Latest news with #SSRIs
IOL News
2 days ago
- Health
- IOL News
Unlocking pleasure: How to enhance your sexual experience when orgasms feel out of reach
There is some consensus among sex educators, therapists and real people that orgasm is not as simple as it is made out to be. But if you're struggling to get there, you're definitely not alone. In fact, research from the National Library of Medicine estimates 10 to 15 percent of women have never had an orgasm. That's millions of people who feel left out of the supposed fireworks, quietly wondering, 'What's wrong with me?' Let's get real for a second: orgasms are often hyped as the pinnacle of sexual pleasure - those legendary 'big O' moments everyone seems to be chasing. In a post from Cosmopolitan Evie Plumb, certified sex educator and founder of Cliterally the Best, explains that stress, anxiety, fatigue, hormonal fluctuations, relationship issues, medications like SSRIs or certain medical conditions can contribute to difficulties in reaching orgasm. There are ways to get closer to pleasure, no matter where you're starting from. Let's bust a myth right away, orgasms aren't just about physical touch. Sure, stimulation matters, but reaching climax is a complex dance involving your brain, hormones, emotions and even your relationship with yourself. There is some consensus among sex educators, therapists and real people that orgasm is not as simple as it is made out to be. And that's not a failure. It's normal. Your pleasure matters. Whether you've never orgasmed or just want to deepen your connection with your body, you're not alone and you're not failing. Everyone's sexual response is different - there's no single 'right' way. So, if you're not climaxing easily (or at all), please know you're not broken. Your body and mind are just responding to a lot of variables, many of which are outside your control. Why pressure kills pleasure Here's something every sex expert agrees on - the harder you try to force an orgasm, the further away it feels. Kiana Reeves, intimacy educator and chief intimacy officer, told Goop, 'Anytime you're in the thinking mind, the goal-oriented mind, you're latching onto something and it takes you completely out of sensation.' In other words, stop treating orgasm like a finish line you're failing to cross. Instead, get curious. Explore what feels good. Let go of what you think 'should' happen. As certified sexologist Michaela d'Artois suggests, treat it like an experiment. Is a soft touch better? Do you prefer lying down or sitting up? Permit yourself to just feel. Ditch the shame There's a lot of noise out there about the 'orgasm gap', especially for women and non-binary folks. There's so much messaging about how women don't orgasm through sex with men but have an easier time on their own. That self-judgment, 'I didn't come, I failed' just adds to the pressure. Make pleasure a priority, literally! Let's be honest, in our busy lives, we schedule everything that matters. Pilates. Coffee dates. Doctor's appointments. But when was the last time you scheduled, time for your own pleasure? D'Artois argues that putting pleasure on the calendar isn't weird, it's self-care. 'Set the intention and build in time to get comfortable: music, candles, maybe some audio erotica.' Treat solo sex like you would any wellness ritual. Explore erogenous zones and experiment Your body is full of nerve endings waiting to be discovered. Try stimulating lubes or oils, maybe soothing CBD, tingly kava, or warming cinnamon. Notice what your body gravitates toward. 'We need a lot of variety to get all of our erectile tissue full and responsive,' says Reeves. For some, arousal oils help blood flow, making everything more sensitive. Relax, don't clench A lot of us tense up when we feel close to orgasm. But as Reeves points out, deep, full-body orgasms often come from softening and relaxing, not clenching. Try this: Focus on deep, slow breaths Allow your pelvic floor to relax and 'blossom' open Pulse between tensing and relaxing, if that helps you tune in Breathing increases blood flow and relaxes muscles, making it easier to get out of your head and into your body. Get creative with touch Vibrators are amazing, but if you're stuck in a rut, try mixing it up: use your hands, non-vibrating toys or even a cool stone wand. Tune into subtle sensations, temperature, texture and pressure. Remember, pleasure isn't just about orgasm. It's about feeling good, period. If you take nothing else away from this, hear this: Your pleasure matters. Whether you've never orgasmed or just want to deepen your connection with your body, you're not alone and you're not failing. Curiosity, compassion and a willingness to explore are your best tools. And if you need support, talk to a sex therapist or educator, they're there to help.
