BMO says lenacapavir approval for prevention a ‘major win' for Gilead
Although largely as expected by investors, BMO Capital says lenacapavir's approval for prevention, now known as Yeztugo, marks 'a major win for Gilead (GILD)' in driving meaningful growth in its pre-exposure prophylaxis business. A clean label, strong clinical data, and a convenient twice yearly dosing regimen, in line with patient physician visits, should drive strong commercial adoption for Yeztugo, says the analyst, who has an Outperform rating and $120 price target on Gilead shares.
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Cautious Optimism for Gilead Sciences Amid Yeztugo's Market Challenges
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Forbes
26 minutes ago
- Forbes
Icons Of Whiskey: Jacob Beam's Bourbon Dynasty
The Beam range of American whiskeys Photo, courtesy James B Beam Distilling Company Jacob Beam, the founder of what eventually became the James B. Beam Distilling Company, stands as a legendary figure in American whiskey history. His spirit of persistence and craftsmanship continues to shape the bourbon industry today. Now owned by Suntory Global Spirits, Jim Beam remains one of the most recognized names in whiskey worldwide. Below is a closer look at Jacob Beam, an Icon of Whiskey, and the distilling empire he built. Jacob Beam, founder of the Beam whiskey dynasty Photo, courtesy James B Beam Distilling Company Jacob Beam was born on February 9, 1760, to Nicolaus and Margaretha Boehm in Bucks County, Pennsylvania. The Boehms were German immigrants with deep farming roots who later anglicized their name to Beam. Growing up on the family farm, Jacob developed a strong work ethic and a keen understanding of farming—skills that would serve him well when he began making whiskey. In the 1780s, Jacob moved to Kentucky, settling near Hardin's Creek in what is now Hardin County. There, he set up a farm and a gristmill. Kentucky's fertile soil, plentiful corn, and easy access to the Ohio River made it a perfect place to distill whiskey. Jacob later moved to Bardstown, which was fast becoming a center for distilling—a reputation it still holds today. Although the Beam family lived in Bardstown, they never operated a distillery there. In 1854, the original distillery was relocated to nearby Nelson County, capitalizing on new railroad connections. After Prohibition, the distillery was rebuilt in Clermont, where it remains to this day. Jacob Beam began distilling whiskey in 1795. His early product—a corn-based whiskey—laid the groundwork for what would become bourbon. Initially, the whiskey was for local sale, but demand quickly grew as its quality was recognized. By the early 1800s, he was selling his whiskey as "Old Jake Beam Sour Mash." That brand would eventually evolve into the Jim Beam known today. Jacob Beam's Impact on Bourbon Jacob's success rested on careful craftsmanship. He blended corn, rye, and barley malt to produce whiskey that was smoother and sweeter than many local spirits of the time. That mash bill eventually became the template for bourbon. He aged it in charred oak barrels—a practice that would become standard for bourbon makers everywhere. His focus on refining recipes and scaling up production while maintaining high quality set the Beam family on a steady path to success. Some of Beam's Master Distillers over the company's history Photo, courtesy Jim Beam/Whiskey University Generations of Beam Distillers When Jacob Beam died in 1834, his son David Beam took over. David expanded operations and eventually handed the reins to his son, David B. Beam, who moved the distillery to Nelson County to benefit from rail shipping. That move helped Old Tub, a Beam whiskey, become one of the first nationally known bourbon brands. Eventually, David B. Beam's son, James Beauregard Beam—Jacob's great-grandson—rebranded the whiskey under his name, 'Jim Beam,' honoring the family legacy and ushering in a new era of recognition. When Prohibition struck in 1920, production halted, although limited sales of 'medicinal whiskey' were allowed to continue. Although the Beam distillery didn't have one of the original medicinal whiskey permits, the government later granted a license as supplies dwindled. Operating under the American Medicinal Spirits name, the Beam family continued limited production, preserving their whiskey-making know-how through the dry years. After Prohibition ended in 1933, James B. Beam