Latest news with #multinational
Medscape
a day ago
- Health
- Medscape
RIPC Shows No Benefit in Noncardiac Surgery
TOPLINE: The application of remote ischemic preconditioning (RIPC), a noninvasive technique used to induce brief episodes of limb ischemia and reperfusion, did not reduce the rates of postoperative myocardial injury and other complications compared with sham RIPC among patients undergoing high- or intermediate-risk noncardiac surgery. METHODOLOGY: Researchers conducted a large, multinational randomized controlled trial (PRINCE) to assess whether RIPC reduces myocardial injury and other complications in high-risk adults undergoing noncardiac surgery. They included 1213 patients (mean age, 70 years; 60% men) undergoing intermediate- or high-risk noncardiac surgical procedures under general anesthesia across 25 hospitals in eight countries. The participants were randomly assigned to receive either RIPC or sham RIPC. The RIPC intervention consisted of three 5-minute cycles of ischemia induced by inflating a blood pressure cuff to 200 mm Hg, with each cycle followed by 5 minutes of reperfusion while the cuff was deflated. The primary outcome was the rate of postoperative myocardial injury, defined by serum cardiac troponin levels exceeding the 99th percentile of the reference limit. TAKEAWAY: The occurrence of myocardial injury did not differ significantly between patients in the RIPC group and those in the sham RIPC group (relative risk, 1.02; P = .84). The number of patients presenting with postoperative troponin values five times above the 99th percentile was not significantly different between the RIPC and sham-RIPC groups. Additionally, prespecified adverse events did not differ significantly between the groups, except for 30-day hospital readmission rates (6% vs 3.5%), and episodes of limb petechiae (1.7% vs 0.2%), which were significantly more frequent in the RIPC group than in the sham RIPC group. IN PRACTICE: 'In contrast to previous findings, the PRINCE trial provides robust evidence of the absence of beneficial effects of RIPC on biochemical and clinical outcomes in high- and intermediate-risk noncardiac surgery patients,' the authors wrote. SOURCE: The study was led by Massimiliano Greco, MD, of Humanitas University in Pieve Emanuele, Italy. It was published online on June 13, 2025, in Circulation. LIMITATIONS: The study did not protocolize anesthesia induction. Preoperative troponin levels were not measured. Additionally, as most participants were from high-income European countries, the findings may have limited generalizability to low- and middle-income settings. DISCLOSURES: This study was funded by the Italian Ministry of Health. The authors declared having no conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Medscape
4 days ago
- Health
- Medscape
Is This Drug a Statin Alternative?
Monotherapy with inclisiran — an injectable small interfering RNA that targets hepatic proprotein convertase subtilisin/kexin type 9 (PCSK9) — reduced levels of low-density lipoprotein (LDL) cholesterol more effectively than placebo or ezetimibe in patients at a low-to-borderline risk for atherosclerotic cardiovascular disease who were not receiving any lipid-lowering therapy, with a favorable safety profile. METHODOLOGY: Previous studies have shown the efficacy of inclisiran in lowering the level of LDL cholesterol when used in combination with statins in patients with a high risk for atherosclerosis; however, its efficacy as a monotherapy without statins remains uncertain. Researchers conducted a 6-month multinational, randomized, phase 3 study to compare the efficacy and safety of inclisiran with those of placebo or ezetimibe in reducing levels of LDL cholesterol. They included 350 participants (mean age, 46.1 years; 62.6% women) with no history of atherosclerotic cardiovascular disease , diabetes, or familial hypercholesterolemia and a fasting LDL cholesterol level of 100-190 mg/dL. Participants were randomly assigned to receive subcutaneous inclisiran (n = 174), oral ezetimibe (n = 89), or matching placebo (n = 87), with inclisiran administered on days 1 and 90. The primary endpoint was the percentage change in the level of LDL cholesterol from baseline to day 150; several secondary endpoints, including the absolute change in LDL and safety, were assessed. TAKEAWAY: By day 150, participants who received inclisiran showed a 47.9% greater reduction in the level of LDL cholesterol than those who received placebo and a 35.4% greater reduction than those who received ezetimibe ( P < .0001 for both). < .0001 for both). The absolute reduction in the level of LDL cholesterol and the percentage reduction in PCSK9 levels were also greater in participants who received inclisiran than in those who received placebo or ezetimibe ( P < .0001 for all). < .0001 for all). In the group who received inclisiran, levels of lipoprotein(a) decreased by 25.2% compared with placebo ( P = .001) and by 24.3% compared with ezetimibe ( P = .0002) by day 150. = .001) and by 24.3% compared with ezetimibe ( = .0002) by day 150. Similar rates of treatment-emergent adverse events were noted across the three groups, with no new safety concerns. IN PRACTICE: 'There is a significant unmet clinical need for therapies that address both statin intolerance and adherence in primary prevention,' the researchers noted. 'Inclisiran is potentially uniquely positioned to meet these challenges owing to its first-in-class mechanism of action, favorable safety profile, and infrequent twice-yearly dosing,' they added. SOURCE: This study was led by Pam R. Taub, MD, of the University of California in San Diego. It was published online on June 9, 2025, in Journal of the American College of Cardiology . LIMITATIONS: A short follow-up duration and limited sample size prevented the researchers from evaluating the cardiovascular outcomes of lowering the level of LDL cholesterol with inclisiran. The analysis lacked direct comparison with statins, anti-PCSK9 monoclonal antibodies, or bempedoic acid. The response of LDL with ezetimibe was lower than that observed in other studies. DISCLOSURES: This study received funding from Novartis Pharma. Two authors reported receiving compensation for serving as principal investigators of this trial, and another author reported serving as a consultant for multiple pharmaceutical companies including the funding agency. Several other authors reported serving as employees of the US or Switzerland wings of the funding agency or being principal investigator, consultants, and/or holding shares in the same.
