
Inside the labs on the frontline in the battle against one of the world's deadliest diseases – as it reaches Europe
A SWARM of blood-sucking mosquitoes encircle me, buzzing around my face.
I'm perched on a bed in a tin-roofed shed and the only barrier to the outside world is a mozzie net filled with holes.
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Sun Health's Isabel Shaw behind a mosquito net at the Ifakara Institute
Credit: © Malaria no More UK/Jordi Matas
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Dr Brian Tarimo carrying out research at the Ifakara Health Institute in Tanzania
Credit: © Malaria no More UK/Jordi Matas
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Studies can aid the ever-growing threat posed by mosquitoes across the globe
Credit: © Malaria no More UK/Jordi Matas
I'm at the Ifakara Health Institute, in rural Tanzania, Africa, nestled among towering palms.
Here, British and African scientists work in converted shipping containers on the front line in the battle against deadly malaria.
Deaths from the infection have been rising. There were 620,000 victims in 2022, up from 560,000 a decade ago — most of them African children under five, according to the World Health Organisation.
After years of progress, with global deaths down from 1.8million in 2004, warmer temperatures, war and Covid-19 pandemic restrictions have fuelled a resurgence of the disease.
The WHO says 249 million cases were reported globally in 2022, up from 233 million in 2019.
Europe was declared malaria-free by the WHO in 2015, but now its threat is edging closer again.
'Smile hides heartbreak'
Malaria-carrying mosquitoes have reached southern Europe, and medical cases of affected holidaymakers coming into Britain are at their highest level in more than 20 years, with 2,106 cases in 2023.
Symptoms are flu-like, but severe cases can be fatal.
People who haven't been regularly exposed to malaria, like those in Europe, don't have the same immunity as those in Africa
Dr Dickson Wilson Lwetoijera, principal research scientist at the institute, tells Sun Health their work could have far-reaching consequences for the whole world.
He says: 'With global travel and population movement, there's every chance the disease could spread to new regions — if that happens in Europe, the consequences could be serious.
Malaria No More UK's campaign film featuring David Beckham
'People who haven't been regularly exposed to malaria, like those in Europe, don't have the same immunity as those in Africa who have lived with the disease for some time, so the risk of severe illness or death is much higher.'
In Tanzania, it's as prevalent as the common cold, but that doesn't erase the devastation this disease has brought to families.
In a dusty neighbourhood in Dar es Salaam, a few hours from Ifakara, I meet Jamima Charles Abel.
She welcomes me into her home — a tiny space along a narrow, muddy street shared by several families. Her smile hides the heartbreak her family has endured.
Her son Eric Daniel Richard, 24, 'loved people', Jamima tells me. He was a hard worker at a local business, supporting his family despite having moved out.
One day last December, he developed flu-like symptoms. Within 24 hours, he was gone.
Jamima, 44, is terrified for her other two children. Just last month, her 17-year-old son caught malaria but has since recovered.
The infection is caused by a parasite called Plasmodium, which is transmitted to humans through the bites of infected female mosquitoes.
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Europe was declared malaria-free by the WHO in 2015, but now its threat is edging closer again
Credit: Getty
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Drones are being used to find and dismantle mosquito breeding grounds
Credit: © Malaria no More UK/Jordi Matas
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An insectary at the institute in Tanzania helps researchers fight against the spread of malaria
Credit: © Malaria no More UK/Jordi Matas
Male mosquitoes don't bite and are therefore harmless. When an infected mosquito bites a person, the parasite enters the bloodstream and infiltrates red blood cells.
Genetically engineered mosquitoes
The Plasmodium parasite is adept at evading the immune system. It means a vaccine, which seems like the simplest option, is far from straightforward.
So scientists are working on other cutting-edge solutions.
A team from Imperial College London, in partnership with a team at Ifakara, has genetically engineered mosquitoes resistant to the malaria parasite.
It's hoped these mozzies will be released into the wild within eight years, dominating and repopulating areas within a few months.
'This is the first malaria-fighting technology that doesn't rely on human behaviour,' Dr Lwetoijera explains. 'With our current tools, like bed nets and insecticides, the biggest challenge is compliance.
'People have to use them consistently for them to work, which isn't always possible.' Funding is one of the biggest challenges scientists face.
And a huge blow came earlier this year when Donald Trump made abrupt cuts to foreign aid, and Keir Starmer announced plans to slash the overseas aid budget to its lowest level in a generation.
