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There's a Shocking Reason Ticks Are So Dangerous (It's Us)

There's a Shocking Reason Ticks Are So Dangerous (It's Us)

Yahoo4 hours ago

When you think about ticks, you might picture nightmarish little parasites, stalking you on weekend hikes or afternoons in the park.
Your fear is well-founded. Tick-borne diseases are the most prevalent vector-borne diseases – those transmitted by living organisms – in the United States. Each tick feeds on multiple animals throughout its life, absorbing viruses and bacteria along the way and passing them on with its next bite.
Some of those viruses and bacteria are harmful to humans, causing diseases that can be debilitating and sometimes lethal without treatment, such as Lyme, babesiosis and Rocky Mountain spotted fever.
But contained in every bite of this infuriating, insatiable pest is also a trove of social, environmental and epidemiological history.
In many cases, human actions long ago are the reason ticks carry these diseases so widely today. And that's what makes ticks fascinating for environmental historians like me.
During the 18th and 19th centuries, settlers cleared more than half the forested land across the northeastern U.S., cutting down forests for timber and to make way for farms, towns and mining operations.
With large-scale land clearing came a sharp decline in wildlife of all kinds. Predators such as bears and wolves were driven out, as were deer.
As farming moved westward, Northeasterners began to recognize the ecological and economic value of trees, and they returned millions of acres to forest.
The woods regrew. Plant-eaters such as deer returned, but the apex predators that once kept their populations in check did not.
As a result, deer populations grew rapidly. With the deer came deer ticks (Ixodes scapularis) carrying borrelia burgdorferi, the bacterium that causes Lyme disease. When a tick feeds on an infected animal, it can take up the bacteria. The tick can pass the bacteria to its next victim. In humans, Lyme disease can cause fever and fatigue, and if left untreated it can affect the nervous system.
The eastern U.S. became a global hot spot for tick-borne Lyme disease starting around the 1970s. Lyme disease affected over 89,000 Americans in 2023, and possibly many more.
For centuries, changing patterns of human settlements and the politics of land use have shaped the role of ticks and tick-borne illnesses within their environments.
In short, humans have made it easier for ticks to thrive and spread disease in our midst.
In California, the Northern Inner Coast and Santa Cruz mountain ranges that converge on San Francisco from the north and south were never clear-cut, and predators such as mountain lions and coyotes still exist there.
But competition for housing has pushed human settlement deeper into wildland areas to the north, south and east of the city, reshaping tick ecology there.
While western black-legged ticks (Ixodes pacificus) tend to swarm in large forest preserves, the Lyme-causing bacterium is actually more prevalent in small, isolated patches of greenery.
In these isolated patches, rodents and other tick hosts can thrive, safe from large predators, which need more habitat to move freely. But isolation and lower diversity also means infections are spread more easily within the tick's host populations.
People tend to build isolated houses in the hills, rather than large, connected developments. As the Silicon Valley area south of San Francisco sprawls outward, this checkerboard pattern of settlement has fragmented the natural landscape, creating a hard-to-manage public health threat.
Fewer hosts, more tightly packed, often means more infected hosts, proportionally, and thus more dangerous ticks.
Six counties across these ranges, all surrounding and including San Francisco, account for 44% of recorded tick-borne illnesses in California.
Domesticated livestock have also shaped the disease threat posed by ticks.
In 1892, at a meeting of cattle ranchers at the Stock Raiser's Convention in Austin, Texas, Dr. B.A. Rogers introduced a novel theory that ticks were behind recent devastating plagues of Texas cattle fever.
The disease had arrived with cattle imported from the West Indies and Mexico in the 1600s, and it was taking huge tolls on cattle herds. But how the disease spread to new victims had been a mystery.
Editors of Daniel's Texas Medical Journal found the idea of ticks spreading disease laughable and lampooned the hypothesis, publishing a satire of what they described as an "early copy" of a forthcoming report on the subject.
The tick's "fluid secretion, it is believed, is the poison which causes the fever … [and the tick] having been known to chew tobacco, as all other Texans do, the secretion is most probably tobacco juice," they wrote.
Fortunately for the ranchers, not to mention the cows, the U.S. Department of Agriculture sided with Rogers. Its cattle fever tick program, started in 1906, curbed cattle fever outbreaks by limiting where and when cattle should cross tick-dense areas.
By 1938, the government had established a quarantine zone that extended 580 miles by 10 miles along the U.S.-Mexico border in South Texas Brush Country, a region favored by the cattle tick.
This innovative use of natural space as a public health tool helped to functionally eradicate cattle fever from 14 Southern states by 1943.
When it comes to tick-borne diseases the world over, location matters.
Take the hunter tick (Hyalomma spp.) of the Mediterranean and Asia. As a juvenile, or nymph, these ticks feed on small forest animals such as mice, hares and voles, but as an adult they prefer domesticated livestock.
For centuries, this tick was an occasional nuisance to nomadic shepherds of the Middle East. But in the 1850s, the Ottoman Empire passed laws to force nomadic tribes to become settled farmers instead. Unclaimed lands, especially on the forested edges of the steppe, were offered to settlers, creating ideal conditions for hunter ticks.
As a result, farmers in what today is Turkey saw spikes in tick-borne diseases, including a virus that causes Crimean-Congo hemorrhagic fever, a potentially fatal condition.
It's probably too much to ask for sympathy for any ticks you meet this summer. They are bloodsucking parasites, after all.
Still, it's worth remembering that the tick's malevolence isn't its own fault. Ticks are products of their environment, and humans have played many roles in turning them into the harmful parasites that seek us out today.
Sean Lawrence, Assistant Professor of History, West Virginia University
This article is republished from under a Creative Commons license. Read the .
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Fewer ECG Abnormalities in Early T2D With Combo Therapy
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Fewer ECG Abnormalities in Early T2D With Combo Therapy

