Study backs Rhythm's colorectal risk model

Rhythm publishes peer-reviewed study validating its next-generation colorectal cancer risk assessment model
Proprietary geneType assessment enhanced and cross-validated using data from nearly 400,000 individuals in UK Biobank
Next generation geneType design continues focus on usability and simplicity, while providing superior performance
Special Report: Rhythm Biosciences has published a peer-reviewed study in PLoS One validating its next-generation colorectal cancer risk assessment model, marking a major step forward in predictive cancer diagnostics.
Rhythm Biosciences (ASX:RHY) said the study detailed updates and improvements to its proprietary geneType colorectal cancer risk assessment, which was enhanced and cross-validated using data from nearly 400,000 individuals in the UK Biobank.
Rhythm said the article titled 'Colorectal cancer risk prediction using a simple multivariable model' described creation and validation of a new risk model that incorporated sex-specific factors and outperformed current models.
The company said as colorectal cancer was a disease associated with many environmental and lifestyle risk factors, the study focused on expanding its geneType model beyond the two primary risk factors – family history and polygenic risk.
Watch: Inside ColoSTAT's road to market
Key findings of study
Rhythm said the study delivered several key findings, most notably development of the enhanced risk model that incorporated three additional risk factors.
These factors were selected for their strong associations with colorectal cancer and ease of use in a clinical setting, improving the model's predictive performance over standard family history assessments.
The company said the most impactful risk factors were identified and integrated into an updated geneType risk model, which was then tested using data from the UK Biobank.
Rhythm said other key findings included:
Commitment to improvement – The study highlighted the importance of including clinical and lifestyle factors in multifactorial diseases like colorectal cancer.
Commercial application – The new model was designed with commercial clinical applications in mind, minimising the number of risk factors while maximising predictive accuracy.
Sex-specific factors – Incorporating sex-specific risk factors enhances model performance across diverse populations.
Superior performance – A multivariable risk assessment is shown to be superior to standard of care of family history assessment in its ability to predict risk of developing colorectal cancer.
'Significantly improve stratified screening'
Rhythm director of scientific affairs Dr Erika Spaeth said publishing the findings in PLoS One underscored its commitment to advancing cancer risk prediction.
'Our new multifactorial model outperforms previous methods based solely on polygenic risk and family history,' she said.
'By integrating clinical and lifestyle factors, we enhance our prediction accuracy for colorectal cancer.
'We're excited about these results and confident that this model will significantly improve stratified screening in the population."
This article was developed in collaboration with Rhythm Biosciences, a Stockhead advertiser at the time of publishing.
This article does not constitute financial product advice. You should consider obtaining independent advice before making any financial decisions.

