Brenus Pharma and InSphero Have Developed 3D Tumor Spheroids Mimicking

LISBON, Portugal--(BUSINESS WIRE)--Brenus Pharma, a French biotech developing next-generation first-in-class immunotherapies, and InSphero, a Swiss leader in 3D cell-based assay technologies, presented promising data at the European Association for Cancer Research 2025 annual congress. These data confirm the use of 3D tumor spheroids for potency testing of STC-1010, Brenus' lead candidate for colorectal cancer.
'This collaboration has enabled us to assess the highly representative and scalable 3D model into our SGC platform. It's a major step forward in our ability to assess potency and accelerate the development of STC-1010 and future candidates.' Benoit Pinteur
Share
Funded through the EUROSTARS program, the collaboration led to vitrified 3D colorectal cancer spheroids using tumor cell lines co-cultured with fibroblasts. The vitrification method preserves morphology, stromal integrity, and viability after thawing, enabling realistic evaluation of STC-1010's therapeutic potential under conditions mimicking in vivo human tumors.
Previous studies showed that STC-1010 antigens were effectively processed by monocyte-derived dendritic cells (mMo-DCs), activating CD8+ T cells. These T cells induced apoptosis in both 2D and 3D colorectal cancer models and released anti-tumor cytokines (IFNγ and Granzyme B). These data reinforce the therapeutic potential of STC-1010.
' This collaboration has enabled us to assess the highly representative and scalable 3D model into our SGC platform. It's a major step forward in our ability to assess potency and accelerate the development of STC-1010 and future candidates.' Benoit Pinteur, CSO of Brenus Pharma.
' We are proud to support Brenus with our cryopreserved 3D tumor models. This work illustrates how advanced in vitro systems can bring immunotherapies closer to clinical reality.' Jan Lichtenberg, CEO of InSphero.
About Brenus Pharma
Brenus Pharma unlocks the potential of immuno-oncology by generating first-in-class immunotherapies that initiate a multi-specific in vivo immune response against tumors. Their proprietary 'off-the-shelf' Stimulated-tumor-Ghost-Cells (SGC) platform mimics patients' tumor cells and makes them visible to the immune system to anticipate, target, and destroy these cells as they appear. Brenus aims to shift the oncology paradigm by making patients active participants in their treatment.

Try Our AI Features

Explore what Daily8 AI can do for you:

Learn with AIFact CheckingText to SpeechAI Summary

Related Articles

San Francisco Chronicle​

4 hours ago

• San Francisco Chronicle​

Florian Wirtz joins list of most expensive soccer signings in history

Florian Wirtz became one of the most expensive players in soccer history when the Germany playmaker joined Liverpool from Bayer Leverkusen on Friday for a fee of up to 116 million pounds ($156 million). Neymar: $262 million (222 million euros) Paris Saint-Germain shattered the world-record transfer fee by signing the Brazil superstar from Barcelona in August 2017. It was more than double the outlay of Manchester United to sign Paul Pogba from Juventus for $116 million a year earlier. It remains the record transfer fee. ___ Kylian Mbappé: $216 million (180 million euros) A few weeks after buying Neymar, PSG also secured a loan deal for Mbappé — then the rising star of French soccer playing for Monaco — that included the option to make the move permanent in 2018. PSG did so, making it an outlay of nearly $500 million on two players. ___ Flush with cash after selling Neymar a year earlier, Barcelona spent most of it in a deal to buy Brazil playmaker Coutinho from Liverpool for a Spanish record fee. ___ Moises Caicedo: $146 million (115 million pounds) The Ecuador midfielder's move was previously the most expensive deal by a British club, with Chelsea buying him from Brighton in August 2023. ___ João Félix: $140 million (126 million euros) Atletico Madrid triggered a buyout clause in Félix's contract to sign the Portugal forward from Benfica in August 2019. ___ Jude Bellingham: $139 million (128.5 million euros) The England star got his big move to Real Madrid from Borussia Dortmund in June 2023, for an initial up-front fee of 103 million euros plus add-ons linked to performance. ___ Antoine Griezmann: $134 million (120 million euros) Atletico could afford to sign Félix after selling France forward Griezmann to Barcelona for a similar fee a few weeks earlier. ___ Neymar: $98 million (90 million euros) Outside from Europe, the biggest transfer deal also involved Neymar when he joined Al Hilal, a team in the Saudi Pro League, from Paris Saint-Germain in August 2023. That came at the height of Saudi Arabia's push to sign high-end soccer talent to ignite the oil-rich state's domestic league. ___

