BioVersys Announces Important BV100 Patent Granted by Chinese Patent Office
BASEL, Switzerland, March 31, 2025 (GLOBE NEWSWIRE) -- Ad hoc announcement pursuant to Art. 53 LR
Important patent around BioVersys' BV100 drug candidate has been granted, protecting the proprietary rifabutin IV formulation technology in China
BV100 patents have now been granted in over 25 countries, including in US, Europe, UK and China
BioVersys AG (SIX: BIOV), a multi-asset, clinical stage biopharmaceutical company focusing on research and development of novel antibacterial products for serious life-threatening infections caused by multidrug-resistant (MDR) bacteria, announced today, that the company was granted important patent claims in China for its BV100 technology.
BV100 is a novel formulation of rifabutin which is suitable for intravenous administration. BV100 is based on the newly identified mode of action for the active uptake of rifabutin into the Acinetobacter baumannii-calcoaceticus complex and is being developed for resistant hospital infections caused by Acinetobacter baumannii, including carbapenem resistant strains (CRAB).
There is a serious lack of effective and safe treatment options for CRAB infections and mortality rates in hospitals can be as high as 50%. CRAB has been designated a priority pathogen by the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC).
While CRAB infections are a serious health threat throughout the world, incidence rates for Acinetobacter infections are particularly high in China and Asia, combined with very high resistance rates of 60-80%. Based on recent epidemiology data, BioVersys expects > 1 million patients annually in China alone suffering from severe CRAB pneumonia and blood stream infections.
Dr. Marc Gitzinger, Chief Executive Officer: 'With the addition of China, we now have patents protecting BV100 granted in all the major markets, covering more than 25 countries. In our commitment to bring BV100 as life-saving medicine to patients as fast as possible, this addition to our patent coverage is key due to the absolute numbers of patients affected by Acinetobacter infections in China. We are preparing to start a Phase 1 clinical trial in China soon, which will enable us to include China in our BV100 Phase 3 registration trial which is planned to start in H2 2025. Accessing the Chinese market will allow BV100 to target a global peak sales potential of USD 800 million and tackle unacceptably high carbapenem resistance rates and associated high mortality rates of up to 50%, from Acinetobacter baumannii hospital infections.'
About BV100
BV100 is a novel formulation of rifabutin suitable for intravenous administration, with a recently discovered novel mode of action showing an active uptake of rifabutin into the Gram-negative bacterial species, Acinetobacter baumannii. For the first time, the lead candidate allows for the targeting of the RNA-polymerase enzyme in Gram-negative bacteria with a human-suitable dose. BV100 is being developed for the treatment of infections caused by Acinetobacter baumannii calcoaceticus complex (ABC), including Carbapenem-Resistant ABC (CRAB) in critically important indications of ventilator associated bacterial pneumonia (VABP), hospital-acquired bacterial pneumonia (HABP) and bloodstream infections (BSI). BV100 was granted QIDP Designation by the U.S. FDA in May 2019 for use in the treatment of VABP, HABP and BSI, making BV100 eligible for priority FDA review, Fast Track designation, and a five-year extension of market exclusivity upon approval of the first QIDP indication.
About Acinetobacter baumannii
Acinetobacter baumannii calcoaceticus complex (ABC) are Gram-negative bacteria found in the environment (e.g., in soil and water) and an opportunistic pathogen in humans, typically infecting critically ill and immunocompromised patients, that can result in severe pneumonia and bloodstream infections in addition to affecting other parts of the body. ABC is considered a significant worldwide threat in the healthcare setting given its ability to survive for prolonged periods on surfaces, combined with its ability to develop or acquire resistance to standard of care antibiotics, e.g. carbapenems. Carbapenem-resistance as well as multidrug-resistance (MDR) rates for ABC are among the highest recorded for any bacteria in current times (The Lancet 2022; 399: 629–55). Incidence and resistance rates for ABC are trending upwards and COVID-19 has exacerbated this significantly. BioVersys forecasts the annual number of carbapenem-resistant A. baumannii infections in hospitals to have surpassed one million globally and due to the limited treatment options, such infections come with high (up to 50%) mortality rates.
