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Bladder Cancer Clinical Trials and Studies 2025: EMA, PDMA, FDA Approvals, Mechanism of Action, ROA, NDA, IND, and Companies

Bladder Cancer Clinical Trials and Studies 2025: EMA, PDMA, FDA Approvals, Mechanism of Action, ROA, NDA, IND, and Companies

Globe and Mail26-03-2025

DelveInsight's, 'Bladder Cancer Pipeline Insight 2025' report provides comprehensive insights about 80+ companies and 100+ pipeline drugs in the Bladder cancer pipeline landscape. It covers the Bladder Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Bladder Cancer pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Explore our latest breakthroughs in Bladder Cancer Research. Learn more about our innovative pipeline today! @ Bladder Cancer Pipeline Outlook
Key Takeaways from the Bladder Cancer Pipeline Report
In March 2025, Janssen Research & Development LLC announced a phase 2, Open-Label, Multi-Center, Randomized Study of TAR-200 in Combination With Cetrelimab and Cetrelimab Alone in Participants With Muscle-Invasive Urothelial Carcinoma of the Bladder Who Are Scheduled for Radical Cystectomy and Are Ineligible for or Refusing Platinum-Based Neoadjuvant Chemotherapy.
In March 2025, Fidia Farmaceutici announced a phase III, single-arm, multicenter, international study to assess the efficacy and safety of ONCOFID-P-B following intravesical instillation in adult patients with histologically and cytologically confirmed CIS, with or without concomitant Ta-T1, who are unresponsive to BCG therapy and unwilling or unfit to undergo radical cystectomy.
In March 2025, Merck Sharp & Dohme LLC announced a study are to learn if people who receive V940 and pembrolizumab are alive and cancer free longer than those who receive placebo and pembrolizumab, and to learn about the safety of V940, pembrolizumab, and EV, and if people tolerate them.
DelveInsight's Bladder Cancer pipeline report depicts a robust space with 80+ active players working to develop 100+ pipeline therapies for Bladder Cancer treatment.
The leading Bladder Cancer Companies such as UroGen Pharma Ltd., Asieris Pharmaceuticals, G1 Therapeutics, Inc., LintonPharm Co. Ltd., Vaxiion Therapeutics, Merck Sharp & Dohme LLC, CG Oncology, Inc., Ferring Pharmaceuticals, SURGE Therapeutics, Halozyme Therapeutics, ImmunityBio, Inc., AstraZeneca, Spectrum Pharmaceuticals, Inc., enGene, Inc., CicloMed LLC, Protara Therapeutics, Hoffmann-La Roche, Astellas Pharma Global Development, Inc., and Five Prime Therapeutics, Inc., and others.
Promising Bladder Cancer Therapies such as Atezolizumab, PGV001, VAX014, BCG Vaccine, Oncofid-P-B, Oncofid-P-B, and others.
Stay informed about the cutting-edge advancements in Bladder Cancer Treatments. Download for updates and be a part of the revolution in cancer care @ Bladder Cancer Clinical Trials Assessment
Bladder cancer Emerging Drugs Profile
UGN-102: UroGen Pharma Ltd.
UGN-102 (mitomycin) for intravesical solution is an investigational drug formulation of mitomycin. It is been developed by utilizing UroGen's proprietary RTGel® technology which is a sustained release, hydrogel-based formulation, UGN-102 is designed to enable longer exposure of bladder tissue to mitomycin, thereby enabling the treatment of tumors by non-surgical means. UGN-102 is delivered to patients using a standard urinary catheter in an outpatient setting. Currently it is in Phase III stage of clinical trial for the treatment of Bladder Cancer.
APL 1202 : Asieris Pharmaceuticals
APL-1202 is an orally available reversible MetAP2 Inhibitor with anti-angiogenic, anti-tumor activities and can also modulate tumor immune microenvironment. It is currently in registration clinical trials in China, either as single agent as first-line treatment for patients with intermediate-risk non-muscle invasive bladder cancer (NMIBC), or in combination with a chemotherapy as second-line treatment in patients with intermediate and high-risk chemo-refractory NMIBC. Currently, the drug is being evaluated in the Phase III stage for Bladder Cancer.
Trilaciclib: G1 Therapeutics, Inc.
