Holyoke police to cite driver who heavily damaged JFK memorial while driving under the influence
HOLYOKE — A driver who crashed into John F. Kennedy Memorial Plaza early Sunday morning, heavily damaging several monuments, will be charged with driving under the influence of drugs and destruction of property.
Officers responding to reports of the 4:25 a.m. crash at Suffolk, Sycamore and Appleton streets found the 26-year-old driver and a passenger inside the vehicle. Firefighters arrived shortly after and helped remove the two from the car, Police Chief Brian Keenan said.
'The driver and passenger were administered Narcan and transported to the hospital to evaluate possible injuries,' he said. Narcan is used to reverse opioid overdoses.
The driver, who is from Springfield, will be cited for the crimes. His name will not be released until charges are leveled, Keenan said.
At least four monuments were toppled, several were smashed, and the lawn and other concrete areas were damaged. The Department of Public Works has been notified, he said.
Read the original article on MassLive.
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Associated Press
29 minutes ago
- Associated Press
Novo Nordisk advances early-stage obesity medication, amycretin, to phase 3 clinical development based on early-phase clinical trial results in people with obesity or excess weight, published in The Lancet
PLAINSBORO, N.J., June 20, 2025 /PRNewswire/ -- Today, results from two early-phase clinical trials evaluating Novo Nordisk's amycretin, an innovative investigational obesity treatment designed to target appetite regulation, were published in The Lancet.1 In a phase 1b/2a clinical trial of 125 adults with overweight or obesity, once-weekly subcutaneous amycretin appeared to be safe and tolerable in trial participants, who also achieved significantly greater weight loss across the full range of doses investigated versus placebo.1 A related phase 1 trial of once-daily oral amycretin in adults with obesity or overweight also showed that treatment was safe and tolerable with an observed reduction in body weight compared to placebo.2 No weight loss plateau was observed in either trial at the end of the respective treatment durations.1,2 Data on subcutaneous amycretin is scheduled to be presented on Sunday, June 22nd, during a late-breaking poster session at the American Diabetes Association's® (ADA) 85th Scientific Sessions.1 'We are pleased with the promising results of amycretin and the feedback from regulatory authorities and are excited to advance both subcutaneous and oral versions of this molecule into phase 3 development for weight management. At Novo Nordisk, we understand that addressing obesity is a complex challenge that many patients face. These results reflect our robust pipeline in obesity, our focus on progressing scientific innovation and expanding the range of options available to patients and healthcare professionals,' said Martin Holst Lange, executive vice president for Development at Novo Nordisk. 'We remain steadfast in our mission to discover and develop therapies that can have a meaningful impact in the lives of those affected by obesity.' Results from the phase 1b/2a trial of subcutaneous amycretin showed treatment-emergent adverse events (TEAEs) were mild or moderate in severity and increased in frequency in a dose-dependent manner. The most frequent reported TEAEs were gastrointestinal in nature. Compared to placebo, participants receiving amycretin observed greater weight loss across the full range of doses investigated.1 Subcutaneous amycretin at multiple doses demonstrated greater weight reduction than placebo at the end of the trial. Participants who received the highest doses (up to 60 mg) reported body weight reductions of up to 24.3% versus 1.1% with placebo after 36 weeks of treatment. Results from this first-in-human phase 1b/2a study support further investigation of potential weight-loss efficacy of amycretin. Results from the published phase 1 trial of oral amycretin showed that the most common TEAEs were related to gastrointestinal symptoms (mainly nausea and vomiting) and decreased appetite; these were most frequent for the higher doses. Trial participants receiving the study treatment demonstrated significantly greater weight loss across the full range of doses investigated versus the placebo group.2 Exploratory results showed participants taking 100 mg per day of oral amycretin achieved