
American climber dies on world's fifth-highest peak in Nepal
KATHMANDU, Nepal — An American mountaineer died on Mount Makalu in eastern Nepal during a climb to raise funds for a children's cancer program, officials said Tuesday, the second death in the Himalayan nation's climbing season that began in March.
The world's fifth-highest mountain, Makalu's peak is 28,000 feet high — almost as tall as Mount Everest, the world's tallest peak at a height of 29,032 feet.
Alexander Pancoe, 39, died Sunday while settling into his sleeping bag at the mountain's second high camp, after returning from an acclimatization trip at the higher camp three, expedition organizer Madison Mountaineering said.
'Alex suddenly became unresponsive,' the company said on its website. 'Despite hours of resuscitation efforts ... they were unable to revive him.'
Nepal's tourism department said it was arranging to bring the body to Kathmandu, the capital.
Pancoe, who survived a brain tumor when younger, had completed the Explorer's Grand Slam — climbing the highest peaks on each of the seven continents and then skiing to both the North and South Poles.
He had been battling chronic myeloid leukemia and was attempting to climb Makalu to raise funds for the pediatric blood cancer program of the Chicago-based Lurie Children's Hospital, said expedition leader Garrett Madison.
He had already raised $1 million to help fund clinical trials and other programs there, Madison added.
In April, a Nepali sherpa died on Mount Annapurna, the world's 10th-highest mountain.
Wedged between India and China, landlocked Nepal is home to eight of the world's 14 highest peaks, including Mount Everest, and its economy is heavily reliant on climbing, trekking and tourism for foreign exchange.
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Reuters
4 hours ago
- Reuters
Data on Novo Nordisk experimental weight-loss drug show mostly mild side effects
June 22 (Reuters) - Novo Nordisk ( opens new tab on Sunday said full results from two late-stage trials of its experimental weight-loss drug CagriSema show that side effects were mainly mild-to-moderate and other outcome results, including blood sugar levels, were positive. The company had previously announced top-line results for the 68-week studies, which found that CagriSema led to nearly 23% weight loss for overweight or obese adults, while overweight type 2 diabetics lost nearly 16% of their weight. Those results, however, disappointed investors, sending Novo's shares lower. The company last month ousted its CEO Lars Fruergaard Jorgensen. The full Phase 3 results were presented in Chicago at the annual meeting of the American Diabetes Association and published in the New England Journal of Medicine. In the obesity trial, 79.6% of CagriSema patients had mainly transient, mild-to-moderate gastrointestinal effects such as nausea, vomiting and constipation, compared with 39.9% of placebo patients. Serious adverse events occurred in 9.8% of CagriSema patients and 6.1% of placebo patients. In the CagriSema group, 6% of patients dropped out of the trial due to adverse events, compared with 3.7% in the placebo group. "Everything was in line with what we expected," Dr. Melanie Davies, lead investigator of the CagriSema diabetes trial, and co-director of the Leicester Diabetes Centre, told Reuters. The percentage of patients who had a glycated hemoglobin, or blood sugar, level of 6.5% or less was 73.5% in the CagriSema group and 15.9% in the placebo group. Dr. Davies acknowledged questions about why many patients in the trials were not given the highest tested dose. "Those patients on lower doses actually had higher weight loss reduction," she said. "We've not really seen that before because we have not had powerful treatments that have got people close to target." CagriSema is a weekly injection that combines Novo's blockbuster GLP-1 drug Wegovy with another molecule, cagrilintide, that mimics a hunger-suppressing pancreatic hormone called amylin. The CagriSema Phase 3 trial results "compared very favorably also with what we've seen with tirzepatide, which was previously the best-in-class," Dr. Davies said. Eli Lilly's (LLY.N), opens new tab tirzepatide, sold under the brand name Zepbound for weight loss, works by stimulating GLP-1 along with a second gut hormone called GIP. It was shown to help obese and overweight adults lose 22% of their weight over 72 weeks. Dr. Davies said it makes sense to have more options for patients, including "theoretical benefits" with amylin, which has been shown in animal studies to boost energy expenditure. If that effect is seen in humans, it could help mitigate the body's metabolic adaptation to weight loss, she said. Novo Nordisk said it plans to file for regulatory approvals for CagriSema in the first quarter of 2026. "We expect to see approval maybe around the beginning of 2027," Martin Holst Lange, head of development at Novo Nordisk, told Reuters. The company is conducting several other trials of CagriSema, including measuring its impact on cardiovascular outcomes. Lange said trial patients given lower doses of the drug often lost as much weight as those given higher doses, suggesting the need for flexibility including longer time periods between dose escalation. "This also allows them to lose their body weight at a pace that isn't too steep. It also mitigates side effects," he said.


