
The chemicals in your drinking water that are harming your health (and how to avoid them)
Forever chemicals are part and parcel of modern life. Whether you're pulling on a waterproof jacket, grabbing a coffee in a paper cup, or unwrapping a takeaway, chances are your body's absorbing them. There's more than 10,000 of these synthetic compounds today, which are prized for their resistance to water, oil and stains. That makes them incredibly useful, but nearly impossible to avoid.
First developed in the 1930s in both Germany and the United States, PFAS became widely commercialised in the 1950s when US company DuPont used PFOA (perfluorooctanoic acid) to create Teflon, the world's first non-stick coating. Their chemical structure – bonding carbon with fluorine – makes them nearly impossible to break down. As a result, they can persist in the environment for hundreds or even thousands of years, earning them the nickname 'forever chemicals'.
Where are they?
This persistence means PFAS are now ubiquitous. They are found in soil, air, drinking water, rainwater, and even the blood of nearly every person on Earth.
Why do we need to avoid them?
The use of the most dangerous PFAS chemicals, PFOA and PFOS (perfluorooctane sulfonic acid), were phased out in the United States, the UK and many other countries beginning in the early 2000s, after studies linked them to cancer, immune system suppression, thyroid disease, liver damage, developmental delays in children, and fertility issues.
However, although they are not used in the manufacture of new products in the UK, those toxic, banned chemicals will never disappear from our environment. They exist in the water we drink and the soil that grows our food. More worrying is that these banned substances have been replaced by newer, supposedly less harmful, forever chemicals. These haven't been shown to cause health problems yet, but that doesn't mean we shouldn't be worried.
Dr Dave Megson, a chemistry and environmental forensics scientist at Manchester Metropolitan University, says: 'I'm still concerned about them. We've banned the two chemicals we know the most about, but the replacement chemicals are very similar. They're just less understood and their toxicity hasn't been fully confirmed. That seems to be the loophole because we haven't proven they're harmful yet, they're still allowed.'
He thinks they will be banned in time and 'we're just waiting for the toxicological data to catch up. We need time to prove how harmful these new PFAS are.'
Ian Cousins, professor of environmental organic chemistry at Stockholm University, thinks that most uses are unnecessary. 'We should not be using them because they're so persistent, and there are alternatives on the market.'
Last month, the UK's Environmental Audit Committee launched a formal inquiry into PFAS contamination and regulation across the UK. They're concerned that the evidence showing they harm human health is not being taken seriously enough. The UK is lagging behind most other developing countries when it comes to regulating forever chemicals.
The EU is moving forward with a comprehensive proposal to restrict the manufacture, use and marketing of approximately 10,000 PFAS. Currently, the UK has banned several specific PFAS chemicals found in firefighting foams, such as Perfluorooctane Sulfonate (PFOS), banned over a decade ago, and Perfluorooctanoic Acid (PFOA), which will be banned from July this year.
It's no surprise, given the UK's lack of regulation that a global study assessing blood serums containing PFAS, found UK concentrations to be amongst some of the highest in the world.
But while we are waiting for the UK government to catch up with the rest of the world, there are measures that worried consumers can take to reduce their exposure.
Ditch plastic bottles and get a water filter
Despite water companies having to dilute contaminated water with purer water or use an alternative source, PFAS are still getting into drinking water. PFAS were found in more than half of samples of Scottish drinking water taken in 2023. PFAS have also been found in both bottled and tap water samples in the UK.
The Environment Agency has identified over 10,000 sites across England as high-risk for PFAS contamination, many associated with firefighting foam which contained now banned PFAS.
Prof Cousins says that people should be especially concerned if they live near an industrial or military site that may have used firefighting foam in the past.
'That is a particularly nasty PFAS and you don't want to be exposed to it. So if you live in that [kind of] area I would consider getting my water tested and install a water filter.'
Several UK sites are under investigation for PFAS contamination from firefighting foam. At AGC Chemicals in Thornton-Cleveleys, Lancashire, over 100 tonnes of PFOA (now a banned chemical) were released between 1950 and 2012, prompting soil and water testing. In Norfolk, RAF Marham is being examined after PFAS were found in local drinking water, with bottled water now being supplied to residents. Duxford's former RAF base, now an Imperial War Museum site, is also being monitored due to potential contamination of nearby aquifers.
