What's next for kids' health in Australia?
At a lab bench in Western Australia, researchers are working on a vaccine that could save millions of lives. Another team is working hard to find less toxic and better treatments for children's cancer, and simultaneously, work on therapies to combat antimicrobial resistance and reduce the incidence of respiratory syncytial virus (RSV) in young babies is underway. These scenes are part of the everyday mission at The Kids Research Institute Australia, where research is transformed into real-world solutions.
Now, with a bold new ten-year strategy, 'Research Reimagined', the Institute is setting its sights even higher.
For 35 years, The Kids (formerly Telethon Kids Institute) has been at the forefront of children's health research, tackling the most pressing health and wellbeing challenges facing young people. Its latest strategy signals a pivotal shift, not just in what it aims to achieve, but how it intends to achieve it.
'We want to establish a pipeline of breakthrough discoveries,' Executive Director of The Kids Research Institute Professor Jonathan Carapetis said. 'But we want to do this in true partnership with our community, our corporate and philanthropic supporters, government and industry.'
The ambition is clear: bold science, global impact, and a commitment to solving the biggest problems for kids and families.
The work happening inside the Institute's labs is extraordinary and broad ranging, but it doesn't stop at medicine. The Institute is deeply engaged in the everyday realities of children's lives.
'Our researchers are also using science and data to help inform governments and service providers on policies and programs,' Professor Carapetis said. 'This includes using evidence from our research to develop best practice programs for physical activity for children under four, and to illustrate the impact of skipping breakfast on kids' school results.'
These findings go beyond data to become actionable programs and policy, helping to shape healthier futures for children across Australia and around the world.
Though headquartered in Perth, The Kids Research Institute is a national and global leader.
'We're known for major public health wins, like reducing neural tube defects by introducing folate into bread or creating the roadmap to eliminate rheumatic heart disease in Australia,' Professor Carapetis said. 'And we're leading the world in accelerating vaccines for Strep A.'
WA's collaborative health and research landscape, along with strong community support through initiatives like Telethon, is ideal for this kind of innovation. It's no coincidence that some of the most significant advances in children's health are being spearheaded right here.
Crucially, Research Reimagined puts equity front and centre. 'While our vision is for all kids to be happy and healthy, it is our duty to ensure that those who have the poorest outcomes receive proportionately more benefits from research,' Professor Carapetis said.
That includes a strong focus on Indigenous child health. The Institute aims to become the world's leading Indigenous child health research organisation, a goal built on deep, sustained partnerships with First Nations communities.
'We believe these partnerships provide pathways to improved outcomes for kids not just in Australia, but globally.'
At its heart, The Kids is powered by a single purpose: giving every child the chance to live a full, healthy life. With Research Reimagined, that mission has entered a new era, where scientific excellence meets social responsibility, and where WA remains at the forefront of a global movement.
