervene and take control at any moment. Federal highway safety regulators opened an investigation into FSD last year after several accidents, and the Department of Justice has conducted its own probe, though the status of that is not known. Tesla has also faced lawsuits over the feature, some resulting in settlements, other dismissed. In one case, a judge ruled against the plaintiffs but only because they hadn't proved Musk 'knowingly' made false statements. Musk says the robotaxis will be running on an improved version of Full Self-Driving and the cabs will be safe. He also says the service will be able to expand rapidly around the country. His secret weapon: Millions of Tesla owners now on the roads. He says an over-the-air software update will soon allow them to turn their cars into driverless cabs and start a side business while stuck at the office for eight hours or on vacation for a week. 'Instead of having your car sit in the parking lot, your car could be earning money,' Musk said earlier this year, calling it an Airbnb model for cars. 'You will be able to add or subtract your car to the fleet.' Musk says Tesla also can move fast to deploy taxis now because of his decision to rely only on cameras for the cars to navigate, unlike Waymo, which has gone a more expensive route by supplementing its cameras with lasers and radar. 'Tesla will have, I don't know,' Musk mused in an conference call with investors, '99% market share or something ridiculous.' Given Waymo's head start and potential competition from Amazon and others, dominating the driverless market to that extent could be a reach. But Dan Ives, a Wedbush Securities analyst and big Musk fan, says this time Musk may actually pull it off because of Tesla's ability to scale up quickly. And even skeptics like Morningstar's Goldstein acknowledge that Musk occasionally does gets things right, and spectacularly so. He upended the car industry by getting people to buy expensive electric vehicles, brought his Starlink satellite internet service to rural areas and, more recently, performed a gee-whiz trick of landing an unmanned SpaceX rocket on a platform back on earth. 'Maybe his timelines aren't realistic," Goldstein says, 'but he can develop futuristic technology products.'
Auto Blog
21 minutes ago
- Auto Blog
Wayfair is selling a ‘spacious' $124 outdoor storage box for only $73, and shoppers say it ‘holds a lot'
Autoblog aims to feature only the best products and services. If you buy something via one of our links, we may earn a commission. Summer is officially here and what better way to celebrate than by adding new outdoor essentials to your home? Wayfair is having its Big Outdoor Sale, where shoppers can save up to 50% on anything from outdoor grills to garage storage solutions. One of our favorite finds is the Keter Novel 90-Gallon Outdoor Storage Box, which is now on sale for just $73. Perfect for your deck, patio, garage, or pool, this versatile box will help you stay organized and ready for action this summer. Keter Novel 90-Gallon Outdoor Storage Box, $73 (was $124) at Wayfair Measuring 24.8 inches high and 49.2 inches wide, this storage box weighs about 23 pounds without any items inside. However, once you start storing your outdoor essentials, it has a weight capacity of a whopping 485 pounds. That means it can be used to hold anything from heavy power tools to bags of soil and fertilizer. Plus, it has a flat top so it can add extra seating wherever you place it. One reviewer said, 'I love this box! Super spacious and it really does pack it all in.' Another added, 'Lightweight but very sturdy and good price. Very easy to assemble.' A third shopper wrote, 'Perfect! It fits on the patio and holds the cushions for the chairs and loungers. It holds a lot! It also locks, if you need to use that feature. Also, [it] can be used as extra seating!' The box is made from a durable, weather-resistant polypropylene resin plastic that prevents denting, peeling, rusting, and fading during extreme conditions. It has a lockable lid and a handle on each side that makes it easy to transport from one place to another. You also won't have to worry about this storage box being an eyesore in your yard due to its subtle and neutral beige and brown color. Another shopper said, 'I love this deck box. Very easy to assemble together. Just snaps in place. Plastic not heavy, but sturdy and lots of space for storage.' Organize your yard with this $73 outdoor storage box. At 41% off, it's a deal you don't want to miss out on. About the Author Victoria Garcia View Profile