The most effective water filters for removing PFAS use reverse osmosis, activated carbon, or ion exchange. Reverse osmosis systems can remove up to ninety-nine per cent of PFAS, while activated carbon filters also work well if the filters are changed regularly. Good examples include Berkey Water Filters, which use carbon elements tested for PFAS removal, and the Aquasana OptimH2O, which combines reverse osmosis and carbon filtration.
Dr Megson offers some reassurance. 'The UK has some of the most tested and regulated water in the world. In known hotspots water is regularly blended and monitored to stay within guidelines.
Get an air filter
Carpets might be cosy and warm underfoot but increasingly researchers are raising concerns over them as a hidden source of PFAS. They are often added to carpets to make them stain and water resistant. Walking on them creates dust that can reach breathing height.
'People think of contamination as something outside, but indoor dust is significant. For example, carpets treated with Scotchgard in the 1990s are now breaking down releasing PFAS as the fibres degrade,' says Dr Megson.
A recent study led by Dr Scott Bartell at the University of California, Irvine, found that people living with carpets consistently showed higher blood PFAS levels than those with bare floors. His conclusion? Carpets are a significant and underestimated source of exposure.
Oliver Jones, professor of chemistry, at RMIT University in Melbourne says that 'if you really want to reduce exposure, you should start by looking at where the largest sources of PFAS to humans are. Evidence suggests it's dust in the air.' He recommends getting an air filter.
While a standard mechanical air filter, known as an HEPA filter can trap particulate-bound PFAS (like those stuck to dust), a better choice would be an activated carbon air filter. The critical difference: they can remove gaseous PFAS from the air. For broader protection, a combination of both HEPA and activated carbon filtration is ideal.
Activated carbon works by adsorbing chemicals at a molecular level, capturing many volatile PFAS compounds that might otherwise circulate freely in your home. Not all air purifiers are created equal, though. Look for units with large activated carbon beds and a high Clean Air Delivery Rate (CADR).
Vacuum with a HEPA filter: a high-efficiency vacuum can reduce PFAS-laden dust. Models like Dyson's Gen5outsize (£1,000) or the more affordable Shark Detect and Empty (£350) both offer strong filtration, though only some include activated carbon filters to trap gases.
Swap parchment and foil and consider alternatives to your non-stick pan
Parchment paper, wax paper and foil are regular fixtures in most kitchens. They are the kind of supplies people use without thinking twice. But research has found that some of these everyday items may be coated with PFAS.
When exposed to high temperatures, especially in ovens or on grills, PFAS can break down and potentially seep into the food. That means cooking something as simple as vegetables in foil, or lining a tray with treated paper, could become a source of unwanted chemical exposure over time.
'There are lots of kitchen items with PFAS, including baking paper, non-stick pans and even dishwasher tablets,', says Dr Megson. 'Not all of them transfer large amounts to your food, but some still do. Some parchment paper contains PFAS. But if you're baking a cake once a month, the exposure is minimal compared to what you get from your diet or potentially your water.'
'It's death by a thousand paper cuts. It might be small amounts, but it all adds up in burger wrappers, coffee cups, dishwasher tablets, makeup and workout clothes,' he says.
A simple solution that creates a similar non-stick effect is to coat your pan with butter and cover it with flour.
The following retailers provide some PFAS-free alternatives: Green Safe Products, Clondakin Group, Nordic Paper.
Stop wearing Lycra leggings to the gym
PFAS are also found in a lot of athletic clothing including popular Lycra leggings. They are added to fabrics to make them water and stain resistant, or to help wick sweat away from the skin, which is common in performance gear. A 2022 investigation by Toxic Free Future found that more than 70 per cent of sportswear tested contained PFAS, including items from well-known brands.
Researchers at Birmingham University also found that sweating makes it easier for the body to absorb these chemicals into the body.
There are plenty of PFAS-free options. Look for those made from natural fabrics, such as organic cotton, hemp and bamboo. These selections represent a range of PFAS-free sportswear options from reputable brands: Patagonia has been working to eliminate PFAS from its products, and offers items like the Cap Cool Daily Shirt. Sweaty Betty's Ultimate Studio Twin Strap Bra Vest is designed without PFAS.
