STATEMENT - CMA reflects on National Indigenous Peoples Day Français
OTTAWA, ON, June 21, 2025 /CNW/ - On this National Indigenous Peoples Day, the Canadian Medical Association (CMA) reflects on the rich history, strength and resilience of First Nations, Inuit and Métis Peoples.
This year marks the 10 th anniversary of the Truth and Reconciliation Commission of Canada's report, which exposed the devastating legacy of Canada's residential schools, and the sixth anniversary of the report from the National Inquiry into Missing and Murdered Indigenous Women and Girls. We acknowledge and honour the stories that survivors have shared to help guide us toward a better future.
With great humility, we continue our own reconciliation journey led by an Indigenous Guiding Circle composed of health leaders, Elders and Knowledge Keepers. This journey includes working in partnership to combat anti-Indigenous racism in health care and to support the medical profession in making the system safer for First Nations, Inuit and Métis patients and providers.
In updating our Code of Ethics and Professionalism, our goal is to better reflect physicians' shared values in supporting patients and providers from Indigenous communities.
Alongside Indigenous partners, we're leveraging our voice to also call on the federal government to reintroduce important First Nations clean water legislation and support First Nations, Inuit and Métis-led health care.
Our commitment extends to amplifying Indigenous voices and highlighting critical issues through the Indigenous Health Journalism Fellowship.
On National Indigenous Peoples Day, we recognize the importance of acknowledging the truth, rebuilding trust and taking the steps necessary to fulfill our promise of transforming the health system to provide culturally safe, trauma-informed care for Indigenous Peoples.
Dr. Margot Burnell
President, CMA
SOURCE Canadian Medical Association
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STATEMENT - CMA reflects on National Indigenous Peoples Day Français
OTTAWA, ON, June 21, 2025 /CNW/ - On this National Indigenous Peoples Day, the Canadian Medical Association (CMA) reflects on the rich history, strength and resilience of First Nations, Inuit and Métis Peoples. This year marks the 10 th anniversary of the Truth and Reconciliation Commission of Canada's report, which exposed the devastating legacy of Canada's residential schools, and the sixth anniversary of the report from the National Inquiry into Missing and Murdered Indigenous Women and Girls. We acknowledge and honour the stories that survivors have shared to help guide us toward a better future. With great humility, we continue our own reconciliation journey led by an Indigenous Guiding Circle composed of health leaders, Elders and Knowledge Keepers. This journey includes working in partnership to combat anti-Indigenous racism in health care and to support the medical profession in making the system safer for First Nations, Inuit and Métis patients and providers. In updating our Code of Ethics and Professionalism, our goal is to better reflect physicians' shared values in supporting patients and providers from Indigenous communities. Alongside Indigenous partners, we're leveraging our voice to also call on the federal government to reintroduce important First Nations clean water legislation and support First Nations, Inuit and Métis-led health care. Our commitment extends to amplifying Indigenous voices and highlighting critical issues through the Indigenous Health Journalism Fellowship. On National Indigenous Peoples Day, we recognize the importance of acknowledging the truth, rebuilding trust and taking the steps necessary to fulfill our promise of transforming the health system to provide culturally safe, trauma-informed care for Indigenous Peoples. Dr. Margot Burnell President, CMA SOURCE Canadian Medical Association
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Gan & Lee Pharmaceuticals Presented Multiple Results in Novel Diabetes Therapies at the American Diabetes Association's 85th Scientific Sessions
