Gaia, Europe's Galactic Cartographer, Is Gone But Not Forgotten
This observatory has probably been the most transformative astronomy project of the 21st century, but there's a good chance you've never heard of it. Just last week, for instance, the Hayden Planetarium at the American Museum of Natural History (AMNH) in New York City debuted a new 'space show' called Encounters in the Milky Way—and this often overlooked spacecraft is its scientific superstar. But you're more likely to know about actor Pedro Pascal's narration in the show than you are to be familiar with the single space mission that serves as the presentation's backbone.
The observatory is called Gaia. And, like so many good things, you wouldn't really miss it until it's gone—and now it is.
Launched in 2013 by the European Space Agency (ESA), it ceased operations this past March, when it used what little fuel it had left to steer into a graveyard orbit around the sun. From its station in a quiescent region of deep space more than 1.6 million kilometers from Earth, Gaia's mission was, in essence, quite simple: it was designed to give us a better sense of where we are—a celestial 'reference frame' on overlapping interplanetary, interstellar and intergalactic scales. To do that, it used twin sky-sweeping telescopes and three instruments, including a billion-pixel camera, to painstakingly measure the distances, positions, motions, and more of about two billion celestial objects, most of them stars in our own galaxy. It made some three trillion observations in all, producing (among many other things) the largest, most precise three-dimensional map of the Milky Way ever made.
[Sign up for Today in Science, a free daily newsletter]
'Gaia was our best galactic cartographer, and I sometimes say that Encounters in the Milky Way is my love letter to it,' says Jackie Faherty, a senior research scientist at the AMNH, who curated the new space show and regularly works with Gaia data. 'It turns out you can learn a lot by determining where and how far off the stars are from you—and especially by how they are moving.... Gaia's creation of this map is something we all should celebrate because it's just as iconic and useful as the maps of Earth we all see in school or pull up on Google. Looking at it, you can find and explore all sorts of different things you want to know.'
From Gaia's map, more than 13,000 peer-reviewed studies have already emerged, and many have concerned the fundamental structure and deep history of the Milky Way. Thanks to Gaia, scientists now can better gauge the amount of dark matter within our galaxy and have been able to track the Milky Way's growth and evolution across eons via relic streams of stars strewn from ancient mergers with other, smaller galaxies.
'Stars retain memories of their origins in their ages, motions and chemical compositions—all of which Gaia measured,' says Amina Helmi, an astronomer at the Kapteyn Astronomical Institute in the Netherlands. She and her colleagues used the mission's data to discover evidence of a major galactic merger that, some 10 billion years ago, shaped our home galaxy into the Milky Way we know today.
'With all that information, it was like a veil being lifted,' Helmi says. 'We could suddenly perform what's sometimes called 'galactic archaeology,' reconstructing the Milky Way's history to see when and how this merger happened with another, smaller galaxy that was about a third to a quarter of our galaxy's mass.... Gaia allows us to look billions of years into the Milky Way's history—before our solar system even formed—to see what actually happened back then, which is absolutely amazing.'
Tracing perturbations from one more recent and ongoing merger, astronomers have even managed to reveal an apparent warp in the Milky Way's disk, offering a new twist—literally—on the classic image of our cosmic home. At smaller scales, the spacecraft has refined the orbits of more than 150,000 asteroids, surveilling hundreds of them to see if they have their own moons. It has spied hints of thousands of worlds and even a few black holes orbiting other stars. At larger scales, it has helped estimate the expansion rate of the universe, and it has also teased out the subtle tugging of the Milky Way's heart upon the solar system across tens of thousands of light-years.
Gaia's sprawling cosmic reckoning is now a cornerstone for most state-of-the-art Earth- and space-based telescopes, which rely on the mission's target-dense celestial map to orient and calibrate their own observations and operations. Whether it's NASA's James Webb Space Telescope, ESA's Euclid mission, the ground-based, U.S.-built Vera C. Rubin Observatory or Europe's under-construction Extremely Large Telescope, practically all of the world's most exciting starlight-gathering telescopes will, in some sense, be guided by Gaia.
And stunningly, the best is yet to come. More than two thirds of the mission's treasure trove of data is still under wraps. It is being prepared in a time-consuming process for two major upcoming milestones: about half of Gaia's total data are targeted for release next year, and the mission's full data are set to arrive no earlier than 2030.