PFAS can be used to waterproof outdoor clothing. The performance clothing company Rab has been actively working to eliminate PFAS from its products. As of autumn/winter 2024, approximately 95 per cent of Rab's fabrics with durable water repellent (DWR) treatments are PFAS-free. Patagonia Torrentshell 3L rain jacket and North Face's Resolve 2 jacket are PFAS- free.
Opt for natural nails
'I think the cosmetics industry has got away [with it] pretty lightly at the moment, whereas the clothing industry has had to do quite a lot,' said Dr Megson.
He is worried about gym users applying make-up. 'I'd expect people to get more exposure through make-up than clothes. A lot of people now wear make-up in the gym because they want to look good while exercising. So they go for the really tough 72-hour formulas because they don't want it to run. The reason it stays on so well is because it's packed with PFAS, which resist sweat and water.'
Many everyday cosmetics like nail polish, lipstick, mascara, and foundation contain chemicals PFAS, added because they help make products more durable, waterproof, and longer-lasting.
Natural and organic beauty products often avoid these synthetic chemicals altogether.
Several UK brands now offer PFAS-free nail varnishes and polishes that focus on safer, non-toxic ingredients. Popular options include Zoya, known for formulas free from harmful chemicals like PFAS and Piggy Paint, which provides non-toxic, water-based polishes safe for sensitive skin. Axiology offers clean beauty products with PFAS-free nail polishes.
Ditch ready meals and plastic packaging
'Fast food packaging is another unnecessary use of PFAS. It's done purely for convenience. It's there to stop grease from soaking through. We don't want a greasy stain on our shorts or trousers when we're eating a burger. But in warm, moist conditions, like with a wrapped burger, more chemicals can transfer. So it's an extra load we really don't need,' says Dr Megson.
'Pizza boxes are some of the worst and most unnecessary use of PFAS,' says Prof Cousins. 'Instead of using chemicals to stop the fats from the pizza escaping the box, they should make thicker boxes.'
Some PFAS-free alternatives include uncoated paper and cardboard, which are suitable for dry foods like sandwiches and pastries and can be recycled or composted. Bioplastic-coated paper, made with plant-based polylactic acid (PLA), offers compostable options. Containers made from sugarcane byproducts, known as bagasse, are naturally grease- and water-resistant, microwave-safe, and home compostable, making them ideal for takeaway plates and containers.
However, the raised awareness about PFAS is having an impact on businesses. McDonald's has committed to eliminating them from its food packaging globally by 2025. While US Tex-Mex chain Chipotle committed to eliminating PFAS from all packaging by 2024 and has made significant progress.
Stop using throw-away coffee cups
To keep hot drinks from soaking through paper cups, they are lined with a thin layer of plastic-like material.
'These cups contain PFAS,' said Prof Cousins. 'Remember though that not all PFAS are the same. They have short chains unlike the older ones that were banned. These substances have not so far been linked to human health effects. However, they are persistent and will accumulate in the environment, which is not a good thing. Toxicity is about dose, so if they continue to accumulate, they are likely to be a problem in the future.'
If you're concerned, a simple way to steer clear is to carry a reusable cup made from materials like stainless steel, glass or silicone.
What else we should be aware of?
Both Dr Megson and Prof Cousins says that we absorb a lot of PFAS through the food chain.
'I wouldn't eat any fish or shellfish from Morecambe Bay. I wouldn't touch the estuary because it is terribly contaminated, says Prof Cousins. I'd be suspicious of eggs reared at home or in these areas, and home-grown vegetables if you live near a hot spot. I would avoid freshwater fish from polluted rivers.'
Strawberries sold in the UK have been found to contain high levels of pesticide residues that include PFAS. A 2022 review of government testing data, analysed by Pesticide Action Network UK (PAN UK), found that nearly all of the strawberry samples, 95 per cent, contained traces of PFAS-related pesticides.
Strawberries appear to be particularly vulnerable due to the types of pesticides used, and the fruit's porous surface. Other fruits and vegetables, including grapes, spinach, cherries, and tomatoes were also found to carry PFAS residues.
