Facility for producing low-cost iPS cells opens in Osaka
A new center for producing low-cost induced pluripotent stem cells from a patient's own blood has opened in Osaka, western Japan.
The Yanai Facility for my iPS Cell Therapy is operated by a foundation affiliated with Kyoto University.
Transplanting tissues derived from a patient's own iPS cells is expected to reduce the risk of immune rejection.
The cost of production is currently estimated at 50 million yen, or about 350,000 dollars, per batch of cells. The facility aims to reduce the figure to about 1 million yen, or about 6,800 dollars, through automation.
The foundation aims to shorten production time from six months to around three weeks, and supply medical institutions with iPS cells for clinical trials starting by fiscal 2028.
The facility is equipped with 14 automated iPS cell culture devices and storage rooms.
Professor Yamanaka Shinya of Kyoto University, who heads the foundation, says he hopes to provide optimal iPS cells at an affordable price.
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NHK
6 hours ago
- NHK
Facility for producing low-cost iPS cells opens in Osaka
A new center for producing low-cost induced pluripotent stem cells from a patient's own blood has opened in Osaka, western Japan. The Yanai Facility for my iPS Cell Therapy is operated by a foundation affiliated with Kyoto University. Transplanting tissues derived from a patient's own iPS cells is expected to reduce the risk of immune rejection. The cost of production is currently estimated at 50 million yen, or about 350,000 dollars, per batch of cells. The facility aims to reduce the figure to about 1 million yen, or about 6,800 dollars, through automation. The foundation aims to shorten production time from six months to around three weeks, and supply medical institutions with iPS cells for clinical trials starting by fiscal 2028. The facility is equipped with 14 automated iPS cell culture devices and storage rooms. Professor Yamanaka Shinya of Kyoto University, who heads the foundation, says he hopes to provide optimal iPS cells at an affordable price.
Japan Times
6 hours ago
- Japan Times
The science of shinrin-yoku: Why forest bathing feels good
Leaves shimmer in shades of verdant green. Sunlight reflected from a rippling creek dances up a tree trunk. Birds chirp, bullfrogs croak and earthy scents of plants and soil fill the air. A visit to a forest soothes our senses. But researchers say that volatile organic compounds released from the trees, whose concentration peaks from June through August in Japan, can do a lot more to make us healthier. Japan is the birthplace of forest bathing, or shinrin-yoku — the process of taking in the forest through your five senses as a means of relaxation. Coined in 1982 by then-Forestry Agency chief Tomohide Akiyama, the concept is now well-established in Japanese culture, and most people consider it a given that it's healing to spend time in the great outdoors. However, doctors such as Qing Li, a clinical professor at Nippon Medical School in Tokyo, have scientifically proven that spending time in nature offers a plethora of medicinal benefits — from enhancing the activity of immune cells and lowering blood pressure and heart rate to reducing stress hormones and levels of anxiety, depression and anger. Qing Li, a clinical professor at Nippon Medical School, has spent decades studying the effects of exposure to nature on the human body. | TOMOKO OTAKE 'It had long been common sense that you can reduce stress by immersing yourself in a beautiful Japanese forest, but it wasn't proven with evidence at all,' Li, a pioneer in the field of forest medicine, says. 'It was only in 2004 that the government gave grants of ¥150 million to look into the science of it to a team of researchers, which I was part of.' Li has analyzed natural killer cells, a type of white blood cell that protects the body from pathogens and cancers. In a seminal study published in 2007 , he took 12 Tokyo-based 'healthy but tired salarymen' from the ages of 37 to 55 on a two-night, three-day forest bathing trip to Iiyama, Nagano Prefecture, a location famous for its beech trees. Blood samples taken before and after the trip showed that the activity and number of natural killer cells, as well as the levels of anti-cancer proteins, increased after forest bathing. But is it really the forest that causes this and not, say, a simple change of scenery? The following year, Li took the same group of corporate warriors on a three-day trip to an urban district of Nagoya with much less greenery than the previous excursion. Li had them walk the same distance and hours as in Iiyama. The trial showed that a trip to the city did not improve the participants' immune cell activity or levels. He followed up with more studies, proving that, yes, forest bathing works for women, too , and its effects last as long as 30 days after a three-day trip. 'That means, if you go on one forest bathing trip of three days once a month, immune levels in the human body can always be kept at high levels,' he says. Other studies have shown that shinrin-yoku reduces the levels of adrenaline, noradrenaline and cortisol, all of which are stress hormones. Phytoncides — aromatic substances released from trees and grass to protect themselves from insects, bacteria and fungi — also stimulate an immune response from the human body. | GETTY IMAGES But why is forest bathing so good for the body? Li says that, while there are still many unknowns, phytoncides — aromatic substances released from trees and grass to protect themselves from insects, bacteria and fungi — play a key role. In a 2009 study , Li compared the levels of immune cell activity in two groups of people: one staying in hotel rooms filled with essential cypress oils vaporized and released from humidifiers and another staying in rooms without the aroma. The results showed that phytoncide exposure in a nonforest environment alone had some effect, Li says. He estimates that the aromatic substances account for about 30% of the therapeutic benefits of forest bathing with the remaining boons coming from the other sensory experiences. How exactly is forest bathing different from regular hikes or nature walks? In forest therapy, the emphasis is on awakening your five senses through the mindful observation of nature without over-exertion, experts say. Since two-thirds of Japan is covered in forests, the nation has more than its fair share of forest bathing destinations to choose from. The Kitamoto Nature Observation Park in Kitamoto, Saitama Prefecture, is one of around 60 'forest therapy bases' in Japan certified by the nonprofit Forest Therapy Society. Just 90 minutes from Tokyo, the 30-hectare forest is blessed with a mixture of cypress, cedar, oak and cherry trees. The Kitamoto Tourism Association organizes forest therapy tours , including two-hour standard tour sessions and special tours combining walks and yoga or local history talks. Fees for most sessions, available in English or Japanese, are between ¥3,000 and ¥6,000. Forest therapy guide Sayuri Ide helps need trekkers not only along hiking routes but through different ways of acceptingf the positive mental benefits of forest bathing. | TOMOKO OTAKE During a recent guided tour, forest therapist Sayuri Ide asked me to pick up a fallen leaf at the park's entrance. When I tore it in half, it smelled like cloth incense. 