The Kids Research Institute Australia is about giving children the best possible chance to grow, thrive, and enjoy life. And with every discovery, they're turning that vision into reality, one child at a time. To find out more,
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The Advertiser
3 days ago
- The Advertiser
Winter viruses can trigger a heart attack or stroke, our study shows
Winter is here, along with cold days and the inevitable seasonal surge in respiratory viruses. But it's not only the sniffles we need to worry about. Heart attacks and strokes also tend to rise during the winter months. In new research out this week we show one reason why. Our study shows catching common respiratory viruses raises your short-term risk of a heart attack or stroke. In other words, common viruses, such as those that cause flu and COVID, can trigger them. Traditional risk factors such as smoking, high cholesterol, high blood pressure, diabetes, obesity and lack of exercise are the main reasons for heart attacks and strokes. And rates of heart attacks and strokes can rise in winter for a number of reasons. Factors such as low temperature, less physical activity, more time spent indoors - perhaps with indoor air pollutants - can affect blood clotting and worsen the effects of traditional risk factors. But our new findings build on those from other researchers to show how respiratory viruses can also be a trigger. The theory is respiratory virus infections set off a heart attack or stroke, rather than directly cause them. If traditional risk factors are like dousing a house in petrol, the viral infection is like the matchstick that ignites the flame. For healthy, young people, a newer, well-kept house is unlikely to spontaneously combust. But an older or even abandoned house with faulty electric wiring needs just a spark to lead to a blaze. People who are particularly vulnerable to a heart attack or stroke triggered by a respiratory virus are those with more than one of those traditional risk factors, especially older people. Our team conducted a meta-analysis (a study of existing studies) to see which respiratory viruses play a role in triggering heart attacks and strokes, and the strength of the link. This meant studying more than 11,000 scientific papers, spanning 40 years of research. Overall, the influenza virus and SARS-CoV-2 (the virus that causes COVID) were the main triggers. If you catch the flu, we found the risk of a heart attack goes up almost 5.4 times and a stroke by 4.7 times compared with not being infected. The danger zone is short - within the first few days or weeks - and tapers off with time after being infected. Catching COVID can also trigger heart attacks and strokes, but there haven't been enough studies to say exactly what the increased risk is. We also found an increased risk of heart attacks or strokes with other viruses, including respiratory syncytial virus (RSV), enterovirus and cytomegalovirus. But the links are not as strong, probably because these viruses are less commonly detected or tested for. Over a person's lifetime, our bodies wear and tear and the inside wall of our blood vessels becomes rough. Fatty build-ups (plaques) stick easily to these rough areas, inevitably accumulating and causing tight spaces. Generally, blood can still pass through, and these build-ups don't cause issues. Think of this as dousing the house in petrol, but it's not yet alight. So how does a viral infection act like a matchstick to ignite the flame? Through a cascading process of inflammation. High levels of inflammation that follow a viral infection can crack open a plaque. The body activates blood clotting to fix the crack but this clot could inadvertently block a blood vessel completely, causing a heart attack or stroke. Some studies have found fragments of the COVID virus inside the blood clots that cause heart attacks - further evidence to back our findings. We don't know whether younger, healthier people are also at increased risk of a heart attack or stroke after infection with a respiratory virus. That's because people in the studies we analysed were almost always older adults with at least one of those traditional risk factors, so were already vulnerable. The bad news is we will all be vulnerable eventually, just by getting older. The triggers we identified are mostly preventable by vaccination. There is good evidence from clinical trials the flu vaccine can reduce the risk of a heart attack or stroke, especially if someone already has heart problems. We aren't clear exactly how this works. But the theory is that avoiding common infections, or having less severe symptoms, reduces the chances of setting off the inflammatory chain reaction. COVID vaccination could also indirectly protect against heart attacks and strokes. But the evidence is still emerging. Heart attacks and strokes are among Australia's biggest killers. If vaccinations could help reduce even a small fraction of people having a heart attack or stroke, this could bring substantial benefit to their lives, the community, our stressed health system and the economy. At-risk groups should get vaccinated against flu and COVID. Pregnant women, and people over 60 with medical problems, should receive RSV vaccination to reduce their risk of severe disease. So if you are older or have predisposing medical conditions, check Australia's National Immunisation Program to see