In a Phase 2a clinical trial, the GLP-1 RA bofanglutide injection demonstrated a favorable safety and tolerability profile after 23 weeks of once weekly treatment in patients with type 2 diabetes mellitus (T2DM), with significant HbA1c reductions alongside comprehensive benefits for body weight, blood pressure and blood lipid profiles. In a Phase 2b clinical trial, the bofanglutide injection showed superior HbA1c and body weight reduction than semaglutide (Ozempic ®) after 24 weeks of bi-weekly treatment in patients with T2DM, along with an acceptable safety and tolerability profile. In a Phase 2 clinical trial, the once-weekly insulin GZR4 injection demonstrated comparable efficacy and safety profiles in patients with T2DM after 16 weeks of treatment. Notably, GZR4 injection achieved superior HbA1c reduction in patients with inadequate glycemic control on prior basal insulin therapy compared to once-daily insulin degludec (Tresiba ®). BEIJING and BRIDGEWATER, N.J., June 21, 2025 /CNW/ -- Gan & Lee Pharmaceuticals (Gan & Lee, stock code: announced that the company presented multiple Phase 2 clinical study results of ultra-long-acting GLP-1 receptor agonist (GLP-1 RA) bofanglutide (research code: GZR18) injection and once-weekly basal insulin analog GZR4 injection during a poster presentation at the American Diabetes Association (ADA)'s 85th Scientific Sessions. Bofanglutide injection and GZR4 injection are investigational drugs that have not yet been launched in any country. Gan & Lee Pharmaceuticals does not recommend the use of any unapproved drugs/indications. Bofanglutide injection: A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 2a Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bofanglutide (GZR18) Injection in Chinese Patients with Type 2 Diabetes Mellitus (T2DM) In this Phase 2a clinical trial (NCT06256523), 36 adults with T2DM who had inadequate glycemic control through diet and exercise and/or irregular use of antidiabetic medications, were randomized to receive either bofanglutide injection (N=27) or placebo (N=9) once weekly (QW) for 23 weeks, with a dose escalating from 1.5 mg to 13 mg. The key efficacy endpoint was HbA1c change from baseline to week 23. After 23 weeks of treatment, the mean HbA1c change from baseline in the bofanglutide groups was -1.81% compared to 0.12% in the placebo group, with an estimated treatment difference of -1.93% points *. The proportion of participants achieving an HbA1c target of <7.0% and ≤6.5% was 57.7% and 46.2%, respectively, compared to zero in the placebo group. In terms of weight management, participants treated with bofanglutide experienced a mean reduction in body weight of 6.92 kg from baseline, corresponding to a 9.3% decrease, compared to a minimal reduction of 1.2% in the placebo group. Furthermore, bofanglutide showed comprehensive improvements over placebo in multiple metabolic parameters, including fasting plasma glucose (FPG), glycated albumin (GA), waist circumference (WC), blood pressure, and lipid profiles. In terms of safety, bofanglutide was well tolerated in patients with T2DM. Consistent with known GLP-1 RAs, the most common adverse events were gastrointestinal-related, primarily observed during the early dose-escalation period with mostly mild to moderate in severity. No hypoglycemic events or investigational product-related serious adverse events were reported during the study. Bofanglutide injection: A Multicenter, Randomized, Open-label, Active comparator-controlled Phase 2 Clinical Trial to Evaluate the Efficacy and Safety of bofanglutide Injection versus Semaglutide (Ozempic ®) in Chinese Patients with T2DM In this Phase 2b clinical trial (NCT06256549), a total of 272 eligible Chinese patients with T2DM, who had inadequate glycemic control either after lifestyle intervention or despite stable use of oral antidiabetic drugs (OADs) for at least 3 months, were randomized to receive bi-weekly (Q2W) 12 mg (N=55), 18 mg (N=54), 24 mg (N=55) bofanglutide injections, or once-weekly (QW) 24 mg (N=54) bofanglutide injections, or 1 mg semaglutide (Ozempic ®, N=54) for 24 weeks of treatment, including the dose-escalation period. The primary endpoint was HbA1c change from baseline to week 24. After 24 weeks of treatment, the mean reductions in HbA1c from baseline were 1.87%, 2.28%, and 1.94% in the bofanglutide groups at 12 mg, 18 mg, and 24 mg Q2W, respectively, and -2.32% in the 24 mg QW group. All these treatment regimens showed greater HbA1c reductions compared to the semaglutide group (-1.60%), with the 18 mg Q2W and 24 mg QW bofanglutide groups demonstrating statistically significant superiority (p<0.001) *. Among drug-naïve patients with inadequate glycemic control despite lifestyle interventions, the 18 mg Q2W bofanglutide group achieved a mean HbA1c reduction of 2.98%, which was significantly greater than that observed with semaglutide (-2.04%; p<0.001)*. The proportions of patients achieving HbA1c target of <7.0% were 63.0% to 73.6% in the Q2W