Latest news with #HUM2N
Irish Examiner
13-06-2025
- Health
- Irish Examiner
Our bodies' biological age: No simple ‘hack' to change how lifestyle and time treat us
IT'S no secret that wellness fads come as quickly as they go. From the low-fat diets of the noughties to the UPF-free food of today, society loves indulging in the newest health hack. The newest wellness trend to emerge is 'biohacking'. You may have heard of it via American entrepreneur Bryan Johnson's infamous anti-ageing quest, or simply by the numerous podcasts that now discuss cell health and biological age. But what really is biohacking? How do you find out your biological age? And does it really determine how long you'll live for? Doctors specialising in stem cell and longevity research explain what biological age really means, how to lower it, and why it's fast becoming the ultimate wellness metric in modern medicine. What is biological age? Biological age — a measurement of how well your body is functioning based on factors like lifestyle, stress, and cellular health — is different to chronological age, as it isn't fixed and you can reverse it. According to longevity experts, biological age provides a more accurate picture of health span than the candles on our birthday cake. And increasingly, it's being treated as something we can influence. The CEO of Cellcolabs, Dr Mattias Bernow, who provided the stem cells for biohacker Bryan Johnson, explains that this measurement is 'a marker of how old your body seems based on your health, lifestyle, and cellular function.' In other words, you might be 50 on paper, but living like someone 35 — or 65. 'Two people who are both 40 years old chronologically might have very different biological ages depending on how they live, their stress levels, their metabolic health and more,' says GP and the founder of longevity clinic HUM2N, Dr Mohammed Enayat. The biggest culprits behind accelerated ageing are changeable: chronic stress, poor sleep, lack of exercise, ultra-processed foods, and environmental toxins are major accelerants. What accelerates biological ageing? The good news is that many of the biggest culprits behind accelerated ageing are changeable. Both Enayat and Bernow point to chronic stress, poor sleep, lack of exercise, ultra-processed foods, and environmental toxins as major accelerants. Parenting itself doesn't inherently age the body but, as Enayat points out, the chronic sleep deprivation and stress associated with caregiving certainly can. Inflammation is another central player. 'These factors contribute to increasing low-grade inflammation,' Bernow explains, 'which plays a key role in age-related decline and the development of chronic disease.' However, he says, this process is not set in stone. 'While we can't control everything, small, consistent changes to reduce these stressors can make a meaningful difference in how we age.' Which lifestyle changes have the strongest scientific backing? When it comes to slowing the clock, it turns out the best advice isn't ground-breaking – it's just often overlooked. Quality sleep, regular physical activity, a balanced whole-food diet, meaningful relationships, and avoiding harmful substances all rank highly on the evidence-based list. Enayat also points to practices such as caloric moderation, intermittent fasting, and resistance training for their 'strong results in slowing biological ageing at a cellular level'. However, these diets impact each sex differently, with intermittent fasting in particular causing more stress on women's bodies while being effective for men, meaning they will affect biological age differently. Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. How big a part do genetics play? Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. 'Genes load the gun, but lifestyle pulls the trigger,' Enayat says, noting that genetics may only account for 20 to 30% of ageing outcomes. Bernow says that emerging research suggests as much as 80% of ageing is governed by one's environment and behaviour. Supplements can claim everything from healthier skin to better energy to thicker hair — but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. Do supplements make a difference? Supplements can claim everything from healthier skin to better energy to thicker hair — but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. However, there are some supplements that have been proven to be helpful if taken correctly and absorbed properly. 'Protein is essential for preserving muscle mass,' says Enayat, while collagen 'may help with skin and joint health,' though its systemic anti-ageing benefits are modest. Fish oil, magnesium, creatine, and polyphenols all show promise too, but Enayat is keen to emphasise that supplements should support — not replace — healthy habits. Bernow cautions that while some supplements, like vitamin D, are well-supported (especially in sun-deprived regions), many products on the market are poorly regulated. 