But because it didn't beam back images ready-made for lush wall posters and desktop backgrounds, Gaia was destined from the start to be 'criminally under-recognized outside astronomy,' says Mark McCaughrean, an astronomer and former senior adviser to ESA. 'And because Gaia provided utterly essential, if mundane, information such as precise stellar distances, it's been doomed with this curse of simultaneous ubiquity and obscurity as many people use its data but take it for granted as just 'coming from a catalog.''
Anthony Brown, an astronomer at Leiden University in the Netherlands, who leads the mission's data processing and analysis group, puts it most succinctly: 'For astronomers, Gaia has become almost like the air you breathe,' he says.
At the heart of Gaia's mapmaking is a technique called astrometry, the measurement of celestial positions and motions in the plane of the sky. Paired with a phenomenon called parallax—the apparent shift of an object's position when viewed from two vantage points—astronomers can use Gaia for determining distances, too. You can see the parallax effect with your own two eyes: hold your thumb out at arm's length and watch as it appears to jump around as you blink one eye and then the other. The closer the object is, the bigger its displacement will be. And the bigger your baseline is between two vantage points, the smaller the displacement will be that you can discern. Your eyes have a baseline of about six centimeters; Gaia's was 300 million kilometers, set by the opposite sides of Earth's orbit around the sun.
A Gaia predecessor, ESA's Hipparcos mission, used that same gigantic baseline to survey the sky from 1989 until it ran out of fuel in 1993. But the technology of the time limited Hipparcos's astrometric reckoning to a precision of about one milliarcsecond, with high-quality measurements only for about 100,000 objects within about 200 parsecs (650 light-years) of the solar system. (A single arc second is a very small angular slice of the heavens, making Hipparcos's milliarcsecond precision all the more noteworthy. The moon, for instance, takes up about 1,800 arc seconds in Earth's sky.)
As impressive as Hipparcos was, Gaia shattered the records set by its precursor—although not without challenges, such as precision-threatening sprays of stray light that leaked around the edges of the spacecraft's sun shield and through a hole punched by an errant micrometeoroid. But ultimately, Brown says, Gaia's measurements achieved on the order of 100 times greater precision—reaching about 10 microarcseconds. And within the Milky Way, the spacecraft's view encompassed 100 times more volume and included 10 times more targets.
The numbers underpinning Gaia are so alien to everyday experience that they border on nonsensical, says Michael Perryman, a former ESA researcher, who has served as project scientist for Hipparcos and Gaia and played a crucial developmental role for both missions. He likens Hipparcos's precision to discerning a second's worth of growth of a human hair from a distance of one meter. Gaia's 100-times-better view, he says, is more like measuring the width of a single hydrogen atom from the same distance.
Another comparison involves the size of the two missions' datasets. When the Hipparcos team printed out its complete catalog, Perryman recalls, it comprised five thick volumes—almost enough to fill a single shelf of a bookcase. Printing out the full Gaia catalog with the same density of information per page, he says, would require about 10 kilometers of shelf space.
'The mind boggles,' he says. 'It's almost incomprehensible; these are numbers and dimensions we're simply not equipped to visualize, so even the analogies are very difficult to grasp.'
The best example of the heights such precision can reach may be Gaia's tour de force determination of the solar system's acceleration with respect to a vast, sky-encompassing field of quasars. Quasars are the conspicuously bright cores of remote galaxies that harbor actively feeding supermassive black holes. As such, quasars are among the most powerful beacons astronomers can use to probe distant regions of the universe. Gaia pinpointed the positions of more than one and a half million of them to establish a fixed backdrop of sorts, against which various minuscule motions of our solar system or other nearby celestial objects could be seen.
One motion Gaia managed to measure was an astonishingly small acceleration of just 0.232 nanometer per second squared—a continuous atom-scale deflection in the solar system's 220-kilometer-per-second trajectory through the Milky Way, attributed to the gravitational pull from our galaxy's center some 26,000 light-years away. Writ large, the displacement adds up to less than a meter per day—and essentially reflects the real-time sculpting of our galactic orbit as the solar system carves a path through the Milky Way's gravitational field.
'It's an almost circular motion around the galactic center, and it's directed toward the supermassive black hole there,' says astronomer Sergei Klioner of Germany's Dresden University of Technology, who led much of the work behind the measurement. 'No other observational data could come anywhere close to competing with Gaia here.... You often hear the term 'astronomical' in the sense of something being very large—but this is an example where Gaia has shown us something that's astronomically small.'