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2 hours ago

• ABC News

Chronically stressed? These small changes can help

Sana Qadar: I thought I knew what it meant to feel stressed, or overworked, or underslept, or close to burnout. I mean, I feel versions of these often enough. But then Dr Rangan Chatterjee told me a story that's almost unbelievable. It's the story of his father. Dr Rangan Chatterjee: So my dad grew up in India. He came to the UK in 1962. And dad basically worked to give his family in the UK, so my mum, me and my brother, and his family back home, a better life. But the way dad worked, looking back now was mind-blowing, honestly. Like, because for 30 years, my dad only slept three nights a week. Sana Qadar: Did you catch that? Three nights a week. Dr Rangan Chatterjee: So he was a consultant physician at Manchester Royal Infirmary. And I can remember this so clearly. Dad would do his day job in the middle of Manchester. So we lived in a suburb of Manchester. So he'd drive home, maybe take him 40 minutes or so. And he'd come in about 6, 6.15pm. Mum would have dinner ready for him. He'd go to the kitchen, he'd have dinner. He'd go upstairs and shave. And then at 7pm, he'd leave the house to do GP house calls all night. And he'd arrive back again at 7am. When he got in at 7am, he'd have breakfast in the kitchen. He'd go upstairs and shave again. And then he'd drive 45 minutes in traffic back to Manchester to do his day job. So for 30 years, dad was doing both of these jobs, and he only slept three nights a week. And I didn't know this at the time. And there was a lot of stress at home. And of course, there's, you know, he was exhausted all the time. Sana Qadar: At the age of 58, all of that chronic stress and sleep deprivation finally caught up with Rangan's father. First, he was diagnosed with lupus, which is an autoimmune disease where the immune system starts attacking healthy tissues and organs. Dr Rangan Chatterjee: And basically he had to medically retire. His kidneys completely failed. He lost the sight in one of his eyes. And then he was literally chained to a dialysis machine three times a week for 15 years. And so what's really interesting for me is, you know, reflecting back now, although my dad's case might seem quite extreme, I have seen many iterations of that in my practice for years. People think they can keep pushing, pushing for more, better job, a bit more money, another promotion, a nicer holiday, whatever it might be. But yeah, the thing is, that quest for more is driving so many people to stress themselves out in the belief that at some point in the future, everything's going to be okay and I can chill and relax. But I've seen time and time again, people come in wishing they'd stopped earlier. Sana Qadar: Dr Rangan Chatterjee is a GP with more than 20 years experience. And his focus and his passion has long been lifestyle medicine. Dr Rangan Chatterjee: In fact, 80 to 90% of what we see as medical doctors today is in some way related to our collective modern lifestyles. Sana Qadar: But you might recognize him from his mega popular podcast, Feel Better, Live More, where he delves into the science of lifestyle medicine and wellbeing. And in his experience, one of the biggest lifestyle factors impacting people's health is chronic stress. Dr Rangan Chatterjee: The 53 year old executive who kept pushing and working every weekend and coming back late until he gets the heart attack. The 46 year old mother who never does anything for herself, everything is for her partner, her children, her elderly parents. I've seen this so many times. And for me, it's always trying to get to the root cause. And I would say for so many people, chronic stress is at the root of many of their short term symptoms and their long term health problems. Sana Qadar: So today on All In The Mind, we are focusing on chronic stress, what it's doing to our brains and bodies, everything from our decision making abilities to our libidos. And we're also finding out the signs and red flags to look out for that tell you your stress levels are unhealthily high. We'll also find out what you can do about it. This is All In The Mind. I'm Sana Qadar. Sana Qadar: Just going back to when you were first talking about your dad's story and how he was working for 30 years while you were growing up. I just wondered, like, whether you or your family did anyone think that his pace of work was nuts? Or was it kind of just normalized, the fact that he was only sleeping three days a week? Dr Rangan Chatterjee: I think as a kid, that's just your normal. You're just like, you're used to dad not being around. Oh, dad's working tonight. Dad's working this Sunday, or whatever it might be. So on a personal level, me and my brother, I'm not sure we were aware. I think it was normalized for us. I do remember mum often saying, why are you doing this? You don't need to work on Christmas Day. You don't need to work on Boxing Day to gain even more money to send home. Why don't you just stay? So I don't want to speak about my parents' marriage in the sense that I don't know what went on. But I certainly think as kids, we didn't really see the full impacts of it. I think for us, it was normalized. Sana Qadar: It's such an immigrant thing for especially that generation to want to work so hard and send quite a lot back home to help sisters and brothers. It's a familiar story in a way. Not that anyone in my family was only sleeping three nights a week, but the other details of it are similar. Dr Rangan Chatterjee: Yeah, but that's why I feel as I've got older, I've just become, I'm pretty non-judgmental these days. I think I used to be. I just think more and more, none of us know what's going on in someone else's life. I think once you really get that, you just become a lot less judgmental and more compassionate to the world around you. Sana Qadar: Now, you would think watching his father's punishing schedule, the chronic stress, the lack of sleep would put Rangan off a career in medicine. But like I said, he followed in his footsteps and also became a doctor. But early on in his medical training, Rangan started to feel like something pretty