'Supplements are not a substitute for healthy habits,' he says, 'but in some cases, they can play a supportive role if used thoughtfully.' How to find out your biological age? If you're curious to find out your own biological age, figuring it out requires a blood test. 'The most validated tests look at DNA methylation patterns,' says Enayat, and suggests well-known tests like the Horvath Clock, GlycanAge, and TruAge. Bernow says that Bryan Johnson uses the DunedinPace test, which claims to show he's ageing at just 0.66 years per calendar year (66% of his chronological age). As for how these experts practise what they preach, they say it's all about balance and consistency. Enayat's daily habits include walking, strength training, or stretching, prioritising plants and healthy fats, regular fasting, cold exposure, and supplementing with omega-3, vitamin D, magnesium, and creatine. 'The goal is consistency, not perfection,' he says. Bernow takes a similar approach, but with less exercise and more socialising — explaining he takes a short morning workout, has plenty of family time, eats balanced meals and drinks minimal alcohol. 'More than anything, I believe in consistency,' he says. 'Longevity isn't about extremes but about the things you do every day, for years.' So, while biohacking might conjure visions of futuristic and expensive tech, the real secret to ageing well is actually much simpler: Prioritise balance and relaxation. Read More Fast-track your fitness with five minutes of exercise each day
Time of India
11-06-2025
- Health
- Time of India
Meet the London doctor who is 41 but biologically 24; here's his secrets to living younger revealed
Some ageing signs around the age of 41 are most expected, like tiredness, slower metabolism and longer recovery. But, in contrast to the statement and common observations, Dr. Mohammed Enayat, a London primary care physician and creator of the HUM2N longevity clinic, is defying the diagnostics. With a cutting-edge and rigorous lifestyle regimen, according to the reports, Enayat says his biological age is only 24 which means 17 years younger than his real age. This happened not because of any magic pill or any cleansing but it is actually the result of self-tracking, scientific understanding and regimen of potent supplements. Biologically 17 years younger than his real age; Dr Enayat reveals his lifestyle secret Dr. Enayat has used his body as a living lab for the last seven years. He tracks his vital health data such as sleep, activity, and recovery using wearable tech like the Oura Ring and the Whoop strap. In addition to that, he takes regular in-depth tests on his blood, urine, and gut microbiome. These points enable him to adjust his diet, exercise regimes, and supplement intake with accuracy. To determine his biological age, Enayat uses sophisticated tools such as GlycanAge and TruAge PACE, which evaluate inflammation and epigenetic markers. His latest scan, done 18 months ago, revealed his biological age at 24. However, he emphasizes that supplements are just half the story: According to Business Insider reports: "While I think these supplements have aided my biological aging reversal, I attribute them as one piece in a much larger universe. " Which 3 core supplement constants used by Dr. Enayat While his supplement regimen changes according to the needs of his body, three have been the constants. These are his core supplements: B complex with folate, magnesium, and omega-3 fatty acids. B Complex with Folate Part of Dr. Enayat's daily supplement intake stems from an individual genetic concern, a methylation defect that causes homocysteine to accumulate, making inflammation and heart disease more likely. To counter this, he takes a methylated B complex with folate, which helps to bring homocysteine levels to normal. He also advises taking B vitamins during periods of high stress or inadequate sleep, when the body demands them. Possible advantages are: Improved mood and cognitive abilities Decreased inflammation Decreased risk of dementia Magnesium Even after consuming magnesium-fortified foods such as leafy greens and legumes, Dr. Enayat found that his magnesium levels were always low. He takes magnesium bisglycinate, a type that is highly absorbed and easy on the digestive system. He says: "When I take magnesium, my muscles hurt less and I go to sleep more easily." Magnesium aids in more than 300 enzymatic processes, and deficiency may not be evident. Even if a mere 2% of Americans are clinically deficient, many are functioning at less-than-optimal levels. Omega-3 fatty acids Famous for maintaining heart health, omega-3 fatty acids also lower systemic inflammation and maintain cognitive function. Although Enayat consumes omega-3-rich foods such as fish and walnuts, he supplements to guarantee daily consumption. According to the recent study published, Nature Aging discovered that adults who took 1 gram of omega-3 per day had biologically younger profiles than their counterparts who did not reflect its potential for longevity. Dr. Enayat introduces test-driven