a mean weight loss of 13.1% versus 1.2% with placebo after 12 weeks.2 Based on these phase 1 results, longer evaluation with more participants is warranted to substantiate the full efficacy findings of oral amycretin on body weight reductions and changes in metabolic parameters. Novo Nordisk will advance both subcutaneous and oral amycretin formulations straight to phase 3 development for weight management based on these and other completed clinical studies, as well as feedback received from regulatory authorities. About amycretin Amycretin is a unimolecular long-acting GLP-1 and amylin receptor agonist under development by Novo Nordisk, to provide a treatment for adults with overweight or obesity and as a treatment for adults with type 2 diabetes. Amycretin is under investigation for oral and subcutaneous administration, and is not approved in the US for weight loss. About the phase 1b/2a subcutaneous amycretin trial The phase 1b/2a trial was a randomized, placebo-controlled, single-center, double-blinded study of 125 participants assessing the safety, tolerability, pharmacokinetics, and effects on body weight after subcutaneous administration of amycretin in people with overweight or obesity.1 Adults with a body mass index of 27-39.9kg/m2 and glycated hemoglobin (HbA1c) <6.5% were eligible for the trial.1 The trial was conducted in 5 parts: a single ascending dose (Part A) for determination of pharmacokinetics and starting dose for the first multiple dose cohort in which the safety and tolerability were explored using dose escalation until 36 weeks of total treatment duration (Part B).1 Lastly, in the multiple ascending dose – dose response parts, body weight loss was explored for up to 36 weeks of dosing by escalating to dose levels of 1.25 mg, 5 mg, and 20 mg, respectively, dosed for 12 weeks (Part E, D and C).1 About the phase 1 oral amycretin trial The phase 1 single-center, randomized, placebo-controlled study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses (Part A) and multiple ascending doses (Part B, 10 days of treatment; Part C/D, 12 weeks of treatment) of 144 adult participants with overweight or obesity.2 The primary endpoint was the number of treatment-emergent adverse events (TEAEs) observed in the trial. The trial evaluated the single-ascending dose and multiple ascending doses for oral amycretin, up to 2 times 50 mg, in people with overweight or obesity, with a total treatment duration of up to 12 weeks.2 About obesity Obesity is a serious chronic, progressive, and complex disease that requires long-term management.3-5 One key misunderstanding is that this is a disease of just lack of willpower, when in fact there is underlying biology that may impede people with obesity from losing weight and keeping it off.3,5 Obesity is influenced by a variety of factors, including genetics, social determinants of health, and the environment.6,7 The prevalence of overweight and obesity is a public health issue that has severe cost implications to healthcare systems.8,9 In the US, about 40% of adults live with obesity.10 About Novo Nordisk Novo Nordisk is a leading global healthcare company that's been making innovative medicines to help people with diabetes lead longer, healthier lives for more than 100 years. This heritage has given us experience and capabilities that also enable us to drive change to help people defeat other serious chronic diseases such as obesity, rare blood, and endocrine disorders. We remain steadfast in our conviction that the formula for lasting success is to stay focused, think long-term, and do business in a financially, socially, and environmentally responsible way. With a US presence spanning 40 years, Novo Nordisk US is headquartered in New Jersey and employs over 10,000 people throughout the country across 12 manufacturing, R&D and corporate locations in eight states plus Washington DC. For more information, visit Facebook, Instagram, and X. Novo Nordisk is committed to the responsible use of our semaglutide-containing medicines which represent distinct products with different indications, dosages, prescribing information, titration schedules, and delivery forms. These products are not interchangeable and should not be used outside of their approved indications. Learn more at Contacts for further information References © 2025 Novo Nordisk All rights reserved. US25SEMO01477 June 2025 View original content to download multimedia: SOURCE NOVO NORDISK INC.