important was missing from the medical system. Dr Rangan Chatterjee: Yeah, I think when I qualified from Edinburgh Medical School back in 2001, I thought that I'd been taught all the tools that I needed to go out there into the world and help my patients. So when you qualify, you start off in hospitals and I did that for quite a few years. And I think there was a frustration early on in my career that what I'd been taught to do was suppress symptoms often with medications. And that was really front of mind for me when I did move into general practice because I thought a lot of these patients who are coming in, we're not really getting to the root cause of their problems. In fact, 80 to 90% of what we see as medical doctors today is in some way related to our collective modern lifestyles. Yet not only do we not get trained in how our lifestyle specifically affects different aspects of our health, we're not really taught how we actually put that into practice. So our default as medical doctors often ends up being prescribing pharmaceutical medications for symptoms that are driven by our lifestyle. And for me, that was very unsatisfactory. And I tell you, Sana, one really seminal day for me was when I finished a long day in NHS general practice where I'd probably seen about 50 patients. And I was tired. It was the end of the day. And I looked at my patient list on my computer screen and I asked myself, Rangan, how many patients have you really helped today? Like honestly. And hand on heart, I thought, well, I think I probably helped about 20% of people. The other 80%, sure, I was professional. I listened to them. I might have sent them for a test or given them a medication to help hide a symptom. But I thought, they're going to be back. I didn't really help them get to the root cause of their problem. So that day, I realized that actually I can't do this for the next 40 years of my career. There must be another way. And for me, that way is what we call lifestyle medicine. Sana Qadar: Lifestyle medicine is a relatively new field. It's a branch of evidence-based health care that focuses on trying to prevent diseases before they start, rather than just treating them once they set in. Chronic diseases like Alzheimer's, heart disease, type 2 diabetes, cancer, and stroke. It's a response to the fact that in the modern post-industrial era, there's been a shift in the kinds of diseases that most affect people in high-income countries. That's a shift from mostly infectious diseases to mostly chronic diseases, which often have lifestyle or environmental drivers. Dr Rangan Chatterjee: I want to be really clear, Sanaa. I'm not blaming people here. I understand that modern life is challenging, and a lot of people are not able to eat as well as they want to. Their jobs mean that they're sedentary for a lot more time than they might choose to be. They're chronically stressed, chronically sleep deprived. I'm not saying that people are doing this to themselves. I'm saying I don't think there's enough awareness that our lifestyle, and if you can personalize and change specific parts, what I call the four key pillars of health, food, movement, sleep, and relaxation, you can have profound impact on all aspects of our health, short-term and long-term. Sana Qadar: And so that brings us back to chronic stress, one of the main lifestyle factors wrecking havoc on people's health. Because stress sets off a whole bunch of responses in the body. It makes your blood pressure rise Dr Rangan Chatterjee: so that more oxygen can be delivered around your body. Sana Qadar: It makes your blood sugar levels rise Dr Rangan Chatterjee: so more glucose can get to your brain. Sana Qadar: It also throws your amygdala, Dr Rangan Chatterjee: which is the emotional reactive part of your brain, into high alert so you're hyper-vigilant. Sana Qadar: And while we evolved this stress response to keep us safe, the problem is our brains can't fully tell the difference between the threat posed by a lion or tiger who wants to eat us versus our email inbox. Dr Rangan Chatterjee: Yeah, you know, the email inbox, the children we have to rush to pick up after work, the elderly parents we're having to look after when we don't even have our tribe community around us anymore, the three social media channels we're trying to keep up to date with, the constant bombardment of negativity on the news, whatever it might be, our bodies are responding in very similar ways, whether it is a real physical threat or the emotional, psychological stresses that are coming at us in the 21st century. So just to tie the loop up, blood pressure going up in the short term when you're running away from a tiger or a lion, great. Blood pressure going up temporarily while you're doing a 30-minute spinning workout at the gym, great, no problem. But blood pressure going up day in, day out to the state of your life, well, that's what's going to increase your risk of a heart attack or stroke. And you talk about the brain, the amygdala, the emotional part of our brain. If you think there's a wild predator there, the emotional part of your brain becomes hyper-vigilant. Why is that important? So you can hear everything, a pinprick, or there's a rustling in the bush. If that's happening to the state of your daily life, well, that's what we call anxiety. So once you understand the stress response, you actually understand stress is there for a reason, but we're not designed to be stressed all the time. Sana Qadar: I want to dive deeper into how chronic stress affects our brains, specifically our mood and cognition, because you might have noticed, I definitely have, that when you're super stressed, you are probably more moody and snappy and you struggle to make decisions. Dr Rangan Chatterjee: Chronic stress has a huge impact on the way we make decisions. Okay, so think about your brain in two parts. It's a slight oversimplification, but I think it really helps us understand this concept. One part is the front of your brain, the prefrontal cortex at the front of your brain, where you make your logical and rational decisions. And then further back, the emotional part of your brain, where the stress response