Yahoo
3 days ago
- Health
- Yahoo
Saptalis Pharmaceuticals Launches Fluoxetine Oral Solution, USP 20 mg/5 mL
HAUPPAUGE, N.Y., June 18, 2025--(BUSINESS WIRE)--Saptalis Pharmaceuticals, LLC. is pleased to announce the commercial launch of Fluoxetine Oral Solution, USP 20 mg/5 mL, a prescription-only selective serotonin reuptake inhibitor (SSRI) developed to treat a range of mental health conditions effectively. This oral formulation is designed to support flexible and individualized treatment, particularly for patients who experience difficulty swallowing solid dosage forms. Fluoxetine Oral Solution is indicated for the following conditions: Acute and maintenance treatment of Major Depressive Disorder (MDD) Acute and maintenance treatment of Obsessive-Compulsive Disorder (OCD) Acute and maintenance treatment of Bulimia Nervosa Acute treatment of Panic Disorder, with or without agoraphobia "We are excited to expand our product portfolio with the introduction of Fluoxetine Oral Solution," said Polireddy Dondeti, Ph.D., President and CEO, of Saptalis Pharmaceuticals, LLC. "This launch reflects our ongoing commitment to providing high-quality, accessible medications that meet the evolving needs of both patients and healthcare professionals." Fluoxetine Oral Solution, USP 20 mg/5 mL is available by prescription and should only be used under the guidance of a licensed healthcare provider to ensure safe and effective treatment. For full prescribing information or to learn more, please visit or contact us at info@ About Saptalis Pharmaceuticals, LLC. Saptalis Pharmaceuticals, LLC. is a rapidly growing company focused on the development, manufacturing, and commercialization of specialty pharmaceutical products, including complex and high-quality generics, with particular expertise in liquid and semi-solid dosage forms. Headquartered in Hauppauge, New York, Saptalis operates fully equipped R&D laboratories and a state-of-the-art commercial manufacturing facility compliant with U.S. FDA cGMP standards. The company is dedicated to delivering innovative solutions that enhance patient care and improve treatment outcomes. View source version on Contacts Peruvemba SatishChief Financial Officer & Chief Commercial Officer(631) 231 2751 x211info@
Yahoo
3 days ago
- Health
- Yahoo
Saptalis Pharmaceuticals Launches Fluoxetine Oral Solution, USP 20 mg/5 mL
HAUPPAUGE, N.Y., June 18, 2025--(BUSINESS WIRE)--Saptalis Pharmaceuticals, LLC. is pleased to announce the commercial launch of Fluoxetine Oral Solution, USP 20 mg/5 mL, a prescription-only selective serotonin reuptake inhibitor (SSRI) developed to treat a range of mental health conditions effectively. This oral formulation is designed to support flexible and individualized treatment, particularly for patients who experience difficulty swallowing solid dosage forms. Fluoxetine Oral Solution is indicated for the following conditions: Acute and maintenance treatment of Major Depressive Disorder (MDD) Acute and maintenance treatment of Obsessive-Compulsive Disorder (OCD) Acute and maintenance treatment of Bulimia Nervosa Acute treatment of Panic Disorder, with or without agoraphobia "We are excited to expand our product portfolio with the introduction of Fluoxetine Oral Solution," said Polireddy Dondeti, Ph.D., President and CEO, of Saptalis Pharmaceuticals, LLC. "This launch reflects our ongoing commitment to providing high-quality, accessible medications that meet the evolving needs of both patients and healthcare professionals." Fluoxetine Oral Solution, USP 20 mg/5 mL is available by prescription and should only be used under the guidance of a licensed healthcare provider to ensure safe and effective treatment. For full prescribing information or to learn more, please visit or contact us at info@ About Saptalis Pharmaceuticals, LLC. Saptalis Pharmaceuticals, LLC. is a rapidly