Now that Gaia has gone dark, there's already talk of what comes next. 'Do we really need another astrometry mission?' asks Brown, who first began working on Gaia in 1997. 'Well, not immediately, but the extremely precise stellar reference frame it gave us—upon which many other observatories depend—will eventually deteriorate because all the stars are moving, right?' ESA is envisioning a follow-on mission, which would potential launching in the 2040s. This time that mission would be optimized for infrared observations to allow astronomers to see through the dust that otherwise clouds their view of the Milky Way's star-packed disk and galactic center.
'It's, in a way, wonderful but also a bit sad that people take Gaia for granted because, my God, it was a tough mission,' Perryman reflects. 'I don't feel sadness that it's gone; I'm just delighted and relieved it lasted so long, and I'm very conscious of how remarkable it is that we live in a time when society is willing to pool its resources to support such things, and we have the technology in place to do them. I hope this period continues—but I worry we've been taking that for granted, too.'

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Medscape
39 minutes ago
- Medscape
Muscle Gains vs Heart Strain: A Deadly Trade-off?
Sudden cardiac deaths (SCDs) appear to be more frequent among men who practice bodybuilding, particularly those competing at high levels. A global study of more than 20,000 athletes is the first to report the incidence of sudden death in this population. As the author noted in the European Heart Journal , the aim was not to demonize bodybuilding but to promote safer practices. Bodybuilding focuses on increasing muscle mass and definition through physical exercise and a targeted diet. Unlike traditional sports, bodybuilding competitions evaluate the aesthetics of the body rather than athletic performance. Researchers identified 20,286 men who had competed in the International Fitness and Bodybuilding Federation (IFBB) events between 2005 and 2020. Using web-based searches, they determined which athletes died. Over a mean follow-up period of 8.1 ± 3.8 years, there were 121 deaths. Among the 99 cases with documented causes, 73 were sudden. The mean age at the time of death was 45 years. Of the 55 nontraumatic sudden deaths — excluding those from car accidents, suicide, or homicide — 46 were classified as SCDs. The overall incidence of deaths (sudden and nonsudden) was 63.61 per 100,000 person-years. Among active competitors, those who died within 1 year of their last IFBB event, the rate rose to 80.58. The incidence of SCDs was 24.18 in the entire cohort and 32.83 among competing athletes, who had a mean age of just 35 years at death. Professional bodybuilders had a fivefold higher risk for SCD than recreational bodybuilders (hazard ratio, 5.23 [3.58-7.64]). Available autopsies showed the presence of cardiomegaly and severe ventricular hypertrophy in 4 out of 5 cases. Risk Factors The study pointed to a broader issue in addition to bodybuilders, which could also affect nonprofessional athletes who practice strength training. What are the possible causes? Univadis Italy , a Medscape Network platform, asked Marco Vecchiato, MD, a specialist and researcher in the Sports and Exercise Medicine Division at the University of Padua, Padua, Italy, and the coordinator of the study. 'Our study had epidemiological purposes and was not designed to identify, in a cause-effect manner, the mechanisms underlying these premature deaths. However, the literature in the field has advanced some plausible hypotheses, suggesting that a combination of factors could contribute significantly to the increased risk,' said Vecchiato. These include: Intense training regimens, such as high-intensity workouts, place major strain on the cardiovascular (CV) and muscular systems. Extreme dietary practices, such as high protein intake and repeated weight cycling between off-season and on-season periods, can place significant stress on metabolic and CV systems. Dehydration techniques, such as rapid fluid loss before events using hydro-saline protocols or diuretics, can be dangerous. The use of doping substances, especially anabolic steroids and similar agents, can severely harm the CV, kidneys, liver, and nervous system. Doping Impact 'It is important to underline that, to date, there are no studies that have exclusively investigated the risk for death and SCD in a population of bodybuilders with the guarantee of not taking doping substances. However, recent evidence published in first-time journals and with long-term monitoring suggested a clear difference in terms of cumulative mortality between athletes with and without a history of anabolic steroid abuse,' said Vecchiato. He noted that performance-enhancing drug use is likely to be widespread at the highest competitive levels. In the US, where bodybuilding is more structured and athletes face intense competitive and aesthetic pressure with serious psychophysical consequences, many athletes speak openly about the use of performance-enhancing drugs. However, in Italy, 'The issue remains mostly hidden and is often not perceived as a medical risk but as 'a necessary means' to obtain a certain physique,' he said. Uncertain Rules Athletes are generally required to undergo regular medical checkups, but does the same apply to bodybuilders? 