We even ingest PFAS through meat, butter and eggs
'We get a lot of our PFAS in our bodies from our diet,' says Dr Megson. Wastewater sludge or slurry which is used as a fertiliser is packed full of PFAS. Animals grazing on contaminated land or drinking polluted water can accumulate PFAS in their tissues, which then passes up to the food chain to humans.
Going organic is the best solution to avoid PFAS. Washing fruit and vegetables thoroughly to try to remove as much of them as possible.
Can you remove PFAS from the body?
Recent research has shown that donating blood or plasma and taking specific medications can help reduce PFAS levels in the body. A 2022 Australian study found that regular blood donations lowered PFAS concentrations by about 10 per cent, while plasma donations, which remove more of the protein-bound PFAS, reduced levels by up to 30 per cent over a year.
Additionally, clinical trials are exploring the use of cholestyramine, used to lower cholesterol. This medication binds to PFAS in the digestive system, helping eliminate them through the liver. While these methods don't eliminate PFAS entirely, they offer promising ways to reduce the body's chemical burden, especially for those with high exposure.
How are microplastics and PFAS linked?
PFAS and microplastics can be linked.
Microplastics are tiny plastic particles (less than 5mm) that result from the breakdown of larger plastic waste or are manufactured at that size, commonly polluting oceans, soil, and even food.
PFAS can bind to or coat microplastics in the environment, effectively hitching a ride on these tiny plastic particles. This combination may increase the potential for PFAS to enter the food chain, as microplastics are ingested by marine life and other organisms. So while they are chemically distinct, they can interact and amplify each other's environmental impact.

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Telegraph
36 minutes ago
- Telegraph
British rocket launch backed by Labour falls further behind in space race
A British rocket start-up backed by Labour has pushed back the date of its first launch and is hunting fresh funding as the UK faces falling further behind in the space race. Orbex, which in January received a £20m investment from the taxpayer, confirmed its first test launch from the Shetland Islands would be in 2026, rather than later this year as hoped. The start-up is building its 62ft Orbex Prime rocket at a factory in Scotland, which is intended to carry small satellites into space. After securing taxpayer support, Orbex is now seeking a further £120m in funding from private investors over the next four years to bring its ambitions to reality, it said in a submission to MPs. The company is also pushing for further government backing, calling for support for its bid to build a new, larger rocket for the European Space Agency. The space organisation, of which the UK is a member, is offering companies up to £144m for its European Launcher Challenge as Europe seeks alternatives to its current reliance on Elon Musk's SpaceX. Orbex has been lobbying for Labour's £7bn National Wealth Fund to back the space sector, which it said in a consultation filing to MPs could 'level the playing field and unlock significant value for the UK economy'. The delay to Orbex's mission comes after a series of setbacks for Britain's fledgling launch industry. After a failed launch from Cornwall in 2023, Sir Richard Branson's Virgin Orbit went bankrupt. Since then, no new attempts at an orbital mission have gone ahead. Now, a number of small rocket companies are seeking to launch from UK soil, largely from Saxavord, a spaceport on the Shetland Islands, although they have faced delays. German start-up, Rocket Factory Augsburg, is still targeting a mission this year from Shetland, although its last test ended with its rocket exploding on the launchpad. Skyrora, a Scottish start-up, is hoping to launch from Shetland next year. A spokesman for Orbex said: 'There are many factors at play in determining our launch schedule, including licensing and launch logistics. This is not unusual.' The spokesman added government support would be needed to build a European rocket: 'National funding commitments and private investment will both be needed for winning bidders. 'UK Government support for our sector will send a clear signal to ESA that UK orbital launch companies like Orbex are a smart choice and long-term partner.'