Dr Sarah Moore, who has worked at Ifakara for 20 years, says: 'Every day, the equivalent of four jumbo jets full of children die of malaria in Africa.
'If aid continues to fall as predicted, it could rise to five. Because it's Africa, no one cares.'
Among other developments, drones are being used to find and dismantle mosquito breeding grounds in Dar es Salaam, such as stagnant water pools, leafy foliage and shaded areas.
Taking our foot off the gas could lead to a surge, including in new places not ready to fight back
At dusk, when mosquitoes begin to stir, experts knock on the doors of locals to set up traps.
Mwanabibi Kharifa Mohamed, a grandmother and mother of four, is one local taking part.
As Alex Limwagu, a research scientist, sets mosquito traps in the garden, Mwanabibi tells me her children have caught the disease more times than she can count — the family can't afford nets — but it never quells her panic.
'I rush straight to the hospital because I know in two minutes they could die,' she says.
Since the mosquito team arrived this year, Mwanabibi has learned more about protecting her family.
'I used to be ignorant,' she says. 'But Alex taught me how mosquitoes breed and how to protect my children. If malaria disappeared, life would be peaceful.'
The WHO wants to reduce global malaria by 90 per cent by 2030.
It believes the ambitious target is 'achievable' — but not without the dedicated scientists on the ground and the funds to keep them going.
Victoria Fowler, head of UK advocacy at the charity Malaria No More UK, says: 'Taking our foot off the gas could lead to a surge, including in new places not ready to fight back.
We need the Government to back the Global Fund to Fight Malaria at the Spending Review this month.
'Standing behind our scientists is crucial to get back on track to beat this killer, saving hundreds of thousands of children's lives and protecting the British public.'
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Wales Online
5 hours ago
- Wales Online
I took Mounjaro and the results changed my life
I took Mounjaro and the results changed my life Jess always struggled to manage her weight, however a year after using the controversial Mounjaro vaccine, she has now lost 100 pounds Jessica shared the moment where she was able to travel abroad - without using a belt extender (Image: Jessica Miles ) For Jess Miles, a 37-year-old secretary from Newcastle Emlyn, weight had always been a shadow in her life. It was a battle that stretched back from her childhood and stubbornly into adulthood. "I've been overweight since I was a kid. It got worse after I had my son, nearly 16 years ago," she says. "I've tried everything - Slimming World, Weight Watchers - you name it! I'd lose a couple of stone, then binge eat, put it all back on and give up until the next time." However, the wake up call came with two gut wrenching moments: stepping on the scale and seeing 24 stone and four pounds, and the whisper of her late mother's final wish. "I lost my mum just before COVID," Jess shared. "One of the last things she ever said to me was that she wanted me to lose weight. She was a big woman too, but after getting diagnosed with diabetes, she changed everything. She went from a size 26 to a 14 - it was really amazing to see. She did it - and she wanted the same thing for me." This echoed through Jess' mind when she looked at herself last year. "Reaching 24 stone.... I cried. Honestly, I felt ashamed of myself. I thought that if I don't do something, I won't live to see my son turn 18." A year ago, Jessica weighed 24 stone and four pounds (Image: Jessica Miles ) Article continues below That's when she found Mounjaro - a weight loss option that has become increasingly familiar in the public eye - for both positive and negative reasons. Jess had started seeing the name crop up on Facebook and TikTok, the latest buzz in weight loss. "It was everywhere," she recalled. "But I didn't know anyone who had tried it. Back then it was so new, so I was very apprehensive about it." It wasn't just the unknown that made her hesitate. It was the cost - upwards of £250 a month. "I kept putting it off, thinking 'I can't afford this'. But one day I just thought, b****r it! Something has to change and nothing else has worked!" Armed with this sudden burst of determination, she booked a consultation with Iechyd Teifi Health, a private clinic. On July 4, 2024, she walked in, shaking hands with the consultant with a pounding heart: "I actually said out loud, 'I don't know what I'm doing here.' I was so incredibly nervous." Jess was honest from the start about her biggest worry: the side effects. "The list was terrifying," she admits. "I have read that there are possible cases of thyroid cancer, liver and kidney issues.... not to mention the more common stuff like nausea or constipation." These concerns weren't unfounded. The NHS website notes, "Common side effects, include: Feeling sick Indigestion Constipation Diarrhoea "There can be some more serious side effects, such as low blood sugar, gallstones and inflammation of the pancreas (pancreatitis)." Fortunately, Jess had no underlying health conditions that would