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Trump administration blocked from cutting local health funding for four municipalities

Trump administration blocked from cutting local health funding for four municipalities

A federal court has temporarily blocked the Trump administration from clawing back millions in public health funding from four Democrat-led municipalities in GOP-governed states.
It's the second such federal ruling to reinstate public health funding for several states.
U.S. District Judge Christopher Cooper in Washington, D.C., issued a preliminary injunction Tuesday sought by district attorneys in Harris County, Texas, home to Houston, and three cities: Columbus, Ohio, Nashville, Tennessee, and Kansas City, Missouri. The decision means the federal government must reinstate funding to the four municipalities until the case is fully litigated.
Their lawsuit, filed in late April, alleged $11 billion in cuts to U.S. Centers for Disease Control and Prevention programs had already been approved by Congress and are being unconstitutionally withheld. They also argued that the administration's actions violate Department of Health and Human Services regulations.
The cities and counties argued the cuts were 'a massive blow to U.S. public health at a time where state and local public health departments need to address burgeoning infectious diseases and chronic illnesses, like the measles, bird flu, and mpox.' The cuts would lead to thousands of state and local public health employees being fired, the lawsuit argued.
The local governments, alongside the American Federation of State, County and Municipal Employees union, wanted the court to reinstate the grants nationwide. But Cooper said in his preliminary injunction that the funds can only be blocked to the four municipalities and in a May 21 hearing expressed skepticism about whether it could apply more widely.
The funding in question was granted during the COVID-19 pandemic but aimed at building up public health infrastructure overall, Harris County Attorney Christian Menefee said in a statement in April.
The four local governments were owed about $32.7 million in future grant payments, Cooper's opinion notes.
The federal government's lawyers said the grants were legally cut because, 'Now that the pandemic is over, the grants and cooperative agreements are no longer necessary as their limited purpose has run out.' They used the same argument in the case brought by 23 states and the District of Columbia over the HHS funding clawback.
Menefee said the cuts defunded programs in Harris County for wastewater disease surveillance, community health workers and clinics and call centers that helped people get vaccinated. Columbus City Attorney Zach Klein said the cuts forced the city to fire 11 of its 22 infectious disease staffers.
Nashville used some of its grant money to support programs, including a 'strike team' that after the pandemic addressed gaps in health services that kept kids from being able to enroll in school, according to the lawsuit.
Kansas City used one of its grants to build out capabilities to test locally for COVID-19, influenza and measles rather than waiting for results from the county lab. The suit details that after four years of work to certify facilities and train staff, the city 'was at the final step' of buying lab equipment when the grant was canceled.
Representatives for HHS, the CDC, the cities and Harris County did not immediately respond to requests for comment Tuesday.
___
The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.

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Live Updates: Israel and Iran Trade New Strikes on 9th Day of War
Live Updates: Israel and Iran Trade New Strikes on 9th Day of War