NBC News
8 hours ago
- NBC News
Outside groups organize to form unbiased, independent vaccine panel
In the wake of Health Secretary Robert F. Kennedy Jr.'s decision to shake up a key federal vaccine advisory committee, outside medical organizations and independent experts are looking for alternate sources of unbiased information and even considering forming a group of their own. A leading contender is a new group led by Michael Osterholm, an infectious disease expert and the director of the Center for Infectious Disease Research and Policy (CIDRAP) at the University of Minnesota. Osterholm is launching the Vaccine Integrity Project at CIDRAP as a potential alternative to the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. 'We've always just taken for granted that routine child immunizations and other vaccines would be readily available and that they would be supported by the public health system,' Osterholm said. 'Now that's in question.' Earlier this month, Kennedy fired all 17 members from ACIP, appointing in their place eight new members, many of whom have expressed vaccine-skeptical views or questioned pandemic restrictions. Kennedy himself has a long history of anti-vaccination activism. The American Academy of Pediatrics has called the new ACIP members a ' radical departure' from the committee's mission of protecting kids. ACIP holds a significant amount of influence over vaccinations in the U.S.; the panel is responsible for setting the childhood vaccination schedule and determining what vaccines are given free of charge under the Vaccines for Children Program. Its recommendations guide what vaccinations are required for attending public school and what shots insurance covers. 'The real risk is that families and patients may not have access to vaccines' if the panel makes changes to their recommendations, said Dr. Molly O'Shea, a pediatrician in Michigan. 'The ramifications are deep,' said Dr. Michelle Taylor, a pediatrician and the director of the Shelby County Health Department in Memphis, Tennessee. 'Any school system that is requiring immunizations for school entry is looking for those ACIP recommendations, either directly from the CDC, from the Department of Education, if they are filtered there, or from their local or state health departments.' CIDRAP is now consulting with multiple medical organizations and public health groups — including the AAP, the American Academy of Family Physicians, the American College of Physicians, the American Pharmacists Association, the National Foundation for Infectious Diseases, as well as insurance providers — to discuss vaccine recommendations. Insurance companies rely on ACIP's guidance on which vaccines to cover. But if enough reputable public health groups come up with recommendations different from ACIP's, Osterholm said those groups could sway insurance companies on which shots to cover. Although vaccination rates have been slipping in recent years, the vast majority of American families do vaccinate their kids. The CDC reported that 92.7% of kindergartners in the 2023-24 school year had received their routine childhood vaccines. Parents depend on guidance from pediatricians on which shots to give and when. Those pediatricians rely on CDC guidance. 'Pediatricians have one goal, and that's to keep every child healthy and safe in every community. That is what we wake up every morning thinking about. That is what we go to sleep thinking about at night,' said Dr. Susan Kressly, the president of the AAP. 'If pediatricians are not standing up for what children and families deserve and need, then who?' Some major medical organizations are voicing their concerns about Kennedy's anti-vaccine actions. The American Medical Association has asked Congress to investigate Kennedy's handling of ACIP. States are also taking action. The Wisconsin Department of Health Services defied the HHS declaration that the federal government would no longer recommend Covid shots for healthy children and pregnant women. 'The recent changes in CDC guidance were not made based on new data, evidence, or scientific or medical studies, nor was the guidance issued following normal processes,' the state's department of health wrote in a press release. The Illinois Department of Public Health criticized Kennedy's gutting of ACIP, saying on X that the secretary had a 'misunderstanding of how vaccine trials work.' ACIP's approach ACIP was formed in 1972 as an independent panel of experts to educate the federal government on vaccines. The committee —composed of experts including pediatricians, geriatricians, infectious disease doctors, immunologists and vaccinologists — has three regular meetings a year to pore over the evidence for new or updated vaccines. All meetings are open to the public and are streamed online. The panel may also be convened outside of those regular meetings. During the Covid pandemic, for example, the committee reviewed rare reports of a heart problem called myocarditis in some young men who'd had the Covid shot. The committee also recommended against the Johnson & Johnson Covid vaccine after it was linked to rare but potentially deadly blood clots. Recommendations from ACIP are usually adopted by the director of the CDC. But there isn't any CDC director at the moment. President Donald Trump's pick for the job, Susan Monarez, has a scheduled confirmation hearing in the Senate on June 25 — the same day Kennedy's new ACIP members will meet for the first time. As head of the Department of Health and Human Services, Kennedy is the ultimate authority and has the ability to override ACIP recommendations. He flexed this rarely used muscle in May by announcing — without any input from ACIP — that the Covid vaccine would no longer be recommended for healthy children and pregnant women. ACIP members have historically gone through an extensive vetting process to ensure their expertise. If members have conflicts of interest, they recuse themselves from votes. An HHS spokesman said its eight new ACIP members were thoroughly vetted, but not did not offer specifics. Two members, Dr. Martin Kulldorff and Dr. Robert Malone, were previously paid experts in trials involving Merck vaccines. Another, Vicky Pebsworth, served as an expert witness in a federal lawsuit brought by activists who sought to outlaw childhood vaccination mandates. The case was dismissed in 2021. Vaccine skepticism isn't necessarily a bad thing. 'True scientists ask critical questions in a way that doesn't presume the answer,' the AAP's O'Shea said. 'What has made America great, however, is our medical and scientific innovation. To undermine that is gravely concerning to me.'


