The simple skin solution everyone is talking about: Here's what to know
Forget fillers and frozen expressions—today's skincare revolution is all about regeneration from within. One of the most talked-about breakthroughs in this space is Polydeoxyribonucleotide (PDRN), a salmon-DNA-derived compound making waves through its natural, skin-reviving powers. In an exclusive chat with India Today, leading aesthetic dermatologist Dr. Amit Bhasin of Prive Clinic, Gurgaon, breaks down why PDRN is fast becoming a favourite for patients and practitioners alike.advertisement'In over 400 cases at my clinic, I've seen PDRN consistently deliver rejuvenation results that are safe, effective, and natural-looking,' says Dr. Bhasin.WHAT IS PDRN, AND HOW DOES IT WORK?PDRN is a low-molecular-weight DNA polymer extracted from salmon trout (Oncorhynchus mykiss), with proven effects on tissue repair, inflammation control, and collagen regeneration.
Its primary mechanism works through the activation of A2A adenosine receptors, which:Promote angiogenesis (blood vessel formation)Stimulate fibroblast proliferationAccelerate tissue healing and skin remodelingWHY PATIENTS ARE CHOOSING PDRN OVER FILLERS'Increasingly, patients are hesitant about neurotoxins and heavy fillers,' notes Dr. Bhasin. 'They want fresher, younger skin without frozen expressions. PDRN gives them exactly that—hydration, glow, and texture improvement—without altering their natural look.'According to him, nearly 95% of patients report visible skin improvement, and satisfaction levels are notably high.advertisementPeriorbital RejuvenationDark circles, puffiness, and under-eye pigmentation respond remarkably well to PDRN through improved microcirculation, collagen stimulation, and inflammatory control.Wrinkle ReductionPDRN improves elasticity, smooths fine lines, and firms skin by regenerating the extracellular matrix and enhancing collagen and elastin synthesis.Superior Skin HydrationPatients report a lasting glow and smoother texture. The treatment boosts hyaluronic acid production and strengthens the epidermal barrier.Pore Size ReductionBy balancing sebum production and improving dermal structure, PDRN helps shrink enlarged pores and refine skin texture.Acne and Post-Acne ScarringPDRN supports faster healing, reduces pigmentation, and prevents acne scarring through fibroblast activation and cytokine regulation.Non-Healing WoundsFor patients with ulcers or chronic wounds, especially when paired with PRP or PRF, PDRN accelerates re-epithelialization and healing.Powerful Combinations: PDRN Plus Other Aesthetic TherapiesDr. Bhasin emphasises that PDRN works even better in synergy with various popular treatments:PRP / PRF: Enhanced tissue repair and anti-inflammationClearLift Laser: Better collagen remodeling and pigmentation controlMicroneedling (PCIT): Improved product penetration and collagen inductionHIFU: Faster recovery and deeper tissue regenerationSkin Boosters / Baby Botox: A glowing finish with no volume overloadPDRN also integrates well withCO2 & Er:YAG LasersMNRFIPL, LED light therapyadvertisementDermal FillersChemical PeelsOxygen & MesotherapyTHE INDIAN SKIN ADVANTAGEDr. Bhasin believes PDRN is particularly suited to Indian skin types, which are prone to pigmentation, inflammation, and acne-related scarring.'It's gentle, adaptable, and works across all ages. Whether it's glow enhancement for brides, anti-aging for professionals, or acne repair for teens—PDRN fits right in,' he explains.Polydeoxyribonucleotide isn't just a trend—it's a cornerstone in the evolving field of skin regeneration. With science-backed mechanisms, high patient safety, and visible aesthetic outcomes, PDRN is closing the gap between cosmetic desire and dermatological healing.Dr. Amit Bhasin's clinical experience with PDRN is a compelling testimony to its future potential—not only as an anti-aging tool but also as a holistic skin-healing therapy.'We're entering the age of skin intelligence—treatments that work with your biology, not against it,' he concludes.
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