New York Times

time11 minutes ago

  • New York Times

Live Updates: Israel and Iran Trade New Strikes on 9th Day of War

President Trump was angry. Earlier this month, Tulsi Gabbard, his director of national intelligence, had posted a three-and-half-minute video to social media describing her visit to Hiroshima, Japan, and outlining the horrors caused by the detonation of a nuclear weapon there 80 years ago. Speaking directly to the camera, Ms. Gabbard warned that the threat of nuclear war remained. 'As we stand here today, closer to the brink of nuclear annihilation than ever before,' she said, 'political elites and warmongers are carelessly fomenting fear and tension between nuclear powers.' Mr. Trump berated Ms. Gabbard for the video, according to two people briefed on the conversation. He said that her discussion of nuclear annihilation would scare people and that officials should not talk about it. Mr. Trump's displeasure with the video laid bare months of his skepticism of Ms. Gabbard and frustrations with her. The president and some administration officials viewed her overseas travel, as the video exemplified, as being as much about self-promotion of her political career as it was about the business of government, multiple officials said, who spoke on the condition of anonymity to discuss internal dynamics of the administration. But the tensions surrounding Ms. Gabbard are now in the open, as Mr. Trump considers mounting a military strike on Iran. Ms. Gabbard, a critic of overseas entanglements, has privately raised concerns of a wider war. And on Friday Mr. Trump said 'she's wrong' when he was asked about her testimony in March that Iran had not decided to build a nuclear weapon. After the video was posted, the president also told Ms. Gabbard that he was disappointed in her, and wished she had used better judgment, according to one of the two people briefed on the conversation. He told Ms. Gabbard that he believed she was using her time working for him to set herself up for higher office. Mr. Trump told Ms. Gabbard that if she wanted to run for president, she should not be in the administration, one of the people briefed on the meeting said. Image Ms. Gabbard and her husband, Abraham Williams, at her swearing-in at the White House in February. Credit... Eric Lee/The New York Times While Ms. Gabbard is a former Democrat, her credentials as a critic of America's long wars in Iraq and Afghanistan and as a skeptic of foreign military interventions appeal to Mr. Trump's base, and her views dovetail with those of some of his other advisers. Her supporters are openly advocating that the president keep her. 'The president needs someone who will give him the right intelligence information, whether he likes it or not,' said Daniel L. Davis, an analyst at the think tank Defense Priorities, which advocates a restrained foreign policy. 'If you put someone else in there, they might only tell him what he wants to hear.' Mr. Davis, a retired Army lieutenant colonel, was Ms. Gabbard's choice for a top intelligence role before criticism from Republicans over his skepticism of Israel's war in Gaza forced her to rescind the appointment. There is no question, officials said, that Ms. Gabbard's standing has been weakened and that she is embattled. But few in the administration want to see her depart. Some say she has people who like her, while others worry about who might replace her. Two officials said that Mr. Trump's anger over the video had faded and that they were back on better terms. Ms. Gabbard continues to brief the president regularly and speaks often to John Ratcliffe, the C.I.A. director, who held Ms. Gabbard's job in the first Trump administration, according to multiple officials. In a statement, the White House press office dismissed any notion she has been sidelined. Steven Cheung, a White House spokesman, said Mr. Trump had 'full confidence' in his national security team. 'D.N.I. Gabbard is an important member of the president's team and her work continues to serve him and this country well,' Mr. Cheung said. Ms. Gabbard was an aggressive supporter of Mr. Trump on the 2024 campaign trail. He and his top advisers valued her input, especially when Mr. Trump was preparing to debate Vice President Kamala Harris — whom Ms. Gabbard had memorably attacked in a Democratic primary debate in 2019. After the election, Mr. Trump quickly decided to nominate her for director of national intelligence. But from the beginning he made clear to associates that he harbored some doubts. Mr. Trump, according to associates, saw her as overly interested in her own success. Mr. Trump drew a contrast between Ms. Gabbard and the other former Democrat he named to his cabinet, Robert F. Kennedy Jr. 'Bobby's a star,' Mr. Trump told one associate. 