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Regeneron price target lowered to $650 from $700 at Citi

Regeneron price target lowered to $650 from $700 at Citi

Citi analyst Geoff Meacham lowered the firm's price target on Regeneron (REGN) to $650 from $700 and keeps a Buy rating on the shares. The company reported mixed itepekimab Phase 3 COPD results in former smokers, the analyst tells investors in a research note. The firm says that wWhile Aerify-1 met its primary endpoint in both dosing arms, Aerify-2 failed to achieve statistical significance improvement at week 52. While Aerify-1 was positive, the path to approval is unclear, contends Citi.
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The US military struck Iran with some of its most elusive weapons: stealth bombers and a hidden submarine
The US military struck Iran with some of its most elusive weapons: stealth bombers and a hidden submarine

Business Insider

time6 hours ago

  • Business Insider

The US military struck Iran with some of its most elusive weapons: stealth bombers and a hidden submarine

The US military relied on two of its most elusive and secretive combat platforms to carry out strikes on Iran's top nuclear facilities, a top general revealed Sunday. Gen. Dan Caine, the chairman of the Joint Chiefs of Staff, said on Sunday that seven US Air Force B-2 Spirit stealth bombers dropped 14 heavy bunker-buster bombs on the facilities as part of a secret, highly complex operation the previous night. The flying-wing B-2, built by US aerospace company Northrop Grumman, features a unique low-observable stealth design that gives it the ability to penetrate enemy airspace heavily defended by surface-to-air missiles without being spotted. Caine told reporters that a US Navy guided-missile submarine also launched more than two dozen Tomahawk cruise missiles from an undisclosed location in the Middle East at Iranian targets. Caine didn't specify what type of submarine was involved in the mission against Iran. The Pentagon declined to disclose the name of the submarine that participated in the operation, and the Navy referred Business Insider to the White House, which did not immediately respond. Guided-missile submarine generally refers to the Navy's Ohio-class SSGNs, which can carry more than 150 BGM-109 Tomahawk Land Attack Missiles, subsonic jet-powered munitions that can be launched from the sea to strike targets over 1,000 miles away. General Dynamics Electric Boat builds the Navy's Ohio-class submarines. These stealthy undersea assets are made with streamlined hulls and quiet propulsion systems, among other technologies, for evading detection. The Ohios, however, are not the only US subs capable of launching Tomahawk missiles. The US military does not typically disclose details of its secretive missile subs, except when it is trying to send a message to adversaries and signal deterrence. President Donald Trump announced Saturday that the US had bombed the Fordow, Natanz, and Esfahan nuclear facilities in what he said was a "spectacular military success" that "completely and totally obliterated" Iran's key enrichment facilities. Beyond the B-2s and the lone submarine, Caine said the operation, called Midnight Hammer, also involved dozens of fighter jets and aerial refueling tankers. He said US forces used 75 precision-guided weapons against Iranian targets. The B-2s dropped 14 bunker-buster bombs — specifically, the GBU-57 Massive Ordnance Penetrator, or MOP, developed by the Air Force Research Laboratory in partnership with Boeing. The big 15-ton weapon is the US military's largest non-nuclear bomb and is regarded as the bomb best suited for hitting Iran's more protected nuclear facilities. The B-2 is the only operational aircraft that can carry the heavy MOP, though the new B-21 Raider will be able to as well. The Spirit can carry two of these munitions. Secretary of Defense Pete Hegseth said the strikes "devastated the Iranian nuclear program." The operation comes as Israeli forces have pounded Iran with relentless strikes over the past 10 days, with fighter jets targeting the country's nuclear program and military capabilities, including air defenses and missile launchers. Tehran has retaliated by launching hundreds of missiles and drones at Israel. Trump, over the past few days, had been weighing whether to join Israel in its bombing campaign. His administration has been tied up in efforts to reach a new nuclear deal with Iran, while Israeli Prime Minister Benjamin Netanyahu has preferred a military approach. He later praised Trump for the US strikes. The US involvement is an escalation in the conflict that could see Iran retaliate against US forces in the Middle East. The Pentagon has a large presence across the region, including warships, aircraft carriers, fighter jets, and ground troops that it says is intended to protect US interests. The president and Pentagon leadership is urging Iran to pursue peace and threatening continued attacks if they do not. It remains to be seen how Iran responds.

