‘Game changer' brain tumour test set to improve care for patients

Patients usually wait six to eight weeks to find out the type of brain tumour.
But the new 'game changer' tool, which assesses the DNA from a sample taken from the tumour, can achieve this in around two hours, experts found.
They said this means that patients can start treatment faster and the test may even help surgical teams while they are performing operations to remove tumours.
Researchers from the University of Nottingham and Nottingham University Hospitals NHS Trust (NUH) assessed the new test on 50 patients.
Publishing their findings in the journal Neuro-Oncology, the research team said the new test was 'in concordance with standard of care' for '90% of cases'.
They said the new test can provide diagnostic results in under two hours from surgery, and detailed tumour classifications within minutes of sequencing.
Usually medics have to send samples away to central analysis facilities for genetic analysis, with patients facing long waits to find out what type of tumour they have.
This long wait is 'traumatic' for patients and can delay chemotherapy and radiotherapy, they experts said.
But the new method, called ROBIN (rapid nanopore brain intraoperative classification), can potentially eliminate this delay, they added.
Professor Matt Loose, from the School of Life Sciences at the University of Nottingham, developed a method to sequence specific parts of human DNA at 'higher depth' using Oxford Nanopore Technologies portable sequencing devices.
The team have now used this method to genetically test brain tumour samples.
'Not only is the test more accurate and quicker, but it is also cheaper than current methods,' he said.
'Our calculations stand at around £450 per person, potentially less when scaled-up.
'Most importantly, it delivers results to the patients when they need them.'
Neurosurgeon Dr Stuart Smith, from the University's School of Medicine and NUH, added: 'Traditionally, the process of diagnosing brain tumours has been slow and expensive.
'Now, with this new technology we can do more for patients because we can get answers so much more quickly which will have a much bigger influence on clinical decision making, in as little as two hours.
'Patients find waiting many weeks for results extremely difficult and this adds to the anxiety and worry at what is already a very difficult time.'
He said the test was so rapid that it could even help surgeons during any operation to assist with their 'surgical strategy'.
Dr Simon Paine, a consultant neuropathologist at NUH, added: 'This new method of diagnosing brain tumours is going to be a game changer, it really is revolutionary. It not only increases the speed at which the results will be available, but the degree of accuracy of the diagnosis as well is incredible.'
Commenting, Dr Simon Newman from The Brain Tumour Charity, said: 'The delivery of an accurate diagnosis within hours of surgery will be transformative for all patients ensuring rapid access to the optimal standard of care and – crucially – removing the uncertainty patients face when having to wait weeks for their diagnosis and prognosis.
'The potential to combine so many separate tests into one and deliver at a localised level is a game changer for driving equity of access to rapid and accurate molecular diagnosis.'

