Fast Five Quiz: Diffuse Large B-Cell Lymphoma
Although diffuse large B-cell lymphoma (DLBCL) is characterized by aggressive clinical behavior, standard treatment can provide good long-term survival outcomes. However, management can be complex, with certain comorbidities exacerbating disease severity and complications such as extranodal involvement significantly affecting prognosis. Understanding the nuances of DLCBL presentation, diagnosis, and management is key to delivering the best outcomes to patients affected by this rapidly progressive disease.
What do you know about DLBCL? Check your knowledge with this quick quiz.
Both primary and secondary Sjögren syndrome are strongly associated DLBCL. Other autoimmune disorders that have been associated with DLBCL include hemolytic anemia, rheumatoid arthritis, systemic lupus erythematosus, and Crohn's disease. In addition to autoimmune disorders, viral infections have also been linked to DLBCL; these include HIV, hepatitis B, hepatitis C, and Epstein-Barr. Further, data have shown that patients with rheumatic diseases have a heightened risk of DLBCL development.
Though fugal or bacterial pneumonia, humoral deficiency, and bone infections (such as osteomyelitis) can occur in patients with DLBCL, data have indicated that survivors of DLBCL were more likely to experience these conditions, rather than being strongly linked to DLBCL itself.
Learn more about DLBCL staging.
In the NCCN's guidelines, PET/CT is the preferred modality for imaging in DLBCL workup. C/A/P CT with contrast can also be used in a complementary setting to help stage the disease and identify other factors such as extranodal disease or visceral involvement, but it is not preferred. Although not essential, head CT/MRI or neck CT/MRI with contrast (as well as bone marrow biopsy) can be useful for workup in selected cases. Specifically, bone marrow biopsy can be helpful in identifying indolent or low-volume disease. However, the NCCN notes that bone marrow biopsy is not needed if PET/CT shows bone disease.
Learn more about DLBCL workup.
Data indicate that extranodal involvement occurs in approximately 30%– 50% of patients with DLBCL; further, it is reported that gastrointestinal involvement is the most common extranodal site. Other affected sites include the skin, bones, spleen, and central nervous system; kidneys, testicles, and the liver can also be impacted, but they are not regarded as the most common.
Learn more about DLCBL and extranodal involvement.
A population-based study involving over 30,000 patients with extranodal DLBCL found that the best outcomes are associated with heart and mediastinal sites, with a 42% reduction in mortality risk compared with involvement of the intestinal tract.
Involvement of the pancreas and hepatobiliary system, respiratory system, or nervous system are associated with significantly greater risks of mortality compared with the intestinal tract. Other factors associated with greater mortality risk include late age at onset, history of other malignancy, late age at presentation, and Black, non-Hispanic ethnicity.
Learn more about DLBCL prognosis.
CAR T therapy is typically utilized as a second-line treatment for patients with relapsed/refractory DLBCL. CD19-directed CAR T-cell therapy is considered ' the standard of care' for relapsed/refractory DLBCL, with three treatments approved for this population. Although a number of factors can lead to CAR T cell therapy resistance, the key mechanism is typically down regulation or loss of CD19 expression.
Abnormal differentiation and dysfunction of T cells can also cause poor response to CAR T therapy, and being unable to collect enough T cells can also negatively affect the impact of CAR T products; however, these factors are not considered key mechanisms for resistance to CAR T-cell therapy. As such, early collection of T-cells in high-risk patients with DLBCL is one strategy to ensure enough T cells are available when needed. Partial response or relapse after CAR T therapy should prompt third-line therapy, such as alternative systemic therapy not previously given, clinical trial, palliative involved-site radiation therapy, or best supportive care.
Learn more about relapsed or refractory DLBCL.