if you are eligible for a free vaccine. For younger people, a healthy lifestyle with regular exercise and balanced diet will set you up for life. Consider checking your heart age (a measure of your risk of heart disease), getting an annual flu vaccine and discuss COVID boosters with your GP. Winter is here, along with cold days and the inevitable seasonal surge in respiratory viruses. But it's not only the sniffles we need to worry about. Heart attacks and strokes also tend to rise during the winter months. In new research out this week we show one reason why. Our study shows catching common respiratory viruses raises your short-term risk of a heart attack or stroke. In other words, common viruses, such as those that cause flu and COVID, can trigger them. Traditional risk factors such as smoking, high cholesterol, high blood pressure, diabetes, obesity and lack of exercise are the main reasons for heart attacks and strokes. And rates of heart attacks and strokes can rise in winter for a number of reasons. Factors such as low temperature, less physical activity, more time spent indoors - perhaps with indoor air pollutants - can affect blood clotting and worsen the effects of traditional risk factors. But our new findings build on those from other researchers to show how respiratory viruses can also be a trigger. The theory is respiratory virus infections set off a heart attack or stroke, rather than directly cause them. If traditional risk factors are like dousing a house in petrol, the viral infection is like the matchstick that ignites the flame. For healthy, young people, a newer, well-kept house is unlikely to spontaneously combust. But an older or even abandoned house with faulty electric wiring needs just a spark to lead to a blaze. People who are particularly vulnerable to a heart attack or stroke triggered by a respiratory virus are those with more than one of those traditional risk factors, especially older people. Our team conducted a meta-analysis (a study of existing studies) to see which respiratory viruses play a role in triggering heart attacks and strokes, and the strength of the link. This meant studying more than 11,000 scientific papers, spanning 40 years of research. Overall, the influenza virus and SARS-CoV-2 (the virus that causes COVID) were the main triggers. If you catch the flu, we found the risk of a heart attack goes up almost 5.4 times and a stroke by 4.7 times compared with not being infected. The danger zone is short - within the first few days or weeks - and tapers off with time after being infected. Catching COVID can also trigger heart attacks and strokes, but there haven't been enough studies to say exactly what the increased risk is. We also found an increased risk of heart attacks or strokes with other viruses, including respiratory syncytial virus (RSV), enterovirus and cytomegalovirus. But the links are not as strong, probably because these viruses are less commonly detected or tested for. Over a person's lifetime, our bodies wear and tear and the inside wall of our blood vessels becomes rough. Fatty build-ups (plaques) stick easily to these rough areas, inevitably accumulating and causing tight spaces. Generally, blood can still pass through, and these build-ups don't cause issues. Think of this as dousing the house in petrol, but it's not yet alight. So how does a viral infection act like a matchstick to ignite the flame? Through a cascading process of inflammation. High levels of inflammation that follow a viral infection can crack open a plaque. The body activates blood clotting to fix the crack but this clot could inadvertently block a blood vessel completely, causing a heart attack or stroke. Some studies have found fragments of the COVID virus inside the blood clots that cause heart attacks - further evidence to back our findings. We don't know whether younger, healthier people are also at increased risk of a heart attack or stroke after infection with a respiratory virus. That's because people in the studies we analysed were almost always older adults with at least one of those traditional risk factors, so were already vulnerable. The bad news is we will all be vulnerable eventually, just by getting older. The triggers we identified are mostly preventable by vaccination. There is good evidence from clinical trials the flu vaccine can reduce the risk of a heart attack or stroke, especially if someone already has heart problems. We aren't clear exactly how this works. But the theory is that avoiding common infections, or having less severe symptoms, reduces the chances of setting off the inflammatory chain reaction. COVID vaccination could also indirectly protect against heart attacks and strokes. But the evidence is still emerging. Heart attacks and strokes are among Australia's biggest killers. If vaccinations could help reduce even a small fraction of people having a heart attack or stroke, this could bring substantial benefit to their lives, the community, our stressed health system and the economy. At-risk groups should get vaccinated against flu and COVID. Pregnant women, and people over 60 with medical problems, should receive RSV vaccination to reduce their risk of severe disease. So if you are older or have predisposing medical conditions, check Australia's National Immunisation Program to see if you are eligible for a free vaccine. For younger people, a healthy lifestyle with regular