Latest news with #cord
Cision Canada
4 days ago
- Health
- Cision Canada
San Raffaele Hospital: World's First Case Study Demonstrates the Effectiveness of Spinal Cord Neurostimulation in a Paraplegic Patient with Severe Conus Medullaris Injury
The study, published in Med by Cell Press and authored by physicians and researchers from the MINE Lab, documents the recovery of walking ability through epidural electrical stimulation in a paraplegic patient with a spinal cord injury at the T11–T12 level. These types of injuries account for over 50% of all spinal cord lesions. MILAN, June 17, 2025 /CNW/ -- A clinical case published in Med – Cell Press by the multidisciplinary team of the MINE Lab – including doctors, physiotherapists, and researchers from San Raffaele Hospital and Vita-Salute San Raffaele University, in collaboration with bioengineers from Scuola Superiore Sant'Anna in Pisa led by Professor Silvestro Micera – describes the remarkable recovery of a 33-year-old man with a traumatic spinal cord injury at the T11–T12 level that extended into the conus medullaris. The injury caused severe motor impairment due to damage to both the central and peripheral nervous systems. After surgically implanting an epidural spinal cord neurostimulator, the team applied specific stimulation and rehabilitation protocols, significantly improving the patient's muscle strength, mobility, and motor control. This research builds on a path that began with the first implantation of a spinal cord neurostimulator in 2023, carried out by the neurosurgical team at IRCCS Ospedale San Raffaele led by Professor Pietro Mortini, Head of Neurosurgery at the hospital and Full Professor of Neurosurgery at Vita-Salute San Raffaele University. The path continued with the publication, in Science Translational Medicine in 2025, of the first results from two implanted patients, demonstrating the effectiveness of the innovative epidural electrical stimulation (EES) protocol for treating spinal cord injuries. "With this case study, we have shown for the first time the effectiveness of epidural electrical stimulation (EES) combined with rehabilitation in restoring lower limb motor functions in a paraplegic patient with a severe conus medullaris injury—the terminal portion of the spinal cord —enabling him to stand and walk short distances," explained Dr. Luigi Albano, neurosurgeon and researcher at San Raffaele Hospital and first author of the study. "Beyond motor recovery, the stimulation also led to clinically significant improvements in neuropathic pain and the patient's overall quality of life." "The results of this study," added Professor Pietro Mortini, "offer new hope to patients with severe spinal cord injuries who have experienced long periods of immobility, making previously unimaginable recovery possible through the integration of advanced neuromodulation and personalized rehabilitation." About Conus Medullaris Injuries The conus medullaris is the terminal segment of the spinal cord, typically located between the first and second lumbar vertebrae (L1–L2). In this region, the central and peripheral nervous systems functionally merge, meaning injuries can impair lower limb motor and sensory functions as well as autonomic control of vital functions like urination, defecation, and sexual activity. Conus medullaris injuries often result from car accidents, falls, or violent trauma and account for more than 50% of spinal injuries involving the spinal cord-root junction. The Case Study The subject of the study is a 33-year-old man who suffered a severe spinal cord injury at the lower thoracic level (T11–T12) four years ago, resulting in paralysis of the lower limbs. Although classified as "incomplete" (ASIA Grade C), the injury severely affected his mobility. Despite two intensive rehabilitation programs following the trauma, the patient remained unable to stand or walk. Tests also showed damage to the nerve roots connecting the spinal cord to the leg muscles (L4–S1), indicating involvement of both the central and peripheral nervous systems—making this a particularly challenging case to treat, as conventional therapies rarely succeed when neural circuits are impaired at multiple levels. To provide a new opportunity, the patient was enrolled in the Neuro-SCS-001 clinical trial, which evaluates the effects of epidural electrical stimulation combined with a personalized rehabilitation program. "We implanted a spinal stimulation system with 32 electrodes between T11 and L1," explained Professor Pietro Mortini. "Once activated, the stimulation re-engaged residual neural circuits, particularly those controlling trunk muscles and hip flexors—key for regaining posture and walking ability. After an initial calibration phase, the patient underwent an innovative rehabilitation program integrating virtual reality exercises using sensory and motor feedback." SOURCE IRCCS Ospedale San Raffaele; UniSR
Yahoo
4 days ago
- Health
- Yahoo
San Raffaele Hospital: World's First Case Study Demonstrates the Effectiveness of Spinal Cord Neurostimulation in a Paraplegic Patient with Severe Conus Medullaris Injury
The study, published in Med by Cell Press and authored by physicians and researchers from the MINE Lab, documents the recovery of walking ability through epidural electrical stimulation in a paraplegic patient with a spinal cord injury at the T11–T12 level. These types of injuries account for over 50% of all spinal cord lesions. MILAN, June 17, 2025 /CNW/ -- A clinical case published in Med – Cell Press by the multidisciplinary team of the MINE Lab – including doctors, physiotherapists, and researchers from San Raffaele Hospital and Vita-Salute San Raffaele University, in collaboration with bioengineers from Scuola Superiore Sant'Anna in Pisa led by Professor Silvestro Micera – describes the remarkable recovery of a 33-year-old man with a traumatic spinal cord injury at the T11–T12 level that extended into the conus medullaris. The injury caused severe motor impairment due to damage to both the central and peripheral nervous systems. After surgically implanting an