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You can spot Alzheimer's YEARS before symptoms appear with groundbreaking new scan...would YOU have it?

You can spot Alzheimer's YEARS before symptoms appear with groundbreaking new scan...would YOU have it?

Daily Mail​26-05-2025

A groundbreaking brain scan could spot the first signs of Alzheimer's years before symptoms strike.
Until now, dementia diagnoses have often relied on questionnaires to indicate problems with memory as well as MRI scans to track loss of brain volume.
But it means many are only diagnosed with the cruel condition once it has progressed.
British scientists, however, found the 'world first' technique—which analyses the cell structure of the brain—spotted subtle changes to the cortical region, the outer layer of the brain, responsible for functions, including memory and decision-making.
It means medics can see changes in the brain far earlier, at a level normally only possible via a post-mortem examination.
Experts said the 'breakthrough' device could herald a new era in fighting the disease.
Although not yet offered to patients suspected of having the disease in the UK, Oxford Brain Diagnostics which developed the technique, said it was in talks with private health providers.
It was also approved by medicines regulator the Food and Drug Administration for use in the US back in January.
Oxford Brain Diagnostics, a spinout company from the University of Oxford, was founded by Dr Steven Chance, former associate professor of neuroscience at Oxford, and Professor Mark Jenkinson, a leading expert in brain imaging.
The technique, called cortical disarray measurement, uses advanced software which analyses MRI scans to pinpoint more subtle signs of neurodegeneration.
Dr Chance said: 'The core technology is founded on my background, looking at the microscopic structure of brains at autopsy for many years. You couldn't do that with a living patient and this is what we needed.'
'More than 20 per cent of those over 50 have Alzheimer's-type changes, small-scale changes that would be otherwise invisible.
'These breakthroughs open up a whole new way of monitoring brain health.'
The technology, he added, could have a 'transformative' impact, bringing hope to 'millions of people who are seeking a non-invasive, precision diagnostic tool to reveal the truth about their brain health'.
David Thomas, head of policy at Alzheimer's Research UK, said: 'Dementia is caused by diseases that often begin years before symptoms appear, and so finding new ways to detect these diseases earlier is vital.
'There is a huge amount of progress happening in this space and it's encouraging to see UK companies contributing to that.
'While this technology shows promise for diagnosing dementia earlier, so far it has only been validated in research settings.
'We're still some way off it being used within the NHS and we would need to see much more real-world clinical data to fully understand its potential.
'Improving early and accurate diagnosis is crucial—not only to give people clarity about their condition but also to ensure they can access the right support and, in future, new treatments as they become available.'
It comes as a landmark study last year also suggested almost half of all Alzheimer's cases could be prevented by tackling 14 lifestyle factors.
To reduce dementia risk throughout life, the commission also made 13 recommendations for both people and governments.
These include making hearing aids available for all those who need it, reducing harmful noise exposure, and increased detection and treatment access for high cholesterol among the over-40s.
Experts claimed the study, published in the prestigious journal The Lancet, provided more hope than 'ever before' that the memory-robbing disorder that blights the lives of millions can be prevented.
Alzheimer's Disease is the most common form of dementia and affects 982,000 people in the UK.
It is thought to be caused by a build-up of amyloid and tau in the brain, which clump together and from plaques and tangles that make it harder for the brain to work properly.
Eventually, the brain struggles to cope with this damage and dementia symptoms develop.
Memory problems, thinking and reasoning difficulties and language problems are common early symptoms of the condition, which then worsen over time.
Alzheimer's Research UK analysis found 74,261 people died from dementia in 2022 compared with 69,178 a year earlier, making it the country's biggest killer.

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BREAKING NEWS England's DEADLIEST maternity units to be investigated as Streeting launches urgent review into scandal-hit NHS services
BREAKING NEWS England's DEADLIEST maternity units to be investigated as Streeting launches urgent review into scandal-hit NHS services

Daily Mail​

time38 minutes ago

  • Daily Mail​

BREAKING NEWS England's DEADLIEST maternity units to be investigated as Streeting launches urgent review into scandal-hit NHS services