About BioVersys
BioVersys AG is a multi-asset, clinical stage biopharmaceutical company focused on identifying, developing and commercializing novel antibacterial products for serious life-threatening infections caused by multi-drug resistant ('MDR') bacteria. Derived from the company's two internal technology platforms (TRIC and Ansamycin Chemistry), candidates are designed and developed to overcome resistance mechanisms, block virulence production and directly affect the pathogenesis of harmful bacteria towards the identification of new treatment options in the antimicrobial and microbiome fields. This enables BioVersys to address the high unmet medical need for new treatments against life-threatening resistant bacterial infections and bacteria-exacerbated chronic inflammatory microbiome disorders. The company's most advanced research and development programs address nosocomial infections of Acinetobacter baumannii (BV100, Phase 3 ready), and tuberculosis (alpibectir, Phase 2a, in collaboration with GlaxoSmithKline (GSK) and a consortium of the University of Lille, France). BioVersys is located in the biotech hub of Basel, Switzerland.
BioVersys contact
Disclaimer
This communication expressly or implicitly contains certain forward-looking statements, such as 'believe', 'assume', 'expect', 'forecast', 'project', 'may', 'could', 'might', 'will' or similar expressions concerning BioVersys and its business, including with respect to the progress, timing and completion of research, development and clinical studies for product candidates. Such statements involve certain known and unknown risks, uncertainties and other factors, which could cause the actual results, financial condition, performance or achievements of BioVersys to be materially different from any future results, performance or achievements expressed or implied by such forward-looking statements. BioVersys is providing this communication as of this date and does not undertake to update any forward-looking statements contained herein as a result of new information, future events or otherwise.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
40 minutes ago
- Yahoo
Collège Boréal strengthens its commitment to building a skilled Francophone workforce in early childhood education
Two projects totalling more than one million dollars will boost recruitment efforts for early childhood educators while helping current staff enhance their skills SUDBURY, Ontario, June 23, 2025 (GLOBE NEWSWIRE) --Collège Boréal is proud to announce two new initiatives designed to support the Francophone early childhood education sector. With funding from the City of Toronto and the Commission nationale des parents francophones (CNPF), more than $1 million is being invested to strengthen recruitment efforts in Francophone child care services across Ontario and to enhance the skills of early childhood professionals currently working in Toronto. Four early childhood education workshops in Toronto Developed in partnership with the City of Toronto, Centennial College, George Brown College, Mothercraft, and Seneca Polytechnic, this project aims to strengthen the expertise of early childhood educators in areas such as mentorship, student supervision, and leadership development through targeted training sessions and interactive workshops. Participants will deepen their understanding of student support and peer mentorship through sessions delivered in person or online. Communities of practice will also be created to encourage knowledge sharing and the application of new learning in the workplace. All staff working in educational settings or with child care agencies that have agreements with the City of Toronto will be eligible to take part in these workshops, which will be offered in French by Collège Boréal. The French-language component of this project is supported by a $220,000 grant. It is funded in partnership with the City of Toronto, the Province of Ontario, and the Government of Canada under the Canada-Ontario Early Childhood Workforce Agreement, which provides federal funding to support the recruitment and retention of qualified child care and early childhood educators. Ontario Diploma in Early Childhood Education: International Recruitment and Recognition of Francophone Credentials Following international recruitment efforts led by the Association francophone à l'éducation des services à l'enfance de l'Ontario (AFÉSEO), Collège Boréal, in collaboration with Collège La Cité, will evaluate nine international diplomas to facilitate the recognition of prior learning. Bridging pathways will be developed, as needed, to help candidates meet Ontario's requirements for early childhood education. As part of Création et appui au réseau d'intervenants en petite enfance en situation minoritaire—a project to create and support a network of early childhood professionals in minority settings launched by the CNPF—this initiative also provides language support and funding to cover tuition fees, among other costs, with the goal of supporting successful integration. The objective is