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Lilly's once-weekly insulin efsitora alfa demonstrated A1C reduction and a safety profile consistent with daily insulin in multiple Phase 3 trials
Lilly's once-weekly insulin efsitora alfa demonstrated A1C reduction and a safety profile consistent with daily insulin in multiple Phase 3 trials

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Lilly's once-weekly insulin efsitora alfa demonstrated A1C reduction and a safety profile consistent with daily insulin in multiple Phase 3 trials

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The complete results from these studies were presented at the American Diabetes Association (ADA) 85th Scientific Sessions 2025. Simultaneously, results from QWINT-1, a first-of-its-kind fixed-dose study, were published in The New England Journal of Medicine, while results from QWINT-3 and QWINT-4 were published in The Lancet. In QWINT-1, efsitora reduced A1C by 1.31% compared to 1.27% for insulin glargine at week 52 for the efficacy estimand.1,2 In the trial, efsitora was titrated to four fixed doses at four-week intervals, as needed for blood glucose control.3 In QWINT-3, efsitora reduced A1C by 0.86% compared to 0.75% for insulin degludec at week 26 for the efficacy estimand.4 In QWINT-4, efsitora reduced A1C by 1.07% compared to 1.07% for insulin glargine at week 26 for the efficacy estimand.5 In these two trials, efsitora was administered using traditional insulin dosing with adjustments based on each patient's glucose level. "The novel fixed-dose regimen used in QWINT-1 for once-weekly efsitora, which consisted of only four single-dose titration options, has the potential to facilitate and simplify insulin therapy, reducing the hesitation often associated with starting insulin to treat type 2 diabetes," said Dr. Julio Rosenstock, senior scientific advisor for Velocity Clinical Research at Medical City Dallas, clinical professor of medicine, University of Texas Southwestern Medical Center, and lead trial investigator for QWINT-1. "A simpler, once-weekly regimen with efsitora may help people with type 2 diabetes initiate and manage insulin therapy with the goal of improving blood sugar levels. Across all QWINT trials, the results showed that once-weekly efsitora controlled glucose as effectively as the most popular once-daily basal insulins." QWINT-1 Primary EndpointEfficacy Estimand Treatment-RegimenEstimand6 Primary Endpoint – A1C Reduction (Resulting A1C) at Week 52 Efsitora -1.31 % (6.92 %) -1.19 % (7.05 %) Glargine -1.27 % (6.96 %) -1.16 % (7.08 %)QWINT-3 Primary and Key Secondary EndpointsEfficacy Estimand Treatment-RegimenEstimand Primary Endpoint – A1C Reduction (Resulting A1C) at Week 26 Efsitora -0.86 % (6.93 %) -0.81 % (6.99 %) Degludec -0.75 % (7.03 %) -0.72 % (7.08 %) Key Secondary Endpoint – Rates of Clinically Significant or Severe Nocturnal Hypoglycemic Events Per Patient-Year of Exposure up to Week 787,8 Efsitora 0.11 Degludec 0.10 Key Secondary Endpoint – Percent Time in Range (70-180 mg/dL) During the FourWeeks Prior to Week 26 Efsitora 62.8 % 61.4 % Degludec 61.3 % 61.0 %QWINT-4 Primary and Key Secondary EndpointsEfficacy Estimand Treatment-Regimen Estimand Primary Endpoint – A1C Reduction (Resulting A1C) at Week 26 Efsitora -1.07 % (7.12 %) -1.01 % (7.17 %) Glargine -1.07 % (7.11 %) -1.00 % (7.18 %) Key Secondary Endpoint – Participants Achieving A1C <7% at Week 26 Without Nocturnal Hypoglycemia Efsitora 39.5 % 38.6 % Glargine 36.6 % 35.9 % Key Secondary Endpoint – Rates of Clinically Significant or Severe NocturnalHypoglycemic Events Per Patient-Year of Exposure up to Week 26 Efsitora 0.67 Glargine 1.00 "Building on Lilly's legacy of innovation in insulin therapy, once-weekly efsitora may offer a significant advancement for people with type 2 diabetes who need insulin by eliminating over 300 injections per year," said Jeff Emmick, M.D., Ph.D., senior vice president of product development at Lilly. "These results reinforce the potential for once-weekly efsitora to help reduce the overall burden of insulin therapy through a simplified treatment approach. We look forward to working with regulatory agencies to bring this innovation to patients around the world." Across the three trials, efsitora demonstrated