comes from when you think you're in danger. Ideally, you want both of those parts online and in balance. But when you're chronically stressed, you switch off the prefrontal cortex, that part of your brain that makes logical and rational decisions, it goes offline. So you're left with the emotional brain ruling the roost, which is one of the reasons why we struggle when we're chronically stressed to make good decisions. In fact, many of us know that feeling at the end of the day when we've not taken a lunch break, we're a bit frazzled, and an email comes in and we need to make a decision, and we can't. We don't have the clarity. And that's because our logical brain has gone offline. And that's why stress reduction practices, you know, a bit of breath work, a 10-minute walk at lunchtime, one minute of jumping jacks or moving your body, whatever it might be, just helps to break the cycle, lower the stress response, and then that front part of your brain where you make those logical decisions from starts to come back online. Sana Qadar: And this also explains why when you're stressed, you can be more emotionally dysregulated. And this is a real problem long term, because chronic stress doesn't just change the functioning of the brain, it can change the structure. For example, there is a well-established link between chronic stress and depression, and we also know that chronic stress can shrink the hippocampus, a part of the brain that's critical for learning and memory. I could go on, but I'll stop there because I think you get the point. Chronic stress is bad for many different reasons. But just two other points I do want to briefly make is that, one, there is plenty of research finding that people from poorer backgrounds often experience higher levels of chronic stress because of the precariousness of their lives. That puts them at a higher risk of being impacted by these kinds of changes in the brain. Second, there's also growing research in Australia, the UK, and the US suggesting Gen Z are the most stressed generation, thanks to a combination of factors, including the COVID pandemic, financial insecurity, and the rising cost of living, and the impact of social media and technology. Sana Qadar: Okay, so I want to ask, when should a person start to be worried about the amount of stress they're feeling? Like, when can you know, what are the signs to look out for that you've been chronically stressed for too long? Dr Rangan Chatterjee: I mean, it's highly individual for all of us. And the problem is that the more you get used to chronic stress, the harder it is to tune into your own body and figure out that, oh my God, I need a break. You know, this is going on for too long. One of the big factors is also that these boundaries between work and home have been decimated with technology. Right? So 25 years ago, there were natural endpoints to the working week. You know, when you left the office, you were kind of done. So, you know, how can people know? Well, one good sign is when their mind is racing at night and they can't switch off to fall asleep. That's a good sign that your mind has been overactive and you've not given yourself a chance to sort of wind down. Sana Qadar: Another sign, Rangan says, is stomach problems. Dr Rangan Chatterjee: We know from a bit of research done a few years ago that in the UK at least, and I've no reason to believe that it will be different in Australia, 84% of UK adults have some form of gastrointestinal symptom each year, which is incredible. The number one cause is not, in my view, diet, it's stress. Sana Qadar: The connection between our stress levels and gut health has been well studied and the relationship seems to go both ways. Our gut can influence our mood and stress levels, as well as our stress levels influencing our gut. It's an idea that was popularized in a big way in a book called Gut by Julia Enders back in 2014. Dr Rangan Chatterjee: Think about it. If you think there's a predator about to attack and you have to keep yourself safe, your body will switch off functions that are not essential to your survival. You do not need to be able to digest food efficiently if your body thinks it's in danger, which is also why some of the time we're trying to eat our healthy whole food meal, but we're also doing it whilst answering work emails. The reality is you're not going to absorb that food properly. Now, I'm not judging. I will also do this despite knowing it, but the truth is sometimes, and I've had patients who think they're intolerant to certain foods, but once I taught them a simple breathing technique called the 3-4-5 breathing technique to help them downregulate their stress response before they eat, they find, oh man, I'm not getting symptoms anymore. Sana Qadar: If you're wondering how that breathing technique works, keep listening. We'll explain that in a moment. Dr Rangan Chatterjee: Now, of course, there are true food allergies. I'm not talking about that, but for some intolerances, you're not actually reacting to the food, you're reacting to the fact that you're eating that food in a stressed out state. So, if you're getting a lot of indigestion, a lot of bloating, constipation, or whatever it might be, that might indicate that you're chronically stressed, right? Sana Qadar: And then just one other sign we'll mention that can tell you you might be chronically stressed is if you find your libido is starting to suffer. Dr Rangan Chatterjee: We, as doctors, are seeing more low libido in younger and younger and age groups than we've ever seen before. Number one factor is chronic stress. Again, think about it through that evolutionary lens. If you think your body's in danger, your body doesn't think, oh, I need to now be able to chill out and procreate with my partner. So, it switches off libido, and this is a massive issue because it affects relationships, it affects how men and women feel about themselves and their vitality. And again, I've treated lots of cases of low libido by helping people lower their stress levels. Sana Qadar: I want to know more about, you mentioned the breathing exercises, I want to know more about tools and tips for de-stressing. What do you