Yahoo

5 hours ago

• Yahoo

Video does not show astronaut exposing 'fake' life in space

"Former Astronaut Karen Nyberg Shows How NASA Fakes Space Flights.." a June 16, 2025 post on X claimed. It shares a video of a woman in front of a space station-like backdrop watching a chip bag float away from her, side-by-side with the same footage being filmed in front of a green screen. A person in a green body suit is manipulating the bag. The video garnered thousands of interactions in posts on X, Threads, Instagram and Facebook. The clip also circulated in posts making similar claims about Nyberg in French, Spanish and Italian. Nyberg is a retired NASA astronaut who completed two spaceflights during her career, including a 166-day stay on the ISS in 2013 (archived here). But she is not the woman in the green screen video. Comments on the post on X included links to previous debunks from USA Today and PolitiFact who named the woman in the video as Paige Windle. In the clip, a person off-camera is heard calling the woman Paige. Windle is the founder of a lifestyle management company and the wife of David Weiss, known online as "Flat Earth Dave," the host of "The Flat Earth Podcast." Contacted by AFP, Weiss confirmed Windle is the one on-camera. "This video never dies. It keeps coming back," Weiss said in a June 17 email. The video was originally posted on Weiss's YouTube channel as part of a series titled "Globebusters," but made no mention of Nyberg (archived here). "Someone took that clip and presented it as Karen Nyberg and it went viral a bunch of times and now it has started again," he said. He said he has repeatedly addressed the false use of the video, sharing with AFP the cover image of a YouTube video he posted in response to the false viral claims (archived here). Astronauts onboard the ISS experience microgravity, causing them and objects to float (archived here). At the altitude of the ISS, gravity is 90 percent of the total gravity one feels on Earth, but an absence of air resistance causes all objects in the ISS to fall at the same rate, producing a weightless appearance. The ISS stays afloat because it moves at a speed that matches the curve of the Earth, causing it to "fall around" the planet while staying at roughly the same altitude. The moon's orbit works in a similar way. NASA uses the ISS in part to study how extended time periods in microgravity and other conditions in space impact the human body as it prepares for future long-term missions in space. On her website, Nyberg features a video she recorded on the ISS where she worked on a quilt (archived here). Unlike in the video filmed in front of the green screen, Nyberg's hair and necklace float throughout the clip due to the microgravity conditions. AFP reached out to Nyberg's representative for comment, but a response was not forthcoming. AFP has previously debunked claims that ISS astronauts faked a video from the station.

UPI

6 hours ago

• UPI

U.S. company to provide $6 billion loan for British nuclear power project

Protesters hold banners outside Hinkley Point power station in Somerset, United Kingdom, in 2011 against EDF Energy's plans to renew the site with two new reactors. The project began in 2017 and has had delays and funding problems File Photo by Ben Birchuk/EPA June 20 (UPI) -- Apollo, a U.S. asset management group, plans to provide a $6 billion loan to the British nuclear project Hinkley Point C being built by a French multinational electric utility company. Hinkley's estimated cost has soared from $23.7 billion to almost $60.6 billion and won't be operational until at least 2029, Baha Breaking News reported. Construction began in 2017. Apollo will provide an investment-grade debt financing package at an interest rate below 7% for the project developer, Electricite de France, sources told CNBC and the Financial Times. Apollo, which was founded in 1990 by Leonard Black, Josh Harris and Marc Rowan, manages capital for institutional and individual investors. Apollo, headquartered in New York City, had revenue of $26.11 billion in 2024 with a net income of $6.373 billion. The loan has a maximum maturity of 12 years. EDF is building two new nuclear reactors at the site in Somerset and will be able to borrow $2 billion each of the three years as part of the package. The company has had a shortfall since China General Nuclear Power Group, which was supposed to provide a third of the cost of the project, stopped providing further financing in 2023. CGN was removed by the British government from another project -- Sizewell C -- because of concerns about Chinese influence. The funding could be used for other British projects by EDF. Jamshid Ehsani, head of global principal structured finance at Apollo, described the deal as the "largest ever" sterling private credit deal. "It's going to help finance a critical, low-carbon nuclear project. This is the business Apollo is in today," he said. "Europe is a huge focus for us."