'In Italy, there are numerous bodybuilding federations, each with its own rules and requirements for membership. Some of these clearly state the obligation to present a competitive sports medical certificate, while others do not mention any specific medical requirements, thus allowing membership even in the absence of a health assessment. In these cases, the activity is not formally classified as a sport but rather as an activity for aesthetic purposes, which allows you to bypass some obligations required for competitive sports, including medical certification,' Vecchiato explained. Although not formally required by regulations, a sports center or gym may still ask a bodybuilder to provide a noncompetitive medical certificate, often for insurance purposes. Under Italian law, such certification is not mandatory for individuals engaging in noncompetitive physical activity unless they are affiliated with a national sports federation or a sports promotion body recognized by the Italian National Olympic Committee, which oversees organized sports and fitness initiatives in the country. 'This heterogeneous regulatory situation means that some athletes are subjected to in-depth sports medical check-ups annually, including a baseline electrocardiogram, stress test, spirometry, urine test, and any further investigations of a higher order, while others receive an evaluation with only an electrocardiogram in resting conditions. Finally, a nonnegligible portion of subjects may never be subjected to any structured medical evaluation, not even when starting or continuing the activity practiced,' he said. 'The first contact with a doctor can therefore only occur after the onset of advanced signs or symptoms, sometimes linked to already structured CV or metabolic damage, making any form of secondary prevention potentially late,' he said. These signs warrant cardiologic or psychological evaluation. 'The general practitioner can play a key role in recognizing warning signs (excessive muscle hypertrophy, extreme weight fluctuations, suspected use of illicit substances, marked and sudden mood changes in the absence of diagnosed mental illnesses, gynecomastia, extensive acne in adults not present during puberty, etc.) and directing them towards cardiological or psychological investigations,' warned Vecchiato. He also noted that 15% of SCDs in this population were traumatic. Obsessive body transformation goals, extreme practices, and substance misuse increase the risk for impulsive or self-harming behavior. This reinforces the need to prioritize the mental health of athletes. Vecchiato concluded that 'in addition to an intensified antidoping practice, the introduction of targeted CV screening and educational campaigns could significantly reduce the associated risks.' Raising awareness can encourage athletes to adopt safer training and nutrition programs and diets, to be supervised by a physician, and to refuse doping.

Yahoo
an hour ago
- Yahoo
BBC threatens legal action against AI start-up Perplexity over content scraping
The BBC is threatening legal action against artificial intelligence search engine Perplexity, in its first effort to clamp down on tech
Yahoo
an hour ago
- Yahoo
NurExone Advances U.S. Growth Strategy with Acceptance into Prestigious ARMI HealthTech Hub Accelerator and Provides Corporate Update
TORONTO and HAIFA, Israel, June 20, 2025 (GLOBE NEWSWIRE) -- NurExone Biologic Inc. (TSXV: NRX) (OTCQB: NRXBF) (FSE: J90) ('NurExone' or the 'Company'), a biotech company developing exosome-based therapies for central nervous system injuries, announced today that it has been accepted into the HealthTech Hub ('HTH') Accelerator Program. Based in Boston, Massachusetts, home to more than 1,000 biotech companies1, HTH is operated by the Advanced Regenerative Manufacturing Institute ('ARMI') and its BioFabUSA initiative. NurExone's acceptance into the prestigious HTH Accelerator Program will support the Company's expansion into the U.S. market following the establishment of Exo-top Inc. ('Exo-TOP'), the Company's wholly owned U.S. subsidiary dedicated to GMP-compliant exosome manufacturing for clinical development and commercial scale-up. HTH, co-led by ARMI and Mass General Brigham, is a competitive accelerator program supported by the U.S. Department of Health and Human Services and Israel's Ministry of Health. The HTH Accelerator Program selects a limited number of innovative companies each year to help them validate U.S. clinical relevance, strengthen commercialization strategies, and build meaningful collaborations with key stakeholders across the U.S. HealthTech landscape. The program is funded by HTH at no cost to participants. Dr. Lior Shaltiel, CEO of NurExone, commented: 'The HTH Acceleration Program offers the kind of U.S.