rebuilt the distillery in Clermont, not far from his Bardstown home. By the 1940s, the brand had experienced rapid growth and established a global presence. In 1945, the company was acquired by Harry Blum, a Chicago-based spirits merchant. It was later sold, in 1967, to American Tobacco, which subsequently changed its name to American Brands in 1969 and later to Fortune Brands. In 1987, the Jim Beam acquired National Distillers, In 2011, Fortune Brands spun off its spirits business as a separate publicly traded company called Beam Inc. The company focused entirely on the whiskey and spirits portfolio, including Jim Beam, Maker's Mark, Knob Creek, and other brands. In 2014, Beam Inc. was acquired by Japan's Suntory Holdings for $16 billion—one of the biggest deals in spirits industry history. The company has had nine Master Distillers over its history: Jacob Beam (1795–1834), David Beam (1834–1854), David M. Beam (1854–1894), James B. Beam (1894–1947), T. Jeremiah Beam (1946–1977), Fred Booker Noe II 1960s–1992, Jerry Dalton (1998–2007), Fred Noe (2007–present), and Freddie Noe (2022–present, as co-Master Distillers). The James B Beam Distilling Company Photo, courtesy James B Beam Distilling Company The Role of the Noe Family The Noes are an old Kentucky family with deep roots in the same region where the Beam family settled. They were farmers and distillers, and over generations, they intermarried with the Beam family. The most famous Noe connection is through Booker Noe (Frederick Booker Noe II), one of the legendary master distillers in modern bourbon history. Jim Beam's daughter, Margaret Beam Noe, married into the Noe family. Her son, Booker Noe, was Jim Beam's grandson. He carried both family lines and became the 6th-generation master distiller. Booker's son, Fred Noe, and his grandson Freddie Noe are the current master distillers at Jim Beam. As Beam descendants, they've continued the family's role in running and shaping Jim Beam's distilling operations for the past century. The Noe name is as central to Beam's distilling legacy as the Beam name itself. Booker's Bourbon, named for Booker Noe, is part of this family's innovative imprint on the modern bourbon world. Beam Distilling Today Now under Suntory Global Spirits, the company still honors the values Jacob Beam instilled: quality, innovation, and true bourbon craftsmanship. Beam Suntory owns a portfolio that includes Jim Beam, Maker's Mark, Knob Creek, and other iconic names. Today, Jim Beam remains one of the best-selling bourbons in the world—a testament to the vision Jacob Beam sparked in the late 1700s along Hardin's Creek. Jacob Beam's legacy as a trailblazer of American bourbon endures, making him a true Icon of Whiskey. Though ownership has changed hands over the years, the commitment to craft, quality, and family tradition he began remains the backbone of Beam's success and a cornerstone of the whiskey world. The Icons of Whiskey is an ongoing series that highlights the leading historical personalities in the whiskey industry worldwide. More From Forbes Forbes America's Top Bourbon, According To The International Wine & Spirit Competition By Joseph V Micallef Forbes America's Best Bourbon, According To The American Distilling Institute By Joseph V Micallef Forbes The Top Bourbons From The 2025 San Francisco World Spirits Competition By Joseph V Micallef
CNET
28 minutes ago
- CNET
9 Foods for Relieving Headaches and Migraines, According to Doctors and Dietitians
June is Migraine and Headache Awareness Month, which got us thinking: Are there any foods that can help with this type of head pain? "The most important thing I tell patients is that migraines are highly individualized," says Dr. Nicholas Church, a board-certified member of the American Board of Family Medicine and the American Academy of Family Physicians. "What helps one person may not help another, and what's a trigger for one might be therapeutic for someone else." A holistic approach is essential because hydration, exercise, sleep and stress management can all play a part in controlling migraines and headaches. With this in mind, Church recommends that patients keep a "headache diary" to track these factors, including the foods they eat or avoid, to see if there are patterns. While no single food or diet change will cure headaches or migraines entirely, they may help provide relief. These are the foods experts recommend you consider. 