path to better health Dr. Enayat is part of a new generation of medical practitioners where clinical knowledge intersects with data-supported self-care. He neither suggests his regimen is one-size-fits-all nor advises everyone to follow the same steps. Rather, he suggests starting with testing, personalizing the process, and being persistent. "Supplements won't make you immortal," he concedes, "but when paired with wisdom and discipline, they can enable you to live younger, longer. " Do you also want to turn back your biological age? Maybe, with wise scientific strategies and foundational supplements anything more than you think might be possible. Also Read | Man mums in China earn Rs 600 for a 5-minute hug; who are they and what's behind this surprising new trend
Economic Times
10-06-2025
- Health
- Economic Times
He is biologically 24 years old at the age of 41, and his longevity secret involves 3 key supplements
Dr. Mohammed Enayat, a 41-year-old longevity expert from London, claims his biological age is just 24. By tracking his health with wearables and diagnostics, he tailors his lifestyle and relies on three daily supplements—B complex with folate, magnesium, and omega-3s. (Screenshot: Instagram/bydr.e) At 41, most people brace for midlife fatigue. But Dr. Mohammed Enayat, a primary care physician and founder of HUM2N longevity clinic in London, is defying that narrative. With cutting-edge diagnostics and a personalized wellness regime, Enayat claims his biological age is just 24—a full 17 years younger than what his passport states. What's behind this age-defying transformation? According to a report from Business Insider , it's not a magic elixir or an exotic detox. It's a meticulous science-backed regimen driven by relentless self-monitoring, strategic lifestyle choices, and three humble yet powerful supplements. For the past seven years, Dr. Enayat has treated his body like a data lab. He wears devices like the Oura Ring and the Whoop strap to monitor his sleep, recovery, and activity. On top of that, he undergoes frequent blood, urine, and microbiome testing. These insights help him fine-tune everything from nutrition to training—and yes, his supplement stack. While the definition of 'biological age' is still a topic of debate, Enayat uses metrics from GlycanAge and TruAge PACE, which assess inflammation and epigenetic changes. His most recent results—taken 18 months ago—indicated a biological age of 24. But Enayat is the first to admit: supplements are just a part of the bigger puzzle. 'While I believe these supplements have supported my biological age reversal, I credit them as one component in a much broader framework,' he told Business Insider . View this post on Instagram A post shared by HUM2N (@hum2n) Though his supplement intake evolves with his body's changing needs, three remain constant in his rotation—B complex with folate, magnesium, and omega-3 fatty acids. These are what he calls his 'core' supplements. One reason Dr. Enayat includes this duo daily is a personal one. 'I have a methylation gene defect,' he said, referring to a condition that leads to elevated homocysteine levels—a marker that increases inflammation and risk for cardiovascular disease. To combat this, he relies on a methylated B complex with folate to normalize his levels. Even without this genetic predisposition, Enayat recommends B vitamins during periods of stress or sleep deprivation, when the body's demand for them increases. The benefits? Improved mood, better brain health, and potential dementia prevention. Despite magnesium being plentiful in foods like dark leafy greens and legumes, Enayat says his levels are consistently low. He turns to magnesium bisglycinate, a highly absorbable form, to fill the gap. 'When I take magnesium, my muscles ache less and I fall asleep more easily,' he noted. While only 2% of Americans are thought to be deficient in magnesium, it remains essential for over 300 enzymatic reactions in the body. Known for their heart-healthy reputation, omega-3 fatty acids also make Enayat's daily lineup. Found naturally in fish, walnuts, and chia seeds, omega-3s reduce inflammation and lower blood pressure. For those who don't get enough through diet—like Enayat—a supplement can help close the gap. A recent Nature Aging study added further intrigue, showing that older adults who consumed a gram of omega-3 daily had younger biological ages than those who didn't. Dr. Enayat is the face of a growing movement where medicine, technology, and personal agency intersect. While he doesn't present his regimen as a universal blueprint, his case offers an exciting glimpse into what's possible when modern science meets old-school discipline. So, can you turn back your biological clock? Maybe not overnight—but for Enayat, it starts with knowing your numbers, trusting the data, and supporting your body from the inside out. Supplements might not be the secret to immortality, but in the right hands, they just might be a step toward living younger, longer.