The Guardian
an hour ago
- The Guardian
I was diagnosed with PCOS – and was soon drowning in misinformation
I suspected I had polycystic ovary syndrome (PCOS) long before it was confirmed. The signs were there: the acne scars that littered my back, the irregular periods, the hair in places on my body that I didn't see on many of my friends. I suspected it from the moment that one of my best friends, who as a girl taught me about bleaching my body hair and waxing my legs, was diagnosed with it as a teenager. Admitting all this publicly feels like an unburdening, but also an invitation to more shame. But I write this because my experience is far from unique. As many as one in 10 women have PCOS, a condition associated with hormonal disturbances that can range from weight gain, 'unwanted' body hair and hair loss, to irregular periods and struggles to conceive children (including an increased risk of miscarriage). It can leave women more likely to develop high blood pressure, high cholesterol, diabetes and heart disease. It is not clear what causes PCOS, but it is known to be passed down generational lines and can be influenced by lifestyle. I was finally diagnosed with PCOS last year, at 30, and have been on a journey to understand what that means ever since. The thing that leaped out at me early on (and has since been uncovered by the BBC) is just how much information, and misinformation, exists around the condition. My Instagram feed is filled with medically unqualified influencers. Sorting through all that to figure out which nutritionists and health professionals to pay attention to, in the absence of adequate support from the doctors and nurses who gave me that initial assessment and diagnosis, has been a battle. I've been encouraged to adopt unrealistic diets (so-called 'PCOS nutritionists' often suggest cutting out gluten, dairy and carbohydrates, despite a lack of evidence to show this is sustainable or useful for the condition); take unregulated supplements that can have significant side-effects; and sign up to expensive health plans and apps. I've been told to stop doing cardio and focus instead on weights and walking, because of the misguided idea that high-intensity exercise will cause my cortisol levels to rise to the degree that it will worsen my symptoms. In reality, all types of exercise can be beneficial. Medical misogyny has been well documented, and women's healthcare is rarely taken seriously. I first asked my GP about symptoms during the pandemic, when, after a blood test, I was told that my hormone levels were normal and I didn't have the condition. Later, having an ultrasound for an unrelated matter, I was unceremoniously told that I had lots of follicles on my ovaries and probably had PCOS. When I mentioned the earlier blood test, the sonographer told me that this is not a good way to diagnose the condition, especially if you are using hormonal birth control. Confusingly, PCOS does not cause cysts on the ovaries. 'They're not actual true cysts,' says Helena Teede, an Australian endocrinologist and expert in PCOS at Monash University in Melbourne. 'They're follicles or eggs that are just developing along a pathway, but they stop developing normally because they don't like the hormones that they're floating around in.' There has long been chatter about renaming PCOS to something that is more representative of the breadth of symptoms it causes. The current name, Teede says, 'completely misses the fact that this is a hormonal condition; that it has long-term impacts; that it is psychological, dermatological, metabolic, reproductive and, beyond fertility, it goes into many other reproductive features. And it really has an impact on quality of life.' She says it's likely that the process to give it a new name will be completed this year – her organisation has opened a survey for anyone who wants to contribute. Another myth is that women with the condition have a significant 'excess' of testosterone. And PCOS does open up some interesting questions about gender. But, says Teede, the idea that testosterone is an exclusively male hormone is false. Plus, women with PCOS do not typically have elevated levels of testosterone; it's more that our bodies are not very good at dealing with it. We have much less of the hormone than most men. After my diagnosis at the ultrasound, I had a follow-up call with a nurse practitioner, where I was told simply that I should put up with my symptoms but come back when I wanted to get pregnant; because, of course, that is the only thing that young women aspire to. When I pushed, I was offered a drug named metformin, which is used to treat insulin resistance and diabetes. It wasn't explained to me how this drug works and why it would be useful for my specific case. But, I have since learned, insulin resistance – when your body struggles to regulate your blood sugar levels – is one of the hallmark symptoms of PCOS and triggers a lot of the other issues that people with the condition face. Teede, however, points out that 'every woman has a different problem and a different life stage that's most important to them, and it's about their interpretation'. Doctors should think holistically about treatment plans for women with PCOS and listen to their concerns. My own contrasting experience, though, is much more common, says Rachel Morman, the chair of the UK PCOS charity Verity: 'After 20 years of doing this work, I'm like: 'Why is this still happening?'' She had a similar conversation with doctors after she was diagnosed in the early 00s, with the added shock of being told that she wouldn't be able to have children at all. While it is true that about 70% of women with PCOS experience fertility struggles, after intervention that number drops significantly; the vast majority of women with the condition are able to get pregnant. Morman has three children now. It's also important for women to know that a lot of the risks associated with PCOS in pregnancy (such as miscarriage, gestational diabetes and pre-eclampsia) are preventable. Before they start trying for a baby, women with the condition should have a full diabetes test and get their blood pressure checked, as well as aim for a healthy diet and active lifestyle. But when doctors tell us that PCOS is