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
17 minutes ago
- Yahoo
Hundreds of people raise $84,000 for Pulmonary Fibrosis Foundation during annual walk in Pittsburgh
Hundreds of people gathered in Pittsburgh's Riverfront Park on Saturday for the Pulmonary Fibrosis Foundation's annual walk. Participants walked on a one or two-mile course in support of those living with pulmonary fibrosis, a group of progressive lung diseases that cause scarring in the lungs, which limits oxygen intake necessary for major organs to function. Pulmonary fibrosis currently affects more than 250,000 Americans, and 50,000 new cases are diagnosed each year, according to PFF. Organizers say individuals and teams from the Pittsburgh region raised more than $84,000 to advance research for a cure for the life-threatening disease. Download the FREE WPXI News app for breaking news alerts. Follow Channel 11 News on Facebook and Twitter. | Watch WPXI NOW
Yahoo
an hour ago
- Yahoo
Campus notes: June 22, 2025
Teagan Graham, Reading, graduated from the University at Buffalo, N.Y., with a bachelor's degree in health and human services/early childhood education. York College The following area students received degrees from York College of Pennsylvania: Master of education: Julianna Kusy, Kutztown; Isabelle Popoter, Spring Township. Master of science in nursing: Elyse Batson, Exeter Township. Bachelor of arts: Isabella Antos, South Heidelberg Township; Lauryn Johnson, Exeter Township; Isabella Hoeltzel, Leesport; Elizabeth Trumbore, Temple. Bachelor of business administration: Gabriel Trevena, South Heidelberg Township. Bachelor of science: Brett Reinert, Douglassville; Haley Akins, Markus Jeschonnek and Brianna Endy, Exeter Township; Alexander LaVerdure, Oley Township;. Bachelor of science in nursing: Morgan Sauers, Gilbertsville; Taryn Boyer, Temple. Items are supplied by the colleges involved.
Yahoo
an hour ago
- Yahoo
What's the difference between an extreme heat watch and warning?
States across the Central and Eastern U.S. are under extreme heat watches and warnings as the areas are facing "dangerous heat," according to the National Weather Service. "Though record high temperatures are expected in the coming days, the duration of the heat, as demonstrated by the numerous record warm morning lows, will make this period especially oppressive," the National Weather Service posted on X June 20. The weather service has issued extreme heat warnings for areas in over a dozen states, as they face the highest temperatures of the year so far. It also issued extreme heat watches in several states and Washington D.C., according to an advisory issued to the agency's website. Here's everything you need to know about the heat wave. Portions of the following states have been placed under an extreme heat warning, according to the National Weather Service: Indiana Iowa Massachusetts Michigan Minnesota Missouri Nebraska New York Ohio Pennsylvania Rhode Island South Dakota Vermont West Virginia Areas where dangerous heat is possible are placed under an extreme heat warning and are asked to prepare in case it happens. Areas where dangerous heat "is happening or about to happen" are placed under an extreme heat warning, according to the weather service. While areas that are placed on a watch are asked to reschedule any planned outdoor activities, people in areas placed under warnings are told to avoid any heavy activity and direct sunlight. People facing extreme heat should do the following, according to NWS: Drink plenty of fluids Stay in an air-conditioned room Stay out of the sun Check up on relatives and neighbors Do not leave young children and pets in unattended vehicles Wear lightweight and loose-fitting clothing outdoors Limit strenuous activities to early morning or evening The extreme heat could negatively impact people's health. "Heat-related illnesses increase significantly during extreme heat and high humidity events," according to the National Weather Service. The following factors increase the possibility of a heat-related illness, according to the National Park Service: High humidity High elevation Strenuous activity Age: Infants, young children and people over 65 are more susceptible to heat illness Pregnancy Obesity Heart disease Poor circulation Fever Mental illness Dehydration Sunburn Prescription drug and alcohol use There are multiple forms of heat illnesses, but heatstroke is the deadliest and most dangerous, according to the NPS. The following are symptoms of heatstroke, according to the Centers for Disease Control and Prevention: Body temperature of 103 degrees or higher Skins that is hot, red, dry or damp Fast, strong pulse Headache Dizziness Nausea Confusion Losing consciousness In the case of a heatstroke, the CDC recommends people do the following: Call 911 immediately Move the person suffering from heatstroke to a cool location Lower the person's body temperature with a cool cloth or bath Do not give the person suffering from a heatstroke water or anything to drink Julia is a trending reporter for USA TODAY. Connect with her on LinkedIn, X, Instagram and TikTok: @juliamariegz, or email her at jgomez@ This article originally appeared on USA TODAY: What's the difference between an extreme heat watch and warning?