Time of India
10-06-2025
- Health
- Time of India
He is biologically 24 years old at the age of 41, and his longevity secret involves 3 key supplements
Tracking the Clock You Might Also Like: No supplements needed: Longevity doctor shares the one daily nutrient that could add years to your life The Three Supplements He Swears By B Complex and Folate: Calming Inflammation at the Gene Level iStock B Complex and Folate Magnesium: For Muscles, Sleep, and Everything In Between You Might Also Like: Longevity decoded: 70-year-old cardiologist reveals the one change that made him stronger than ever iStock Magnesium Omega-3s: The Anti-Aging Fat iStock Omega 3 At 41, most people brace for midlife fatigue. But Dr. Mohammed Enayat , a primary care physician and founder of HUM2N longevity clinic in London, is defying that narrative. With cutting-edge diagnostics and a personalized wellness regime, Enayat claims his biological age is just 24—a full 17 years younger than what his passport behind this age-defying transformation? According to a report from Business Insider, it's not a magic elixir or an exotic detox. It's a meticulous science-backed regimen driven by relentless self-monitoring, strategic lifestyle choices, and three humble yet powerful the past seven years, Dr. Enayat has treated his body like a data lab. He wears devices like the Oura Ring and the Whoop strap to monitor his sleep, recovery, and activity. On top of that, he undergoes frequent blood, urine, and microbiome testing. These insights help him fine-tune everything from nutrition to training—and yes, his supplement the definition of 'biological age' is still a topic of debate, Enayat uses metrics from GlycanAge and TruAge PACE, which assess inflammation and epigenetic changes. His most recent results—taken 18 months ago—indicated a biological age of Enayat is the first to admit: supplements are just a part of the bigger puzzle. 'While I believe these supplements have supported my biological age reversal, I credit them as one component in a much broader framework,' he told Business his supplement intake evolves with his body's changing needs, three remain constant in his rotation—B complex with folate, magnesium, and omega-3 fatty acids . These are what he calls his 'core' reason Dr. Enayat includes this duo daily is a personal one. 'I have a methylation gene defect,' he said, referring to a condition that leads to elevated homocysteine levels—a marker that increases inflammation and risk for cardiovascular combat this, he relies on a methylated B complex with folate to normalize his levels. Even without this genetic predisposition, Enayat recommends B vitamins during periods of stress or sleep deprivation, when the body's demand for them increases. The benefits? Improved mood, better brain health, and potential dementia magnesium being plentiful in foods like dark leafy greens and legumes, Enayat says his levels are consistently low. He turns to magnesium bisglycinate, a highly absorbable form, to fill the gap.'When I take magnesium, my muscles ache less and I fall asleep more easily,' he noted. While only 2% of Americans are thought to be deficient in magnesium, it remains essential for over 300 enzymatic reactions in the for their heart-healthy reputation, omega-3 fatty acids also make Enayat's daily lineup. Found naturally in fish, walnuts, and chia seeds, omega-3s reduce inflammation and lower blood pressure. For those who don't get enough through diet—like Enayat—a supplement can help close the gap.A recent Nature Aging study added further intrigue, showing that older adults who consumed a gram of omega-3 daily had younger biological ages than those who didn' Enayat is the face of a growing movement where medicine, technology, and personal agency intersect. While he doesn't present his regimen as a universal blueprint, his case offers an exciting glimpse into what's possible when modern science meets old-school can you turn back your biological clock? Maybe not overnight—but for Enayat, it starts with knowing your numbers, trusting the data, and supporting your body from the inside out. Supplements might not be the secret to immortality, but in the right hands, they just might be a step toward living younger, longer.