have put her at severe risk with the treatment. Through further discussion with the doctors at her workplace, Jess was given the green light to proceed - with agreement to have regular blood tests to keep everything in check. From the moment she took her first injection, almost a year ago, Jess says something shifted. "I had my first injection the day of my consultation. That night, I remember sitting down to eat and I just... couldn't," she said. "There was a full plate of food in front of me, and I managed about a quarter of it. I physically couldn't eat more. It was shocking. Normally I'd eat massive portions without a second thought." That initial shock was quickly followed by nausea, a side effect that lingered for the first few weeks and continues to take hold. "I wasn't used to it in the beginning. I felt sick a lot, especially the first weekend. I barely ate anything," Jess says. "But weirdly, I sort of needed that reset. It forced me to stop and think about what I was putting in my body." That thought struck after a late night stop at her local chippy. "I had a portion of chips and my gosh was I ill that night. It must have been all the grease and fat... From that point on, I realised I had to actually change what I eat." Jess didn't give up all her favourite foods - she didn't need to. But her relationship with them has changed. "Chocolate used to be my downfall. I used to be able to eat a whole bar of Galaxy in one sitting. Now? A square or two and I am genuinely satisfied." Jessica shared that she had always struggled with her weight but since taking the injection has seen an incredible difference (Image: Jessica Miles ) Her drastic change in appetite has also impacted her daily routine. "I don't eat breakfast now. A coffee keeps me going until about half ten and then I'll have a small portion of fruit before lunch. If I have a proper lunch, sometimes I don't have supper. I have cut down on all my snacking. The injection has changed everything." And yet in those early months, people didn't believe it would last. "I think a lot of my family and friends thought I'd give up like I always had before, and I don't blame them! I had a history of starting strong and then slipping back into old habits. "But this time was different. They started to take notice when I hit that two-stone mark. That's when they realised I was serious." Stay informed on the latest health news by signing up to our newsletter here Jess' biggest cheerleader wasn't around to see it, but Jess knows that her mother is with her in spirit. "Honestly, she remains my biggest motivator, through all the tough moments. I know my mother is looking down on me and is proud of what I have achieved!" Week by week, stone by stone, the weight has come off. "I weigh myself every morning before work. I go in and tell the girls, 'I lost three pounds!' and they're just as excited as I am. Everyone has just been so amazing and supportive." For Jess, her biggest milestone came during a shopping trip. "I didn't really want to go clothes shopping because of how much my weight was fluctuating, but it got to the point where I was looking stupid going to work because of how oversized my normal clothes were. "I remember on that trip, picking up a t-shirt in New Look in my usual size 24, without thinking - it drowned me. So I grabbed a size 18 - still too big. I ended up buying a size 16. I hadn't been that size since school." She stood in front of the store, holding the old size against her body - gobsmacked. "I nearly cried. It wasn't about the clothes. It was seeing for the first time how far I come. No matter how much I look in the mirror, I can't register the changes, but in that moment it became undeniable." Now 49 weeks in, Jess has lost seven stone and two pounds - exactly 100 pounds. Jessica said that her friends and family can't get over the difference Mounjaro has made (Image: Jessica Miles ) "I still can't believe it," she says. "That weight is basically equal to a size of a small child.... it's crazy! It blows my mind." Beyond the physical changes, there has also been a change in mindset. "A small part of me used to dread weekends. I've got a little balloon business on the side, and I'd find myself sweating, exhausted putting party displays up. But I now find myself with this new lease of energy that makes me get up and want to do it." That renewed energy carried through to every part of her life - even travelling, something that once brought discomfort and embarrassment. "We went to Mallorca last year and to get on that plane and not need a belt extender? Oh my god, that was the best day of my life!" Those kind of moments - picking up a smaller size, getting through the weekend without feeling breathless, not using a belt extender - have defined Jess' year. She is now a comfortable size 18, with aspirations of reaching a size 16. "I'd say lose another two stone and I am happy. I am now preparing for my final injection - I will be stopping after this month. With the £250 a month I have been spending, I plan on putting it towards going to the gym and swimming to tone up! "I am so proud. I have honestly never been happier and that's really