Latest news with #postpartumDepression
Yahoo
4 days ago
- Business
- Yahoo
Sage, following Setbacks, to sell to Supernus for $561M
This story was originally published on BioPharma Dive. To receive daily news and insights, subscribe to our free daily BioPharma Dive newsletter. Sage Therapeutics, a brain drug developer that's dealt with a series of clinical setbacks, has agreed to be acquired by Supernus Pharmaceuticals in a deal worth $561 million. Supernus on Monday said it would pay $8.50 per share for Sage, an offer valuing shares at a roughly 27% premium to their previous closing price. The deal also includes a contingent value right worth up to $3.50 per share if certain sales and commercial milestones related Sage's lone product, the postpartum depression drug Zurzuvae, are met. Sage earlier this year turned down a $7.22-per-share offer from Zurzuvae development partner Biogen and sued the company, arguing it was being undervalued. The company has been evaluating 'strategic alternatives,' a process that included a search for a buyer, ever since. Sage has gone through a roller coaster ride since its founding more than a decade ago. Launched by Third Rock Ventures and run for many years by biotech veteran Jeff Jonas, the company aimed to develop brain drugs for a variety of conditions, from epilepsy and tremors to Huntington's disease. The company went public in 2014 to support that work and saw its share price swell to nearly $200 apiece a few years later as a pair of depression medicines advanced through testing. It brought to market not only the first medicine for postpartum depression, Zulresso, but the first pill for the condition, called Zurzuvae. It cut a multibillion-dollar partnership deal with Biogen, too. But Zulresso, a 60-hour infusion, never generated significant sales and Sage stopped marketing it at the end of the year. And the company had initially hoped to bring Zurzuvae to market for major depressive disorder — a much larger opportunity — but changed course and laid off staff after U.S. regulators asked for additional testing. Sage has suffered setbacks elsewhere, too, with experimental drugs failing studies in epilepsy, tremors, Alzheimer's, Huntington's and Parkinson's disease over the years. Company shares closed on Friday at $6.70 apiece and have fallen so low in recent months that Sage's board accused Biogen of lowballing the company with an earlier bid. The deal with Supernus feels 'like an unremarkable outcome for a company that was once one of the hottest stories' in brain drug research, wrote Stifel analyst Paul Matteis in a note to clients Monday. Matteis added that, for investors, though, the acquisition 'is a good end to the Sage story given the host of challenges facing the company.' In a separate note, RBC Capital Markets' Brian Abrahams called Supernus' offer 'fair' given the 'considerable time' it would have taken for Sage to become profitable. Abrahams also wrote that there is a 'very low likelihood' that Sage hits the majority of the sales targets that would bump up its sale price. Sage stockholders would get $1 per share if Zurzuvae hits $250 million in sales in the U.S. by 2027, and similar payouts if U.S. drug sales reach $300 million by 2028 and $375 million by 2030. Zurzuvae generated $72 million in U.S. sales in 2024. Biogen and Sage split U.S. profits. Recommended Reading Moderna inks another gene editing deal Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Yahoo
19-05-2025
- Health
- Yahoo
This one Oura Ring setting was a game changer for me after I had my baby
When you buy through links on our articles, Future and its syndication partners may earn a commission. I write about fitness tech for a living, but for the first four months of my son's life, I took everything off. I was struggling with postpartum depression, and devices telling me how little I'd moved, slept, or recovered was the last thing I needed. Women's Health Week This article is part of Tom's Guide's Women's Health Week — a series of content that explores how technology and the right workouts can support and empower women through every phase of life. Months later, when I finally felt strong enough to pop my Apple Watch and Oura Ring back on (an insignificant action to most, but a milestone to me), I leaned on a few features that really helped. I paused my rings on my Apple Watch, for example, removing the pressure to exercise on days when all I could do was sit on the sofa with my baby. I also used enabled Rest Mode on my Oura Ring — read on to find out what it does, why I did it and how to use it. According to Oura, Rest Mode allows you to 'focus on recovery when you feel tired, unwell, or need to slow down.' The Oura equivalent of pausing your Apple Watch rings, Rest Mode pauses your Activity Progress Goal, Activity Score and all activity-related contributors, allowing you to focus on rest. The Readiness and Sleep insights will also be adjusted to help you prioritize rest — something I wasn't getting with a newborn, but removing the pressure of not meeting activity goals helped. Oura says Rest Mode is designed for when you're feeling under the weather, when you're injured, sick, or traveling. If your Oura ring notices a spike in your average body temperature, you might get a notification that suggests switching to Rest Mode on your home