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4 days ago

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Those who experience menopause later in life, after age 55, have a higher risk of breast cancer because their bodies were exposed to reproductive hormones for longer periods. Menopausal hormone therapy (MHT) is another consideration. Many people use MHT during perimenopause to manage symptoms such as hot flashes, but some types of MHT increase breast cancer risk. The risk appears to be higher with combined estrogen and progesterone treatment compared to estrogen alone. MHT can increase breast cancer risk, but the level of risk depends on the specific type of HRT used. Combination MHT, which contains both estrogen and progesterone, poses a higher risk than estrogen-only therapy. Estrogen-only MHT is typically used by those who have had hysterectomies. It does not appear to be linked to an increased breast cancer risk, making it a safer option for appropriate candidates. MHT may increase the initial risk of developing breast cancer and make it more likely that cancer will be detected at advanced stages. According to this occurs partly because combination MHT increases breast density, making mammograms less effective at spotting early cancers. The risk appears greater with daily progesterone use compared to less frequent dosing schedules. The dose and duration of MHT also play a significant role in breast cancer risk. Higher doses carry a greater risk than lower doses, and this increased risk can persist for more than 10 years after treatment stops. These findings apply to both synthetic hormones and bioidentical products, despite marketing claims that natural hormones are safer. Anyone considering MHT should discuss their risk factors with healthcare professionals to weigh the benefits of symptom relief against potential cancer risks. Reproductive history : Never having children or having a first child after age 30 increases the risk. Pregnancy lowers breast cell exposure to circulating estrogen. The more children a person has, the greater the protection against breast cancer. : Never having children or having a first child after age 30 increases the risk. Pregnancy lowers breast cell exposure to circulating estrogen. The more children a person has, the greater the protection against breast cancer. Lifestyle factors : A lack of physical activity and excessive alcohol consumption can contribute to increased risk. Smoking, particularly if started at a young age, also elevates breast cancer risk. : A lack of physical activity and excessive alcohol consumption can contribute to increased risk. Smoking, particularly if started at a young age, also elevates breast cancer risk. Medical factors : Previous breast biopsies showing atypical cells, family history of breast or ovarian cancer, and genetic mutations such as BRCA1 or BRCA2 significantly increase risk. Radiation exposure to the chest area, particularly during adolescence, also contributes to elevated risk. : Previous breast biopsies showing atypical cells, family history of breast or ovarian cancer, and genetic mutations such as BRCA1 or BRCA2 significantly increase risk. Radiation exposure to the chest area, particularly during adolescence, also contributes to elevated risk. Dense breast tissue: Dense breast tissue has a higher risk of developing breast cancer and may require additional screening methods beyond standard mammography. Maintain a moderate weight : Working toward and maintaining a moderate weight through balanced nutrition and regular physical activity significantly reduces risk. : Working toward and maintaining a moderate weight through balanced nutrition and regular physical activity significantly reduces risk. Exercise regularly : Aim for at least 150 minutes of moderate-intensity aerobic activity per week, plus two sessions of strength training exercises each week. : Aim for at least 150 minutes of moderate-intensity aerobic activity per week, plus two sessions of strength training exercises each week. Limit alcohol consumption : Restrict alcohol intake to no more than one drink per day, as alcohol consumption is linked to increased breast cancer risk at any level of intake. : Restrict alcohol intake to no more than one drink per day, as alcohol consumption is linked to increased breast cancer risk at any level of intake. Follow screening guidelines : Adhere to the recommended mammography schedules, typically once or twice a year, depending on age and risk factors. People with a higher risk may need additional screening methods. : Adhere to the recommended mammography schedules, typically once or twice a year, depending on age and risk factors. People with a higher risk may need additional screening methods. Consider preventive medications: For high risk individuals, medications like tamoxifen or raloxifene may reduce breast cancer risk by around 40% . These decisions require careful discussion with oncologists or breast specialists. A person should contact a doctor if they notice any symptoms of breast cancer. Postmenopausal individuals should be particularly vigilant because they no longer experience monthly breast changes related to menstrual cycles, making new abnormalities more significant. Any persistent change lasting more than 2 weeks warrants medical evaluation. Although regular self-examinations are not a replacement for professional screening, they can help people become familiar with their normal breast tissue and detect changes early. Invasive ductal carcinoma (IDC) accounts for about 80% of breast cancer cases and breast cancer mainly develops in those around the age of 62. Generally, yes. After menopause, the body produces much less estrogen and progesterone, the hormones that many breast cancers depend on to grow and spread. With lower hormone levels after menopause, these cancers receive weaker growth signals and tend to develop more slowly. This hormonal change creates a less favorable environment for cancer growth compared to the higher hormone levels present during reproductive years. Yes, postmenopausal breast cancer is typically less aggressive. Many breast cancers in older individuals are 'hormone-receptor-positive,' meaning they have receptors that allow hormones to fuel their growth. These hormone-positive cancers respond well to treatments that block hormones or prevent the body from making them, essentially cutting off the cancer's fuel supply. Postmenopausal breast cancer risk increases significantly with age. The relationship between menopause and breast cancer stems from cumulative hormonal exposure and age-related cellular changes. Risk factors include MHT, excess weight, family history, and lifestyle factors. People can reduce their risk by maintaining a moderate weight, engaging in regular exercise, limiting alcohol consumption, and following screening guidelines. While postmenopausal breast cancers are often hormone receptor-positive and slower-growing, early detection remains crucial for optimal outcomes. Symptoms may be subtle but include new lumps, breast changes, and nipple abnormalities. Breast Cancer Menopause Cancer / Oncology