Cadence Unveils Millennium M2000 Supercomputer with NVIDIA Blackwell Systems to Transform AI-Driven Silicon, Systems and Drug Design

The new Cadence Millennium M2000 Supercomputer accelerates the build-out of AI infrastructure, advances physical AI machine design and pushes the frontiers of drug design.
The new Cadence Millennium M2000 Supercomputer features NVIDIA Blackwell systems and delivers AI-accelerated simulation at unprecedented speed and scale across engineering and drug design workloads.
The new Cadence Millennium M2000 Supercomputer harnesses Cadence's broad array of EDA, system design and analysis, and molecular software solvers to perform massive simulations that were previously impossible.
Cadence best-in-class simulation software integrated with NVIDIA Blackwell-accelerated compute enables unmatched scale and speed
Delivers up to 80X higher performance and 20X lower power
Optimized for a broad range of workloads across EDA, system design and drug design
SANTA CLARA, Calif., May 07, 2025--(BUSINESS WIRE)--At its annual flagship user event, CadenceLIVE Silicon Valley 2025, Cadence (Nasdaq: CDNS) today announced a major expansion of its Cadence® Millennium™ Enterprise Platform with the introduction of the new Millennium M2000 Supercomputer featuring NVIDIA Blackwell systems, which delivers AI-accelerated simulation at unprecedented speed and scale across engineering and drug design workloads.
The new supercomputer integrates Cadence's industry-leading solvers with NVIDIA HGX B200 systems, NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs and NVIDIA CUDA-X libraries and solver software. This powerful combination delivers dramatic reductions in simulation run times and up to 80X higher performance versus CPU-based systems for electronic design automation (EDA), system design and analysis (SDA), and drug discovery applications. The supercomputer provides a tightly co-optimized hardware-software stack that enables breakthrough performance with up to 20X lower power across multiple disciplines, accelerating the build-out of AI infrastructure, advancing physical AI machine design and pushing the frontiers of drug design.
"The Millennium M2000 Supercomputer will drive the next leap in AI-accelerated engineering by leveraging our massively scalable solvers, dedicated NVIDIA Blackwell-accelerated computing and AI to help designers continue to push the limits of what is possible," said Anirudh Devgan, president and CEO of Cadence. "Purpose-built for the most advanced AI models of today and tomorrow, the Millennium M2000 Supercomputer delivers unprecedented designer productivity to propel the next generation of AI infrastructure, physical AI systems and drug discovery."
"From biology to chip design, the world's most complex engineering challenges require simulation at scales and speeds only possible with accelerated computing," said Jensen Huang, founder and CEO of NVIDIA. "Built with NVIDIA Blackwell, CUDA-X and Cadence's computational software, the Millennium M2000 Supercomputer is a new class of infrastructure: an AI factory for science to drive breakthroughs that will transform discovery across disciplines."
The next generation of infrastructure AI, physical AI and sciences AI requires sophisticated computational capability in data centers and edge devices. Building upon the success of the Millennium M1 Supercomputer, which delivers breakthrough performance and energy efficiency for high-fidelity computational fluid dynamics (CFD) simulations, the Millennium M2000 Supercomputer harnesses Cadence's broad array of EDA, SDA and molecular software solvers to perform massive simulations that were previously impossible, transforming approaches to semiconductor and 3D-IC design, data center digital twins, drug discovery modeling and other engineering challenges across the hyperscale computing, automotive, data center, and aerospace and defense markets.

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