growing company focused on the development, manufacturing, and commercialization of specialty pharmaceutical products, including complex and high-quality generics, with particular expertise in liquid and semi-solid dosage forms. Headquartered in Hauppauge, New York, Saptalis operates fully equipped R&D laboratories and a state-of-the-art commercial manufacturing facility compliant with U.S. FDA cGMP standards. The company is dedicated to delivering innovative solutions that enhance patient care and improve treatment outcomes. View source version on Contacts Peruvemba SatishChief Financial Officer & Chief Commercial Officer(631) 231 2751 x211info@ Error al recuperar los datos Inicia sesión para acceder a tu cartera de valores Error al recuperar los datos Error al recuperar los datos Error al recuperar los datos Error al recuperar los datos
New York Post
6 days ago
- Health
- New York Post
Drug that makes our ‘brains happier' can also fight tumors: study
This will brighten your mood. A surprising new study has found that some common medication used to make people feel better might also be effective in the fight against cancer. 'These drugs have been widely and safely used to treat depression for decades, so repurposing them for cancer would be a lot easier than developing an entirely new therapy,' Dr. Lili Yang, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, said in a press release. 3 A surprising new study has found that some common medication used to make people feel better might also be effective in the fight against cancer. Tyler Olson – Yang and her team found that selective serotonin reuptake inhibitors, or SSRIs — medications like Prozac and Celexa that millions of Americans take daily — can help T-cells tackle tumors with greater aplomb. 'It turns out SSRIs don't just make our brains happier; they also make our T-cells happier — even while they're fighting tumors,' she said. In lab tests using both mouse and human tumor models — spanning melanoma, breast, prostate, colon and bladder cancers — SSRIs shrunk tumors by over 50%. The drugs heightened killer-T‑cell activity, enhancing their ability to locate and destroy cancer cells. 'SSRIs made the killer T cells happier in the otherwise oppressive tumor environment by increasing their access to serotonin signals, reinvigorating them to fight and kill cancer cells,' Yang said. 3 Yang and her team found that selective serotonin reuptake inhibitors, or SSRIs — medications like Prozac and Celexa that millions of Americans take daily — can help T-cells tackle tumors with greater aplomb. KMPZZZ – While serotonin is primarily known for regulating mood, it also plays a crucial role in managing sleep, gut health, appetite, libido and blood clotting. Now, it's being given its proper due in combatting this devastating disease. The research, which was published in the journal Cell, has exciting implications for cancer treatment, since SSRIs are already FDA-approved, paving the way for clinical trials. 'Studies estimate the bench-to-bedside pipeline for new cancer therapies costs an average of $1.5 billion,' she said. 'When you compare this to the estimated $300 million cost to repurpose FDA-approved drugs, it's clear why this approach has so much potential.' 3 'It turns out SSRIs don't just make our brains happier; they also make our T cells happier — even while they're fighting tumors,' she said. Daniel – Even better? When SSRIs were paired with existing cancer immunotherapy, the results were even more dramatic. Treated mice saw tumors shrink dramatically, and in some cases, vanish altogether. 'Immune checkpoint blockades are effective in fewer than 25% of patients,' study co-author James Elsten-Brown, a graduate student in the Yang lab, said. 'If a safe, widely available drug like an SSRI could make these therapies more effective, it would be hugely impactful.'