to help these new recruits quickly obtain official certification from the College of Early Childhood Educators of Ontario. In addition to strengthening the supply of qualified professionals, this initiative—funded with $800,000 from the CNPF—aims to improve the quality of educational services for Francophone children and families across Ontario. Positive outcomes observed by employers during a 2024 pilot project led by AFÉSEO demonstrate the initiative's success and the smooth integration of new talent into Ontario's communities. Quote 'The implementation of these two innovative projects focused on recruitment and skills development in early childhood education once again reflects Boréal's responsiveness and commitment to the communities it serves. These initiatives are making a tangible contribution to increasing the number of qualified Francophone early childhood educators and ensuring the continuous improvement of services available to Francophone children in Ontario, starting at a very young age.' − Manager, Professional Services in Early Childhood Education, Collège Boréal Online resources Professional Services in Early Childhood Education Toronto Children's Services Commission nationale des parents francophones Association francophone à l'éducation des services à l'enfance de l'Ontario Research & Innovation Boréal Information Benoît ClémentManager, Communications and Media Relations705-560-6673, ext. Created in Sudbury in 1995, Collège Boréal is a French-language post-secondary education and training institution committed to the development and growth of the various Ontario communities it serves. Through its 34 sites including 8 campuses in 27 communities, Collège Boréal offers a high level of expertise in post-secondary education, basic training, apprenticeship, immigrant services, employment services, customized training and applied research. To find out more about Collège Boréal's programs and services, please visit our website at or follow us on Facebook, Instagram, LinkedIn and X. A photo accompanying this announcement is available at: in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Business Upturn
an hour ago
- Business Upturn
Trump's airstrike on Iran, crypto investors flock to Blockchain Cloud Mining for risk aversion This crypto market is shaken
London, UK, June 23, 2025 (GLOBE NEWSWIRE) — June 2025, US President Trump once again drew the world's attention back to the crosshairs of the Middle East war. As the US military precisely struck Iran's nuclear facilities, the entire international financial market has intensified, and the crypto market has also been caught in turmoil. In this chaotic situation, more and more investors are turning their attention to a more stable option: blockchain cloud mining. In particular, Blockchain Cloud Mining, a platform regulated by the UK, compliant and transparent, is rapidly becoming a new generation of digital safe-haven asset allocation tools. On the evening of June 21, 2025, the US Air Force dispatched stealth bombers and unmanned fighter jets to carry out air strikes on multiple Iranian nuclear-related targets, including the three core facilities of Natanz, Fordow and Isfahan. Although the White House claimed that it was 'necessary defense to prevent nuclear proliferation', Iran said that it 'has been regarded as a formal declaration of war' and threatened to block the Strait of Hormuz, causing panic in the global crude oil supply. The shadow of war once again looms over the world: oil prices soared, gold prices hit new highs, Nasdaq and Dow Jones plummeted, and U.S. bond yields plummeted. At the same time, the cryptocurrency market also experienced violent fluctuations, with Bitcoin falling to $103,000 at one point, and mainstream currencies such as DOGE and XRP fluctuating by more than 12% in a day. Data from mainstream trading platforms such as Robinhood and Coinbase show that a large number of users reduced their holdings within 48 hours and turned to stablecoins, fiat currencies or other low-risk configurations. It is in this atmosphere of spreading anxiety that an investment method that does not rely on the rise and fall of currency prices but can obtain sustainable crypto returns has quickly gained attention: BlockchainCloudMining. Why do crypto investors choose BlockchainCloudMining? ⦁ Register to get an instant reward of $12. ⦁ High profit levels and daily dividends. ⦁ No other service fees or management fees. ⦁The platform supports settlement of more than 9 cryptocurrencies such as DOGE, BTC, ETH, SOL, USDC, USDT, XRP, LTC, and BCH. ⦁The company's affiliate program allows you to refer friends and receive up to $50,000 in referral bonuses. ⦁McAfee® security. Cloudflare® security. 