Wes Streeting has today announced a 'rapid national investigation' into England's maternity units following a litany of scandals that have rocked the NHS. The new investigation is intended to provide truth to families suffering harm, as well as driving urgent improvements to care and safety. It comes after Mr Streeting met families who have lost babies and amid the ongoing investigations at some NHS trusts into poor maternity care. Announcing the move at the Royal College of Obstetricians and Gynaecologists, he said the 10 most at risk units will be investigated. It will also look at the maternity and neo-natal system as a whole. The review will be based on the similar investigation taken into the overall review of the NHS carried out by Lord Darzi. It follows a series of maternity failures including Shrewsbury and Telford and East Kent NHS Trusts, with a record number of services now failing to meet safety standards. Last year, the maternity regulator also found two-thirds of services either 'require improvement' or are 'inadequate' for safety. In a statement, Mr Streeting said: 'Over the last year, I've been wrestling with how we tackle problems in maternity and neonatal units, and I've come to the realisation that while there is action we can take now, we have to acknowledge that this has become systemic. 'It's not just a few bad units. Up and down the country, maternity units are failing, hospitals are failing, trusts are failing, regulators are failing. 'There's too much obfuscation; too much passing the buck and giving lip service.' He added: 'I have been meeting bereaved families from across the country who have lost babies or suffered serious harm during what should have been the most joyful time in their lives. 'What they have experienced is devastating—deeply painful stories of trauma, loss, and a lack of basic compassion—caused by failures in NHS maternity care that should never have happened. 'Their bravery in speaking out has made it clear. We must act and we must act now. 'I know nobody wants better for women and babies than the thousands of NHS midwives, obstetricians, maternity and neonatal staff, and that the vast majority of births are safe and without incident, but it's clear something is going wrong. 'That's why I've ordered a rapid national investigation to make sure these families get the truth and the accountability they deserve, and ensure no parent or baby is ever let down again. I want staff to come with us on this, to improve things for everyone. 'We're also taking immediate steps to hold failing services to account and give staff the tools they need to deliver the kind, safe, respectful care every family deserves. 'Maternity care should be the litmus test by which this Government is judged on patient safety, and I will do everything in my power to ensure no family has to suffer like this again.' Frontline midwives have previously warned working in the NHS is like playing a 'warped game of Russian roulette ', as there was a risk of harm or death at any time, partly due to 'dangerously' low staffing levels. The Royal College of Midwives (RCM) suggests staff shortages and lack of funding is making it harder for midwives to deliver better quality services. The RCM's latest calculation is that England is short of 2,500 midwives. It also comes as another report into the 'postcode lottery' of NHS maternity care last May also ruled good care is 'the exception rather than the rule'. A hugely-anticipated parliamentary inquiry into birth trauma, which heard evidence from more than 1,300 women, found pregnant women are being treated like a 'slab of meat'. At the time, Health Secretary Victoria Atkins labelled testimonies heard in the report 'harrowing' and vowed to improve maternity care for 'women throughout pregnancy, birth and the critical months that follow'.

Streeting launches investigation into NHS maternity services
Streeting launches investigation into NHS maternity services

Telegraph

timean hour ago

  • Telegraph

Streeting launches investigation into NHS maternity services

Wes Streeting has announced a national investigation into the state of maternity care. Speaking at Royal College of Obstetricians and Gynaecologists World Congress, the Health Secretary said he was launching the review after meeting dozens of families who had been bereaved by failings. Last week he met parents whose babies had died at hospitals including in Nottingham, Leeds and East Kent, Shrewsbury and Telford, Morecambe Bay. Mr Streeting said: 'I know nobody wants better for women and babies than the thousands of NHS midwives, obstetricians, maternity and neonatal staff, and that the vast majority of births are safe and without incident, but it's clear something is going wrong. 'That's why I've ordered a rapid national investigation to make sure these families get the truth and the accountability they deserve, and ensure no parent or baby is ever let down again. I want staff to come with us on this, to improve things for everyone.' He added: 'We're also taking immediate steps to hold failing services to account and give staff the tools they need to deliver the kind, safe, respectful care every family deserves.' Maternity services have been plagued by a succession of scandals, leading families to call for a national statutory inquiry. While many of the scandals are historical, Mr Streeting is understood to have apologised to them for not ensuring more swift action from the Government.

My cocaine bender left me BLIND – I had ‘devil eyes' for months and was chased by a man with a bible
My cocaine bender left me BLIND – I had ‘devil eyes' for months and was chased by a man with a bible

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timean hour ago

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My cocaine bender left me BLIND – I had ‘devil eyes' for months and was chased by a man with a bible