bofanglutide group, 75.0% in the QW bofanglutide group, and 70.0% in the semaglutide group. For the HbA1c ≤6.5% target, the corresponding proportions were 58.2% to 67.9%, 69.2%, and 62.0%, respectively. Furthermore, the mean change in body weight for all bofanglutide groups from baseline to week 24 ranged from -4.26 to -6.54 kg, compared to -3.25 kg in the semaglutide group *. Bofanglutide also greatly improved FPG, blood pressure, lipid profiles, and other metabolic parameters. In this study, bofanglutide was g enerally well tolerated, with safety and tolerability consistent with other known GLP-1 RAs. The most common adverse events were gastrointestinal-related, mostly mild to moderate in severity, and no sever e hypoglycemic events were observed. GZR4 injection: A Multicenter, Randomized, Open-label, Active-controlled, Treat-to-target Phase 2 Clinical Study Comparing the Efficacy and Safety of GZR4 Injection Versus Insulin degludec (IDeg, Tresiba ®) in Chinese patients with T2DM This Phase 2 clinical study (NCT06202079) enrolled a total of 83 Chinese patients with T2DM who had inadequate glycemic control on OADs (Part A), and 96 patients with inadequate control on OADs combined with basal insulin therapy (Part B). Participants were randomized to receive QW GZR4 injection (Part A: N=42; Part B: N=41) or once-daily IDeg (Tresiba ®) injection (Part A: N=48; Part B: N=48) for 16 weeks of treatment. The primary efficacy endpoint was the change in HbA1c from baseline to week 16. After 16 weeks of treatment, in patients from Part A, the mean change in HbA1c was comparable between GZR4 groups and IDeg groups (−1.50% versus -1.48%, p = 0.90). The proportion of participants achieving HbA1c target of <7.0% was 59.5% in the GZR4 group and 70.7% in the IDeg group, while the proportion achieving HbA1c target of ≤6.5% was 38.1% and 29.3%, respectively. In patients from Part B, GZR4 demonstrated significantly greater HbA1c reduction compared to IDeg (-1.26% vs -0.87%; p<0.01), with a higher proportion of patients achieving HbA1c targets of <7.0% and ≤6.5% (52.1% vs 29.2%; 25.0% vs 10.4%). In addition, improvements from baseline in FPG and time in range (TIR) were comparable between the GZR4 group and IDeg group. GZR4 achieved effective glycemic control without the need for a loading dose at the first administration, while the total weekly insulin dosage (mole) for GZR4 was approximately 40–50% of that for IDeg (p<0.001). In terms of safety, the incidence of adverse events was similar between the two groups. 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Forward-looking statements Forward-looking statements are based on our expectations and assumptions as of the date of the statements. Actual results may differ materially from those expressed in these forward-looking statements due to a variety of factors, and we can give no assurance that such results will be achieved in the future. We undertake no obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. About Gan & Lee Gan & Lee Pharmaceuticals developed the first Chinese domestic insulin analog. Currently, Gan & Lee has six core insulin products, including five insulin analog varieties: long-acting glargine injection (Basalin ®), fast-acting lispro injection (Prandilin™), fast-acting aspart injection (Rapilin ®), mixed protamine zinc lispro injection (25R) (Prandilin™25), aspart 30 injection (Rapilin ® 30), and one human insulin injection - mixed protamine human insulin injection (30R) (Similin ® 30). The company has two approved medical devices in China, namely reusable insulin injection pen (GanleePen), and disposable pen needle (GanleeFine ®). In China's 2024 National Insulin-Specific Centralized Procurement, Gan & Lee Pharmaceuticals ranked first among all selected companies in terms of procurement demand for insulin analogs. The company is also making strides in international markets, with the disposable pen needle (GanleeFine ®) approved by the US Food and Drug Administration (FDA) in 2020 and received GMP inspection approval from the European Medicines Agency (EMA) in 2024. These achievements significantly boost Gan & Lee's competitiveness in both international and domestic markets. In the future, Gan & Lee will strive for comprehensive coverage in diabetes treatment. Moving forward with its mission to become a world-class pharmaceutical company, Gan & Lee will also actively develop new chemical entities and biological drugs, focusing on treatments for metabolic diseases, cardiovascular diseases, and other therapeutic areas.