exercise and balanced diet will set you up for life. Consider checking your heart age (a measure of your risk of heart disease), getting an annual flu vaccine and discuss COVID boosters with your GP. Winter is here, along with cold days and the inevitable seasonal surge in respiratory viruses. But it's not only the sniffles we need to worry about. Heart attacks and strokes also tend to rise during the winter months. In new research out this week we show one reason why. Our study shows catching common respiratory viruses raises your short-term risk of a heart attack or stroke. In other words, common viruses, such as those that cause flu and COVID, can trigger them. Traditional risk factors such as smoking, high cholesterol, high blood pressure, diabetes, obesity and lack of exercise are the main reasons for heart attacks and strokes. And rates of heart attacks and strokes can rise in winter for a number of reasons. Factors such as low temperature, less physical activity, more time spent indoors - perhaps with indoor air pollutants - can affect blood clotting and worsen the effects of traditional risk factors. But our new findings build on those from other researchers to show how respiratory viruses can also be a trigger. The theory is respiratory virus infections set off a heart attack or stroke, rather than directly cause them. If traditional risk factors are like dousing a house in petrol, the viral infection is like the matchstick that ignites the flame. For healthy, young people, a newer, well-kept house is unlikely to spontaneously combust. But an older or even abandoned house with faulty electric wiring needs just a spark to lead to a blaze. People who are particularly vulnerable to a heart attack or stroke triggered by a respiratory virus are those with more than one of those traditional risk factors, especially older people. Our team conducted a meta-analysis (a study of existing studies) to see which respiratory viruses play a role in triggering heart attacks and strokes, and the strength of the link. This meant studying more than 11,000 scientific papers, spanning 40 years of research. Overall, the influenza virus and SARS-CoV-2 (the virus that causes COVID) were the main triggers. If you catch the flu, we found the risk of a heart attack goes up almost 5.4 times and a stroke by 4.7 times compared with not being infected. The danger zone is short - within the first few days or weeks - and tapers off with time after being infected. Catching COVID can also trigger heart attacks and strokes, but there haven't been enough studies to say exactly what the increased risk is. We also found an increased risk of heart attacks or strokes with other viruses, including respiratory syncytial virus (RSV), enterovirus and cytomegalovirus. But the links are not as strong, probably because these viruses are less commonly detected or tested for. Over a person's lifetime, our bodies wear and tear and the inside wall of our blood vessels becomes rough. Fatty build-ups (plaques) stick easily to these rough areas, inevitably accumulating and causing tight spaces. Generally, blood can still pass through, and these build-ups don't cause issues. Think of this as dousing the house in petrol, but it's not yet alight. So how does a viral infection act like a matchstick to ignite the flame? Through a cascading process of inflammation. High levels of inflammation that follow a viral infection can crack open a plaque. The body activates blood clotting to fix the crack but this clot could inadvertently block a blood vessel completely, causing a heart attack or stroke. Some studies have found fragments of the COVID virus inside the blood clots that cause heart attacks - further evidence to back our findings. We don't know whether younger, healthier people are also at increased risk of a heart attack or stroke after infection with a respiratory virus. That's because people in the studies we analysed were almost always older adults with at least one of those traditional risk factors, so were already vulnerable. The bad news is we will all be vulnerable eventually, just by getting older. The triggers we identified are mostly preventable by vaccination. There is good evidence from clinical trials the flu vaccine can reduce the risk of a heart attack or stroke, especially if someone already has heart problems. We aren't clear exactly how this works. But the theory is that avoiding common infections, or having less severe symptoms, reduces the chances of setting off the inflammatory chain reaction. COVID vaccination could also indirectly protect against heart attacks and strokes. But the evidence is still emerging. Heart attacks and strokes are among Australia's biggest killers. If vaccinations could help reduce even a small fraction of people having a heart attack or stroke, this could bring substantial benefit to their lives, the community, our stressed health system and the economy. At-risk groups should get vaccinated against flu and COVID. Pregnant women, and people over 60 with medical problems, should receive RSV vaccination to reduce their risk of severe disease. So if you are older or have predisposing medical conditions, check Australia's National Immunisation Program to see if you are eligible for a free vaccine. For younger people, a healthy lifestyle with regular exercise and balanced diet will set you up for life. Consider checking your heart age (a measure of