why I am sharing my story. I have seen so much bad conversation surround this injection and people who are on it are too embarrassed to even talk about it - but I am living proof of it working. "If you have no underlying health conditions - and I say this in big, bold, capital letters - then I would 100% advise anyone to take it. The impact it has had on me has been out of this world." There is a slight sting that this injection may become readily available over the counter after a short consultation - at the cost of an NHS prescription. The possibility was difficult pill for Jess to swallow, she confessed. "I was heartbroken," she says frankly. "One of the girls in work told me and I was swearing, ranting and raving. People are going to be able to walk into a doctors and get it for free when I've spent thousands. "That did hit me quite hard." Still, she understands the benefits of wider access - especially when done safely and with the right medical support. "I know it's safer through the NHS, because they have your full medical history. That's what really matters - making sure it's done properly." And for Jess, peace of mind was worth every penny. "I know I could've gotten it cheaper online, but I didn't trust it. I wanted to be supported and monitored. I felt safe doing through the clinic and I don't regret that." As Jess prepares to step into the next phase of her journey - one without Mounjaro, but with motivation - she hopes her story helps others feel less alone. She's already had dozens of people reach out through her social media. "Some people message me saying I've inspired them to try it. Others are asking about the side effects. I always say the same - for me it was mainly constipation and some nausea at the start. But nothing major. The nausea only hits if you overeat, because your body just can't handle it anymore." Article continues below Her routine is different now, more mindful. Smaller meals. Higher protein. Regular movement - even if it's just walking the dogs or getting her steps in during her lunch break. Yet her message is clear: "Be honest. Don't take it if you have underlying conditions. It's not a shortcut, it's hard work - but it does work."


Time Out
7 hours ago
- Time Out
The Half-Life of Marie Curie
On my seven-month-old baby's bookshelf sits a brightly illustrated children's book about Marie Curie. Its pages celebrate her love of science, her marriage to physicist Pierre Curie, and her status as the first woman to win a Nobel Prize. These are the facts most often recited, but women are rarely one-dimensional. Alongside moments of triumph, often lie moments of despair and self-doubt. It is one of those lesser-known chapters that Lauren Gunderson explores in The Half-Life of Marie Curie, a play that premiered off-Broadway at the Minetta Lane Theatre in 2019, and was later released as an audio drama on the Audible platform. The play now makes its Australian premiere at Sydney's Ensemble Theatre under the direction of Liesel Badorrek (The Glass Menagerie). Gunderson, frequently referred to as 'the most produced living playwright in America', has a signature formula across her 20-plus plays: identify a compelling duo, hone in on a pivotal historical moment, inject sharp, rhythmic dialogue, and keep it snappy – 90 minutes or less. The result is a biographical vignette interspersed with theatrical poetry. The plays often just recount history – however, at its best, her formula can thrillingly heighten a core emotional conflict. In this case, it's the friendship between Marie Curie and Hertha Ayrton, and the impact these women had on each other. Though often relegated to a footnote in Curie's story, here Ayrton commands center stage... The narrative begins at Curie's (Gabrielle Scawthorn) home in Paris, shortly after she wins her second Nobel Prize, amid personal scandal. Her affair with fellow scientist Paul Langevin has ignited a media frenzy, threatening to overshadow her legacy and forcing her into self-imposed house arrest. Enter Hertha Ayrton (Rebecca Massey), a mathematician and engineer, who quite literally bursts through the door of Curie's exile and whisks her off to the British seaside. There they frolic, quarrel, and find themselves in each other. Despite its title, The Half-Life of Marie Curie seems more captivated by the woman history barely remembers – Hertha Ayrton –than the woman it promises to center. Though often relegated to a footnote in Curie's story, here Ayrton commands center stage: sassy, witty, progressive, a suffragist, and the persistent voice on Curie's shoulder declaring how extraordinary she is. Massey has all the best lines, crafting a performance that's physical, sharp, and full of warmth and joy. She's the best friend everyone wants – the kind who shows up, speaks truth, and doesn't let you drown. Through Ayrton, Gunderson poses the play's most potent questions: What makes someone become themselves? And what makes them worth saving? These are big, existential inquiries – about art, science, nature – that, while thematically rich, don't always sit comfortably within Curie's historical context. As a result, Curie is too often sidelined, reduced