advise people do? Because, you know, work is still stressful, the news is stressful, like modern life doesn't fully change, we have to change how we relate to it. What do you suggest people do? Dr Rangan Chatterjee: Yeah, so the first thing I want to say here is that one thing that 23 years of medicine has taught me is there's very rarely one thing that works for everybody. We've all got different gut microbiomes, we've all got different emotional histories, and so we respond to different things. Let me give you a selection of things that I recommend to people and then people can sort of play around and see what works for them. I believe the way you start your day has a huge impact on the rest of your day. So, I think a useful way to look at the way we start the day is through the lens of what I call micro stress doses. Okay, so what's a micro stress dose? It's a little dose of stress that in isolation we can handle just fine, but when those micro stress doses accumulate, they get you closer and closer to what I call your personal stress threshold. And at your personal stress threshold is when things start to go wrong. So, let's say you went to bed late because you were watching Netflix and your alarm goes off on your phone at 6am. That is what I call micro stress dose number one or MSD number one. Okay, because it jolted you out of a deep sleep. You look at it, you go, I'm still tired, you put snooze on. Six minutes later, the alarm goes on again. Micro stress dose number two. Then whilst you're in bed, you open up your email app. Oh man, there's three work emails I didn't do from yesterday. I need to get onto that today. You're nodding your head a lot here at the moment. Sana Qadar: (Laughs) you're describing my mornings pretty much. Dr Rangan Chatterjee: MSD number three. Okay, then you go to the news app and see about some gas explosion that has happened that's killed people, whatever it might be. Okay, and I don't mean that to sound negative. Obviously, if people are dying with something, I'm deeply compassionate about that. The point I'm trying to make is that many people I've seen in practice over the years, in the first hour of the day, they've accumulated 10 to 15 micro stress doses. It means you are very near your personal stress threshold, which means you have less capacity in the day to deal with it. So it won't take much to tip you over. So going back to your question, some of us have got more agency to make decisions and change things than others. I'm saying that for some of us, we don't need to start our day with 10 to 15 micro stress doses. If you had an alarm clock instead of your phone, for example, that can be game changing. Sana Qadar: Simple, but effective. Rangan also recommends a morning routine that he recognizes people can sometimes balk at the idea. Dr Rangan Chatterjee: They're like, oh man, I don't have time for a morning routine. The thing is, everyone already has a morning routine. The question is, are you conscious of that morning routine? Right? You've got a routine, that routine I just mentioned. That's a morning routine (both laughing). Sana Qadar: That's my routine, the emails and the social media. Dr Rangan Chatterjee: You're repeating that routine every day. Fine, but that's going to have an impact on you. So I believe a nice framework to think about a morning routine is what I call the three M's, mindfulness, movement, and mindset. You don't have to do all three, but I think if you have the time, all three can be done quite beautifully in quite a short period of time. So mindfulness could be anything like a bit of meditation, breath work, whatever, drinking a coffee in silence, right? Just paying attention to the coffee and not actually scrolling your emails or Instagram at the same time. Movement can be some stretches, a few weights, whatever it might be. And mindset is something to put you in the positive frame of mind. So it could be reading a little bit or journaling. Now I get it. A lot of people will be going, I don't have time for any of that in the morning. Okay. Let me give you an example of one of my patients who said that to me. She was a single mother. I think she was about early forties from recollection. She had really bad skin that was flaring up lots and it was making her life miserable. And I got a strong sense that chronic stress was driving her skin flare ups. So what I suggested about a little morning routine, she said, I don't have time for any of this stuff. Right. I said, okay, do you have 15 minutes? No. Do you have 10 minutes? No. Do you have five minutes? Well, yeah, I've got five minutes. I said, okay, great. So M number one mindfulness, she did what I call the three, four, five breaths. Let me just explain what that is because I mentioned it before as well. Anytime your out breath is longer than your in breath, you help to switch off the stress part of your nervous system and activate the relaxation part of your nervous system. Okay. So three, four, five breath is simply you breathe in for three, you hold for four and you breathe out for five. One of those breaths takes 12 seconds. Five of them takes simply one minute and it will literally change your physiology in just that one minute. Sana Qadar: And this is something you can do obviously at any time, not just as part of a morning routine before a big meeting, before an exam. But the question I have is, is the breathing exercise or even the routine enough on its own to actually have a long lasting impact? Dr Rangan Chatterjee: Well, it is because I'll tell you why. So let's go back to that patient then. So she did one minute of three, four, five breathing, two minutes of movements, and she used to love yoga, but since she became a mother, she never had time. So she did three or four of her favorite yoga moves and then she did two minutes of mindset. And for her, it was just affirmations. Now, there is quite a bit of research on affirmations and what they can do for our wellbeing and our stress levels. They're a little bit controversial. Not everyone buys into the research, but nonetheless, I think it's a very positive, empowering thing for someone to do. So she would say for two minutes, I'm