100% uptime guarantee and excellent 24/7 human online technical support. How to get started with BlockchainCloudMining Step 1: Register an account In this case, we chose BlockChainCloudMining as our cloud mining service provider. Go to the service provider of your choice to register and create a new account. BlockChainCloudMining offers a simple registration process, just enter your email address and create an account to participate. After registration, users can start mining Bitcoin and other cryptocurrencies immediately. Step 2: Purchase a mining contract Currently, BlockChainCloudMining offers a variety of mining contracts, each with a unique return on investment (ROI) and a specific contract period. After purchasing a contract, you can receive earnings the next day, and you can also choose to withdraw to your crypto wallet or continue to purchase other contracts. (The platform has launched a number of stable income contracts, for more contract details, please log in to the official website of Collective shift of Robinhood and Coinbase users In the past 72 hours, several crypto analysis bloggers have found that users from Robinhood and Coinbase are turning to cloud mining platforms on a large scale. Some popular KOLs said on the X platform: 'Instead of wandering anxiously in the exchange, it is better to use BTC for production.' This is exactly the concept emphasized by BlockchainCloudMining – let assets 'generate coins' instead of just 'store coins' When will the next impact come? Will Iran retaliate? Will the United States expand its military operations? Will OPEC intervene in the crude oil market? There are no answers to these. But what can be confirmed is that the logic of war is diffuse, and the sense of security of assets is scarce. At this moment when the smoke of gunpowder has not yet dissipated, the real winners are not speculators who sell high and buy low, but those long-termists who have a stable, continuous and transparent source of income. For more details, please visit the official website: Or contact the company email: [email protected] Disclaimer: The information provided in this press release is not a solicitation for investment, nor is it intended as investment advice, financial advice, or trading advice. Cryptocurrency mining and staking involve risk. There is potential for loss of funds. It is strongly recommended you practice due diligence, including consultation with a professional financial advisor, before investing in or trading cryptocurrency and securities. Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash
Business Upturn
an hour ago
- Business Upturn
Travis Credit Union Named One of Forbes' Best-In-State Credit Unions 2025
By GlobeNewswire Published on June 23, 2025, 19:30 IST VACAVILLE, Calif., June 23, 2025 (GLOBE NEWSWIRE) — Travis Credit Union is proud to announce its inclusion in the Forbes list of America's Best-In-State Credit Unions 2025. This recognition underscores the institution's unwavering commitment to remarkable member service, financial education, and community engagement. Notably, Travis Credit Union ranked among the top three credit unions in the highly competitive state of California, underscoring its exceptional performance. This marks the fourth time Travis Credit Union has received this recognition, having also been honored in 2020, 2021, and 2022. The Forbes ranking, compiled in collaboration with Statista Inc., is based on an extensive survey of approximately 26,000 U.S. customers who evaluated banks and credit unions on key factors such as trust, customer service, digital services, financial advice, and overall satisfaction. For 2025, only 213 banks and 228 credit unions nationwide earned this distinction. 'Being recognized as one of the Best-In-State Credit Unions is a testament to the dedication and hard work of our team,' said Kevin Miller, president and chief executive officer at Travis Credit Union. 'We are honored to serve our members and remain steadfast in our mission to promote financial wellness and community empowerment.' Founded in 1951 and headquartered in Vacaville, California, Travis Credit Union has consistently been recognized for its innovative financial solutions, member-centric approach, and active involvement in local communities. The institution offers a wide range of services, including personal and business banking, loans, and financial education resources. For more information about Travis Credit Union and its services, please visit About Travis Credit Union Travis Credit Union, based in Vacaville, Calif., has been recognized at the federal, state and local levels for its longstanding financial education and financial advocacy efforts. In 2024, TCU was named as a Best Regional Credit Union by Newsweek. It was also selected as a Best-In-State Credit Union by Forbes and has also earned the U.S. Air Force Distinguished Credit Union of the Year award. Founded in 1951 on Travis Air Force Base, TCU today serves 12 Northern California counties. It is the twelfth largest credit union in California, with 250,000 members and $5 billion in assets. Learn more about our mission at Disclaimer: The above press release comes to you under an arrangement with GlobeNewswire. Business Upturn takes no editorial responsibility for the same. Ahmedabad Plane Crash GlobeNewswire provides press release distribution services globally, with substantial operations in North America and Europe.