Associated Press
29 minutes ago
- Associated Press
Banyan & Bamboo Launches AI-Powered '365 Beauty Blueprint' for Personalized Aesthetic Wellness in Austin
Austin's most soulful med spa is now one of its smartest. Banyan & Bamboo Day Spa + Med Spa unveils the '365 Beauty Blueprint' - a regenerative aesthetic protocol blending advanced facial mapping with deeply personalized, year-round wellness planning. Austin, TX, Texas, United States, June 21, 2025 -- Women-Led Spa Debuts Year-Round Aesthetic Strategy Backed by AI Banyan & Bamboo Day Spa + Med Spa, a boutique, women-led studio in the heart of Austin, today announces the launch of its signature 365 Beauty Blueprint, a highly personalized treatment plan guided by advanced AI skin mapping. This milestone reflects the spa's commitment to natural, data-backed results in regenerative aesthetics, setting a new standard for long-term self-care. In a field often driven by fleeting trends and one-size-fits-all treatments, Banyan & Bamboo introduces a new kind of beauty planning - one rooted in personalization, cellular science, and soulful care. Banyan & Bamboo's AI skin analysis and 365-day treatment plan is one of the most personalized options for injectables and facial care in Austin. 'We don't believe in one-size-fits-all beauty,' says Jennifer Rushing, Owner and Founder. 'We co-create yearlong blueprints that support skin, confidence, and health from the inside out.' Precision Meets Personalization: The 365 Beauty Blueprint At the heart of the new offering is AI-powered skin analysis - a diagnostic tool that maps hydration, pigmentation, texture, sun damage and aging markers. These insights allow the team to design evolving treatment plans that respond to each client's changing skin needs. The 365 Beauty Blueprint integrates: Every service within the protocol is selected to support internal wellness and natural-looking refinement. Regenerative Aesthetics in a Spa-Like Setting Blending clinical innovation with spa-caliber care, Banyan & Bamboo offers a slower, deeper, and more restorative alternative to volume-focused chains. Each visit includes in-depth consultation, customized protocols, and education - empowering clients to feel confident, cared for, and in control of their treatment journey. 'Our clients aren't here for a quick fix,' says Lindsey R., Spa Manager and Guest Experience Coordinator. 'They come to us because we spend time, educate them, and offer treatments that support long-term beauty and wellness.' Shifting the Industry Toward Longevity and Intention Since opening its doors, Banyan & Bamboo has cultivated one of the most loyal client communities in Central Texas. With the 365 Beauty Blueprint, the studio deepens its philosophy: beauty is not a single service, it's a long-term relationship. From hormone-safe skincare to regenerative injectables, each blueprint is crafted with intention and backed by science. The result is an customized aesthetic plan that's as restorative as it is effective - one that meets modern clients where they are and grows with them. 'Austin deserves more than cookie-cutter med spas,' adds Rushing. 'Our goal is to bring intention, expertise, and a little bit of Austin soul into every appointment.' Award-Winning Service In addition to the launch of the 365 Beauty Blueprint, Banyan & Bamboo is also celebrating a recent recognition as the Best Day Spa + Med Spa in Austin of 2025 by the prestigious Evergreen Awards. This accolade highlights their exceptional contributions to the wellness and aesthetics industry, particularly their blend of clinical precision and personalized care. Known for offering a standout menu of evidence-based aesthetic and wellness services, the spa's commitment to the natural, sustainable approach to beauty is reflected in their award. Banyan & Bamboo's regenerative aesthetics, including neuromodulators, dermal fillers, biostimulants, and cutting-edge injectable wellness therapies, consistently deliver natural results, backed by advanced AI-powered skin analysis for hyper-customized facial treatment plans. This focus on personalized, regenerative aesthetics, combined with their holistic approach, has fostered loyalty and built lasting relationships with clients. Owner and Founder Jennifer Rushing's leadership and the spa's deep connection with their clients have played a pivotal role in the studio's success, creating an environment where beauty meets wellness in a thoughtful, intentional way. About Banyan & Bamboo Day Spa | Med Spa Banyan & Bamboo is a boutique day spa and med spa in Austin, TX, specializing in regenerative aesthetics and clinical wellness treatments. The women-led studio offers AI-driven skin analysis, facial balancing, PRF therapies, injectable wellness services, and customized treatment blueprints. Built on the belief that science and soul should coexist, the spa delivers natural-looking results that last - inside and out. Media Contact: Name: Jennifer Rushing Title: Owner & Founder Email: [email protected] Contact Info: Name: Jennifer Rushing Email: Send Email Organization: Banyan & Bamboo Website: Release ID: 89162872 Should any errors, concerns, or inconsistencies arise from the content provided in this press release that require attention or if a press release needs to be taken down, we kindly request that you immediately contact us at [email protected] (it is important to note that this email is the authorized channel for such matters, sending multiple emails to multiple addresses does not necessarily help expedite your request). Our efficient team will be at your disposal for timely assistance within 8 hours – taking necessary measures to rectify identified issues or providing guidance on the removal process. We prioritize delivering accurate and reliable information.