happy, I'm calm, I'm stress-free. I'm happy, I'm calm, I'm stress-free. Remember, this took her five minutes. Sana Qadar: Rangan says that over the next 10 days, this patient's skin flare-ups reduced significantly. Dr Rangan Chatterjee: Because it's not just about those five minutes. What do those five minutes do? They remind you of what it feels like to be calm and relaxed. Once you started doing that, she was much more likely to stop at lunch and go for a 10 minute walk around her office block. She was much more likely to pay a bit more attention to her evening meal and make it a bit healthier. Sana Qadar: Basically, that small change had a ripple effect. Now, despite his own busy schedule, there's a lot that Rangan does in his own life as well to keep stress at bay. Things like having a hobby, he plays guitar, journaling daily, making time for some form of physical activity every day. Dr Rangan Chatterjee: I now, at this stage in my career, have quite a bit of autonomy. And I recognize that, okay? Not everyone does. I'm able to structure things so that I can. Sana Qadar: And one of the ways he's restructured his life recently is he quit his medical practice. He did that to free up time to focus on his podcast and his books and his public speaking and his role as a visiting professor of health education and communication at Chester Medical School. It's a very different life to his 30s when he was working full-time, taking care of his young family, and helping to care for his ailing father. Sana Qadar: I'm curious to know, what do you think your father would think about the life you've carved out for yourself and the work life you've carved out for yourself? Dr Rangan Chatterjee: Yeah, that's a great question. I actually think about this quite a lot. You know, dad died, I think, yeah, 12 years ago, just over 12 years ago. One of the things on a personal level that used to make me sad was that all the things that my dad would have been proudest about, you know, as an Indian immigrant to the UK in the 1960s, the fact that, you know, I had my own primetime BBC One TV show. I've had six Sunday Times bestselling books. I have the largest health podcast in Europe, whatever it might be. My dad got to see none of those things. And it used to really upset me. But at the same time, now I realize that if my dad was still alive, I wouldn't be doing any of these things. Because, well, there's two reasons for that. One is, and if there's anyone listening who's a carer, you know, they'll know how stressful life is when you're a carer. You know, I came back to the northwest of England to help my mum and my brother look after my dad. I didn't have time for anything else. You know, it was hard enough just to look after dad, just about keep my job going and see my wife. Right? It was very, very stressful. So number one, if dad was still alive, I don't think I'd have time to do the things that I've done. But secondly, the most important things I've learned have come from my dad's death. And now I've reframed my dad's death to believe that dad actually gave me a gift through him dying. Because the man I am today, the questions I started to ask myself after my dad died, I'm not sure any of those things would have happened until dad had died. So actually, again, I understand the death of a parent is a really challenging time for most people. I'm not expecting or asking anyone else to reframe their own parents' death in this way. But I do believe that life is simply a set of experiences and it's the story we put onto those experiences that ultimately determine the quality of our life. And I'm able to 12 years on now, reframe my dad's death as being, that was a gift to me. Because all this wisdom, I hope that I can share with people that really helps them. A huge part of that has been through my dad's death. Sana Qadar: And you mentioned other patients you've worked with who had also kind of worked themselves to the bone, regretted not stopping earlier. I'm wondering, do you know if your father wished he hadn't worked quite so hard by the time he got sick? Did he wish he had stopped earlier? Dr Rangan Chatterjee: You know, there's only one question I would love to ask my dad if I was still alive. And I don't know the answer. One of the questions, the only question is, dad, was it worth it? Because being truthful, although dad worked himself to ill health, I've changed my view on this over the past years. I now think, Rangan, you have no right to think that your dad made a mistake. You don't know that. Dad may say, if he was alive, he may go, I'd do that all over again. Because my only purpose in life was to look after my family back home and to give you and your brother the very best start in life that I could. Now, if that is true, which I believe it to be true, my dad may say, well, I kind of did that, right? I looked after everyone at home and look at what you're now doing, son. Look at how many people you're helping all over the world with what you do. I would do that all over again. So I'm hypothesizing here. I honestly don't know. Do I believe my dad could have done those things and not got ill at the same time? Yeah, I do believe that was possible. But how can I possibly know? But he never said to me, to be clear, I wish I'd stopped earlier. So I'm speculating. Sana Qadar: Rangan, it's been so lovely chatting to you. Thank you for sharing your family story and the story of your patients and everything you've learned over the course of your career. We really appreciate it. Dr Rangan Chatterjee: Yeah, thanks so much for having me on. Sana Qadar: That is Dr. Rangan Chatterjee, until recently a practicing GP, and he's also the host of the Feel Better Live More podcast. Rangan is going to be touring Australia in mid-July with live events in Melbourne, Sydney and Brisbane. If you want to find out more, just search An Evening with Dr. Rangan Chatterjee. He'll be at Melbourne Town Hall, the State Theatre in Sydney and Brisbane City Hall. That is it for All in the Mind this week. Thanks to producer Rose Kerr, senior producer James Bullen, and sound engineer Tegan Nicholls. I'm Sana Qadar. Thank you for listening. I'll catch you next week.