epidural spinal cord neurostimulator, the team applied specific stimulation and rehabilitation protocols, significantly improving the patient's muscle strength, mobility, and motor control. This research builds on a path that began with the first implantation of a spinal cord neurostimulator in 2023, carried out by the neurosurgical team at IRCCS Ospedale San Raffaele led by Professor Pietro Mortini, Head of Neurosurgery at the hospital and Full Professor of Neurosurgery at Vita-Salute San Raffaele University. The path continued with the publication, in Science Translational Medicine in 2025, of the first results from two implanted patients, demonstrating the effectiveness of the innovative epidural electrical stimulation (EES) protocol for treating spinal cord injuries. "With this case study, we have shown for the first time the effectiveness of epidural electrical stimulation (EES) combined with rehabilitation in restoring lower limb motor functions in a paraplegic patient with a severe conus medullaris injury—the terminal portion of the spinal cord—enabling him to stand and walk short distances," explained Dr. Luigi Albano, neurosurgeon and researcher at San Raffaele Hospital and first author of the study. "Beyond motor recovery, the stimulation also led to clinically significant improvements in neuropathic pain and the patient's overall quality of life." "The results of this study," added Professor Pietro Mortini, "offer new hope to patients with severe spinal cord injuries who have experienced long periods of immobility, making previously unimaginable recovery possible through the integration of advanced neuromodulation and personalized rehabilitation." About Conus Medullaris Injuries The conus medullaris is the terminal segment of the spinal cord, typically located between the first and second lumbar vertebrae (L1–L2). In this region, the central and peripheral nervous systems functionally merge, meaning injuries can impair lower limb motor and sensory functions as well as autonomic control of vital functions like urination, defecation, and sexual activity. Conus medullaris injuries often result from car accidents, falls, or violent trauma and account for more than 50% of spinal injuries involving the spinal cord-root junction. The Case Study The subject of the study is a 33-year-old man who suffered a severe spinal cord injury at the lower thoracic level (T11–T12) four years ago, resulting in paralysis of the lower limbs. Although classified as "incomplete" (ASIA Grade C), the injury severely affected his mobility. Despite two intensive rehabilitation programs following the trauma, the patient remained unable to stand or walk. Tests also showed damage to the nerve roots connecting the spinal cord to the leg muscles (L4–S1), indicating involvement of both the central and peripheral nervous systems—making this a particularly challenging case to treat, as conventional therapies rarely succeed when neural circuits are impaired at multiple levels. To provide a new opportunity, the patient was enrolled in the Neuro-SCS-001 clinical trial, which evaluates the effects of epidural electrical stimulation combined with a personalized rehabilitation program. "We implanted a spinal stimulation system with 32 electrodes between T11 and L1," explained Professor Pietro Mortini. "Once activated, the stimulation re-engaged residual neural circuits, particularly those controlling trunk muscles and hip flexors—key for regaining posture and walking ability. After an initial calibration phase, the patient underwent an innovative rehabilitation program integrating virtual reality exercises using sensory and motor feedback." Photo - - Patient Information Email: iocammino@ View original content to download multimedia: SOURCE IRCCS Ospedale San Raffaele; UniSR View original content to download multimedia: Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Pink Villa
30-05-2025
- Entertainment
- Pink Villa
Sneak-peek into Kiara Advani's pregnancy diet: Secret behind mom-to-be's radiant glow
Kiara Advani is soon going to embrace motherhood as she is expecting her first child with Sidharth Malhotra. Just a few days back, she flaunted her baby bump for the first time after she made her debut appearance at the MET Gala 2025. Keeping her fans involved in her lifestyle, the soon-to-be mom recently shared a glimpse of the special diet she has been relishing to ensure a healthy baby. On May 30, Kiara Advani posted a picture of her colorful lunch plate on her Instagram stories. She didn't write anything alongside, but let her post do the talking. As we can see, the salad plate consists of Tomatoes, Lettuce, Cucumber, Zucchini, and Pomegranates. Take a look It was earlier this month that the soon-to-be mom made her debut appearance at the biggest international fashion event, the Met Gala. She opted for a customized Gaurav Gupta black gown that had a golden breastplate. What made her outfit all the more unique was a beautiful umbilical cord right at the front- a perfect choice to express a mother's love for her child. She left her curly hair open with a subtle make-up, and no wonder, she looked like a dream, exuding her pregnancy glow. In fact, her supportive husband, Sidharth Malhotra, also accompanied his pregnant wife as she made a milestone achievement on the global stage. In a behind-the-scenes video shared online, Kiara had even expressed her love for the attire for its detailing. The brief that she gave her designer was, "This is the next phase of my life, and I want that to be a part of the expression of my outfit." She also spoke with the Allure at the event about the new phase of her life. When asked what excites her most about the pregnancy, she said, "I mean, there's so much to look forward to. It's just the beginning, so yeah, very excited." Sidharth and Kiara announced that they're expecting their first child earlier this year in February. On the professional front, Kiara will be next seen in YRF Spy-universe, War 2 alongside Hrithik Roshan and Jr NTR. Directed by Ayan Mukerji, the film is set to be released on August 14, 2025.