-based insight and guidance needed at this stage of our growth. As we establish Exo-TOP to manufacture clinical-grade exosomes in the U.S., the HTH will help us sharpen our regulatory and scale-up strategies and pursue meaningful commercial collaboration opportunities. This is a timely and strategic opportunity to accelerate our commercialization pathway in the world's largest healthcare market 2.' NurExone's participation in the HTH Accelerator Program is expected to enhance its visibility within the U.S. regenerative medicine ecosystem and to support its mission to bring novel exosome-based therapeutics to patients with unmet needs. Omnibus Plan Approval The Company is pleased to announce that, further to its press release dated June 4, 2025, at the Company's annual general and special meeting held on June 18, 2025 (the 'Meeting'), disinterested shareholders ratified and approved the amended and restated omnibus incentive plan (the 'Omnibus Plan'), a copy of which is available under the Company's SEDAR+ profile at The Omnibus Plan is a hybrid plan that provides flexibility to grant-equity incentive awards in the form of stock options ('Options'), restricted shares ('Restricted Shares') and restricted share units ('RSUs'). The Omnibus Plan is a hybrid 10% rolling and 10% fixed share-based compensation plan that amends and restates the Company's previous equity incentive plan approved by shareholders on June 4, 2024 (the 'Previous Plan'). The Previous Plan was a 20% fixed share-based compensation plan whereby the maximum number of common shares in the capital of the Company ('Common Shares') reserved for issuance was set at 13,166,085, representing 20% of the issued and outstanding Common Shares as of the effective date. The Omnibus Plan now includes (i) a 10% 'rolling' Option component that shall not exceed 10% of the Company's total issued and outstanding Common Shares from time to time; and (ii) a 10% fixed component permitting up to 7,800,781 RSUs and Restricted Shares in the aggregate. Additionally, the Omnibus Plan was amended to increase the number of securities issuable to insiders of the Company. The Previous Plan provided, that unless approved by disinterested shareholders, (i) the maximum number of securities issuable to insiders collectively would not exceed 10% of the Company's securities at any time and (ii) the maximum number of securities issuable to insiders collectively in any twelve-month period would not exceed 10% of the Company's total issued and outstanding securities as at the date any award was granted to an insider. Now, the Omnibus Plan provides the following that (i) the maximum number of the Company's securities issuable to insiders collectively shall not exceed 20% of the Company's total issued and outstanding Common Shares at any point in time and (ii) the maximum number of the Company's securities issuable to insiders collectively, in any 12-month period, when combined with all of the Company's other share compensation arrangements, shall not exceed 20% of the Company's total issued and outstanding securities, calculated as at the date any award is granted or issued to any insider. RSU Grants In addition, the Company announced that it has granted an aggregate of 1,125,000 RSUs to certain officers and directors of the Company pursuant to the terms and conditions of the Omnibus Plan. Each RSU vests on the one-year anniversary of the grant date and may be settled, upon their vesting, into one Common Share. The RSUs and underlying Common Shares are subject to the Exchange Hold Period (as such term is defined under the policies of the TSX Venture Exchange ('TSXV')). About NurExone NurExone Biologic Inc. is a TSXV, OTCQB, and Frankfurt-listed biotech company focused on developing regenerative exosome-based therapies for central nervous system injuries. Its lead product, ExoPTEN, has demonstrated strong preclinical data supporting clinical potential in treating acute spinal cord and optic nerve injury, both multi-billion-dollar marketsi. Regulatory milestones, including obtaining the Orphan Drug Designation, facilitates the roadmap towards clinical trials in the U.S. and Europe. Commercially, the Company is expected to offer solutions to companies interested in quality exosomes and minimally invasive targeted delivery systems for other indications. NurExone has established Exo-Top Inc., a U.S. subsidiary, to anchor its North American activity and growth strategy. For additional information and a brief interview, please watch Who is NurExone?, visit or follow NurExone on LinkedIn, Twitter, Facebook, or YouTube. For more information, please contact: Dr. Lior ShaltielChief Executive Officer and DirectorPhone: +972-52-4803034Email: info@ Dr. Eva ReuterInvestor Relations – GermanyPhone: +49-69-1532-5857Email: Allele Capital PartnersInvestor Relations – +1 978-857-5075Email: aeriksen@ press release contains certain 'forward-looking statements' that reflect the Company's current expectations and projections about its future results. Wherever possible, words such as 'may', 'will', 'should', 'could', 'expect', 'plan', 'intend', 'anticipate', 'believe', 'estimate', 'predict' or 'potential' or the negative or other variations of these words, or similar words or phrases, have been used to identify these forward-looking statements. Forward-looking statements in this press release include, but are not limited to, statements relating to: the; the Company's acceptance into the prestigious HTH Accelerator Program will support the Company's expansion into the U.S. market; the Company's participation in the HTH Accelerator Program is expected to enhance its visibility within the U.S. regenerative medicine ecosystem and support its mission as discussed herein; each RSU will be settled into one Common Share; and the NurExone platform technology offering novel solutions to drug companies interested in minimally invasive targeted drug delivery for other indications, including recovery of optic nerve function and overall visual health. These statements reflect management's current beliefs and are based on information currently available to management as at the date hereof. In developing the forward-looking