'This is a camphor leaf, and it is used as an insect repellent,' she says. In the forest, Ide walks slowly, often pausing along the trail. She asks me to take a deep breath, listen to the rustling of leaves and the murmur of a stream, and notice the layered shades of green in the canopy overhead. We drop a leaf into the water and watch how its shadow looks more intricate than the leaf itself. We eat mulberries freshly picked from a tree, take a break for herb tea and, at the end of our two-hour walk, lie down beneath a big tree for a short, restful nap. At one point, Ide asks me what shape of leaves I like best. I say I like round ones, and she nods in agreement. 'We live in such a square world,' Ide says, referring to smartphones and PC screens. 'I want more people to appreciate the beauty of roundness in nature.' Li personally recommends Akasawa Recreation Forest , known as the birthplace of shinrin-yoku, in Agematsu, Nagano Prefecture. It is known for a cypress forest so full of phytoncides that it keeps mosquitoes away. The Okutama forest therapy base , featuring five 'therapy roads' whose distances range from 1.3 to 12 kilometers and which includes some barrier-free routes, is another good venue, he says. Even in central Tokyo, numerous phytoncide-rich spots offer relief, such as the Shinjuku Gyoen park in Shinjuku Ward, the Institute for Nature Study in Minato Ward and the Rikugien and the Koishigawa gardens in Bunkyo Ward.
Japan Times
a day ago
- Japan Times
Humans adapted to diverse habitats before trekking out of Africa
Small bands of Homo sapiens made a few failed forays leaving our home continent before the species finally managed to launch a major dispersal out of Africa roughly 50,000 years ago, going first into Europe and Asia and eventually the rest of the world. So why was this migration successful after the prior ones were not? New research is offering insight. It documents how human hunter-gatherers in Africa began about 70,000 years ago to embrace a greater diversity of habitats such as thick forests and arid deserts, acquiring an adaptability useful for tackling the wide range of conditions awaiting beyond the continent. "Why the dispersal 50,000 years ago was successful is a big question in human origins research. Our results suggest that one part of the reason is that humans had developed the ecological flexibility to survive in challenging habitats," said Loyola University Chicago archeologist Emily Hallett, co-leader of the study published in the journal Nature. Looking at an array of archeological sites in Africa, the study detailed how human populations expanded their range into the forests of Central and West Africa and the deserts of North Africa in the roughly 20,000 years preceding this dispersal. Some examples of archeological sites dating to this time that illustrate the expansion of human niches to harsh deserts include locales in Libya and Namibia, and examples of expansion to forested habitats include locales in Malawi and South Africa. Homo sapiens arose roughly 300,000 years ago, inhabiting grasslands, savannahs and various other African ecosystems. Impalas graze at the Singita Grumeti Game Reserve in Tanzania. | REUTERS "Starting from about 70,000 years ago, we see that they suddenly start to intensify this exploitation of diverse habitats and also expand into new types of habitat in a way we don't see before. They exploit more types of woodland, more types of closed canopy forests, more types of deserts, highlands and grasslands," said archeologist and study co-leader Eleanor Scerri of the Max Planck Institute of Geoanthropology in Germany. "An Ice Age was coming, which means drier conditions in parts of Africa. It seems possible that humans responded to this squeeze by learning how to adapt to new niches," Scerri added. The increased ecological flexibility of the species appears to have reflected cultural and social advances such as passing knowledge from one generation to the next and engaging in cooperative behavior, the researchers said. "This must have entailed profound changes in their interaction with the natural environment, as it allowed them to occupy not only new environments in Africa, but entirely new conditions in Eurasia as well," said evolutionary biologist and study co-leader Michela Leonardi of the Natural History Museum in London. "Another way to phrase this is that the ability to live in a variety of environments in Africa is not directly the adaptation that allowed a successful out of Africa, but rather a sign that humans by that point were the ultimate generalist, able to tackle environments that went from deep forest to dry deserts," said University of Cambridge evolutionary ecologist and study co-leader Andrea Manica. "This flexibility is the key trait that allowed them, later on, to conquer novel challenges, all the way to the coldest tundras in Siberia." Trekking out of Africa, Homo sapiens encountered not only new environments and unfamiliar animals and plants, but also other human species, including the Neanderthals and Denisovans. The ecological flexibility learned in Africa may have provided an edge when Homo sapiens encountered these other humans, both of whom disappeared relatively soon thereafter, the researchers said. Genetic evidence indicates that today's people outside of Africa can trace their ancestry to the population of humans, numbering perhaps only in the thousands, who engaged in that pioneering migration out of Africa approximately 50,000 years ago. "I think that adaptability and innovation are hallmarks of our species, and that they allowed us to succeed in every environment we encountered," Hallett said. "At the same time, we are almost too good at adapting to different places, to the detriment of most other species on Earth."