News.com.au

13 hours ago

• News.com.au

Wirtz wants to 'win everything' for Liverpool after record move

Florian Wirtz said he wants to win it all at Liverpool after completing a blockbuster move from Bayer Leverkusen on Friday, which could reportedly rise to a Premier League record fee. Reports in England said the Premier League champions will pay an initial £100 million ($134 million) for Wirtz, comfortably surpassing their own record outlay, with a further £16 million in performance-related add-ons making it a British record deal. However, German media suggested the fee could be even higher, starting at 130 million euros (£111 million, $149 million) with add-ons taking it to 150 million euros. One of European football's elite young stars, Wirtz has been hailed as one of the "best in the world" by former Leverkusen coach and ex-Liverpool midfielder Xabi Alonso, who is the new boss of Real Madrid. "I would like to win everything every year!" Wirtz told the club's website. "In the end, we want to be successful. Last season they won the Premier League so my goal is for sure to win it again and also to go further in the Champions League. I'm really ambitious." The 22-year-old played a crucial role in Leverkusen's greatest season as they claimed a first-ever Bundesliga title and the German Cup in 2023/24 without losing a single game under Alonso. Their only defeat that season, during which Wirtz was crowned Bundesliga player of the year, came in the Europa League final to Atalanta, denying Leverkusen a memorable treble. Bayern Munich restored their grip on the German game last season, with Leverkusen a distant second, and Wirtz is joining an exodus from the BayArena. Netherlands defender Jeremie Frimpong has already made the move from Leverkusen to Liverpool last month. - 'New adventure' - "I'm really excited to have a new adventure in front of me," added Wirtz, who turned down the option of joining Bayern for the move to England. "This was also a big point of my thoughts: that I want to have something completely new, to go out of the Bundesliga and to join the Premier League." After largely keeping their powder dry in the transfer market during Arne Slot's first season in charge, the Reds are splashing out to strengthen a side that romped to a record-equalling 20th English top-flight title. Bournemouth left-back Milos Kerkez is poised to make the move to Anfield in a £40 million deal. Liverpool have also been linked with Newcastle striker Alexander Isak and Crystal Palace centre-back Marc Guehi. Where Wirtz's fits into Slot's plans remains to be seen. He largely played behind a central striker at Leverkusen and has operated from a wider role for Germany. A return of 57 goals and 65 assists in 197 games for Leverkusen is evidence that he carries a threat both as a creator and a goalscorer. "The people say I'm a creative player, and I hope I can bring this creativity to the team and also the joy on the pitch," said Wirtz. "I try to make assists, goals and run for the team to defend. I hope I can just make the team one step better." Liverpool are already blessed with an abundance of forward options, with Mohamed Salah, Luis Diaz and Cody Gakpo all offering a goal threat. However, Diogo Jota, Darwin Nunez and Federico Chiesa now face even stiffer competition to get into Slot's starting line-up, raising the prospect of Liverpool selling some of that trio to free up further transfer resources.