your risk of heart disease), getting an annual flu vaccine and discuss COVID boosters with your GP. Winter is here, along with cold days and the inevitable seasonal surge in respiratory viruses. But it's not only the sniffles we need to worry about. Heart attacks and strokes also tend to rise during the winter months. In new research out this week we show one reason why. Our study shows catching common respiratory viruses raises your short-term risk of a heart attack or stroke. In other words, common viruses, such as those that cause flu and COVID, can trigger them. Traditional risk factors such as smoking, high cholesterol, high blood pressure, diabetes, obesity and lack of exercise are the main reasons for heart attacks and strokes. And rates of heart attacks and strokes can rise in winter for a number of reasons. Factors such as low temperature, less physical activity, more time spent indoors - perhaps with indoor air pollutants - can affect blood clotting and worsen the effects of traditional risk factors. But our new findings build on those from other researchers to show how respiratory viruses can also be a trigger. The theory is respiratory virus infections set off a heart attack or stroke, rather than directly cause them. If traditional risk factors are like dousing a house in petrol, the viral infection is like the matchstick that ignites the flame. For healthy, young people, a newer, well-kept house is unlikely to spontaneously combust. But an older or even abandoned house with faulty electric wiring needs just a spark to lead to a blaze. People who are particularly vulnerable to a heart attack or stroke triggered by a respiratory virus are those with more than one of those traditional risk factors, especially older people. Our team conducted a meta-analysis (a study of existing studies) to see which respiratory viruses play a role in triggering heart attacks and strokes, and the strength of the link. This meant studying more than 11,000 scientific papers, spanning 40 years of research. Overall, the influenza virus and SARS-CoV-2 (the virus that causes COVID) were the main triggers. If you catch the flu, we found the risk of a heart attack goes up almost 5.4 times and a stroke by 4.7 times compared with not being infected. The danger zone is short - within the first few days or weeks - and tapers off with time after being infected. Catching COVID can also trigger heart attacks and strokes, but there haven't been enough studies to say exactly what the increased risk is. We also found an increased risk of heart attacks or strokes with other viruses, including respiratory syncytial virus (RSV), enterovirus and cytomegalovirus. But the links are not as strong, probably because these viruses are less commonly detected or tested for. Over a person's lifetime, our bodies wear and tear and the inside wall of our blood vessels becomes rough. Fatty build-ups (plaques) stick easily to these rough areas, inevitably accumulating and causing tight spaces. Generally, blood can still pass through, and these build-ups don't cause issues. Think of this as dousing the house in petrol, but it's not yet alight. So how does a viral infection act like a matchstick to ignite the flame? Through a cascading process of inflammation. High levels of inflammation that follow a viral infection can crack open a plaque. The body activates blood clotting to fix the crack but this clot could inadvertently block a blood vessel completely, causing a heart attack or stroke. Some studies have found fragments of the COVID virus inside the blood clots that cause heart attacks - further evidence to back our findings. We don't know whether younger, healthier people are also at increased risk of a heart attack or stroke after infection with a respiratory virus. That's because people in the studies we analysed were almost always older adults with at least one of those traditional risk factors, so were already vulnerable. The bad news is we will all be vulnerable eventually, just by getting older. The triggers we identified are mostly preventable by vaccination. There is good evidence from clinical trials the flu vaccine can reduce the risk of a heart attack or stroke, especially if someone already has heart problems. We aren't clear exactly how this works. But the theory is that avoiding common infections, or having less severe symptoms, reduces the chances of setting off the inflammatory chain reaction. COVID vaccination could also indirectly protect against heart attacks and strokes. But the evidence is still emerging. Heart attacks and strokes are among Australia's biggest killers. If vaccinations could help reduce even a small fraction of people having a heart attack or stroke, this could bring substantial benefit to their lives, the community, our stressed health system and the economy. At-risk groups should get vaccinated against flu and COVID. Pregnant women, and people over 60 with medical problems, should receive RSV vaccination to reduce their risk of severe disease. So if you are older or have predisposing medical conditions, check Australia's National Immunisation Program to see if you are eligible for a free vaccine. For younger people, a healthy lifestyle with regular exercise and balanced diet will set you up for life. Consider checking your heart age (a measure of your risk of heart disease), getting an annual flu vaccine and discuss COVID boosters with your GP.