Hindustan Times
06-05-2025
- Entertainment
- Hindustan Times
Kiara Advani eats pizza, gives pep talk to her baby before Met Gala debut: ‘I am feeling hot in this new body'
A sweet behind-the-scenes clip of Kiara Advani has surfaced on social media, offering a glimpse into her pre-Met Gala 2025 preparations. The footage shows Kiara enjoying a slice of pizza, calling herself "hot' in her new body and sharing tender moments with her unborn child. Also read: Met Gala 2025: Sidharth Malhotra wins hearts through adorable moment with Kiara Advani The actor made her debut at the Met Gala 2025 in a stunning ensemble designed by Gaurav Gupta. In the clip, which has emerged on social media, the mom-to-be is seen munching on a slice of pizza while surrounded by her squad. She flashes a playful smile as she quips, "It's my MET diet'. Opening up about the look, she said, 'My brief to Gaurav was this is the next phase of my life that I want that to be a part of the expression and of this outfit... I love the way we have interpreted the theme and the way it tied up with me doing this for my baby like André Leon Talley paved the way for the next generation'. During her fitting, Kiara spoke about being pregnant, saying, 'I just want to tell you all that after a long time, I know this is my new body, but I am really feeling hot in this new body'. A post shared by DietSabya® (@dietsabya) Kiara's ensemble featured two hearts linked by a golden chain, representing a mother and child connected through an umbilical cord. Kiara loved the detailing, as she mentioned, "The umbilical cord is actually such a sweet detail.... It's like saying 'Hey buddy, you are on the steps of the Met',' she said in the video, while holding her baby bump. For her much-anticipated Met Gala debut, Kiara wore a creation by designer Gaurav Gupta, which was titled Bravehearts. In sync with the 2025 MET Gala's theme Superfine: Tailoring Black Style, the piece features a sculpted gold breastplate, forged into two crystal-encrusted hearts connected by a chain umbilical cord. The look was finished with a double-paneled white cape, a nod to André Leon Talley's 2010 MET appearance. Anaita Shroff Adajania facilitated the collaboration between Kiara and Gaurav. In February, Sidharth and Kiara announced that they are expecting their first child. They shared the news on their Instagram accounts by posting a picture in which they hold a pair of baby socks. They wrote, 'The greatest gift of our lives (baby emoji) Coming soon (heart, evil eye, folded hands emojis).' The couple got married in Jaisalmer, Rajasthan, in 2023 after dating since 2020. In 2021, they even starred together in the army film Shershaah.
Hindustan Times
06-05-2025
- Entertainment
- Hindustan Times
Met Gala 2025: Sidharth Malhotra wins hearts through adorable moment with Kiara Advani
Actor Sidharth Malhotra might not have walked the Met Gala 2025 red carpet alongside wife Kiara Advani, but he was by her side, supporting her every step. He was spotted escorting Kiara, who is expecting her first baby, to the lobby, and the couple was seen walking hand-in-hand. Also read: Kiara Advani flaunts baby bump for her Met Gala 2025 debut, stuns in custom Gaurav Gupta gown. See pics A heartwarming video of Sidharth has surfaced on social media. The video captures Sidharth entering a hotel lobby in New York, where he poses for photos with fans. However, the sweetest part of the clip is Sidharth's support for his pregnant wife, Kiara Advani, as he helps her navigate the lobby. In the video, Kiara glides through the lobby, clutching Sidharth's hands for support, while her team carefully manages the elaborate train of her gown. In another sweet moment, the couple is seen strolling the lobby area hand-in-hand. Ever since the video surfaced on social media, his fans have shared their admiration for the actor by dropping heart emojis in the comment section. Sidharth also showered praise on Kiara, gushing over her look at the Met Gala and expressing his love and admiration for her. He took to Instagram Story to repost Kiara's pictures from the MET Gala 2025 and penned a special message for the mom-to-be and their unborn baby. He wrote, 'Both Bravehearts' along with a red heart emoji. Kiara turned heads at the Met Gala 2025, confidently showcasing her baby bump in a breathtaking gown designed by renowned Gaurav Gupta, marking her debut at the fashion gala. The look was meticulously curated in collaboration with stylist Anaita Shroff Adajania. Kiara wore a dramatic black gown featuring a metallic breastplate and flowing white train. The look's centerpiece was a heart-shaped plaque symbolising her baby, attached to the breastplate by a golden thread representing the umbilical cord. Titled Bravehearts, the couture piece paid homage to the spirit of the Black Dandy, a symbol of defiance, elegance, and individuality.
