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Latest Starship Explosion Drastically Decreases SpaceX's Chances of Reaching Mars Without Having to Wait Years

Latest Starship Explosion Drastically Decreases SpaceX's Chances of Reaching Mars Without Having to Wait Years

Yahoo4 hours ago

With tech billionaire Elon Musk out of the White House after his disastrous turn as a bureaucrat, he can now focus on more pressing subjects — such as his SpaceX Starship rockets that keep on exploding into fiery columns of fire, with the latest dramatic failure this past Wednesday in Texas, when the massive spacecraft hadn't even left the ground yet.
This recent setback ratchets up the pressure on Musk even further, who faces a hard deadline and steep technical challenges in his vaunted goal to reach Mars.
Much of that deadline is self-imposed, as CNN points out in an excoriating new breakdown of the situation. In May, Musk said he plans to send an unmanned crew to Mars next year, but the latest blast — the latest in a string of similar explosions that have plagued Starship — seem almost certain to set him back enough to force SpaceX to miss a crucial celestial launch opportunity called a transfer window.
Depending on the position of Earth and Mars from one another, the distance between the two planets can vary from 35 million to over 200 million miles. To make the journey shorter and to save cost on fuel, explorers must time their rocket launch during the transfer window, a period when Mars and Earth are in an optimal alignment that minimizes the journey's length.
The next transfer window for Mars is in late 2026 and will only last for a few weeks; miss it, and the journey will be way more expensive and far longer to be practical.
To still make the deadline, Musk faces the extraordinary challenge of fixing any technical challenges with Starship and present an upgraded version of the vehicle and the Super Heavy rocket booster in time before the Mars transfer window next year.
In addition, SpaceX has to figure out how to fuel Starship, which needs to be topped off with propellant in orbit before making its journey to the red planet. This would involve launching numerous Starships into space and using them to fuel up the one headed to the Red Planet — a process that will pose a spectacular logistical challenge of its own.
"We've never done that," Bruce Jakosky, professor emeritus of geological sciences at the University of Colorado Boulder, told CNN. "Nobody's done that — transferring fuel from one spacecraft to another in orbit autonomously."
Another technical challenge SpaceX needs to solve is Starship's heat shield, which has to survive entry into Mar's atmosphere and the journey back to Earth. Back in May, Musk himself conceded that it posed "one of the toughest problems to solve."
And all that is without getting into the technical feasibility of human flight to Mars, including how to shield any crew from cosmic radiation.
Before any of that, of course, Starship needs to stop exploding.
More on SpaceX: Elon's Explosion at Trump Appears to Have Cost Him a HUGE Deal

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Vertex Presents Positive Data for Zimislecel in Type 1 Diabetes at the American Diabetes Association 85th Scientific Sessions
Vertex Presents Positive Data for Zimislecel in Type 1 Diabetes at the American Diabetes Association 85th Scientific Sessions

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time26 minutes ago

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Vertex Presents Positive Data for Zimislecel in Type 1 Diabetes at the American Diabetes Association 85th Scientific Sessions