A PARTY animal was almost killed by a five-day cocaine bender - leaving him in a coma with such bloodshot "devil eyes" for months. Dave Mullen snorted his first "naive" line of the Class A drug on his 17th birthday after being offered it in a pub. 9 9 The former carpet fitter admitted he got a taste for it, sniffing it while drinking on football away days and lads' holidays. But the occasional dabble quickly spiralled into an addiction by 19, that at his worst saw him sink 15 pints a day and snort thousands of pounds worth of cocaine in seven-day benders. A shocking photo taken in August 2021 shows Dave with bloodshot eyes after waking up from a coma in ICU following a drug -induced psychosis. His eyes remained red for months afterwards. And they were so startling that when he went back to work, completing a job in an old people's home, a man chased him with a bible fearing he was the devil. Despite almost dying, Dave admits he only managed a few months sober before falling back into his dangerous habits for three more years. It was only after a hospital trip in March 2024, when doctors said he could die, that he decided to quit and begin his path to sobriety. Dave is now 15 months sober from alcohol and drugs and says he's finally been able to escape the "prison" he'd lived in for 15 years. The content creator is now sharing his story to warn others about the dangers of substance abuse. Dave, from Salisbury in Wiltshire, said: "Cocaine goes hand-in-hand with alcohol and at a weak or naive moment as I was young [17], someone offered me a line and I took it. "I would get some [cocaine] for the weekend football and before long this turned into an addiction; it wasn't for enjoyment anymore. Inside Europe's 'cocaine capital' where gangsters bomb cafes, gun down children & X in terrifying wave of drug violence "I was going on holiday to Ayia Napa at 17 and it was like The Inbetweeners 'lads on tour' - it was just relentlessly pushed down your throat as soon as you hit an age. "At 19 I noticed it had become an addiction. It was clear not only to me but my friends and people around that I had a bit of a problem with it." Things only got worse over the next few years, which Dave puts down to " mental health episodes". "I would go through periods to escape my mental health and I would just go out for five, six, seven days and I would just be gone," he added. "I always found a way to put myself in a situation where I could get cocaine for free or very cheap, but the amount I would do would be thousands of pounds worth." While addicted to cocaine, Dave says he lost friends and struggled to keep a job. When he ended up in hospital in August 2021, he says people thought this was his turning point as he was so close to death - but it took another hospital trip to be the wake-up call he needed. Dave, now 34, said: "In my case, those photos I've shared where I ended up in intensive care was not my turning point. "This was a result of a four or five-day bender. I ended up going into a drug-induced psychosis and I completely lost my mind. "I was completely blind; I had no vision. "Six weeks later my eyes were still bloodshot and my eyes were like this for two months." 9 9 9 Since going sober, Dave has swapped his cocaine addiction for the gym and has set up a TikTok page (@darkdays2brighterways) to document his sobriety journey. He says he has been left with a lot of mental trauma following his years of drug use but a constant runny nose is his only physical set-back so far. In the future, he hopes to set up a support group under the name Dark Days 2 Brighter Ways to help others suffering with addiction. How cocaine destroys your health, face and life The nose One of the most recognisable signs of cocaine overuse is a collapsed nose. The drug is snorted via the nose. Because it is a vasoconstrictor, meaning it narrows the blood vessels, blood flow is reduced. As the nasal tissue becomes starved of oxygen in the blood, it becomes damaged. FRANK, a national drug advisory service, says: 'Over time, snorting cocaine damages the cartilage in your nose that separates your nostrils. 'Heavy users can lose this cartilage and end up with one large nostril and a misshapen nose.' Users may also have difficulty with breathing and damage to nasal passages can also lead to chronic sinus infections. The mouth and facial deformity Chronic cocaine use doesn't only affect the nose - it can also harm the roof of the mouth or the hard palate, causing palatal perforation, according to UK Addiction Treatment Centres. Palatal perforation can lead to severe issues, such as difficulty speaking or voice changes, problems with eating and drinking and higher risk of infections due to the open gap between the nose and mouth. With the potential loss of nose cartilage, destruction of nasal tissue and sinuses and the mouth, the face may change shape with chronic cocaine use. Use of the drug can also cause the face to bloat and eyes to become bloodshot. Mental health Regular use of cocaine can dampen a person's mood. It can make them feel depressed, run down, anxious or paranoid, FRANK warns. It says: 'Cocaine can bring previous mental health problems to the surface too, and if a relative has had mental health problems, there might be an increased risk for you.' Infections Constant cocaine use will weaken your body's immune system. This makes it harder to fight off any infection - or blood-borne diseases that may occur when sharing needles. Heart The heart comes under a lot of pressure from cocaine use. It increases blood clots, which in turn can lead to heart attacks, pulmonary embolisms, strokes and deep vein thrombosis. 'It can also cause inflammation and death of the heart muscle, deterioration of the heart's ability to contract, as well as aortic ruptures, angina and permanently increased blood pressure,' says the Priory Group. Life-ruining The impact of cocaine use goes beyond obvious health issues. It can cause social withdrawal, financial problems, loss of job or reputation and risky behaviour, such as unsafe sex or driving when high. If you or someone you know is struggling with cocaine use, seeking professional help is crucial to prevent further harm. Try visiting Talk to FRANK, the NHS website, Narcotics Anonymous or Cocaine Anonymous. Dave said: "I want to spread awareness as it really did ruin my life. "[In March 2024], I was told I was going to die again and something about walking out of that hospital alone - I said I didn't want to do this anymore. "I was trapped in a life that was a prison with no enjoyment. "I would have walked out of the hospital and gone straight to the pub but I thought to myself, 'I'm not going to have a drink today'. "Fifteen months later and I'm here. I have a TikTok account and I still haven't looked back. "I feel completely reborn and I'm now excited for my future. "I don't think we're educated enough about the dangers of these drugs or alcohol. "We're told drugs are illegal but in this day and age, no one really pays attention to the law. "I think my story and the pictures in particular show that it's dangerous. "I don't want cocaine to be so normalised and acceptable in society." 9 9 9 9

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