News.com.au

20 hours ago

• News.com.au

Unusual way of flying to Europe in business that's often cheaper and quicker than well-worn routes

When travelling to Europe, Australians typically choose from a limited range of options when it comes to airlines and stopover points. It's Qantas via Singapore, or increasingly direct from Perth to London, or one of the major Middle Eastern carriers – Qatar, Emirates and Etihad – via their homebases in Doha, Dubai or Abu Dhabi. But there's another option that has flown under the radar, pardon the pun, which is strange given it's often quicker and cheaper. Thai Airways has a growing presence in Australia and its convenient daily services to Bangkok offer a host of options for getting to popular destinations in Europe. The airline is renowned for its exceptional on-board service and high-end, restaurant-quality cuisine, so the time and cost savings only make it more of an appealing consideration. And those wanting to splash out and fly at the pointy end of the plane in business class can also nab more affordable fares than those travelling via the Middle East on larger carriers. The time and cost comparison is clear when measuring Thai Airways with popular carriers. crunched the numbers looking at a flight to the two most popular destinations for Australians – London and Paris – in early autumn, on the shoulder of peak season. Flying from Sydney to London on Qatar involves 25 hours and 30 minutes of travel, including a 95-minute stopover in Doha, at a cost of $9508 roundtrip in business class. Qantas can deliver you fastest, with a total flying time of 23 hours and 55 minutes, inclusive of a brief 90-minute transit in Perth, but it'll set you back $10,298 return. By comparison, flying Thai Airways to London requires 25 hours and 25 minutes, including the 3 hours and 20 minutes transit time in Bangkok, for $9464 return at the pointy end of the plane. Those heading to the French capital can secure even bigger savings. Flying business class on Etihad to Paris via Abu Dhabi will take 24 hours and 20 minutes, including a 140-minute stopover, and cost $10,536. Qantas can get you there in 24 hours and 35 minutes, with a two-and-half hour stopover in Perth, for $11,344, while a ticket on Qatar sets you back $9288 and takes 25 hours and 40 minutes, with an almost four-hour stop in Doha. But flying Thai Airways from Sydney to Paris takes 24 hours and 20 minutes, with an almost three-hour stop in Bangkok, for $9188. There are periods throughout the year where the cost difference for a business class ticket between Thai Airways and the major carriers is even greater. For example, in August, in the midst of peak season, return business fares to London are $1600 cheaper on Thai Airways, while a trip to Paris in the same period is about $1500 cheaper. The airline has invested heavily in expanding its international services over recent years, adding dozens of new routes, with several in Europe. In addition to London and Paris, Australians transiting via Bangkok can now fly directly onto Copenhagen, Milan, Brussels, Oslo, Stockholm, Zurich, Munich, Frankfurt and Istanbul. A stack of new aircraft are on the way in coming years. It also recently announced plans to roll out a new business class and premium economy offering across its entire long-haul fleet of Airbus A350s, Boeing 787s and Boeing 777s. In particular, the 'state-of-the-art' business suites are set to impress, with privacy doors and a host of tech features, like huge screens, Bluetooth audio and wireless battery charging. It has also bolstered its presence in Australia, now offering twice-daily flights from Sydney and Melbourne to Bangkok, as well as recently relaunching its direct service from Perth to the Thai capital. Thai Airways operates twice-daily services from Sydney and Melbourne to Bangkok, and once a day from Perth to Bangkok.