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2 private satellites undock after pioneering life-extension mission

2 private satellites undock after pioneering life-extension mission

Yahoo18-04-2025

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Two commercial satellites have completed an undocking maneuver high above Earth, signaling the successful end to a pioneering spacecraft life-extension mission.
The Mission Extension Vehicle-1 (MEV-1), developed by Northrop Grumman Corporation's Space Logistics LLC, docked with Intelsat's IS-901 communications satellite in 2020 in a graveyard orbit, a few hundred miles above geosynchronous orbit (GEO), an orbital belt 22,236 miles (35,786 kilometers) above Earth.
MEV-1, which launched atop a Russian Proton rocket in October 2019 from Baikonur Cosmodrome in Kazakhstan, then brought IS-901 back to GEO and allowed it to restart its operations. But now, after extending the life of IS-901 for five years, the mission has come to an end.
IS-901 has been taken back into the GEO graveyard — where decommissioned satellites are positioned to remove them safely from the active GEO belt — by MEV-1. There, the two spacecraft undocked. Just as the 2020 rendezvous was the first docking between commercial spacecraft in GEO, this marks the first such commercial undocking.
Related: Watch Northrop Grumman's MEV-1 dock with Intelsat 901!
This is not the end for MEV-1, however, as the spacecraft is currently relocating to the next servicing mission, according to Northrop Grumman. This is all part of the company's plans to provide life-extension services for satellites in GEO.
"The first-of-its kind technology that extended a satellite's life is paving the way for an entire infrastructure of future on-orbit satellite servicing missions for a variety of customers," Rob Hauge, president of Northrop Grumman Space Logistics, said in an April 9 statement. "We are continuing to invest in next-generation capabilities to deliver the most technologically advanced servicing capabilities to support and maintain new and existing space-based assets."
MEV-1 is not the only player in the satellite life-extension game. Northrop Grumman Space Logistics' follow-on spacecraft, MEV-2, is currently docked to Intelsat 10-02 and will continue providing life-extension services for an additional four years.
— Private Astroscale probe will refuel Space Force satellites high above Earth on landmark 2026 mission
— Ailing Intelsat satellite begins new life in orbit after historic servicing mission success
— NASA cancels multibillion-dollar on-orbit satellite servicing mission
The U.S. Space Force also recently tapped Northrop Grumman for the Elixir refueling payload program, which will "enable the Space Force to refine tactics and procedures for rendezvous and proximity operations, docking, refueling, and undocking of on-orbit vehicles," according to a different Northrop Grumman statement.
Meanwhile, Astroscale U.S. will attempt to refuel a pair of Space Force spacecraft in 2026, following an announcement at the 40th Space Symposium in Colorado Springs earlier this month. Elsewhere, China launched its own experimental refueling spacecraft, Shijian 25, in January this year.
Countries and companies are pursuing life extension and satellite-servicing capabilities for a range of uses and reasons, including reducing space debris, potential cost savings and enabling flexible and sustainable satellite operations.

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Satellite image of an Iranian airport shows an American-made F-14 Tomcat that Israel turned into a burned wreck
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Satellite image of an Iranian airport shows an American-made F-14 Tomcat that Israel turned into a burned wreck

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Novo Nordisk's subcutaneous and oral amycretin data published in The Lancet and presented at ADA 2025
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Novo Nordisk's subcutaneous and oral amycretin data published in The Lancet and presented at ADA 2025