Yahoo
6 days ago
- Business
- Yahoo
Gates Industrial (GTES) Gets Target Hike as Margin Expansion Confidence Grows
Gates Industrial Chemical Corporation (NYSE:GTES) is one of the 8 cheap beginner stocks to buy right now. Jeffrey Hammond, a KeyBanc analyst, raised his price target for Gates Industrial Chemical Corporation (NYSE:GTES) from $23 to $26 on June 9 while maintaining the stock's rating of Overweight. This decision comes after meetings with investors and meetings with Ivo Jurek, the company's CEO. Gates Industrial is effectively controlling manageable elements to boost earnings without depending on higher volume, even as demand trends are erratic. By innovating and gaining market share, the company is also appears to be growing in its markets. Even in the absence of a notable end-market rebound, Hammond stated he is now more confident that Gates Industrial Chemical Corporation (NYSE:GTES) will be able to meet its margin targets by the end of 2026. This confidence is a result of the company's proven ability to improve profit margins and penetrate more markets. Gates Industrial Chemical Corporation (NYSE:GTES) is a multinational producer of fluid power and power transmission solutions. The company supplies products to original equipment manufacturers (OEMs) as well as replacement channel clients in a variety of industrial and consumer markets. While we acknowledge the potential of GTES as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you're looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock. Read More: and Disclosure: None.
Zawya
12-06-2025
- Business
- Zawya
Why Pan-African investment corridors are needed?
The world is changing – and so fast that it is not waiting for Africa. In the past decade, leading economies in the West quietly shifted their global focus from the ideals of economic integration and soft power diplomacy to policies anchored on technological sovereignty, national security, and internal economic resilience. The transition from the post-Cold War 'peace dividend' to a 'defence dividend' mindset signals a more fragmented, competitive and militarised global economy. These developments represent both a risk and opportunity for Africa. The unfolding changes present great investment opportunities for Africa, such as emerging and old powers restructuring supply chains, looking out for new markets and sources of critical minerals and input. The continent's abundant resources, growing markets, and youthful population position it as a promising region for long-term investors. Multinational companies keen to reduce dependence on single-source suppliers in Asia and Europe will find Africa as an additional and strategic option. The continent will remain a central pole in the emerging multipolar world as the global race for critical minerals such as lithium, cobalt and rare earths gains pace to power new technologies and energy value chains. Despite optimism, Africa stands at a critical crossroads. Major power reorientation intersects with ongoing economic fragilities, budget cuts, increased debt challenges and political uncertainties. Read: Will Africa's financial stability fund rise to the debt challenge?African economies already behind in the digital divide risk further marginalisation as major powers accelerate economic nationalism and seek to hoard strategic technologies. The European Union's Green Deal Industrial Plan favours its own industries through provision of predictable regulatory framework and grant subsidies to facilitate green transition. On the other hand, the United States of America's Inflation Reduction Act aims to bring home critical supply chains to outcompete external actors. Africa is ill prepared to prop up its own domestic industries, to navigate the raising barriers for exports from the continent. The militarisation of the global economy is likely to motivate capital away from start-ups and Small and Medium Sized Enterprises that were power solutions for Africa to security related initiatives. It is a wakeup call for Africa. Time is ripe for the continent to accelerate its brilliant plans developed over decades. The plans include the Lagos Plan of Action, The New Economic Partnership for African Development (Nepad) and the African Union Agenda 2063 to drive economic development. The African Continental Free Trade Area promises to create one of the world's largest markets of over 1.4 billion people. Africa must rethink its development models away from aid dependency to catalysing productivity and domestic revenue mobilisation. The continent must strengthen regional economic blocks as strategic building nodes for the continental free trade area. An intentional and deliberate investment in the youthful demographics to gain access to science, technology, engineering and mathematics (STEM) education, local innovation hubs and participate in research and development. Read: Future of business in Africa will be shaped by partnershipsAfrica's future growth is closely tied to its ability to integrate markets by leveraging the regional economic communities such as Economic Community of West African States (Ecowas), Southern African Development Community (SADC), East African Community (EAC) and Common Market for Eastern and Southern Africa (Comesa). The African Union (AU) should create pan-African investment corridors rather than the current individual nation-state approaches. The region should articulate a continental doctrine for security engagement based on a pan-African security strategy to resist fragmented bilateral defence deals. As global investors reallocate capital to the environmental, social and governance (ESG) aligned portfolios, Africa offers compelling opportunity in its renewable assets. Africa's wakeup call is an invitation to investors both local and international who are willing and ready to take a long-term view to build partnerships, as well as align with the continent's ambitions to tap into demographic growth, resource abundance, digital transformation and regional integration. For this to work, Africa must initiate a multipolar balancing act that leverages competition for maximum benefit. © Copyright 2022 Nation Media Group. All Rights Reserved. Provided by SyndiGate Media Inc. (
