Medscape at 30: Three Decades of Amazing Breakthroughs
Medscape turns 30 in 2025. As part of the Medscape 2050 project speculating on what the field will look like 25 years from now, we're looking back at medical history as told through Medscape news coverage. A walk down memory lane, for sure, but also a celebration of the breakthroughs, headlines, and reporting that helped define medicine since 1995.
July 5, 1996: Dolly the Sheep Cloned
The birth of the first cloned animal led to some interesting cloning coverage over the years, whether from claims of a cloned human baby, ethical concerns surrounding human cloning, and advances in animal cloning as more than just a curiosity:
Single Genetic Difference May Make Humans Easier to Clone
Knockout Pigs Heralded as Future Organ Source
FDA: Meat of Cloned Animals Safe to Eat
1998: Discovery of Human Embryonic Stem Cells
A groundbreaking and polarizing discovery. Just over a year later, Medscape would look at the fallout, and advances would attempt to eliminate ethical concerns by tricking mouse and human cells to exhibit all the traits of embryonic stem cells. Coverage would span many conditions over the years:
Is New Stem Cell Research Major Step Toward Diabetes Cure?
Stem Cell Therapy Among Hot Topics at AAO 2017
Promising New Data on Stem Cell Therapy for Parkinson's
1997: da Vinci Robotic Surgical System Begins Development
Minimally invasive robotic surgery via the da Vinci system was approved by the FDA in 2000, and by 2011, it was in use in more than 2000 hospitals around the world. Between 2011 and 2012, however, adverse event reports rose 34%, prompting this detailed Medscape slideshow, Robotic Surgery: Too Much, Too Soon?
2000: First Draft of the Human Genome Announced
It wasn't perfect, it had gaps and wasn't fully understood, but the turn of the century marked the first map of the human genome, paving the way for what we now see as precision and personalized medicine. In 2020, Medscape commissioned a thorough charting of the genome over its first 20 years to see what grew from that first announcement.
Early 2000s: Rise of Direct-to-Consumer (DTC) Genetic Testing (eg, 23andMe)
Inexpensive genetic testing led to the advent of offering tests to consumers, and the most famous purveyor, 23andMe, debuted in 2006. This marked a shift in how people access and interpret genetic data — and raised concerns. It's been a bumpy ride:
Ethical Considerations in DTC Genetic Testing
23andMe Relaunches Lower-Risk DTC Genetic Tests
FDA OK's First DTC Genetic Risk Tests
23andMe Notifies Customers of Data Breach Into Its 'DNA Relatives' Feature
23andMe's Business Woes Raise Genetic Data Privacy Concerns: Ethicist
2009: Electronic Health Record (EHR) Adoption Incentivized by HITECH Act
EHRs, now ubiquitous, started slow in 2009, with one report estimating adoption in US hospitals at less than 2%. All that changed of course, with Medscape eventually releasing annual reports on physicians and EHRs. And in 2024, we even asked if physicians should be compensated for their time using EHRs.
Don't Get Too Hung Up on 'Meaningful Use' in an EHR
EHR Adoption Grows Rapidly in Office-Based Physician Groups
2012: CRISPR-Cas9 Gene Editing Discovered
2016: First CRISPR Clinical Trial in Humans
Gene editing, and the ethical arguments that went with it, took the medical world by storm a little over a decade ago. Medscape has been covering its potential therapeutic (and controversial) applications ever since including the 2018 birth of 'gene-edited babies' in China.
5 Things to Know About CRISPR
New CRISPR Tools More Precise, but Targeting Mishaps a Worry
CRISPR Gene Editing in Limelight at ASHG 2016
Bioethicist: History Tells Us CRISPR Fears Are Overblown
2016: Semaglutide Shows Superior Glucose Control and Weight Loss in SUSTAIN-6 Trials
The hype begins. Not only shown effective for glucose control, semaglutide also demonstrated marked cardiovascular risk reduction in 2016. While that was nearly 10 years ago, it feels like we haven't had a day without GLP-1 news since.
Oral GLP-1 Agonists Could Be Game Changers for Obesity
Treating Obesity: Will New Miracle Drugs End the Crisis?
GLP-1s Treat and Even Reverse Some Forms of Liver Disease
GLP-1 Agonists Reduce Recurrent Atrial Fibrillation
July-October 2017: CAR T-Cell Therapy Approved for Leukemia
The FDA approved tisagenlecleucel-T (Kymriah, Novartis) and soon after a xicabtagene ciloleucel (Yescarta, Kite Pharma), the first two CAR T-cell therapies in 2017, opening the door for personalized cancer treatment and further progress beyond treating blood cancers.
CARs Motor Through Leukemia, Part 2: 'Landscape Changing'
CAR T Cells and Beyond: Breakthroughs and Challenges Ahead
Outpatient CAR T: Safe, Effective, Accessible
Next-Gen CAR T-Cell Therapy: Expanding Beyond Blood Cancers
December 2020: mRNA Vaccines Approved
After effectiveness of the Pfizer and Moderna COVID vaccines was documented, the FDA granted emergency use of both vaccines within a week of each other. This opened the door for further mRNA usage, including potential cancer vaccines.
4 Things to Know About Moderna's mRNA Cancer Vaccine
New mRNA Vaccines in Development for Cancer and Infections
'Encouraging' Early Data for mRNA Vaccine in Glioblastoma
New mRNA Vaccine May Shield Against C difficile Infections
2023: FDA Approvals in Medical Artificial Intelligence (AI), Especially Diagnostics, Increase
While AI was not invented in 2023, that year became a tipping point in everything AI — from diagnostics to drug development to medical scribes, inspiring the first Medscape Physicians and AI Report, done annually since. A sampling of the flood of Medscape coverage:
Minding the Machine: Assessing the Case for AI Regulations in Healthcare
Harnessing FDA-Approved AI Technologies in Your Medical Practice
The Protein Problem: The Unsolved Mystery of AI Drug Dev
This Bill Could Make It Legal for AI to Prescribe Medicine
AI vs Physicians in 2050: Happy Future or No Future?
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