1. Omega-3-rich foods like flaxseed and salmon "I recommend omega-3-rich fish, such as salmon, mackerel and sardines," says Church. "These fish are high in anti-inflammatory fats (EPA and DHA), which can reduce inflammation throughout the body, including in the vascular system and brain." Citing a 2021 randomized controlled trial, Church explains that because migraines are believed to involve inflammatory and vascular changes in the body, omega-3 fatty acids may help reduce their frequency or intensity when eaten regularly. "The study's findings also align with earlier data showing that omega-3s help regulate prostaglandins, which play a role in headache inflammation," says Church. Prostaglandins are hormone-like substances that impact bodily functions like inflammation, pain and menstrual cramps. Fatty fish also contain vitamin D, coenzyme Q10 and B vitamins like riboflavin, which support healthy brain metabolism. Kiran Campbell, a registered dietitian nutritionist at MyNetDiary, also mentions a 2024 meta-analysis revealing that omega-3 fatty acids can reduce the frequency, duration and severity of migraines. She adds that plant-based sources include chia seeds, walnuts, flaxseed and algae oil. Example foods: salmon, mackerel, sardines, chia seeds, walnuts, flaxseed and algae oil Chia and flax seeds are great sources of omega-3s. mikroman6/Getty Images 2. Magnesium-rich foods like kale and pumpkin seeds Daniel Redwood, the director of Human Nutrition and Functional Medicine at the University of Western States, explains, "Attention to the potential importance of magnesium in migraine grew in prominence with the discovery (Ramadan, 1989) that people with migraines had lower levels of this mineral in their red blood cells, serum and brain tissue." Dr. Paul Daidone, medical director at True Self Recovery, seconds this, stating that food rich in magnesium -- like pumpkin seeds, spinach and avocado -- may reduce the severity and occurrence of migraines. He cites a 2022 study examining the potential connection between magnesium deficiency and migraine, which describes how magnesium deficiency is implicated in migraine attacks due to processes like cortical spreading depression, oxidative stress, neurotransmitter imbalance and electrolyte imbalance. "Although clinical evidence of the acute dietary magnesium deficiency as a direct migraine trigger remains limited, scientists are investigating the involvement of intra- and extracellular magnesium levels in migraine pathogenesis," Daidone explains. Dr. Schonze Del Pozo, a board-certified internal medicine physician and medical director at East Sacramento Concierge, states that many of the patients she sees for headaches and migraines are deficient in magnesium. She also cites a 2012 study in the Journal of Neural Transmission entitled "Why all migraine patients should be treated with magnesium." As a result, she recommends a healthy diet of magnesium-rich dark leafy greens like spinach, kale, broccoli and Swiss chard. Example foods: pumpkin seeds, spinach and avocado, kale, broccoli and Swiss chard 3. Ginger "Many swear by ginger as a way to help with migraines," states Dr. Maria Knöbel, a general practitioner and medical director of Medical Cert UK. "Studies have proven that ginger reduces nausea and can decrease the inflammation that leads to migraine pain. Ginger has helped patients during my practice, whether they take it as ginger tea or in supplement form." She references a 2014 study that found ginger powder to be as effective as the medication sumatriptan in treating acute migraine attacks, but with fewer side effects. Ginger tea may be especially beneficial because, Knöbel states, "It's important to drink enough water, as well as eat ginger. Drinking enough water might stop your migraine from getting any worse." Church also recommends ginger because it contains natural anti-inflammatory compounds like gingerol. "I've had patients find relief from migraines or migraine-related nausea using ginger tea, powder or chews," he explains. A 2019 study also found that 400mg of ginger extract, in addition to 100mg of the non-steroidal anti-inflammatory drug ketoprofen, may help treat migraine attacks. Ginger tea combines the benefits of ginger with the hydration of water.4. Nuts and seeds like walnuts and sunflower seeds "Another group of foods I recommend are nuts and seeds, including almonds, pumpkin seeds, sunflower seeds and walnuts," Church states. "Like leafy greens, these