'Tulsi? Tulsi wants to be a star.' Mr. Trump's implication was that unlike Mr. Kennedy, Ms. Gabbard did not have what it took to succeed in politics. Image Ms. Gabbard with Mr. Trump, Robert F. Kennedy Jr. and Tucker Carlson during a campaign event in Georgia in October. Credit... Kenny Holston/The New York Times And soon after her swearing-in, he began to complain about her effectiveness. At the same time, Mr. Trump — long mistrustful of the intelligence community — questioned whether there needed to be an Office of the Director of National Intelligence at all. A senior intelligence official said Ms. Gabbard had overseen a 25 percent cut in the size of her office. And Ms. Gabbard has repeatedly told people in the White House that she is willing to be the last director of national intelligence, according to an official. The office, Ms. Gabbard said, could be reabsorbed into the C.I.A., or become something akin to the National Security Council, a bare-bones oversight group. At least for a time, the kind of foreign policy restraint Ms. Gabbard favors appeared to gain traction this spring. In White House discussions about Israel and Iran, Ms. Gabbard raised the range of possible consequences of an Israeli strike against Iran, saying it could trigger a wider conflict that brought in the United States. Vice President JD Vance, at times also a skeptic of military intervention, made similar arguments and was among those who supported Mr. Trump's impulse to initially try to negotiate a deal with Iran. As the C.I.A. delivered intelligence reports that Israel intended to strike Iran regardless, Mr. Trump and senior aides became more publicly supportive of the Israeli campaign. Ms. Gabbard did not attend a key meeting at Camp David, where Mr. Ratcliffe presented assessments about Iran's nuclear program. Ms. Gabbard, according to officials, was on Army Reserve duty. Other people with knowledge of the matter have said she was not invited. (Karoline Leavitt, the White House press secretary, said Ms. Gabbard had met daily with Mr. Trump and his team.) Then on Tuesday, Mr. Trump contradicted Ms. Gabbard in public. After the Israeli strikes began, a journalist on Air Force One asked Mr. Trump about Ms. Gabbard's testimony in March that Iran had not decided to make a nuclear bomb. 'I don't care what she said,' Mr. Trump said. 'I think they were very close to having it.' He made similar comments on Friday. Image Mr. Trump, aboard Air Force One this week, contradicted Ms. Gabbard's assessment of Iran's nuclear program. Credit... Kenny Holston/The New York Times An official from Ms. Gabbard's office said her position was not at odds with Mr. Trump's. In her testimony, Ms. Gabbard reported the consensus opinion of the intelligence community: that Iran's supreme leader had not authorized the country to build a nuclear weapon. But Ms. Gabbard had also noted Iran's large stocks of enriched uranium and a shift in tone that was 'likely emboldening nuclear weapons advocates within Iran's decision-making apparatus.' But Mr. Trump's Air Force One remark came off as a rebuke. To a certain extent, some officials said, courting Mr. Trump's displeasure is a hazard of any intelligence job in his administration. Mr. Trump believes the intelligence community undermined him in his first term, and his long-held skepticism that it is part of a disloyal deep state continues. Ms. Gabbard, when briefing Mr. Trump, presents a range of options and assessments. But it is difficult to talk about the findings of spy agencies and not raise Mr. Trump's ire, the official said. Ms. Gabbard's most important job as director of national intelligence is overseeing, and delivering, the president's daily intelligence brief. But the brief is actually produced a few miles from her office at the C.I.A., and many of those working on the document are detailed from the agency. Ms. Gabbard announced internally last month that she would physically move the production of the brief to her headquarters, known as Liberty Crossing. Within the administration, several senior officials saw it as a way to try to enhance her own relevance at a time when Mr. Trump was questioning the relevance of the office. Others said it was an expensive decision that would be logistically difficult to carry out. Ultimately, the White House put the move on pause, according to multiple people briefed on the matter. Ms. Gabbard has influential defenders inside and outside the government. Mr. Vance, seen as the most senior voice for a less hawkish, more restrained foreign policy, issued a long social media post defending the administration's support of Israel's attack on Iran. He added to that a message supporting Ms. Gabbard. He also released a statement calling her a 'patriot.' Her supporters insist that she remains relevant and that, over time, her skepticism of American intervention in Ukraine and caution on military action against Iran will once more prevail. The possible delay of any decision by Mr. Trump to strike Iran represents an opportunity for diplomacy and critics of American military intervention to make the case for restraint, some of Ms. Gabbard's supporters said. Olivia C. Coleman, a spokeswoman for Ms. Gabbard's office, dismissed the reports of dissatisfaction or tensions with the White House as 'lies made up by bored, irrelevant anonymous sources with nothing better to do than sow fake division.' 'The director,' Ms. Coleman said, 'remains focused on her mission: providing accurate and actionable intelligence to the president, cleaning up the deep state and keeping the American people safe, secure and free.'