Trilaciclib, is a first-in-class therapy designed to improve outcomes for people with cancer who are treated with chemotherapy. It is a transient IV-administered CDK4/6 inhibitor, a novel therapeutic approach which is given before chemotherapy that temporarily blocks progression through the cell cycle. Currently the drug is being evaluated in Phase II for the treatment of Bladder Cancer.
Catumaxomab: LintonPharm Co.,Ltd.
Catumaxomab is a bispecific antibody that binds to EpCAM (the epithelial cell adhesion molecule) on the tumor cell--and CD3 on the T cell, recruits immune accessory cells through FcγR binding at the same time. The drug kills tumor cells by engaging T cell and accessory cell mediated cytotoxicity and has the potential to induce long-term vaccinal effects which has been verified in animal models. The drug is in Phase I/II stage of clinical trials for the treatment of bladder cancer.
VAX 014: Vaxiion Therapeutics
VAX014 is a novel rBMC-based oncolytic immunotherapy. VAX014is a first-in-class tumor-targeted oncolytic agent based on Vaxiion's proprietary rBMC technology. It works by specifically targeting and delivering a novel fast-acting pre-formed oncolytic protein toxin directly to tumor cells that express either α3β1 or α5β1 integrin(s), both commonly found to be selectively expressed in many solid tumor types. The drug is in Phase I stage of clinical trials for the treatment of bladder cancer.
Learn more about Bladder Cancer Drugs opportunities in our groundbreaking Bladder Cancer Research and development projects @ Bladder Cancer Unmet Needs
Bladder Cancer Companies
UroGen Pharma Ltd., Asieris Pharmaceuticals, G1 Therapeutics, Inc., LintonPharm Co. Ltd., Vaxiion Therapeutics, Merck Sharp & Dohme LLC, CG Oncology, Inc., Ferring Pharmaceuticals, SURGE Therapeutics, Halozyme Therapeutics, ImmunityBio, Inc., AstraZeneca, Spectrum Pharmaceuticals, Inc., enGene, Inc., CicloMed LLC, Protara Therapeutics, Hoffmann-La Roche, Astellas Pharma Global Development, Inc., and Five Prime Therapeutics, Inc., and others.
Bladder cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration
Oral
Parenteral
Intravenous
Subcutaneous
Topical
Bladder Cancer Products have been categorized under various Molecule types such as
Monoclonal Antibody
Peptides
Polymer
Small molecule
Gene therapy
Discover the latest advancements in Bladder Cancer Treatment by visiting our website. Stay informed about how we're transforming the future of Oncology @ Bladder Cancer Market Drivers and Barriers, and Future Perspectives
Scope of the Bladder Cancer Pipeline Report
Coverage- Global
Bladder Cancer Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
Bladder Cancer Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
Bladder Cancer Companies- UroGen Pharma Ltd., Asieris Pharmaceuticals, G1 Therapeutics, Inc., LintonPharm Co. Ltd., Vaxiion Therapeutics, Merck Sharp & Dohme LLC, CG Oncology, Inc., Ferring Pharmaceuticals, SURGE Therapeutics, Halozyme Therapeutics, ImmunityBio, Inc., AstraZeneca, Spectrum Pharmaceuticals, Inc., enGene, Inc., CicloMed LLC, Protara Therapeutics, Hoffmann-La Roche, Astellas Pharma Global Development, Inc., and Five Prime Therapeutics, Inc., and others
Bladder Cancer Therapies- Atezolizumab, PGV001, VAX014, BCG Vaccine, Oncofid-P-B, Oncofid-P-B, and others.
For a detailed overview of our latest research findings and future plans, read the full details of Bladder Cancer Pipeline on our website @ Bladder Cancer Drugs and Companies
Table of Content
Introduction
Bladder Cancer Executive Summary
Bladder Cancer: Overview
Bladder Cancer Pipeline Therapeutics
Bladder Cancer Pipeline Therapeutic Assessment
Late Stage Products (Phase III)
UGN-102: UroGen Pharma Ltd.
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Trilaciclib: G1 Therapeutics, Inc.
Early Stage Products (Phase I)
VAX 014: Vaxiion Therapeutics
Inactive Products
Bladder Cancer Key Companies
Bladder Cancer Key Products
Bladder Cancer - Unmet Needs
Bladder Cancer - Market Drivers and Barriers
Bladder Cancer - Future Perspectives and Conclusion
Bladder Cancer Analyst Views
Bladder Cancer Key Companies
Appendix
About Us
DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.
Media Contact
Company Name: DelveInsight
Contact Person: Yash Bhardwaj
Email: Send Email
Phone: 09650213330
Address: 304 S. Jones Blvd #2432
City: Las Vegas
State: NV
Country: United States
Website: https://www.delveinsight.com/report-store/medical-marijuana-market-insight