– Results from the study continue to demonstrate the transformative potential of zimislecel with consistent and durable patient benefit – – All 12 patients with at least one year of follow-up who received a full dose of zimislecel as a single infusion achieved ADA-recommended target HbA1c levels <7% and >70% time-in-range (70-180 mg/dL), and 10/12 patients were insulin free – – Data presented at ADA simultaneously published in the New England Journal of Medicine – – Vertex to host investor webcast tonight, June 20, 2025, at 7:15 p.m. CT / 8:15 p.m. ET – BOSTON, June 20, 2025--(BUSINESS WIRE)--Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced simultaneous presentation and publication of updated data from the Phase 1/2 portion of the Phase 1/2/3 FORWARD-101 clinical trial of zimislecel (VX-880), an investigational stem cell-derived, fully differentiated islet cell therapy, in people with type 1 diabetes (T1D) with impaired hypoglycemic awareness and severe hypoglycemic events (SHEs). The data were featured in an oral presentation at the American Diabetes Association (ADA) annual conference in Chicago as part of the symposium, "Innovation and Progress in Stem Cell-Derived Islet-Cell Replacement Therapy," from 6:15-6:30 p.m. CT (abstract 2025-A-1921) and published online by the New England Journal of Medicine. The data are from 12 patients who received the full dose of zimislecel as a single infusion and were followed for at least one year, as of October 2024. Results from the study to date continue to demonstrate the transformative potential of zimislecel with consistent and durable patient benefit with longer follow-up. All 12 participants: Demonstrated engraftment with glucose-responsive endogenous C-peptide production, which was durable through one year of follow-up. Achieved the ADA targets of HbA1c <7% and time in range of >70%. Were free of SHEs from day 90 onwards. Had a reduction in exogenous insulin use (mean reduction in daily insulin dose: 92%). 10/12 (83%) no longer required exogenous insulin at Month 12. Achieved the Phase 1/2 primary endpoint of elimination of SHEs with HbA1c <7%. Zimislecel continues to be generally well tolerated. Most adverse events (AEs) were mild or moderate, and there were no serious AEs related to zimislecel treatment. As previously reported, two patient deaths occurred, both unrelated to treatment with zimislecel. The safety profile is generally consistent with the immunosuppressive regimen used in the study, the infusion procedure, and complications from long-standing diabetes. "These data on the first fully differentiated, stem cell-derived, off-the-shelf islet cell therapy continue to be unprecedented. The magnitude, consistency and durability of the results from all 12 patients with more than one year of follow-up reinforce the transformative potential of zimislecel for people living with T1D complicated by severe hypoglycemia," said Carmen Bozic, M.D., Executive Vice President, Global Medicines Development and Medical Affairs, and Chief Medical Officer at Vertex. "We are excited to complete enrollment and dosing in the Phase 1/2/3 Program and look forward to potential regulatory submissions next year." "It's remarkable to see 12 out of 12 patients with baseline HbA1c above 7% and multiple severe hypoglycemic events reach consensus targets for glycemic control by both HbA1c and time in range as well as elimination of severe hypoglycemic events," said Michael R. Rickels, M.D., M.S., Medical Director, Pancreatic Islet Cell Transplant Program, Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases, Presenting Author and Steering Committee Co-Chair for the zimislecel clinical program, and author on the New England Journal of Medicine paper. "As I think about my patients and the unmet need in the type 1 diabetes community, the results we've seen so far for restoring endogenous insulin secretion with a stem cell-derived islet therapy bring me hope and confidence for a transformative treatment option for individuals with type 1 diabetes in the not-so-distant future." About Type 1 DiabetesT1D results from the autoimmune destruction of insulin-producing beta cells in pancreatic islets. Insulin deficiency results in hyperglycemia and can lead to acute life-threatening complications such as diabetic ketoacidosis. People with T1D are reliant on lifelong treatment with exogenous insulin that requires careful monitoring of blood glucose levels. Even with the availability of advanced exogenous insulin delivery and glucose monitoring systems, people with T1D can have periods of very low and very high blood sugar levels. Exogenous insulin has a narrow therapeutic range and carries an inherent risk of causing low blood sugar levels or hypoglycemic events, which can potentially result in arrhythmias, seizures, coma and even death. Due to the