Perth Now
3 days ago
- Perth Now
Visit from Aussie vet lifts spirits of young patients at PCH
A well-timed visit from vet and TV personality Chris Brown lifted the spirits of young patients at Perth Children's Hospital on Thursday. Dr Brown popped into the ward, alongside support dog Murphy, with Telethon gifts in hand as he chatted to youngsters like Kate Wagner. The 16-year-old has been in hospital for more than a year following a severe bacterial meningitis infection in May last year. She has been battling a serious central nervous system infection since, and is often in a lot of pain. Kate and Dr Brown bonded over their love of kelpies, discovering they both own the breed. Missing her own pup back home, Kate showered cavoodle Murphy with all the pats and scratches. 'It's really good (having support dogs at PCH) because a lot of the time you can't go outside,' she said. 'So, even bringing up my own dogs, I can't go see them or anything . . . there's weeks at a time I can't see a dog — I'm dog deprived!' Kate's mum, Jo Wagner, said they found out just hours before the visit that Kate had had a stroke sometime in the past few days. Channel 7's Dr Chris Brown with Kate Wagner. Credit: Kelsey Reid / The West Australian It means she's due to start another gruelling round of treatment to try get her infection under control. 'It's just awesome, the joy that it gives kids. Kate's got the biggest smile on her face,' Ms Wagner said. 'It's so hard because she's really sick, she's in so much pain, and so . . . it's just beautiful . . . animals just do something, (they) bring joy.' Channel 7's Dr Chris Brown pictured with PCH volunteer Moira Bancroft and two Captain Starlight volunteers. Credit: Kelsey Reid / The West Australian Dr Brown said it was a pleasure to see kids doing it tough in hospital 'embrace something different in their day'. 'Often the kids in here have pets at home they're missing. So dogs like Murphy become sort of that temporary replacement pet for them, to have a pat and just to feel that little touch of unconditional love again,' Dr Brown said. Telethon weekend is October 18 and 19.
West Australian
3 days ago
- West Australian
Australian vet Dr Chris Brown visits young patients at Perth Children's Hospital with support dog Murphy
A well-timed visit from vet and TV personality Chris Brown lifted the spirits of young patients at Perth Children's Hospital on Thursday. Dr Brown popped into the ward, alongside support dog Murphy, with Telethon gifts in hand as he chatted to youngsters like Kate Wagner. The 16-year-old has been in hospital for more than a year following a severe bacterial meningitis infection in May last year. She has been battling a serious central nervous system infection since, and is often in a lot of pain. Kate and Dr Brown bonded over their love of kelpies, discovering they both own the breed. Missing her own pup back home, Kate showered cavoodle Murphy with all the pats and scratches. 'It's really good (having support dogs at PCH) because a lot of the time you can't go outside,' she said. 'So, even bringing up my own dogs, I can't go see them or anything . . . there's weeks at a time I can't see a dog — I'm dog deprived!' Kate's mum, Jo Wagner, said they found out just hours before the visit that Kate had had a stroke sometime in the past few days. It means she's due to start another gruelling round of treatment to try get her infection under control. 'It's just awesome, the joy that it gives kids. Kate's got the biggest smile on her face,' Ms Wagner said. 'It's so hard because she's really sick, she's in so much pain, and so . . . it's just beautiful . . . animals just do something, (they) bring joy.' Dr Brown said it was a pleasure to see kids doing it tough in hospital 'embrace something different in their day'. 'Often the kids in here have pets at home they're missing. So dogs like Murphy become sort of that temporary replacement pet for them, to have a pat and just to feel that little touch of unconditional love again,' Dr Brown said. Telethon weekend is October 18 and 19.