screen. This is because the ring has noticed your body is under strain, and is suggesting that you should focus on recovery. If, like I did, you're turning on Rest Mode when you're not sick, here's the steps you'll need to follow: Go to the Menu in the top left corner of the Oura app home screen — the menu icon has three horizontal lines From here, scroll down and select the Rest Mode icon Then select Turn on Rest Mode Once you have enabled Rest Mode, the data you see on your home screen will be different. At the bottom of your home screen, you'll be able to see that Rest Mode is enabled. When you're feeling better, simply tap the notification banner at the bottom of the home screen, or go back to the Rest Mode setting on the sidebar and select 'Turn off and delete tags'. It's worth noting that once you turn Rest Mode off, your Activity Goal and Score will slowly return to normal, taking into account the time you've been resting. I had Rest Mode on for a couple of months as I mentally recovered, so it took my ring a week to ease me back into my normal goals. During this period, I was still able to view my step count, active calories, and calorie burn if I wanted to, but I found the mental break from hitting fitness targets was what I needed. Remember, these devices are designed to motivate you, not stress you out. If you're feeling overwhelmed, take them off, re-set, and remember that all movement is medicine, whether you're tracking it or not. How to set up menstrual tracking on your Apple Watch Which fitness trackers are the best for tracking women's health Samsung Galaxy Ring is changing the game for cycle tracking — here's how
Times
18-05-2025
- Entertainment
- Times
Die, My Love review — Jennifer Lawrence bombs in a maternal splatterfest
It's only taken eight years, but Jennifer Lawrence has finally delivered a companion piece for her outré mommy-horror Mother! And this one's terrible too, possibly even worse. At least Mother! demonstrated (pretentious) conceptual coherence, with Lawrence serving as a metaphor for the planet while her baby represented environmental destruction. In Die, My Love we're treated to a splatterfest that features Lawrence as a former writer called Grace who moves with her selfish, seedy, beer-swilling husband Jackson (Robert Pattinson) to a run-down woodland abode somewhere in middle America and has a baby that triggers an all-consuming psychotic breakdown. Fine on paper, and clearly the subject of postpartum depression can handle more big screen engagement than the few paltry mainstream titles that have attempted it
Washington Post
18-05-2025
- Entertainment
- Washington Post
Jennifer Lawrence stirs Oscar talk in Cannes for 'Die, My Love'
CANNES, France — Last year, the Cannes Film Festival produced three best actress nominees at the Oscars. This year's edition may have just supplied another. In Lynne Ramsay's 'Die, My Love,' Jennifer Lawrence and Robert Pattinson play a married couple with a newborn who move into an old country house. In Ramsay's messy and moving marital psychodrama, Lawrence plays an increasingly unhinged young mother named Grace whose postpartum depression reaches darkly hallucinatory extremes.
Yahoo
18-05-2025
- Entertainment
- Yahoo
‘Die My Love' Review: Jennifer Lawrence Is a Mother Grappling with Postpartum Depression (and Punk-Rock Angst) in Lynne Ramsay's Showy Mess of a Marital Psychodrama
In one of the terrifyingly labored and overwrought scenes that make up Lynne Ramsay's 'Die My Love,' Grace (Jennifer Lawrence), who's suffering from an acute case of mental trauma — the film would have you believe it's postpartum depression, though you could make a good case that it's not — has had enough of the noisy dog that her partner, Jackson (Robert Pattinson), brought home for no good reason. The two are living in the country, in a home that Jackson inherited from his uncle, a house that definitely qualifies as a fixer-upper. These two just haven't bothered to fix it up. They have a baby, you see, a sweet little boy, and ever since he came into their lives everything has been falling apart. The dog literally never stops yapping (it's the most annoying dog in history), so Grace, who has brought over a shotgun, asks Jackson to shoot it. He says: Are you kidding that's crazy! So Grace picks up the shotgun and does the deed herself. More from Variety Ezra Miller Speeds Down the Cannes Red Carpet at 'Die, My Love' Premiere in Surprise Festival Appearance Visceral Chilean Docs Head to Cannes for Fifth Annual Showcase, Featuring Chile and Cuba's Parallel Battles, a Chilean Cowboy, an Argentine Sex Worker Man Dressed Up as Bird Shocks Cannes Red Carpet at Jennifer Lawrence and Robert Pattinson's 'Die, My Love' Premiere It's clear that she's got a problem. Yet I couldn't help but wonder why Jackson, with a new baby to deal with, brought home that dog in the first place — or, more to the point, why he seemed so flagrantly insensitive to the fact that Grace didn't want a dog. This situation typifies the dynamic of 'Die My Love,' which is as follows: Grace acts out in delirious, raging, violent, inexplicable ways — and Jackson, while understandably dismayed at her behavior, reacts to it by rarely lifting a finger to do anything that would help her. Is he insensitive or just dumb? Pattinson, in a rare bad performance, just plays him as an unpleasant clueless bro. 