are rich in magnesium, and some also provide vitamin E, which has been shown to help with menstrual migraines and migraines with aura." A 2015 study reflected this. Example foods: almonds, pumpkin seeds, sunflower seeds and walnuts 5. Cinnamon "Cinnamon contains a high amount of antioxidants that may also reduce headache frequency," Campbell explains. "Stir it into your morning oatmeal or tea, or bake it into muffins and breads." She cites a randomized, double-masked, placebo-controlled 2020 trial, stating, "Studies suggest that cinnamon supplementation may lower inflammation, cutting down on migraine frequency, severity and duration." The antioxidants in cinnamon may help treat headaches and migraines. FreshSplash/Getty Images 6. Foods rich in vitamin B2 like eggs and lean meats "A well-known [1998] randomized controlled trial found that 400 mg of riboflavin daily significantly reduced migraine frequency and severity over a three-month period," Church says. Though this high dose usually comes from supplementation, riboflavin-rich foods support the same metabolic processes in migraine prevention. These foods can include eggs, dairy and lean meats. "Riboflavin is essential for mitochondrial energy production, and many researchers believe that migraines stem in part from dysfunction in energy metabolism within brain cells," Church adds. Redwood adds, "There exists a small but promising body of research on the effectiveness of some nutritional supplements for migraines, especially riboflavin (vitamin B2), coenzyme Q10 and magnesium. The first research-based indicator of riboflavin's potential as a migraine treatment appeared in a small 1946 article by a medical physician, published in the Canadian Medical Association Journal, which reported dramatic effectiveness from what would now be considered low-dose B2 supplements." A 2022 systematic review and meta-analysis found that supplementation of 400mg/day of vitamin B2 for three months affected the duration, frequency and pain score of migraine attacks. Example foods: Eggs, dairy and lean meats 7. Turmeric Curcumin is the active compound in turmeric and, according to Campbell, is "high in antioxidant power and shines especially when paired with omega-3s." To add it to your diet, consider sprinkling it into smoothies, curries or teas. Campbell references a randomized, double-masked, placebo-controlled 2021 trial that concluded, "Present findings revealed that n-3 fatty acids and curcumin co-supplementation can be suggested as a promising new approach in migraine headache management." However, more studies are needed. When combined with omega-3s, turmeric may help with migraine headache management. Rawlstock/Getty Images 8. Whole grains like oats and quinoa Church mentions that whole grains like quinoa, brown rice and oats may also be beneficial since they "provide a steady release of glucose, preventing blood sugar crashes that can trigger headaches, and are good sources of fiber, B vitamins and trace minerals." He cites a 2023 cross-sectional study of 12,710 participants with all data collected from a 1999-2004 National Health and Nutrition Examination Survey. It found that for every 10 grams of fiber added to the diet, there was an 11% reduction in the odds of having severe headaches or migraines. "By providing magnesium, iron, and B vitamins, whole grains support brain health, oxygen delivery and a stable glucose supply, which are all relevant to migraine prevention," concludes Church. A 2023 comprehensive review also found that curcumin is a promising candidate for preventing and controlling migraines due to its anti‑inflammatory, antioxidative, anti-protein aggregate and analgesic effects. However, additional studies are needed. Example foods: quinoa, brown rice and oats 9. Water-rich foods like cucumber and watermelon Dr. Kimberly Idoko, a developmental neurobiologist and board-certified neurologist, reveals that dehydration can also trigger headaches, which is why staying hydrated can significantly improve migraine treatments. "Water-rich foods like cucumber, watermelon and citrus fruits also help you stay hydrated," adds Church. To prevent dehydration-caused headaches or migraines, enjoy more water-rich foods like watermelon. Anucha Muphasa/500px/Getty Images Foods that may trigger migraines and headaches Chocolate, cheese and alcohol: "In one [2007] study of over 500 migraine sufferers, 44% reported at least one food as a trigger. Among the