Israel-Iran ConflictLive Updates: Israel and Iran Trade New Strikes on 9th Day of War
Israel-Iran ConflictLive Updates: Israel and Iran Trade New Strikes on 9th Day of War

New York Times

time15 minutes ago

  • New York Times

Israel-Iran ConflictLive Updates: Israel and Iran Trade New Strikes on 9th Day of War

President Trump was angry. Earlier this month, Tulsi Gabbard, his director of national intelligence, had posted a three-and-half-minute video to social media describing her visit to Hiroshima, Japan, and outlining the horrors caused by the detonation of a nuclear weapon there 80 years ago. Speaking directly to the camera, Ms. Gabbard warned that the threat of nuclear war remained. 'As we stand here today, closer to the brink of nuclear annihilation than ever before,' she said, 'political elites and warmongers are carelessly fomenting fear and tension between nuclear powers.' Mr. Trump berated Ms. Gabbard for the video, according to two people briefed on the conversation. He said that her discussion of nuclear annihilation would scare people and that officials should not talk about it. Mr. Trump's displeasure with the video laid bare months of his skepticism of Ms. Gabbard and frustrations with her. The president and some administration officials viewed her overseas travel, as the video exemplified, as being as much about self-promotion of her political career as it was about the business of government, multiple officials said, who spoke on the condition of anonymity to discuss internal dynamics of the administration. But the tensions surrounding Ms. Gabbard are now in the open, as Mr. Trump considers mounting a military strike on Iran. Ms. Gabbard, a critic of overseas entanglements, has privately raised concerns of a wider war. And on Friday Mr. Trump said 'she's wrong' when he was asked about her testimony in March that Iran had not decided to build a nuclear weapon. After the video was posted, the president also told Ms. Gabbard that he was disappointed in her, and wished she had used better judgment, according to one of the two people briefed on the conversation. He told Ms. Gabbard that he believed she was using her time working for him to set herself up for higher office. Mr. Trump told Ms. Gabbard that if she wanted to run for president, she should not be in the administration, one of the people briefed on the meeting said. Image Ms. Gabbard and her husband, Abraham Williams, at her swearing-in at the White House in February. Credit... Eric Lee/The New York Times While Ms. Gabbard is a former Democrat, her credentials as a critic of America's long wars in Iraq and Afghanistan and as a skeptic of foreign military interventions appeal to Mr. Trump's base, and her views dovetail with those of some of his other advisers. Her supporters are openly advocating that the president keep her. 'The president needs someone who will give him the right intelligence information, whether he likes it or not,' said Daniel L. Davis, an analyst at the think tank Defense Priorities, which advocates a restrained foreign policy. 'If you put someone else in there, they might only tell him what he wants to hear.' Mr. Davis, a retired Army lieutenant colonel, was Ms. Gabbard's choice for a top intelligence role before criticism from Republicans over his skepticism of Israel's war in Gaza forced her to rescind the appointment. There is no question, officials said, that Ms. Gabbard's standing has been weakened and that she is embattled. But few in the administration want to see her depart. Some say she has people who like her, while others worry about who might replace her. Two officials said that Mr. Trump's anger over the video had faded and that they were back on better terms. Ms. Gabbard continues to brief the president regularly and speaks often to John Ratcliffe, the C.I.A. director, who held Ms. Gabbard's job in the first Trump administration, according to multiple officials. In a statement, the White House press office dismissed any notion she has been sidelined. Steven Cheung, a White House spokesman, said Mr. Trump had 'full confidence' in his national security team. 'D.N.I. Gabbard is an important member of the president's team and her work continues to serve him and this country well,' Mr. Cheung said. Ms. Gabbard was an aggressive supporter of Mr. Trump on the 2024 campaign trail. He and his top advisers valued her input, especially when Mr. Trump was preparing to debate Vice President Kamala Harris — whom Ms. Gabbard had memorably attacked in a Democratic primary debate in 2019. After the election, Mr. Trump quickly decided to nominate her for director of national intelligence. But from the beginning he made clear to associates that he harbored some doubts. Mr. Trump, according to associates, saw her as overly interested in her own success. Mr. Trump drew a contrast between Ms. Gabbard and the other former Democrat he named to his cabinet, Robert F. Kennedy Jr. 'Bobby's a star,' Mr. Trump told one associate. 