something we should be concerned about only if we want to get pregnant, that is extremely frustrating, considering the wide range of effects it has on our bodies. Morman says that while there is a lot more information available now than when she was diagnosed, some treatment options have become worse: hair removal treatments used to be offered on the NHS for women diagnosed with PCOS, but not any more. As Teede acknowledges: 'One of the reasons why people go to alternative sources of information is because they're not satisfied with what they get from the health practitioners.' Misinformation about PCOS abounds, and much of it is repeated by medical professionals. To help counteract this, Teede helped to develop the extensively researched international evidence-based guidelines for PCOS in 2023, which I now regard as the holy grail of information about the condition. Her team has also created an app called AskPCOS, which can help women to find the right treatment pathways. It doesn't cover everything, but it is thorough, uses up-to-date research and doesn't make bold claims about 'curing' PCOS, as some people do on social media. 'There are a whole lot of individual practitioners, most of whom are not actually practitioners, who are there for financial gain,' says Teede. 'The biggest challenge I have is the misinformation, and then associated with that, the harm that's done by denigrating actual evidence-based strategies. Which, in the end, does a disservice for women with the condition.' She is not wholly against what she terms 'complementary therapies' (ie supplements and diets), as long as women undertake them clear-eyed and unswayed by false claims. But she does not believe people will stop looking to these types of practitioners for support until there are more trustworthy medical repositories, alongside legal liability for people who provide misinformation. Having researched PCOS over the past year (though there's still much to learn), here's what I've tried: in terms of monitoring the metabolic symptoms, I've checked my blood pressure and had screenings for diabetes and high cholesterol. My levels were fine. I've come off my birth control (some types of pill can help with the symptoms of PCOS; this one didn't) and started taking a well-researched supplement called myo-inositol, which may help with insulin resistance. But I've since come off it because it made me dizzy, a known side-effect for some people. I get periods most months, though I did so before I was put on the pill in my teens, so this may not have affected my ovulation. In terms of cosmetic treatments, I have moved away from laser hair removal, which can cause women with PCOS to experience paradoxical hypertrichosis – the regrowth of darker hairs, seemingly stimulated by the laser. Instead, I have begun electrolysis, the only way to permanently remove hairs. I'm on a break from it as the treatment has been slow and moderately painful, causing breakouts that take weeks to heal. Thankfully, the acne on my face has never been severe, but I have got topical treatment for it from an online dermatologist and benzoyl peroxide from my GP. My body acne has taken longer to get under control; I had a private online consultation with a dermatologist, which cost me £100, and have found reasonably priced skincare products that mostly work for me (shout out to Cerave). The reason I am sharing this is not so that others with PCOS can attempt to mirror my journey. Everyone is different. For example, some women are comfortable with having visible facial hair. It is not inherently shameful and I hate that it is considered to be so. Instead, I am sharing because it shows how much time and energy I have had to put into dealing with PCOS. As it stands, all women with the condition need to go on a journey of evidence-based self-education, because it is unlikely that their primary care doctors will be able to adequately direct them, and there are very few accessible specialists. We have to test out treatments and cosmetic procedures – many unregulated – for ourselves, working through trial and error. Perhaps one of the biggest learnings I've taken from this year has been around mental expenditure. While we undoubtedly have to demand better treatment from our doctors, and ask them to seek out research, those of us with chronic conditions have personal choices to make. Even in an ideal system, where I could be supported on and off medication with all the necessary tests, I would still have to make a judgment call about how much time and energy to invest in 'managing' my PCOS. It is lifelong and incurable, and, for me at least, learning to live with it has become just as important as tackling some of the issues that it causes. That is not to say people with PCOS should give up – learn to embrace their facial hair or uncomfortable acne, or the more serious difficulties related to heart health or diabetes – but it does move it in my mind from a space of hopelessness to one of pragmatism. And it has allowed me to give myself a mental break. 'You do need to have at least four periods a year, because otherwise it's a higher risk of getting cancer of the womb, for example,' says Teede. She says that people with PCOS must go for an annual checkup, including blood pressure tests. 'But you don't need to carry that around permanently,' she adds. The other brilliant news is that, in the background, things are changing. A new study shows that awareness of the syndrome has grown massively in the past eight years. In the UK, there is collaborative work happening to make sure that the syndrome becomes a research priority, including an all-party parliamentary group. 'We'll actually have proper pathways for PCOS treatment, so hopefully that should improve standard of care,' says Morman. For me, I had my foray into the land of misinformation and I battled my way out of it. I have sought out community with other women who have the condition, and I'm taking steps to mitigate its potential effect on my fertility in the future. Most of all, I feel incredibly thankful that I have been diagnosed in an era where there are women like Teede and Morman who are fighting for the recognition and evidence-based treatment of PCOS. We are not at a loss. We are at the bright beginning.