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Ovarian Cancer Market Forecast to 2034: Advancing Treatment Frontiers and Epidemiological Shifts
Ovarian Cancer Market Forecast to 2034: Advancing Treatment Frontiers and Epidemiological Shifts

Globe and Mail

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  • Globe and Mail

Ovarian Cancer Market Forecast to 2034: Advancing Treatment Frontiers and Epidemiological Shifts

Ovarian cancer remains a significant global health challenge, often diagnosed at an advanced stage due to non-specific symptoms and a lack of effective early screening. It encompasses a spectrum of histological subtypes, including high-grade serous (HGSOC), low-grade serous (LGSOC), and epithelial tumors, each with unique biological and clinical features. High recurrence rates and poor long-term survival continue to drive the urgent need for improved treatment options and earlier detection. DelveInsight's latest report, ' Ovarian Cancer – Market Insight, Epidemiology, and Market Forecast – 2034,' provides a comprehensive overview of the disease's burden across the US, EU4 (Germany, France, Italy, Spain), the UK, and Japan. It offers in-depth segmentation by subtype, stage, age group, and biomarker status, alongside historical and projected epidemiological trends. 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Request a sample and uncover the latest breakthroughs shaping the Ovarian Cancer market landscape and future outlook Some of the key insights of the Ovarian Cancer Market Report: • In 2024, the ovarian cancer market in the 7MM was valued at USD 2.7 billion. • Market size is expected to grow with the launch of new ovarian cancer therapies. • The U.S. held the largest share, reaching USD 1.92 billion in 2024. • Total incident ovarian cancer cases in the 7MM were 61K in 2024. • The U.S. reported the highest number of high and low-grade serous ovarian cancer cases. • There were approximately 37.6K serous ovarian cancer cases in the 7MM in 2024. • In January 2025, IPS HEART received Orphan Drug Designation (ODD) from the FDA for GIVI-MPCs, recognizing their potential to create new muscle with full-length dystrophin in Becker Muscular Dystrophy (BMD). 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High-grade serous ovarian cancer (HGSOC), the most prevalent subtype, continues to be treated with a combination of surgery and platinum-based chemotherapy. However, the emergence of maintenance therapies—especially PARP inhibitors—has reshaped post-treatment strategies for patients with BRCA or HRD mutations, helping reduce recurrence rates and extend progression-free survival. The future of ovarian cancer care is increasingly personalized, with clinical trials exploring novel options like immunotherapy, vaccine-based approaches, and radiation strategies for advanced or recurrent disease. These innovations reflect a broader trend toward therapies tailored to molecular profiles and disease stage, moving away from one-size-fits-all treatment. However, disparities in access to care remain a major challenge. Socioeconomic, racial, and geographic barriers often limit timely diagnosis and appropriate treatment, particularly in underserved populations. 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About DelveInsight About DelveInsight DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform, PharmDelve. Media Contact Company Name: DelveInsight Contact Person: Jatin Vimal Email: Send Email Phone: +14699457679 Address: 304 S. Jones Blvd #2432 City: Las Vegas State: Nevada Country: United States Website:

S&P/TSX composite ends lower, U.S. stock markets mixed
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Winnipeg Free Press