'Tulsi? Tulsi wants to be a star.' Mr. Trump's implication was that unlike Mr. Kennedy, Ms. Gabbard did not have what it took to succeed in politics. Image Ms. Gabbard with Mr. Trump, Robert F. Kennedy Jr. and Tucker Carlson during a campaign event in Georgia in October. Credit... Kenny Holston/The New York Times And soon after her swearing-in, he began to complain about her effectiveness. At the same time, Mr. Trump — long mistrustful of the intelligence community — questioned whether there needed to be an Office of the Director of National Intelligence at all. A senior intelligence official said Ms. Gabbard had overseen a 25 percent cut in the size of her office. And Ms. Gabbard has repeatedly told people in the White House that she is willing to be the last director of national intelligence, according to an official. The office, Ms. Gabbard said, could be reabsorbed into the C.I.A., or become something akin to the National Security Council, a bare-bones oversight group. At least for a time, the kind of foreign policy restraint Ms. Gabbard favors appeared to gain traction this spring. In White House discussions about Israel and Iran, Ms. Gabbard raised the range of possible consequences of an Israeli strike against Iran, saying it could trigger a wider conflict that brought in the United States. Vice President JD Vance, at times also a skeptic of military intervention, made similar arguments and was among those who supported Mr. Trump's impulse to initially try to negotiate a deal with Iran. As the C.I.A. delivered intelligence reports that Israel intended to strike Iran regardless, Mr. Trump and senior aides became more publicly supportive of the Israeli campaign. Ms. Gabbard did not attend a key meeting at Camp David, where Mr. Ratcliffe presented assessments about Iran's nuclear program. Ms. Gabbard, according to officials, was on Army Reserve duty. Other people with knowledge of the matter have said she was not invited. (Karoline Leavitt, the White House press secretary, said Ms. Gabbard had met daily with Mr. Trump and his team.) Then on Tuesday, Mr. Trump contradicted Ms. Gabbard in public. After the Israeli strikes began, a journalist on Air Force One asked Mr. Trump about Ms. Gabbard's testimony in March that Iran had not decided to make a nuclear bomb. 'I don't care what she said,' Mr. Trump said. 'I think they were very close to having it.' He made similar comments on Friday. Image Mr. Trump, aboard Air Force One this week, contradicted Ms. Gabbard's assessment of Iran's nuclear program. Credit... Kenny Holston/The New York Times An official from Ms. Gabbard's office said her position was not at odds with Mr. Trump's. In her testimony, Ms. Gabbard reported the consensus opinion of the intelligence community: that Iran's supreme leader had not authorized the country to build a nuclear weapon. But Ms. Gabbard had also noted Iran's large stocks of enriched uranium and a shift in tone that was 'likely emboldening nuclear weapons advocates within Iran's decision-making apparatus.' But Mr. Trump's Air Force One remark came off as a rebuke. To a certain extent, some officials said, courting Mr. Trump's displeasure is a hazard of any intelligence job in his administration. Mr. Trump believes the intelligence community undermined him in his first term, and his long-held skepticism that it is part of a disloyal deep state continues. Ms. Gabbard, when briefing Mr. Trump, presents a range of options and assessments. But it is difficult to talk about the findings of spy agencies and not raise Mr. Trump's ire, the official said. Ms. Gabbard's most important job as director of national intelligence is overseeing, and delivering, the president's daily intelligence brief. But the brief is actually produced a few miles from her office at the C.I.A., and many of those working on the document are detailed from the agency. Ms. Gabbard announced internally last month that she would physically move the production of the brief to her headquarters, known as Liberty Crossing. Within the administration, several senior officials saw it as a way to try to enhance her own relevance at a time when Mr. Trump was questioning the relevance of the office. Others said it was an expensive decision that would be logistically difficult to carry out. Ultimately, the White House put the move on pause, according to multiple people briefed on the matter. Ms. Gabbard has influential defenders inside and outside the government. Mr. Vance, seen as the most senior voice for a less hawkish, more restrained foreign policy, issued a long social media post defending the administration's support of Israel's attack on Iran. He added to that a message supporting Ms. Gabbard. He also released a statement calling her a 'patriot.' Her supporters insist that she remains relevant and that, over time, her skepticism of American intervention in Ukraine and caution on military action against Iran will once more prevail. The possible delay of any decision by Mr. Trump to strike Iran represents an opportunity for diplomacy and critics of American military intervention to make the case for restraint, some of Ms. Gabbard's supporters said. Olivia C. Coleman, a spokeswoman for Ms. Gabbard's office, dismissed the reports of dissatisfaction or tensions with the White House as 'lies made up by bored, irrelevant anonymous sources with nothing better to do than sow fake division.' 'The director,' Ms. Coleman said, 'remains focused on her mission: providing accurate and actionable intelligence to the president, cleaning up the deep state and keeping the American people safe, secure and free.'