an overall safety profile similar to two of the most commonly used daily basal insulin therapies for the treatment of type 2 diabetes. In QWINT-1, efsitora resulted in approximately 40% fewer hypoglycemic events compared to insulin glargine, with estimated combined rates of severe or clinically significant hypoglycemic events per patient-year of exposure of 0.50 with efsitora vs. 0.88 with insulin glargine at 52 weeks. In QWINT-3, these rates were 0.84 with efsitora vs. 0.74 with insulin degludec at 78 weeks. In QWINT-4, estimated combined rates of severe or clinically significant hypoglycemic events per patient-year of exposure were 6.6 with efsitora vs. 5.9 with insulin glargine at 26 weeks. Lilly plans to submit efsitora for the treatment of adults with type 2 diabetes to global regulatory agencies by the end of this year. About the QWINT clinical trial programThe QWINT Phase 3 global clinical development program for insulin efsitora alfa (efsitora) in diabetes began in 2022 and has enrolled more than 3,000 people living with type 2 diabetes across four global registration studies. QWINT-1 (NCT05662332) was a parallel-design, open-label, treat-to-target, randomized controlled clinical trial comparing the efficacy and safety of efsitora as a once-weekly basal insulin using a fixed dose escalation to daily insulin glargine for 52 weeks in insulin-naïve adults with type 2 diabetes. The trial randomized 795 participants across the U.S., Argentina and Mexico to receive efsitora once weekly or insulin glargine once daily, administered subcutaneously. Participants treated with efsitora received a starting dose of 100 units of insulin, followed by escalation to fixed dosages of 150 units, 250 units and 400 units every four weeks, as needed, until achieving a target fasting blood glucose of 80-130 mg/dL. Participants with fasting blood glucose greater than 130 mg/dL on or after 16 weeks were transferred to flexible dosing. The primary objective of the trial was to demonstrate non-inferiority in reducing A1C at week 52 with efsitora compared to daily use of insulin glargine. QWINT-3 (NCT05275400) was a multicenter, randomized, parallel-design, open-label trial comparing the efficacy and safety of efsitora as a once-weekly basal insulin to insulin degludec for 78 weeks after a three-week lead-in followed by a five-week safety follow up period, in adults with type 2 diabetes who are currently treated with basal insulin. The trial randomized 986 participants across the U.S., Argentina, Hungary, Japan, Korea, Poland, Puerto Rico, Slovakia, Spain and Taiwan to receive efsitora once weekly or insulin degludec once daily, administered subcutaneously. The primary objective of the study was to demonstrate non-inferiority in reducing A1C at week 26 with efsitora compared to insulin degludec. QWINT-4 (NCT05462756) was a parallel-design, open-label, treat-to-target, randomized controlled clinical trial comparing the efficacy and safety of efsitora as a weekly basal insulin to insulin glargine for 26 weeks in adults with type 2 diabetes who have previously been treated with basal insulin and at least two injections per day of mealtime insulin. The trial randomized 730 participants across the U.S., Argentina, Germany, India, Italy, Mexico, Puerto Rico and Spain to receive efsitora once weekly or insulin glargine once daily, both of which were administered subcutaneously along with insulin lispro. The primary objective of the trial was to demonstrate non-inferiority in reducing A1C at week 26 with efsitora compared to insulin glargine. About insulin efsitora alfaInsulin efsitora alfa (efsitora) is a once-weekly basal insulin, a fusion protein that combines a novel single-chain variant of insulin with a human IgG2 Fc domain. It is specifically designed for once-weekly subcutaneous administration, and with its low peak-to-trough ratio, it has the potential to provide more stable glucose levels (less glucose variability) throughout the week. About Lilly Lilly is a medicine company turning science into healing to make life better for people around the world. We've been pioneering life-changing discoveries for nearly 150 years, and today our medicines help tens of millions of people across the globe. Harnessing the power of biotechnology, chemistry