'Die My Love' presents us with a case of the blind leading the damned. Postpartum depression is a syndrome that was once in the shadows, and there are ways it remains so. It's still misunderstood and under-treated and not empathized with enough. Yet 'Die My Love' serves up a showy yet strange, in many ways baffling hyperbolic projection of what can take place in the hearts and minds of women during the first months (or even years) of motherhood. This is the first film directed by Lynne Ramsay in seven years, since the startling Joaquin Phoenix depravity-and-revenge drama 'You Were Never Really Here' (2017), and what she establishes in the film's early scenes, which feature a lot of in-your-face drinking and fucking, is that Grace and Jackson are a kind of dissolute punk-rock couple, the sort of nihilist parents who aren't going to let having a baby get in the way of their Budweiser regimen. That's okay; they have a right to keep drinking and raise a kid at the same time. But there's very little sense that either of them has decided to become a responsible adult. She's an aspiring writer who says, as soon as the baby is born, that she's done with writing. He's got…some kind of job, that he seems to do occasionally, on the road (we have no idea what it is), but mostly the two are just hanging out in that house. There's very little structure to their lives, or to the movie, beyond Ramsay's art-house showbiz instinct to keep cranking up the shock level of Grace's behavior. It's not really a dialogue-driven movie. Grace and Jackson never have a simple conversation about future plans, or health insurance, or buying groceries, or about how they intend to parent. They just seem like morose post-collegiate slackers who had a baby because they like to fuck a lot and, you know, shit happens. So when Grace starts to act out in a way that makes it seems like she's totally not with the mommy program, the context the movie has created for that is: These two already seem like they're not really with the mommy-and-daddy program. There's never a moment, for instance, when we see them beholding their son with joy; he's more like an accessory they have to take care of. And while there's no simple template for how postpartum depression expresses itself, it can often be incredibly inward. Grace's total alienation from motherhood, on the other hand, is flamboyantly outward. As a filmmaker, Ramsay is a mood poet who favors violence and needle drops (there's a lot of Scorsese in her blood), in this case literal ones, since our two hipster parents have a turntable. Grace first starts to transition into derangement when Toni Basil's 'Mickey' is playing, and the song starts to skip and repeat, and Grace keeps saying 'All right! All right!' and then licks the window pane. Ramsay has a lavish gift for staging that sort of baroque rock 'n' roll breakdown. (A little later, Grace will crash through that same window.) From the start, though, the film almost seems to be getting high on the dysfunctional flamboyance of the behavior it's showing you. 'Die My Love' keeps saying: This may be mental illness…but wow, is it ever cinema! On some level we're watching Grace crack up because wallowing in this much trauma is fixating. In pre-feminist times (say, the 1950s), it was the definition of unenlightened patriarchal myopia to view a woman as 'irrational' or 'overemotional' or — Freud's word — 'hysterical.' But just as many aspects of the past, including those that once seemed retrograde, can be reclaimed with a new consciousness, the notion that a new mother has every right to be irrational in her despair — something that just about everyone in the movie, notably Jackson's mother, Pam (Sissy Spacek), tells Grace — is very much at the center of where we are now. That, in its way, is progress. Because it's reality. The burdens of motherhood can be every bit as staggering as the joys. But 'Die My Love,' for all of Ramsay's talent, isn't designed to explore that experience. It's designed, rather, as a kind of thesis movie: reckless on the surface but overdetermined. And I think that's why Jennifer Lawrence's performance feels so explosive but, at the same time, so emotionally reined in. In 'Die My Love,' you feel the power of her presence, the hellbent quality of her rage. When it comes to chewing out a blabby cashier, crawling around like an animal, trashing the bathroom and pouring soap products all over the floor, or bashing her head on a mirror, she's an ace wastrel. But the very force of her destruction makes us want to go: What is happening? We want the film to offer some kind of answer. Jackson checks Grace into a mental hospital, and she gets 'better,' to the extent that that means she emerges eager to bake cakes and hide her darkness behind a sunny agreeability that looks like a parody of happy-homemaker domesticity. But by now we're onto the film; we're just waiting for that façade to crack. Frankly, it looked to me like Grace, whether or not she's suffering from postpartum depression, has borderline personality disorder. But that would be a different movie. By the time 'Die My Love' reaches its voluptuously incendiary yet somehow rather rote ending, you may wish you were watching a different movie. Best of Variety The Best Albums of the Decade