limitations and complexities of exogenous insulin treatment, it can be difficult for people with T1D to achieve and maintain good glucose control. Exposure to prolonged periods of high blood glucose levels, or hyperglycemia, can lead to long-term complications such as nerve damage, kidney disease/failure, eye disease (including vision loss), cardiovascular disease, stroke and even death. HbA1c is a measure of average blood glucose over the most recent ~2-3 months, and the consensus guidance is to maintain an HbA1c of <7% to reduce the risk of long-term complications; only ~1 in 4 people with T1D globally meet this clinical target. Current standards of care do not address the underlying cause of the disease and leave people with T1D susceptible to both hypo- and hyperglycemia and their associated morbidity and mortality. There is no cure for T1D. About ZimislecelZimislecel (VX-880) is an investigational allogeneic stem cell-derived, fully differentiated, insulin-producing islet cell therapy manufactured using proprietary technology. Zimislecel is being evaluated for patients who have T1D with impaired hypoglycemic awareness and severe hypoglycemia. Zimislecel has the potential to restore the body's ability to regulate glucose levels by restoring pancreatic islet cell function, including glucose-responsive insulin production. Zimislecel is delivered by an infusion into the hepatic portal vein and requires chronic immunosuppressive therapy to protect the islet cells from immune rejection. The zimislecel trial has expanded to additional sites that are currently active and enrolling in the U.S., Canada and Europe. Zimislecel has been granted Regenerative Medicine Advanced Therapy (RMAT) and Fast Track designations from the U.S. Food and Drug Administration, Priority Medicines (PRIME) designation from the European Medicines Agency (EMA), and has secured an Innovation Passport under the Innovative Licensing and Access Pathway (ILAP) from the UK Medicines and Healthcare products Regulatory Agency (MHRA). Zimislecel is investigational and has not been approved by health authorities globally. About VertexVertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia and acute pain, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including neuropathic pain, APOL1-mediated kidney disease, IgA nephropathy, primary membranous nephropathy, autosomal dominant polycystic kidney disease, type 1 diabetes and myotonic dystrophy type 1. Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 15 consecutive years on Science magazine's Top Employers list and one of Fortune's 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on LinkedIn, Facebook, Instagram, YouTube and X. Special Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, (i) statements by Carmen Bozic, M.D., and Michael R. Rickels, M.D., M.S., in this press release, (ii) plans, expectations for, and the potential benefits of zimislecel, (iii) expectations for the Phase 1/2/3 clinical trial for zimislecel, including expectations for the trial to complete enrollment and dosing, and (iv) plans for potential regulatory submissions next year. While Vertex believes the forward-looking statements contained in this press release are accurate, these forward-looking statements represent the company's beliefs only as of the date of this press release and there are a number of risks and uncertainties that could cause actual events or results to differ materially from those expressed or implied by such forward-looking statements. Those risks and uncertainties include, among other things, that data from a limited number of patients may not be indicative of final clinical trial results, that data from the company's research and development programs may not support registration or further development of its potential medicines in a timely manner, or at all, due to safety, efficacy, that timelines for regulatory submissions may be longer than anticipated, and other risks listed under the heading "Risk Factors" in Vertex's most recent annual report and subsequent quarterly reports filed with the Securities and Exchange Commission at and available through the company's website at You should not place undue reliance on these statements, or the scientific data presented. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available. (VRTX-GEN) Investor Event and Webcast Vertex will host an investor event on Friday, June 20, 2025, at 7:15 p.m. CT/8:15 p.m. ET, in Chicago, to discuss the positive zimislecel data in type 1 diabetes. A live webcast of the presentation and Q&A portions can be accessed through the Investor Relations section of Vertex's website at An archived webcast will be available on the company's website. View source version on Contacts Vertex Pharmaceuticals IncorporatedInvestors: InvestorInfo@ Media: mediainfo@ orInternational: +44 20 3204 5275