By GlobeNewswire Published on June 21, 2025, 04:34 IST Subcutaneous amycretin phase 1b/2a data on the safety, tolerability and weight loss potential in people with overweight or obesity was published in The Lancet and presented at the American Diabetes Association (ADA) Scientific Sessions. 1,2 and presented at the American Diabetes Association (ADA) Scientific Sessions. Oral amycretin phase 1 data on the safety, tolerability and weight loss potential in people with overweight or obesity was also published in The Lancet. 3 Findings from the clinical trials indicate amycretin appeared tolerable with a safety profile consistent with other GLP-1 and amylin receptor agonists.1,2,3 Bagsværd, Denmark, 20 June 2025 – Novo Nordisk announces subcutaneous amycretin data being presented at the American Diabetes Association (ADA) 85 th Scientific Sessions in Chicago, US.1 Full results of two clinical trials evaluating the safety, tolerability and weight loss potential of subcutaneous and oral amycretin in people with overweight or obesity were published today in The Lancet medical journal.1,3 Amycretin is the first treatment that combines GLP-1 and amylin receptor agonism biology in a single molecule. The published and presented results from the once-weekly subcutaneous amycretin phase 1b/2a clinical trial showed that participants who received the treatment demonstrated significantly greater weight loss across the full range of doses investigated compared to placebo. Data being presented at ADA were collected from two parts of the trial; dose escalation (amycretin 60 mg), and dose escalation and maintenance (amycretin 20 mg, 5 mg and 1.25 mg).1,2 No plateauing in weight reduction was observed at the end of treatment (ranging from 20 to 36 weeks) with all tested doses, suggesting that a longer treatment duration may potentially contribute to additional weight loss.1,2 Estimated mean change in body weight from baseline with once-weekly subcutaneous (SC) amycretin: 1,2 * Dose Treatment % Weight change % Weight change duration (SC amycretin) (placebo) 60 mg 36 weeks -24.3% -1.1%20 mg** 36 weeks -22.0% 1.9%5 mg** 28 weeks -16.2% 2.3% 1.25 mg** 20 weeks -9.7% 2.0% * If all people adhered to treatment i.e. if all people followed the planned dosing schedule for the full trial period without any treatment discontinuations. ** Administered during a 12-week maintenance period. Once-weekly subcutaneous amycretin treatment escalated up to 60 mg appeared tolerable with a safety profile consistent with other GLP-1 and amylin receptor agonists.1,2 The number of treatment-emergent adverse events (TEAEs) increased in a dose-dependent manner, were mostly gastrointestinal, and were comparable to the rate and profile of TEAEs reported in early-phase studies of GLP-1 receptor, GLP-1 receptor/gastric inhibitory polypeptide (GIP) receptor, and amylin receptor agonists.1,2 The majority of TEAEs were mild to moderate in severity and resolved by the end of the study period.1,2 Of the participants who discontinued the trial, the majority were due to non-TEAE reasons.1,2 'As pioneers in obesity innovation, we are exploring multiple biological pathways to develop potentially transformative medicines that support the individual needs and preferences of people with obesity on their weight loss journey towards overall improved health,' said Martin Holst Lange, executive vice president for Development at Novo Nordisk . 'Amycretin is the first investigational treatment that combines GLP-1 and amylin receptor agonism biology in one molecule, working on distinct pathways and offering complementary effects on appetite control. The findings published and presented today are encouraging. We are excited to advance the clinical development of subcutaneous and oral amycretin into phase 3 to assess its potential as a therapeutic option for weight management.' The published once-daily oral amycretin phase 1 clinical trial data showed that participants receiving amycretin achieved greater weight loss compared to placebo.3 After 12 weeks of treatment with amycretin up to 50 mg and up to 2 times 50 mg, participants achieved a mean change in body weight of -10.4% and -13.1% respectively, compared to -1.2% with placebo.3 There were no apparent signs of weight loss plateauing within the 12 weeks of treatment in either of these amycretin-treated groups.3 Once-daily oral amycretin appeared to have an acceptable safety profile and was tolerable in all tested doses, with TEAEs in line with what was expected from targeting GLP-1 and amylin receptors.3 All reported TEAEs occurred in a dose-proportional manner, were mild to moderate in severity, and mostly gastrointestinal. No new safety signals appeared during the study.3 Based on the findings from the oral and subcutaneous amycretin trials, Novo Nordisk recently announced it will advance amycretin into phase 3 trials to further investigate the treatment as a potential new therapeutic option for weight management.4 About amycretin Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development by Novo Nordisk, to provide an efficacious and convenient treatment for adults with overweight or obesity and for adults with type 2 diabetes. Amycretin is developed for subcutaneous and oral administration. Oral amycretin Phase 1 trial – The trial evaluated the single-ascending dose and multiple ascending doses for oral amycretin, up to 2 times 50 mg, in 144 people with overweight or obesity, with a total treatment duration of up to 12 weeks. Subcutaneous amycretin Phase 1b/2a trial – The trial investigated the safety, tolerability, pharmacokinetics, and proof-of-concept of once-weekly subcutaneous amycretin in 125 people with overweight or obesity. The trial was a combined single ascending dose, multiple ascending dose and dose-response trial investigating three different maintenance doses with a total treatment duration of up to 36 weeks. About Novo Nordisk Novo Nordisk is a leading global healthcare company founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat serious chronic diseases built upon our heritage in diabetes. We do so by pioneering scientific breakthroughs, expanding access to our medicines, and working to prevent and ultimately cure disease. Novo Nordisk employs about 77,400 people in 80 countries and markets its products in around 170 countries. For more information, visit , Facebook , Instagram , X , LinkedIn and YouTube . Contacts for further information _______________________ References The Lancet: Dahl K, Toubro, S, Dey S, et al. Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: Results of a randomised, controlled, phase 1b/2a study. Dahl, K, et al. (2025). Amycretin, a Novel, Unimolecular GLP-1 and Amylin Receptor Agonist: Results of a Phase 1b/2a Clinical Trial. Poster 2002-LB. American Diabetes Association (ADA) 85th Scientific Sessions, Chicago, US, June 20 – 23, 2025. The Lancet: Gasiorek A, Heydorn A, Gabery S, et al. Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, randomised, placebo-controlled study. Novo Nordisk Company Announcement. Novo Nordisk to advance subcutaneous and oral amycretin for weight management into phase 3 clinical development. Available at: Attachment Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash GlobeNewswire provides press release distribution services globally, with substantial operations in North America and Europe.

Diabetes drug may cut migraine days in half with little weight loss: Study

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Diabetes drug may cut migraine days in half with little weight loss: Study

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