Winnipeg Free Press
a day ago
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Manitoba's MDs mandate steps to end anti-Indigenous racism
Manitoba's doctors are embarking on a path the profession's regulator hopes will eliminate anti-Indigenous racism in medical care. The College of Physicians and Surgeons of Manitoba is mandating that MDs complete a course of anti-racism training before November 2027. Two other initiatives go into effect as of today — National Indigenous Peoples Day. The first, a standard of practice, requires that doctors report racist behaviour. The other is a restorative practices program to provide education and support to physicians who cause harm to First Nations, Métis or Inuit patients, either intentionally or unintentionally. MIKAELA MACKENZIE / FREE PRESS The college is moving toward a restorative justice standard, says registrar Ainslie Mihalchuk. 'It is very difficult to practise medicine in Manitoba in any context without interacting with, supporting, caring for people who have Indigenous ancestry or who are from our First Nations and Inuit population and who have had suffered the health effects of colonialism,' Dr. Ainslie Mihalchuk, registrar of the college, said Friday. 'That is part of why we feel it's important that, to practise in Manitoba, you need a baseline understanding of how colonialism impacts health. If you can have that understanding, then you inherently will be a better provider for the people here.' A report on race, ethnicity and Indigenous identity released Tuesday by Shared Health and the University of Manitoba's Ongomiizwin Indigenous Institute of Health and Healing revealed issues in seeking and receiving health care in the province. It showed that Indigenous patients in hospital emergency departments were most likely to leave without being seen and against medical advice, including higher-acuity patients. 'The data supports that we have opportunity to do better,' Mihalchuk said. 'This is about understanding needs of humans and that the needs of certain groups of humans are different than others, and that it's on us as leaders and providers in the health system to recognize that this data points to the fact that our systems are not serving these people in the best way. 'That should lead us to collectively try and say, 'What do we need to do differently?'' She pointed to other examples of anti-Indigenous racism in Canadian health care — from the death of Brian Sinclair, who died after waiting 34 hours without being seen at the Health Sciences Centre ER in 2008 to Joyce Echaquan, a mother of seven, who died in 2020 at a hospital north of Montreal moments after recording health-care staff hurl racist remarks at her, to experiments performed on residential school students. 'We were part of that. The medical profession, the healing profession has participated in that,' Mihalchuk said. 'I think we need to understand how, although we might see ourselves as nice people, there's a lack of trust — that's not on individuals. It's on systems and societies and structures that are older and bigger than we are,' Mihalchuk said. The college self-regulates 3,500 physicians in Manitoba. The 30 per cent of internationally trained doctors in the province may have had no exposure 'to the stories of how Manitoba came to be and who lived here before,' Mihalchuk said. The province often relies on foreign-trained doctors to work in rural and remote communities and areas with large Indigenous populations, she said. 'Asking for people to have a common understanding of the human beings that they're serving in the practise of medicine doesn't feel like a big ask, because we believe that it's a good investment.' There are four college-approved courses — three for those in active practice and the fourth is the Indigenous health program that's part of undergraduate or post-graduate medical training at the University of Manitoba. Mihalchuk said the college received advice from an Indigenous advisory circle about the training and how to discipline those who don't meet the new standard. Wednesdays Sent weekly from the heart of Turtle Island, an exploration of Indigenous voices, perspectives and experiences. Rather than the traditional rigid, 'blame, shame, punish' approach, the college is moving toward a restorative justice approach, she said. 'It's more about healing the harm and going through a process that keeps both parties — the complainant and the person complained about — intact and whole at the end of a process that's not about blame, shame and punish. 'We are leaders,' she continued, 'in the country who are doing this work and really it's about creating a safe space to work on this together as a profession and to contribute to 'better.'' Doctors Manitoba said in an email it is providing professional development funding for the training that counts toward the hours of continuing education doctors have to complete every year to improve their practice and maintain their licence. Carol SandersLegislature reporter Carol Sanders is a reporter at the Free Press legislature bureau. The former general assignment reporter and copy editor joined the paper in 1997. Read more about Carol. Every piece of reporting Carol produces is reviewed by an editing team before it is posted online or published in print — part of the Free Press's tradition, since 1872, of producing reliable independent journalism. Read more about Free Press's history and mandate, and learn how our newsroom operates. Our newsroom depends on a growing audience of readers to power our journalism. If you are not a paid reader, please consider becoming a subscriber. Our newsroom depends on its audience of readers to power our journalism. Thank you for your support.