Rats in Boston may be spreading potentially deadly disease, Tufts University study says
Rats in Boston may be spreading potentially deadly disease, Tufts University study says

CBS News

timean hour ago

  • CBS News

Rats in Boston may be spreading potentially deadly disease, Tufts University study says

Tufts study says rats in Boston could be spreading potentially deadly disease Tufts study says rats in Boston could be spreading potentially deadly disease Tufts study says rats in Boston could be spreading potentially deadly disease Rats in Boston may be spreading a potentially deadly disease, according to a Tufts University study. The disease is called leptospirosis, which is caused by a bacterium called Leptospira. It is typically found in tropical areas, but a link has been found between rats and leptospirosis in other urban areas. Researchers worked on the study for six years, testing different brown rats from the Boston area, including the Boston Public Garden and Boston Common. They found that most rat populations in Boston carry the disease-causing bacteria, which can infect both humans and animals. Researchers warn that the disease's prevalence is expected to increase with climate change. Leptospirosis is typically spread through direct exposure to urine or a "urine-contaminated environment, which then can serve as an infection source for additional rats and other mammals, including humans," the study says. Leptospirosis can be spread through contact with water, soil, and eating food that has been contaminated with animal urine. The bacteria can survive in both water and soil for months. There are around one million cases of leptospirosis in humans around the world every year, and around 60,000 deaths, according to the CDC. Symptoms of leptospirosis Leptospirosis can be deadly if not treated, causing organ failure, trouble breathing, and death, the CDC says. Symptoms of the disease include: Fever Headache Chills Body aches Rash Diarrhea or vomiting Jaundice Red eyes Seek treatment immediately if you think you may have been infected with leptospirosis. Here are some recommended ways to prevent infection: Avoid contact with potentially infected animals Cover any open wounds, including cuts and scratches Wear waterproof clothing and shoes near floodwater or infected soil Research leptospirosis cases if you intend to go swimming A vaccine for leptospirosis is available in the United States for both cats and dogs. If you are concerned that your pet may have contracted the disease, visit the CDC website for more information.

Northern lights may be visible in these 9 US States tonight
Northern lights may be visible in these 9 US States tonight

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timean hour ago

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Northern lights may be visible in these 9 US States tonight

When you buy through links on our articles, Future and its syndication partners may earn a commission. Unsettled geomagnetic activity could bring northern lights to parts of the U.S. tonight (June 19–20). A coronal mass ejection (CME) released during a relatively small C5.5 solar flare on June 17 may deliver a glancing blow to Earth sometime tonight. This, combined with fast solar wind streaming from a large Earth-facing coronal hole, could fuel geomagnetic storm conditions overnight, according to NOAA's Space Weather Prediction Center (SWPC). Space weather forecasters at SWPC predict a chance of minor G1 geomagnetic storm conditions (Kp 5) between 2 a.m. and 5 a.m. EDT (0600–0900 GMT) on June 20. (Kp is a measurement of geomagnetic activity, with an index that ranges from 0 to 9; higher Kp indicates stronger auroral activity.) You can keep up with the latest forecasts and geomagnetic storm warnings with our aurora forecast live blog. In the U.S., Alaska has the highest chance of seeing the northern lights tonight. If predicted G1 storms are reached, auroras could be visible down to Michigan and Maine, and perhaps even further according to NOAA. Below we have listed 9 states that appear either fully or in part above the possible view line for auroras tonight, according to NOAA's Space Weather Prediction Center. They are ordered most likely to least likely based on their proximity to the center of the auroral oval and how much of each state is within or near the view like Connecticut, Rhode Island, Nebraska, Iowa and Illinois are very close to the possible view line but would require stronger geomagnetic activity than forecast for visibility. That being said, geomagnetic storms have surprised us in the past, whereby forecasted G1 conditions jump to G2 or even G3. So it's worth keeping your eyes on the skies and those aurora alerts switched on. Remember, auroras can be fickle. Sometimes they can appear much farther south than predicted, and other times they barely show up at all. There are many conditions that have to align for the perfect show. It is possible that many more states could witness auroras tonight, or perhaps far fewer will. Alaska Montana North Dakota Minnesota Wisconsin Michigan (especially the Upper Peninsula) Maine Vermont New Hampshire If you live in one of the 9 states forecasted to have a chance of seeing the northern lights tonight, head to a north-facing vantage point as far away from light pollution as possible! The best time to look for auroras will be about 1 a.m. local time, as our window of darkness for observing the northern lights shrinks during summer months. Use your mobile phone to scan the skies, as the camera is great at picking up faint auroras before your eyes spot them. This can help you pinpoint where in the sky you should be focusing your attention. But remember to keep an eye out elsewhere too as auroras can pop up in front, behind or even above you! Happy aurora hunting. If you want to make sure you're all clued up on when to look for auroras, download a space weather app that provides forecasts based on your location. One option I use is "My Aurora Forecast & Alerts," available for both iOS and Android. However, any similar app should work well. I also use the "Space Weather Live" app, which is available on iOS and Android, to get a deeper understanding of whether the current space weather conditions are favorable for aurora sightings.

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