Muscle-preserving drugs could generate over $30 billion in sales by 2035, TD Cowen says
Muscle-preserving drugs could generate over $30 billion in sales by 2035, TD Cowen says

Yahoo

time7 hours ago

  • Yahoo

Muscle-preserving drugs could generate over $30 billion in sales by 2035, TD Cowen says

By Bhanvi Satija (Reuters) -Treatments designed to help patients preserve muscle while losing weight with popular obesity drugs by Eli Lilly and Novo Nordisk could generate more than $30 billion in sales by 2035, analysts at TD Cowen said on Friday. About a dozen companies are racing to develop such therapies, most of which are being tested in combination with Lilly's Zepbound or Novo's Wegovy, both of which target the GLP-1 protein to help control appetite. The initial Wall Street estimates for muscle-preserving therapies follow promising mid-stage results from experimental drugs developed by Regeneron and Scholar Rock. Investors are closely watching mid-stage data from Lilly's muscle mass-preserving drug, bimagrumab, which is scheduled for presentation at a medical conference next week. Analysts have projected that obesity drugs sales could reach $150 billion a year by the early 2030s. The unmet need to preserve muscle will grow with the use of GLP-1 drugs for obesity, said TD Cowen analyst Tyler Van Buren. Doctors have raised concerns that patients may experience a decrease in overall strength due to muscle loss associated with Zepbound and Wegovy, while experts suggest that more muscle can help patients maintain long-term weight loss. Van Buren said that the first such treatment could launch by 2028, although regulatory challenges remain because these treatments must demonstrate additional health benefits to secure approval. "We believe quality of weight loss and lean mass preservation ... is far too important for long-term health outcomes to be ignored and that this will be figured out," Van Buren said. Some of the new drugs target the myostatin protein, which is associated with muscle growth, and are expected to see broader use due to their superior safety profile, capturing the majority of the market share, Van Buren said. Other drugs target activin, a protein with multiple biological functions. Van Buren said that activin-based drugs will be reserved for patients at higher risk of losing strength, forecasting sales of about $5 billion by 2035.

The US military struck Iran with some of its most elusive weapons — stealth bombers and a hidden submarine
The US military struck Iran with some of its most elusive weapons — stealth bombers and a hidden submarine

Business Insider

time8 hours ago

  • Business Insider

The US military struck Iran with some of its most elusive weapons — stealth bombers and a hidden submarine

The US military relied on two of its most elusive and secretive combat platforms to carry out strikes on Iran's top nuclear facilities, a top general revealed Sunday. Gen. Dan Caine, the chairman of the Joint Chiefs of Staff, said on Sunday that seven US Air Force B-2 Spirit stealth bombers dropped 14 heavy bunker-buster bombs on the facilities as part of a secret, highly complex operation the previous night. The flying-wing B-2, built by US aerospace company Northrop Grumman, features a unique low-observable stealth design that gives it the ability to penetrate enemy airspace heavily defended by surface-to-air missiles without being spotted. Caine told reporters that a US Navy guided-missile submarine also launched more than two dozen Tomahawk cruise missiles from an undisclosed location in the Middle East at Iranian targets. Caine didn't specify what type of submarine was involved in the mission against Iran. The Pentagon declined to disclose the name of the submarine that participated in the operation, and the Navy referred Business Insider to the White House, which did not immediately respond. Guided-missile submarine generally refers to the Navy's Ohio-class SSGNs, which can carry more than 150 BGM-109 Tomahawk Land Attack Missiles, subsonic jet-powered munitions that can be launched from the sea to strike targets over 1,000 miles away. General Dynamics Electric Boat builds the Navy's Ohio-class submarines. These stealthy undersea assets are made with streamlined hulls and quiet propulsion systems, among other technologies, for evading detection. The Ohios, however, are not the only US subs capable of launching Tomahawk missiles. The US military does not typically disclose details of its secretive missile subs, except when it is trying to send a message to adversaries and signal deterrence. President Donald Trump announced Saturday that the US had bombed the Fordow, Natanz, and Esfahan nuclear facilities in what he said was a "spectacular military success" that "completely and totally obliterated" Iran's key enrichment facilities. Beyond the B-2s and the lone submarine, Caine said the operation, called Midnight Hammer, also involved dozens of fighter jets and aerial refueling tankers. He said US forces used 75 precision-guided weapons against Iranian targets. The B-2s dropped 14 bunker-buster bombs — specifically, the GBU-57 Massive Ordnance Penetrator, or MOP, developed by the Air Force Research Laboratory in partnership with Boeing. The big 15-ton weapon is the US military's largest non-nuclear bomb and is regarded as the bomb best suited for hitting Iran's more protected nuclear facilities. The B-2 is the only operational aircraft that can carry the heavy MOP, though the new B-21 Raider will be able to as well. The Spirit can carry two of these munitions. Secretary of Defense Pete Hegseth said the strikes "devastated the Iranian nuclear program." The operation comes as Israeli forces have pounded Iran with relentless strikes over the past 10 days, with fighter jets targeting the country's nuclear program and military capabilities, including air defenses and missile launchers. Tehran has retaliated by launching hundreds of missiles and drones at Israel. Trump, over the past few days, had been weighing whether to join Israel in its bombing campaign. His administration has been tied up in efforts to reach a new nuclear deal with Iran, while Israeli Prime Minister Benjamin Netanyahu has preferred a military approach. He later praised Trump for the US strikes. The US involvement is an escalation in the conflict that could see Iran retaliate against US forces in the Middle East. The Pentagon has a large presence across the region, including warships, aircraft carriers, fighter jets, and ground troops that it says is intended to protect US interests. The president and Pentagon leadership is urging Iran to pursue peace and threatening continued attacks if they do not. It remains to be seen how Iran responds.

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