statements in this press release, we have applied several material assumptions, including: the Company's acceptance into the prestigious HTH Accelerator Program will allow it to support the Company's expansion into the U.S. market; the Company's participation in the HTH Accelerator Program will give the Company the ability to enhance its visibility within the U.S. regenerative medicine ecosystem and support its mission as discussed herein; each RSU will be settled into one Common Share; and the NurExone platform technology offering novel solutions to drug companies interested in minimally invasive targeted drug delivery for other indications, including recovery of optic nerve function and overall visual health Forward-looking statements involve significant risk, uncertainties and assumptions. Many factors could cause actual results, performance or achievements to differ materially from the results discussed or implied in the forward-looking statements. These risks and uncertainties include, but are not limited to risks related to: the Company's early stage of development; lack of revenues to date; government regulation; market acceptance for its products; rapid technological change; dependence on key personnel; dependence on the Company's strategic partners; the fact that preclinical drug development is uncertain, and the drug product candidates of the Company may never advance to clinical trials; the fact that results of preclinical studies and early-stage clinical trials may not be predictive of the results of later stage clinical trials; the uncertain outcome, cost, and timing of product development activities, preclinical studies and clinical trials of the Company; the uncertain clinical development process, including the risk that clinical trials may not have an effective design or generate positive results; the inability to obtain or maintain regulatory approval of the drug product candidates of the Company; the introduction of competing drugs that are safer, more effective or less expensive than, or otherwise superior to, the drug product candidates of the Company; the initiation, conduct, and completion of preclinical studies and clinical trials may be delayed, adversely affected or impacted by unforeseen issues; the inability to obtain adequate financing; the inability to obtain or maintain intellectual property protection for the drug product candidates of the Company; risks that the Company's intellectual property and technology won't have the intended impact on the Company and/or its business; the Company's inability to carry out its pre-clinical trials and realize upon the stated benefits of the pre-clinical trials; the inability of the Company to realize on the benefits of exosomes; the inability of the Company to produce and/or supply exosomes for a wide range of applications; the inability of the Company's products to be used for patient treatment; there not being broader adoption in the field and/or cell therapy applications; the inability of the Company to fulfill its intended future plans and expectations; there not being growing clinical demand for innovative treatments in spinal cord, optic nerve, and/or other therapeutic areas; the Company's inability to realize upon the stated potential for exosome-loaded drugs in regenerating or repairing damaged nerves; the Company's inability to maintain its ongoing commitment to using its ExoTherapy platform to advance the field of regenerative medicine and/or cell therapy applications; the Company's inability to expand into further studies; the Company will not receive all required regulatory approvals; the Company will not have clinical and/or commercial breakthroughs in regenerative medicine; the Company will be unable to enhance its presence in key markets; the NurExone platform technology not offering novel solutions to drug companies interested in minimally invasive targeted drug delivery for other indications; the Company will not realize its future development plans, operational initiatives, and strategic objectives; the Company will not advance its therapeutic programs and clinical milestones; the Company will not engage with regulatory agencies; the Company's acceptance into the prestigious HTH Accelerator Program will not support the Company's expansion into the U.S. market; the Company's participation in the HTH Accelerator Program will not enhance its visibility within the U.S. regenerative medicine ecosystem and will not support its mission as discussed herein; each RSU will not be settled into one Common Share; and the risks discussed under the heading 'Risk Factors' on pages 44 to 51 of the Company's Annual Information Form dated August 27, 2024, a copy of which is available under the Company's SEDAR+ profile at These factors should be considered carefully, and readers should not place undue reliance on the forward-looking statements. Although the forward-looking statements contained in this press release are based upon what management believes to be reasonable assumptions, the Company cannot assure readers that actual results will be consistent with these forward-looking statements. These forward-looking statements are made as of the date of this press release, and the Company assumes no obligation to update or revise them to reflect new events or circumstances, except as required by law. Neither TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this release. i Spinal cord injury, Glaucoma 1