Webb telescope spots infant planets in different stages of development
By Will Dunham
WASHINGTON (Reuters) -The James Webb Space Telescope has observed two large planets at different stages of infancy - one with an atmosphere brimming with dusty clouds and the other encircled by a disk of material - orbiting a young sun-like star in a discovery that illustrates the complex nature of how planetary systems develop.
The two gas giant planets, both more massive than our solar system's largest planet Jupiter, were directly imaged by Webb in a planetary system located in the Milky Way galaxy about 310 light years from Earth in the direction of the constellation Musca. A light-year is the distance light travels in a year, 5.9 trillion miles (9.5 trillion km).
Astronomers have detected more than 5,900 planets beyond our solar system - called exoplanets - since the 1990s, with less than 2% of these directly imaged like these two. It is rare to find exoplanets in their early developmental stages.
The birth of a planetary system begins with a large cloud of gas and dust - called a molecular cloud - that collapses under its own gravity to form a central star. Leftover material spinning around the star in what is called a protoplanetary disk forms planets.
This planetary system was observed by Webb very early in its developmental history. The star, named YSES-1, is about the same mass as the sun. The two planets orbit a long distance from the star, each probably needing thousands of years to complete a single orbit.
While the sun is roughly 4.5 billion years old, this star is approximately 16 million years old, a veritable newborn. The researchers were surprised to find that the two neonatal planets observed by Webb appeared to be at different stages of development.
The innermost of the two has a mass about 14 times greater than Jupiter and orbits the star at a distance 160 times greater than Earth orbits the sun and more than five times as far as our solar system's outermost planet Neptune.
The planet is surrounded by a disk of small-grained dust, a state one might expect in a very early stage of formation when it is still coalescing, or perhaps if there has been a collision of some kind or a moon is in the process of taking shape. Webb spotted water and carbon monoxide in its atmosphere.
The outermost planet has a mass about six times greater than that of Jupiter and orbits the star at 320 times the distance of Earth to the sun. Its atmosphere is loaded with silicate clouds, differing from our solar system's gas giants. Webb also detected methane, water, carbon monoxide and carbon dioxide in the atmosphere. It has no disk of material around it.
The puzzling combination of traits presented by these two planets in the same system illustrates "the complex landscape that is planet formation and shows how much we truly don't know about how planetary systems came to be, including our own," said astrophysicist Kielan Hoch of the Space Telescope Science Institute in Baltimore, who led the study published this week in the journal Nature.
"Theoretically, the planets should be forming around the same time, as planet formation happens fairly quickly, within about one million years," Hoch said.
A real mystery is the location where the planets formed, Hoch added, noting that their orbital distance from the host star is greater than would be expected if they formed in the protoplanetary disk.
"Furthermore, why one planet still retains material around it and one has distinct silicate clouds remains a big question. Do we expect all giant planets to form the same way and look the same if they formed in the same environment? These are questions we have been investigating for ages to place the formation of our own solar system into context," Hoch said.
In addition to amassing a trove of discoveries about the early universe since becoming operational in 2022, Webb has made a major contribution to the study of exoplanets with its observations at near- and mid-infrared wavelengths.
"Webb is revealing all sorts of atmospheric physics and chemistry happening in exoplanets that we didn't know before, and is currently challenging every atmospheric model we used pre-Webb," Hoch said.
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By GlobeNewswire Published on June 21, 2025, 04:34 IST Subcutaneous amycretin phase 1b/2a data on the safety, tolerability and weight loss potential in people with overweight or obesity was published in The Lancet and presented at the American Diabetes Association (ADA) Scientific Sessions. 1,2 and presented at the American Diabetes Association (ADA) Scientific Sessions. Oral amycretin phase 1 data on the safety, tolerability and weight loss potential in people with overweight or obesity was also published in The Lancet. 3 Findings from the clinical trials indicate amycretin appeared tolerable with a safety profile consistent with other GLP-1 and amylin receptor agonists.1,2,3 Bagsværd, Denmark, 20 June 2025 – Novo Nordisk announces subcutaneous amycretin data being presented at the American Diabetes Association (ADA) 85 th Scientific Sessions in Chicago, US.1 Full results of two clinical trials evaluating the safety, tolerability and weight loss potential of subcutaneous and oral amycretin in people with overweight or obesity were published today in The Lancet medical journal.1,3 Amycretin is the first treatment that combines GLP-1 and amylin receptor agonism biology in a single molecule. The published and presented results from the once-weekly subcutaneous amycretin phase 1b/2a clinical trial showed that participants who received the treatment demonstrated significantly greater weight loss across the full range of doses investigated compared