Reuters
an hour ago
- Reuters
Data on Novo Nordisk experimental weight-loss drug show mostly mild side effects
June 22 (Reuters) - Novo Nordisk ( opens new tab on Sunday said full results from two late-stage trials of its experimental weight-loss drug CagriSema show that side effects were mainly mild-to-moderate and other outcome results, including blood sugar levels, were positive. The company had previously announced top-line results for the 68-week studies, which found that CagriSema led to nearly 23% weight loss for overweight or obese adults, while overweight type 2 diabetics lost nearly 16% of their weight. Those results, however, disappointed investors, sending Novo's shares lower. The company last month ousted its CEO Lars Fruergaard Jorgensen. The full Phase 3 results were presented in Chicago at the annual meeting of the American Diabetes Association and published in the New England Journal of Medicine. In the obesity trial, 79.6% of CagriSema patients had mainly transient, mild-to-moderate gastrointestinal effects such as nausea, vomiting and constipation, compared with 39.9% of placebo patients. Serious adverse events occurred in 9.8% of CagriSema patients and 6.1% of placebo patients. In the CagriSema group, 6% of patients dropped out of the trial due to adverse events, compared with 3.7% in the placebo group. "Everything was in line with what we expected," Dr. Melanie Davies, lead investigator of the CagriSema diabetes trial, and co-director of the Leicester Diabetes Centre, told Reuters. The percentage of patients who had a glycated hemoglobin, or blood sugar, level of 6.5% or less was 73.5% in the CagriSema group and 15.9% in the placebo group. Dr. Davies acknowledged questions about why many patients in the trials were not given the highest tested dose. "Those patients on lower doses actually had higher weight loss reduction," she said. "We've not really seen that before because we have not had powerful treatments that have got people close to target." CagriSema is a weekly injection that combines Novo's blockbuster GLP-1 drug Wegovy with another molecule, cagrilintide, that mimics a hunger-suppressing pancreatic hormone called amylin. The CagriSema Phase 3 trial results "compared very favorably also with what we've seen with tirzepatide, which was previously the best-in-class," Dr. Davies said. Eli Lilly's (LLY.N), opens new tab tirzepatide, sold under the brand name Zepbound for weight loss, works by stimulating GLP-1 along with a second gut hormone called GIP. It was shown to help obese and overweight adults lose 22% of their weight over 72 weeks. Dr. Davies said it makes sense to have more options for patients, including "theoretical benefits" with amylin, which has been shown in animal studies to boost energy expenditure. If that effect is seen in humans, it could help mitigate the body's metabolic adaptation to weight loss, she said. Novo Nordisk said it plans to file for regulatory approvals for CagriSema in the first quarter of 2026. "We expect to see approval maybe around the beginning of 2027," Martin Holst Lange, head of development at Novo Nordisk, told Reuters. The company is conducting several other trials of CagriSema, including measuring its impact on cardiovascular outcomes. Lange said trial patients given lower doses of the drug often lost as much weight as those given higher doses, suggesting the need for flexibility including longer time periods between dose escalation. "This also allows them to lose their body weight at a pace that isn't too steep. It also mitigates side effects," he said.