San Francisco Chronicle
6 days ago
- Health
- San Francisco Chronicle
More dental problems as you get older? Aging may not be the real reason
Older people are living longer and keeping more of their teeth. That's good news — but it also means that seniors need to be more vigilant than ever about oral health. Over the past 20 years, the portion of adults 65 and older with no teeth fell from about 32% to an all-time low of 17%, according to the most recent report from the National Institute of Dental and Craniofacial Research. Among those 75 and older, it fell from 38% to 22%. 'More people are keeping more of their teeth for longer,' said Dr. Don Curtis, a professor at UCSF School of Dentistry. 'So there's more teeth to take care of and more teeth that are vulnerable to chronic disease.' Older adults are at higher risk than younger populations for developing many dental problems, including periodontal disease (gum disease), root cavities and oral cancer. About 66% of U.S. adults 75 and older have periodontitis (serious gum disease) compared to 42% in the overall adult population, according to one 2016 estimate. Aging may not be the reason These dental issues aren't necessarily due to aging itself, but rather other things that often happen with your overall health, mobility, dexterity and cognition as you age that can in turn affect your oral health, dentists say. For example, many older adults take multiple prescription medications to manage chronic diseases like diabetes, heart disease and osteoporosis. One of the most common side effects of using multiple medications is dry mouth, or having less saliva (hyposalivation), which can make you more susceptible to cavities — one major contributor to losing teeth. Even some common medications for allergies can disrupt saliva flow, as can SSRIs, a class of antidepressants whose side effects can include grinding and clenching. Grinding over time can wear down tooth enamel and make a person more vulnerable to tooth loss. 'Hundreds of medications can cause disturbed salivary flow,' said Dr. Elisa Chavez, a professor at the University of Pacific School of Dentistry in San Francisco. 'Often, people aren't thinking about it or it doesn't strike them as critical. But these are things that can increase risk of developing cavities.' More than 30% of patients over age 60 suffer from dry mouth, according to one 2014 study in the Journal of Dentistry. Gum recession also tends to become more common with age. Recession exposes more of the roots of the teeth where plaque accumulates, which can cause decay and heighten the risk of gum disease. 'The average 70-year-old is more vulnerable to decay because of gum recession than a 7-year-old,' Curtis said. 'Everyone thinks once they're an adult they're not going to get cavities anymore but that's not the case.' Studies have also found that people with diabetes, a chronic condition that's more common in older adults, are at higher risk for gum disease and loose teeth. Some older adults also have problems with mobility because of arthritis or tremors, which can make it harder to brush and floss regularly or get to the dentist as often as they used to. Cognitive impairment can also complicate matters, making it harder to remember daily oral hygiene or to point out a new problem, like bleeding gums. One 2013 study found that among homebound elderly adults, 96% said they had not seen a dentist since becoming homebound. 'For patients who have significant cognitive issues, having regular dental visits are important because they may not be able to identify things like a well older adult would,' Chavez said. 'Those opportunities for intervention early on are really important in that population.' But, perhaps hearteningly, 'Poor oral health is not an inevitability of aging,' Chavez said. 'You can maintain good oral health,' she said. 'The thing is to identify risk factors — the presence of chronic diseases that result in loss of ability to care for yourself or get regular care, and medications that can have an impact.' Interdental brushes, and other solutions Let your dentist know if you've been diagnosed with a new condition or started any new medications since you last saw them, Chavez said. This includes flagging any changes in your ability to maintain daily oral hygiene. 'Dentists and hygienists can give you points and ideas about oral hygiene aids,' she said. For older adults with limited dexterity, for instance, at-home tools like interdental brushes, oral rinses, irrigation devices and power toothbrushes can be helpful, according to a 2021 study led by UCSF's Curtis that examined how to treat older adults with periodontal disease. Curtis recommends using an electric toothbrush with a timer. 'Without a timer, many people often think they spent adequate time but they haven't so they're leaving plaque, which is what leads to potential decay and inflammation associated with periodontal disease,' he said. After eating, brush first, then floss, then brush a little more, Curtis said. This is because flossing helps break up plaque colonies between the teeth. If you grind your teeth, consider a night guard, which can help lessen damage and tooth loss. Older adults with gum recession can also ask their dentist about a high-fluoride varnish. In 2022, a Department of Veterans Affairs study of about 68,000 older adults found that the topic varnish applied over the roots helped decrease decay by 29% over a three-year period. 'Dentures are not a foregone conclusion,' Chavez said. 'We can maintain oral health into older ages and that's exactly what we want to do.'