Novo Nordisk advances early-stage obesity medication, amycretin, to phase 3 clinical development based on early-phase clinical trial results in people with obesity or excess weight, published in The Lancet
Novo Nordisk advances early-stage obesity medication, amycretin, to phase 3 clinical development based on early-phase clinical trial results in people with obesity or excess weight, published in The Lancet

Associated Press

time15 minutes ago

  • Associated Press

Novo Nordisk advances early-stage obesity medication, amycretin, to phase 3 clinical development based on early-phase clinical trial results in people with obesity or excess weight, published in The Lancet

PLAINSBORO, N.J., June 20, 2025 /PRNewswire/ -- Today, results from two early-phase clinical trials evaluating Novo Nordisk's amycretin, an innovative investigational obesity treatment designed to target appetite regulation, were published in The Lancet.1 In a phase 1b/2a clinical trial of 125 adults with overweight or obesity, once-weekly subcutaneous amycretin appeared to be safe and tolerable in trial participants, who also achieved significantly greater weight loss across the full range of doses investigated versus placebo.1 A related phase 1 trial of once-daily oral amycretin in adults with obesity or overweight also showed that treatment was safe and tolerable with an observed reduction in body weight compared to placebo.2 No weight loss plateau was observed in either trial at the end of the respective treatment durations.1,2 Data on subcutaneous amycretin is scheduled to be presented on Sunday, June 22nd, during a late-breaking poster session at the American Diabetes Association's® (ADA) 85th Scientific Sessions.1 'We are pleased with the promising results of amycretin and the feedback from regulatory authorities and are excited to advance both subcutaneous and oral versions of this molecule into phase 3 development for weight management. At Novo Nordisk, we understand that addressing obesity is a complex challenge that many patients face. These results reflect our robust pipeline in obesity, our focus on progressing scientific innovation and expanding the range of options available to patients and healthcare professionals,' said Martin Holst Lange, executive vice president for Development at Novo Nordisk. 'We remain steadfast in our mission to discover and develop therapies that can have a meaningful impact in the lives of those affected by obesity.' Results from the phase 1b/2a trial of subcutaneous amycretin showed treatment-emergent adverse events (TEAEs) were mild or moderate in severity and increased in frequency in a dose-dependent manner. The most frequent reported TEAEs were gastrointestinal in nature. Compared to placebo, participants receiving amycretin observed greater weight loss across the full range of doses investigated.1 Subcutaneous amycretin at multiple doses demonstrated greater weight reduction than placebo at the end of the trial. Participants who received the highest doses (up to 60 mg) reported body weight reductions of up to 24.3% versus 1.1% with placebo after 36 weeks of treatment. Results from this first-in-human phase 1b/2a study support further investigation of potential weight-loss efficacy of amycretin. Results from the published phase 1 trial of oral amycretin showed that the most common TEAEs were related to gastrointestinal symptoms (mainly nausea and vomiting) and decreased appetite; these were most frequent for the higher doses. Trial participants receiving the study treatment demonstrated significantly greater weight loss across the full range of doses investigated versus the placebo group.2 Exploratory results showed participants taking 100 mg per day of oral amycretin achieved a mean weight loss of 13.1% versus 1.2% with placebo after 12 weeks.2 Based on these phase 1 results, longer evaluation with more participants is warranted to substantiate the full efficacy findings of oral amycretin on body weight reductions and changes in metabolic parameters. Novo Nordisk will advance both subcutaneous and oral