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  • Winnipeg Free Press

S&P/TSX composite ends lower, U.S. stock markets mixed

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GICs are simple and safe – and a lousy way to build wealth
GICs are simple and safe – and a lousy way to build wealth

Globe and Mail

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  • Globe and Mail

GICs are simple and safe – and a lousy way to build wealth

This may be a naive question, but if I have $7,000 in cash to contribute to my tax-free savings account, why would I invest it in a dividend exchange-traded fund rather than a guaranteed investment certificate yielding 4 per cent to 4.5 per cent? GICs have their place in a well-balanced portfolio. Because their principal value doesn't fluctuate and their returns are guaranteed, they provide stability and peace of mind during periods of market volatility. That's why, for the fixed-income portion of one's portfolio, GICs are a good solution. However, that stability comes at a cost – several costs, actually. First, GICs don't offer any growth potential. If you invest in a five-year GIC that yields 4 per cent (a rate you'd be hard-pressed to find right now, by the way), you'll make 4 per cent annually – no more, no less. You'll feel like a genius if the stock market treads water or falls over that period, but if the market rises substantially, that GIC won't look nearly so appealing. History has clearly favoured stocks over GICs. Over the past decade, the S&P/TSX Composite Index has posted an annualized total return of about 9 per cent, including dividends. No GIC can keep up with that. True, the stock market had plenty of ups and downs over that period, but volatility is the price investors pay for the superior returns that stocks deliver. Your dividend and DRIP questions answered The financial – and emotional – benefits of dividend ETFs A second drawback is that GICs lock up your money for a fixed period. If you need the cash to buy a new car or replace your furnace, you won't be able to access your funds (exceptions are sometimes made in unusual circumstances, depending on the financial institution). For that reason, you should only purchase a GIC if you're certain you won't need the funds before the maturity date. A third downside of GICs is that the interest is taxed at your full marginal rate. This isn't a factor in a TFSA, registered retirement savings plan or other registered account in which investment earnings are not subject to tax. But in a non-registered account, the tax hit on interest tops out at more than 50 per cent in most provinces for the highest income bracket. On an after-tax basis, GICs may not even keep up with inflation. Dividend stocks and dividend ETFs don't have the same drawbacks. In addition to providing the potential for capital appreciation, dividend stocks and ETFs also typically increase their income over time. Many companies – such as banks, utilities and power producers – have been raising their dividends for years, driven by their growing earnings, out of which dividends are paid. The yield of a GIC, on the other hand, is fixed. Stocks and ETFs are also more liquid than GICs. If you need the money for an unexpected expense, you can always sell a portion of your holdings. Finally, dividend stocks and ETFs also win in the tax department. Thanks to the dividend tax credit, the income from dividends is generally taxed at much lower rates than interest from a GIC. In Ontario, for example, someone with $100,000 of income would pay combined federal and provincial tax of 31.48 per cent on interest but just 8.92 per cent on eligible dividends. In the lowest income brackets, the tax rate on dividends is actually negative in many provinces. According to an Ontario resident with taxable income of $52,886 or less would have an effective tax rate on eligible dividends of negative 7.55 per cent for 2025. Because the dividend tax credit is a non-refundable credit, the government won't send you a cheque for the negative amount, but you can use the credit to offset your other taxes owing. Let me be clear: I am not trying to steer you away from GICs. I own them myself. They are especially useful if you are saving for a large future expense, such as a home purchase or a child's postsecondary education, and don't want to put your principal at risk. Many investors also use GICs for the fixed-income portion of a balanced portfolio. Building a GIC 'ladder' – with maturities ranging from one to five years – can be a useful way to diversify your GIC holdings and control your interest rate risk. When the one-year GIC matures, you would roll the proceeds into a new five-year GIC, and so on. But for long-term growth of both capital and income, stocks and ETFs are the clear winner. So don't let your desire for safety prevent you from enjoying the historically higher returns that stocks offer. E-mail your questions to jheinzl@ I'm not able to respond personally to e-mails but I choose certain questions to answer in my column.

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