to a figure of gloom. She is the catalyst for the audience to hear Ayrton's worldview, rather than the other way around. Gunderson's Marie feels like a faint sketch of the scientific titan that I came to revere during my university physics studies. Here, she is made small. On one hand, there's something refreshing about seeing a woman of such legendary stature portrayed as fallible – torn by heartbreak, plagued by self-doubt, unsure of how to move forward. But this portrayal lingers on it a bit too long. This take on Curie is stuck in a single emotional register: brooding, passive, and more consumed by rejection than inflamed by the institutional sexism that shut her out of her own lab. The result is a character who feels diminished to her worst summer. To her credit, Scawthorn brings depth where she can. She infuses Curie's desperation with stakes that feel novel, nuanced and grounded. But she's let down by this production. The staging relies on ethereal video projections cast onto sheer curtains, encircling a central dais (perhaps a nod to Ayrton's work on arc lamps). But the effect is more clinical than intimate. The bulky wooden platform limits movement and undercuts the unpolished banter of the relationship at the play's heart. Aside from a hilarious, engaging drunken reconciliation atop the dais, the physicality seems cumbersome, and there is very little visual variety to enhance the emotional arc. The lighting by Verity Hampson and video projections by Cameron Smith bring to life the theatrical poetry elements that effectively bridge the show's time jumps, and create visually captivating moments. Is this the first woman to win a Nobel Prize? Or a damsel in distress? The portrayal leans so hard into her mediocrity, it risks erasing her fire altogether. That said, perhaps Gunderson is intent on proving she was just as ordinary as you or I, so that we may feel that we can also do great things. Ultimately, it's Massey's Ayrton who anchors the play. She is the rambunctious spark – jibing, compassionate, insistent – and she transforms Curie's despair into something bigger. Even when the text falters or the staging feels distant, she keeps the light on and the laughs rolling.


Scottish Sun
8 hours ago
- Scottish Sun
David ‘Syd' Lawrence dead at 61: First British-born black cricketer to represent England dies after MND battle
Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) ENGLAND cricket legend David "Syd" Lawrence has died aged 61 following a battle with motor neurone disease. The ex-Gloucestershire star was the first British-born black cricketer to play for England. Sign up for Scottish Sun newsletter Sign up 3 David 'Syd' Lawrence has died aged 61 Credit: PA 3 Lawrence was diagnosed with motor neurone disease last year Credit: Getty The former fast bowler left an amazing legacy on the sport and was recently awarded an MBE in the King's birthday honours list. Lawrence, who was diagnosed with motor neurone disease last year, was incredibly proud to be honoured. He said last week: "It is not something I ever thought would sit after my name. "I am absolutely delighted that it will do so for however long I am here and will be a part of my legacy when I am gone." Following Lawrence's sad passing, a family statement said: "'Syd' was an inspirational figure on and off the cricket field and no more so than to his family who were with him when he passed." The ECB have paid tribute to Lawrence, calling him a "pioneering" player who left an "indelible mark" on the sport in this country. ECB chair Richard Thompson said: "David 'Syd' Lawrence was a true trailblazer of English cricket and a man of immense courage, character, and compassion. "His impact on the game extended far beyond the boundary ropes. As a fast bowler, he thrilled crowds with his pace and passion. As a leader and advocate, he broke barriers and inspired change, becoming a powerful voice for inclusion and representation in our sport. 3 England stars including Ben Stokes paid tribute to Lawrence Credit: Sky Sports "Even in the face of his illness, David showed extraordinary strength and dignity, continuing to uplift others with his resilience and spirit. He leaves behind a legacy that will endure in the hearts of all who love cricket. "Our thoughts are with his family, friends, and the entire cricketing community at this time." Lawrence played five test matches for England, only for his international career to be brutally cut short by a serious knee injury in 1992. He left an incredible mark on Gloucestershire, playing 280 matches for them over a 16-year span. Lawrence later returned to the club as president in 2022. Paying tribute to their legendary former fast bowler and executive, Gloucestershire wrote: "Gloucestershire Cricket is devastated to learn of the passing of former player and Club President, David 'Syd' Lawrence MBE, aged 61. "Everyone at Gloucestershire Cricket would like to send their best wishes to David's family during this terribly sad time." England star paid tribute to Lawrence ahead of today's match-up with India at Headingley. Stars including Ben Stokes took part in a minute's applause in honour of the cricket icon.