amycretin formulations straight to phase 3 development for weight management based on these and other completed clinical studies, as well as feedback received from regulatory authorities. About amycretin Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development by Novo Nordisk, to provide a treatment for adults with overweight or obesity and as a treatment for adults with type 2 diabetes. Amycretin is under investigation for oral and subcutaneous administration, and is not approved in the US for weight loss. About the phase 1b/2a subcutaneous amycretin trial The phase 1b/2a trial was a randomized, placebo-controlled, single-center, double-blinded study of 125 participants assessing the safety, tolerability, pharmacokinetics, and effects on body weight after subcutaneous administration of amycretin in people with overweight or obesity.1 Adults with a body mass index of 27-39.9kg/m2 and glycated hemoglobin (HbA1c) <6.5% were eligible for the trial.1 The trial was conducted in 5 parts: a single ascending dose (Part A) for determination of pharmacokinetics and starting dose for the first multiple dose cohort in which the safety and tolerability were explored using dose escalation until 36 weeks of total treatment duration (Part B).1 Lastly, in the multiple ascending dose – dose response parts, body weight loss was explored for up to 36 weeks of dosing by escalating to dose levels of 1.25 mg, 5 mg, and 20 mg, respectively, dosed for 12 weeks (Part E, D and C).1 About the phase 1 oral amycretin trial The phase 1 single-center, randomized, placebo-controlled study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses (Part A) and multiple ascending doses (Part B, 10 days of treatment; Part C/D, 12 weeks of treatment) of 144 adult participants with overweight or obesity.2 The primary endpoint was the number of treatment-emergent adverse events (TEAEs) observed in the trial. The trial evaluated the single-ascending dose and multiple ascending doses for oral amycretin, up to 2 times 50 mg, in people with overweight or obesity, with a total treatment duration of up to 12 weeks.2 About obesity Obesity is a serious chronic, progressive, and complex disease that requires long-term management.3-5 One key misunderstanding is that this is a disease of just lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off.3,5 Obesity is influenced by a variety of factors, including genetics, social determinants of health, and the environment.6,7 The prevalence of overweight and obesity is a public health issue that has severe cost implications to healthcare systems.8,9 In the US, about 40% of adults live with obesity.10 About Novo Nordisk Novo Nordisk is a leading global healthcare company that's been making innovative medicines to help people with diabetes lead longer, healthier lives for more than 100 years. This heritage has given us experience and capabilities that also enable us to drive change to help people defeat other serious chronic diseases such as obesity, rare blood, and endocrine disorders. We remain steadfast in our conviction that the formula for lasting success is to stay focused, think long-term, and do business in a financially, socially, and environmentally responsible way. With a US presence spanning 40 years, Novo Nordisk US is headquartered in New Jersey and employs over 10,000 people throughout the country across 12 manufacturing, R&D and corporate locations in eight states plus Washington DC. For more information, visit Facebook, Instagram, and X. Novo Nordisk is committed to the responsible use of our semaglutide-containing medicines which represent distinct products with different indications, dosages, prescribing information, titration schedules, and delivery forms. These products are not interchangeable and should not be used outside of their approved indications. Learn more at Contacts for further information References © 2025 Novo Nordisk All rights reserved. US25SEMO01477 June 2025 View original content to download multimedia: SOURCE NOVO NORDISK INC.

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