Business Insider
10-06-2025
- Health
- Business Insider
A 41-year-old longevity doctor says his 'biological age' is 24. He takes 3 supplements daily.
Dr. Mohammed Enayat, the founder of a longevity clinic, claims to have reversed his age by 17 years. He told Business Insider that supplements are a part of his longevity routine. He takes B complex and folate, magnesium, and omega-3 fatty acids daily. A doctor who owns a longevity clinic and claims to have reversed his biological age by 17 years shared the three supplements he takes daily. Dr. Mohammed Enayat, a primary care doctor and the founder of London's HUM2N longevity clinic, told Business Insider that he has been closely tracking his health for the past seven years, using wearable tech, including an Oura ring and Whoop strap, plus regular blood, urine, and microbiome tests. Enayat changes his longevity routine depending on the results, including the supplements he takes. However, he has taken what he sees as his "core" supplements, B complex and folate, magnesium, and omega-3 fatty acids daily in cycles over the past several years, he said. "While I believe these supplements have supported my biological age reversal, I credit them as one component in a much broader framework," Enayat added. In general, dietitians recommend people prioritizing getting their nutrients from food. There's no consensus on how to define or measure biological age, but Enayat used GlycanAge and TruAge PACE, which measure inflammation and epigenetics, respectively. According to his most recent tests taken 18 months ago, he had a " biological age" of 24, which is 17 years younger than his chronological age. B complex and folate Enayat takes a vitamin B complex and folate supplement. "I have a methylation gene defect, which means that my homocysteine, one of the markers, rises high, which is very pro-inflammatory. So to bring that down, I have to be on a good B complex and a folate supplement," he said. Having high levels of homocysteine can increase the risk of blood clots, heart attack, and stroke. But you can lower your levels through supplementation and eating foods that contain B vitamins, including fish, poultry, legumes, seeds, eggs, dairy products, and leafy greens. More broadly, studies have linked B vitamins to better mood and the prevention of dementia, but more research is needed. "Even without a methylation-related gene defect, I would still consider taking a methylated B complex, particularly during periods of high stress, poor sleep, or intensive training, as these increase the demand for B vitamins," Enayat said. Magnesium Magnesium is found in legumes, dark leafy greens, nuts, seeds, and whole grains. It plays a key role in many biological processes, including building strong bones, regulating blood sugar and blood pressure, and muscle function. Enayat's magnesium levels are below the recommended amount, he said, because he doesn't get enough from his diet. This is relatively uncommon — around 2% of Americans have low magnesium levels. For this, he takes a form of magnesium called bisglycinate because it's easier for the body to absorb. "It works really well to bring my levels up," he said. When he takes magnesium, he finds that his muscles ache less and he falls asleep more easily. Omega-3 fatty acids Omega-3 fatty acids, found in foods including oily fish, walnuts, and chia seeds, have been linked to better heart health, lower inflammation, and lower blood pressure. Enayat has naturally low levels of omega three fatty acids, so he takes a daily supplement. There's strong evidence to suggest that eating fatty fish weekly is protective against cardiovascular disease. But, it's unclear whether taking it in supplement form provides the same protection. However, there's some evidence to suggest that taking omega-3 supplements might have anti-aging effects. A study on 777 participants with an average of 75, published in the journal Nature Aging earlier this year, found that those who consumed a gram of omega-3s every day had lower "biological ages" than those who didn't.