and genetic medicine, our scientists are urgently advancing new discoveries to solve some of the world's most significant health challenges: redefining diabetes care; treating obesity and curtailing its most devastating long-term effects; advancing the fight against Alzheimer's disease; providing solutions to some of the most debilitating immune system disorders; and transforming the most difficult-to-treat cancers into manageable diseases. With each step toward a healthier world, we're motivated by one thing: making life better for millions more people. That includes delivering innovative clinical trials that reflect the diversity of our world and working to ensure our medicines are accessible and affordable. To learn more, visit and or follow us on Facebook, Instagram, and LinkedIn. P-LLY The efficacy estimand represents the treatment effect on all participants who adhered to the study drug without initiating rescue therapy for persistent severe hyperglycemia. From a baseline of 8.20% for efsitora and 8.28% for insulin glargine. Participants treated with efsitora received a starting dose of 100 units of insulin, followed by escalation to fixed dosages of 150 units, 250 units and 400 units every four weeks, as needed, until achieving a target fasting blood glucose of 80-130 mg/dL. Participants with fasting blood glucose greater than 130 mg/dL on or after 16 weeks were transferred to flexible dosing. From a baseline of 7.80% for both efsitora and insulin degludec. From a baseline of 8.18% for both efsitora and insulin glargine. The treatment-regimen estimand represents the estimated average treatment effect regardless of treatment discontinuation or introduction of rescue therapy for persistent severe hyperglycemia. Blood glucose <54 mg/dL. Nocturnal hypoglycemia was defined as any event that occurred at night between midnight and 6 a.m. Cautionary Statement Regarding Forward-Looking StatementsThis press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about insulin efsitora alfa as a potential treatment for people with type 2 diabetes and the timeline for future readouts, presentations, and other milestones relating to insulin efsitora alfa and its clinical trials and reflects Lilly's current beliefs and expectations. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of drug research, development, and commercialization. Among other things, there is no guarantee that future study results will be consistent with study results to date, that insulin efsitora alfa will prove to be a safe and effective treatment for type 2 diabetes, that insulin efsitora alfa will receive regulatory approval, or that Lilly will execute its strategy as expected. For further discussion of these and other risks and uncertainties that could cause actual results to differ from Lilly's expectations, see Lilly's Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release. Trademarks and Trade NamesAll trademarks or trade names referred to in this press release are the property of the company, or, to the extent trademarks or trade names belonging to other companies are referenced in this press release, the property of their respective owners. Solely for convenience, the trademarks and trade names in this press release are referred to without the ® and ™ symbols, but such references should not be construed as any indicator that the company or, to the extent applicable, their respective owners will not assert, to the fullest extent under applicable law, the company's or their rights thereto. We do not intend the use or display of other companies' trademarks and trade names to imply a relationship with, or endorsement or sponsorship of us by, any other companies. Refer to: Niki Biro; niki_biro@ 317-358-9074 (Media)Michael Czapar; czapar_michael_c@ 317-617-0983 (Investors) View original content to download multimedia: SOURCE Eli Lilly and Company Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Annual Fight For Air Climb at Soldier Field raises over $350K for lung health
Annual Fight For Air Climb at Soldier Field raises over $350K for lung health

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Annual Fight For Air Climb at Soldier Field raises over $350K for lung health

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