most common triggers were chocolate, cheese and alcohol, " reveals Dr. Adam Lowenstein, a board-certified plastic surgeon who runs the Migraine Surgery Specialty Center. Gluten: "Gluten can be a highly inflammatory food substance, especially among those who are prone to sensitivities or gluten allergy," explains Trista Best, a registered dietitian at The Candida Diet, environmental health specialist and adjunct nutrition professor. "This inflammation causes a host of health conditions, including migraines." When it comes to caffeine, moderation is "The most fascinating study I've seen on the role of nutrition in the treatment of headaches (Hering-Hanit and Gadoth, 2003) was published in Cephalalgia, the premier headache journal. Over a 5-year period, doctors at a neurology clinic in Israel treated 36 children and adolescents (average age 9) with severe daily or near-daily headaches who drank an average of 11 quarts of cola drinks per week," says Redwood. "At the end of a gradual withdrawal period (because too speedy a withdrawal can trigger even worse headaches), 33 of these 36 young people were headache-free, a truly stunning result. Nearly all cola drinks contain substantial amounts of caffeine (Chou and Bell, 2007)." Note: 11 quarts of cola per week is extreme, and the average person doesn't consume this much caffeine. Moderate caffeine intake is still OK, according to Amelia Ti, a registered dietitian and diabetes educator in New York City who is also part of CNET's medical review board. However, when it comes to caffeine, Church notes, "Caffeine, used strategically, can enhance the absorption of pain relievers and constrict dilated blood vessels in the brain, which may ease migraine pain. This is why many over-the-counter headache medications include it. Studies have shown that 40–100 mg of caffeine (the amount in a small cup of coffee or strong tea) can reduce migraine or tension headache pain. But, chronic overuse can lead to rebound headaches, so moderation is key." Added sugars and highly processed foods: "Research has shown that people following a 'Western' diet, which includes substantial amounts of added sugars and other highly processed foods, are at greater than average risk for developing migraines, while the risk is significantly lower than average for those following a healthier diet," states Redwood. Mercola adds that in addition to adding foods rich in specific nutrients like magnesium and B vitamins, you'll want to eliminate triggers like processed foods that contain nitrates, MSG, added sugars or yeast.
Gizmodo
28 minutes ago
- Gizmodo
Amazon Isn't Waiting for Prime Day, This Three-Port USB-C Charger Is Almost Free
Anyone who has wrestled with a tangle of cables and chargers is familiar with the frustration all too well. Modern living means multiple devices and each one seems to have its own power source. That's why Amazon's latest deal is such a breath of fresh air: the Anker 65W three-port charger is available at an all-time low price and it's a smart buy if you're looking to simplify their power needs. Right now, the Anker Nano II 65W three-port charger is on sale for just $29, thanks to an extra coupon that brings the price down from its original $55. That's a solid 48% off the original price and it puts this powerful charger within easy reach for most shoppers. It truly is the single charger that most people will ever need for their daily tech. See at Amazon The selling point of the Anker Nano II 65W is its combination of speed, versatility, and portability. At full load, a single device plugged into the main USB-C port can receive up to 65W of power—enough to fast charge a 13-inch MacBook Pro at full speed. When several devices are connected, the charger intelligently divides power between the three ports to give each device its optimal charge without throttling. That means you can charge your phone, tablet, and laptop all at the same time. The Anker charger is about the same size as an AirPods Pro case so you can just slip it in a bag or even a pocket. In spite of the small size, it packs a heavy punch courtesy of innovative GaN II technology. This latest generation of gallium nitride (GaN) technology offers a 100% increase in operating frequency which is an innovative stacked architecture and an enhanced circuit board. At just $29, it's an absolute bargain especially when you consider the time, space, and frustration it can save you on a daily basis. See at Amazon