Daily Mirror
12 hours ago
- Daily Mirror
'I'm a gut health scientist - what I eat daily is tasty and boosts weight loss'
Jordan Haworth, a gut health scientist who is known as Mr Gut Health online, has shared what he eats in a day to support his gut health and weight loss Our digestive system, often referred to as our guts, is crucial for digesting food, absorbing nutrients, and expelling waste. It's vital to look after our guts, which are instrumental in breaking down what we eat so that the body can produce the necessary chemicals for proper functioning. Studies have shown that gut health can influence both our physical and mental wellbeing. Connections have been made between the gut and various aspects of health including the immune system, autoimmune diseases, heart disease, cancer, and more. A gut health expert has divulged his dietary habits, adhering to the Mediterranean diet, renowned for bolstering gut health and offering additional perks like aiding weight management. The Mediterranean diet promotes a style of eating reflective of the culinary traditions of countries bordering the Mediterranean Sea, such as Spain and Greece. It favours a plethora of wholesome foods including whole grains, fruits, vegetables, seafood, legumes, and nuts. Jordan Haworth, known online as Mr Gut Health, is an experienced gut health scientist with over seven years under his belt. Revealing his daily intake as a "full time gut health scientist", Jordan begins with ginger and turmeric shots to "kick start the old immune system". Research suggests that the combination of ginger and turmeric could help diminish inflammation and pain, enhance immunity, and guard against chronic illnesses. The Manchester-based scientist kicked off his day with a spoonful of Psyllium jelly to "detox his gut". In an earlier video, Jordan demonstrated how he concocted the "gut health jelly" using just three ingredients. He mixed three teaspoons of Psyllium husk with 150ml of pressed juice such as grape, and a dash of lime to "make it sour". After letting it chill in the fridge for 10 minutes, it was ready to go. Jordan touted it as a "low calorie prebiotic jelly" packed with 12g of fibre to "keep you full". For breakfast, he tucked into a bowl of 5% Greek yoghurt, citing that the "fat in dairy is good for your brain". However, he didn't share any of the additional ingredients he might have thrown in. Alongside this, Jordan enjoyed some green tea and walnuts, which he also hailed as "good for your brain". Green tea is renowned for its potential health benefits, including bolstering cognition and aiding weight management. Walnuts, on the other hand, are a fantastic source of omega-3 fatty acids and antioxidants, boasting anti-inflammatory properties. Come lunchtime, Jordan whipped up a chicken and chickpea pasta salad, praising it as a great source of fibre. He dressed it with extra virgin olive oil, a cornerstone of the Mediterranean diet, and tossed in extras like cucumber, tomatoes, olives and feta cheese. After downing a matcha energy drink to keep him fuelled, Jordan sat down to dinner: a watermelon feta salad paired with "fresh, crispy mackerel" and potato wedges. He rounded off the day with a pair of kiwis. Kiwis, packed with vitamin C and dietary fibre, are a fantastic choice. Some even suggest that consuming kiwi before going to bed can enhance your sleep quality, thanks to its serotonin content, a neurotransmitter instrumental in sleep regulation. Always seek advice from a GP or dietician prior to making significant alterations to your diet or embarking on a new eating regimen.