Yahoo
38 minutes ago
- Yahoo
Woman Says She Will No Longer Participate in Her Boyfriend's Family Events After Several Slights: ‘I Don't Feel Welcome'
A woman shared on Reddit that she and her boyfriend have been kept at a distance by his family The woman was upset that her boyfriend's sister-in-law didn't postpone her pregnancy announcement for a few days so that the couple could be present The woman now refuses to attend any family events due to feeling slightedA woman claims her boyfriend's family has kept her at a distance — and now she doesn't want to have anything to do with them. In a post on Reddit's "Am I the A------" forum, the 31-year-old woman detailed her fractured relationship with her boyfriend's family. The couple has been together for almost three years, and in the beginning, his family members 'were kind and really put in effort to get to know me," the OP (original poster) said. "His sister (27F) and his sister-in-law (29F) would text me to plan dinner together, we'd work out together, etc. The feeling was mutual," she continued. But then things began to change. 'Slowly, I've noticed them both distancing themselves from me with no apparent reason to my knowledge,' she wrote. According to the OP, her boyfriend's brother once reached out to ask if the couple wanted to go to Hawaii with him and his wife. The OP and her boyfriend took a few hours to consider and then said yes. 'His brother responds back saying 'never mind, we decided to go with a smaller group' essentially just removing us since everyone else was still going,' she claimed. 'They went on their trip and blocked me and my bf from seeing their social media stories (to this day we're still blocked but haven't spoken up about it to them). There was never an apology or an attempt to communicate what happened, it was just swept under the rug.' The OP also mentioned another incident in which the family had texted them to come over on a Thursday night. She and her boyfriend couldn't attend, but told the family they would see them that Sunday, which was Father's Day. 'The sister texts us a video that night that the SIL/brother are announcing their first pregnancy and that we missed it," she wrote. "There was no attempt to reschedule the announcement so that we could all be present for it. They could've easily said the news on Father's Day, just days later.' Feeling upset and slighted, the woman had a conversation with her boyfriend and expressed her 'concerns that his family is making it clear they don't value our presence." "Whenever we go over to the family home, it feels like everyone goes quiet and dilutes their personality until we leave," she noted. The conversation ended with the OP telling her boyfriend that she will no longer attend his family's events, nor will she congratulate the sister-in-law on her pregnancy due to her "standoffish" behavior. 'I will not go where I don't feel welcome. Today he went to the family home alone and I stayed at home," the OP finished her post, asking fellow Redditors, "AITA [am I the a------]?" For many users, the answer was a resounding yes. Some suggested that she was wrongly perceiving certain situations as slights. 'You can't expect someone to postpone their pregnancy announcement — they invited you, and they shared the video afterwards," one person wrote. "They are allowed to keep that separate from Father's Day, and to share the information with people separately. And refusing to congratulate his SIL is just churlish. It is almost always better to build bridges than burn them." Others questioned whether the woman was leaving facts out of her post to explain why there is a perceived distance between her and the boyfriend's family. 'This sounds a bit like a situation where there are missing reasons somewhere,' a reader said. 'The expectation that they postpone pregnancy announcement is too much." The same reader suspected that the family 'slowly distanced themselves for some reasons you are choosing to not analyze.' However, other commenters sympathized with the OP — particularly regarding the Hawaii invite that was rescinded — and encouraged a direct conversation. Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. 'I'd want closure, and if I have to make family dinner awkward for everyone to get that closure, I will,' one person wrote. 'Then let them know that since they don't see you as family, that you will not be treating them as such and simply cut them off.' Read the original article on People