to placebo. Data being presented at ADA were collected from two parts of the trial; dose escalation (amycretin 60 mg), and dose escalation and maintenance (amycretin 20 mg, 5 mg and 1.25 mg).1,2 No plateauing in weight reduction was observed at the end of treatment (ranging from 20 to 36 weeks) with all tested doses, suggesting that a longer treatment duration may potentially contribute to additional weight loss.1,2 Estimated mean change in body weight from baseline with once-weekly subcutaneous (SC) amycretin: 1,2 * Dose Treatment % Weight change % Weight change duration (SC amycretin) (placebo) 60 mg 36 weeks -24.3% -1.1%20 mg** 36 weeks -22.0% 1.9%5 mg** 28 weeks -16.2% 2.3% 1.25 mg** 20 weeks -9.7% 2.0% * If all people adhered to treatment i.e. if all people followed the planned dosing schedule for the full trial period without any treatment discontinuations. ** Administered during a 12-week maintenance period. Once-weekly subcutaneous amycretin treatment escalated up to 60 mg appeared tolerable with a safety profile consistent with other GLP-1 and amylin receptor agonists.1,2 The number of treatment-emergent adverse events (TEAEs) increased in a dose-dependent manner, were mostly gastrointestinal, and were comparable to the rate and profile of TEAEs reported in early-phase studies of GLP-1 receptor, GLP-1 receptor/gastric inhibitory polypeptide (GIP) receptor, and amylin receptor agonists.1,2 The majority of TEAEs were mild to moderate in severity and resolved by the end of the study period.1,2 Of the participants who discontinued the trial, the majority were due to non-TEAE reasons.1,2 'As pioneers in obesity innovation, we are exploring multiple biological pathways to develop potentially transformative medicines that support the individual needs and preferences of people with obesity on their weight loss journey towards overall improved health,' said Martin Holst Lange, executive vice president for Development at Novo Nordisk . 'Amycretin is the first investigational treatment that combines GLP-1 and amylin receptor agonism biology in one molecule, working on distinct pathways and offering complementary effects on appetite control. The findings published and presented today are encouraging. We are excited to advance the clinical development of subcutaneous and oral amycretin into phase 3 to assess its potential as a therapeutic option for weight management.' The published once-daily oral amycretin phase 1 clinical trial data showed that participants receiving amycretin achieved greater weight loss compared to placebo.3 After 12 weeks of treatment with amycretin up to 50 mg and up to 2 times 50 mg, participants achieved a mean change in body weight of -10.4% and -13.1% respectively, compared to -1.2% with placebo.3 There were no apparent signs of weight loss plateauing within the 12 weeks of treatment in either of these amycretin-treated groups.3 Once-daily oral amycretin appeared to have an acceptable safety profile and was tolerable in all tested doses, with TEAEs in line with what was expected from targeting GLP-1 and amylin receptors.3 All reported TEAEs occurred in a dose-proportional manner, were mild to moderate in severity, and mostly gastrointestinal. No new safety signals appeared during the study.3 Based on the findings from the oral and subcutaneous amycretin trials, Novo Nordisk recently announced it will advance amycretin into phase 3 trials to further investigate the treatment as a potential new therapeutic option for weight management.4 About amycretin Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development by Novo Nordisk, to provide an efficacious and convenient treatment for adults with overweight or obesity and for adults with type 2 diabetes. Amycretin is developed for subcutaneous and oral administration. Oral amycretin Phase 1 trial – The trial evaluated the single-ascending dose and multiple ascending doses for oral amycretin, up to 2 times 50 mg, in 144 people with overweight or obesity, with a total treatment duration of up to 12 weeks. Subcutaneous amycretin Phase 1b/2a trial – The trial investigated the safety, tolerability, pharmacokinetics, and proof-of-concept of once-weekly subcutaneous amycretin in 125 people with overweight or obesity. The trial was a combined single ascending dose, multiple ascending dose and dose-response trial investigating three different maintenance doses with a total treatment duration of up to 36 weeks. About Novo Nordisk Novo Nordisk is a leading global healthcare company founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 77,400 people in 80 countries and markets its products in around 170 countries. For more information, visit , Facebook , Instagram , X , LinkedIn and YouTube . Contacts for further information _______________________ References The Lancet: Dahl K, Toubro, S, Dey S, et al. Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: Results of a randomised, controlled, phase 1b/2a study. Dahl, K, et al. (2025). Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist: Results of a Phase 1b/2a Clinical Trial. Poster 2002-LB. American Diabetes Association (ADA) 85th Scientific Sessions, Chicago, US, June 20 – 23, 2025. The Lancet: Gasiorek A, Heydorn A, Gabery S, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, randomised, placebo-controlled study. Novo Nordisk Company Announcement. Novo Nordisk to advance subcutaneous and oral amycretin for weight management into phase 3 clinical development. Available at: Attachment Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash GlobeNewswire provides press release distribution services globally, with substantial operations in North America and Europe.

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