Fast Company
10-06-2025
- Business
- Fast Company
17 ways global team leaders can balance consistency and regional autonomy
For managers overseeing teams across multiple countries, striking the right balance between global consistency and local autonomy can determine whether your team feels aligned or alienated. It requires clarity on what must remain uniform—brand values, strategy, success metrics—as well as the flexibility to adapt delivery, communication, and leadership styles to local norms. Leaders who master this balance can minimize friction while creating environments where innovation, trust, and performance thrive across borders. To that end, 17 members of Fast Company Executive Board share their top strategies for navigating this complex but critical dynamic. 1. IMPLEMENT AGILE METHODOLOGIES. To balance global consistency with local autonomy, implement agile methodologies like Scrum. Shared cadences (sprints), rituals (standups, retros), and artifacts (backlogs, demos) provide a scalable structure across regions. Agile isn't just for software—it drives cross-functional alignment, transparency, and adaptability while respecting cultural and market-specific needs. – Jack Borie, Ubix Labs 2. INCLUDE REGIONAL AND LOCAL EXPERTS IN BRAND MESSAGING. Global companies' brand messaging and positioning must include regional and local market experts. Yes, this may complicate and lengthen the process, but you must capture market nuances. In the end, you will have invested in your key regions, and the authenticity will be appreciated and should put you a step ahead of your competitors. – Mack McKelvey, SalientMG 3. STAY TRUE TO YOUR IDENTITY. When you create your identity and corresponding persona, never lose sight of who you are as an organization, regardless of the regionality issues. Your mission, vision, and organization credo should remain consistently applied. – Hudson Garrett Jr, Community Health Associates 4. USE SHARED VALUES IN DAILY DECISION-MAKING. Identify the shared values that transcend countries and cultures, and use these in daily decision-making. These will enable you to rise above implementation disagreements to the common ground of the team, no matter how dispersed or how varied their backgrounds. – Amy Radin Pragmatic Innovation Partners LLC 5. LEVERAGE THE STRENGTHS OF EACH REGION. We balance global consistency with local autonomy by letting regional strengths shine: France's stellar engineering, the U.S.'s marketing and sales expertise, and India's outstanding customer support. Our product platform and values remain constant, while we empower local teams to adapt as needed. This approach creates a unified company while maximizing the distinctive advantages each culture brings. – Dan Amzallag, Ivalua 6. ESTABLISH SHARED SUCCESS MEASURES. Set shared measures of success. That keeps everyone aligned while giving local teams the space to execute in ways that work for their market. Have clear goals, flexible paths. – Cliff Jurkiewicz, Phenom 7. ALLOW LOCAL LEADERS FLEXIBILITY WITHIN GLOBAL FRAMEWORKS. Empower local leaders while maintaining clear global frameworks. This strategy ensures alignment with the company's vision while allowing flexibility to meet specific market needs. It's about balance—guidance with freedom to innovate. – Katrina (Katya) Rosseini, KRR Ventures 8. ASK AND LISTEN TO LOCAL TEAMS. Start by ditching the one-size-fits-all mindset. What works in New York might flop in Singapore. The key? Set clear global principles, then flex locally. Ask, listen, and be willing to adapt—doing so is sometimes harder than your old office chair. Consistency builds trust, but autonomy drives relevance. You need both to lead across borders. – Stephanie Harris, PartnerCentric 9. LEAN INTO SOFT SKILLS. The power of 'soft skills' can shine when localizing across regions while maintaining global consistency. Whether it's active listening to those working in other parts of the world, or paying attention to the small details that matter to specific cultures and locales, these are just a few of the ways that global leaders can be better managers, striking a balance between global and local. – Irina Soriano, Seismic 10. KEEP YOUR OFFERINGS CONSISTENT, BUT ADD LOCAL FLAIR. The overall product or service must be consistent, and that means it should always revolve around the company's mission. However, it can and should include local flair, which can be taste, packaging, and other aspects, as it sells in different places. It should include local workers at that plant abroad who can contribute to decisions on how the local plant operates. – Baruch Labunski, Rank Secure 11. IDENTIFY WHAT MATTERS MOST IN EACH COUNTRY. As they teach in the Stanford MBA program, 'Different countries are different.' Identify the five to seven things that matter, and let it rip on the rest. The customer value stays constant, but the path to delivering value to the customer can vary. – Shayne Fitz-Coy, Sabot Family Companies 12. DETERMINE WHAT CAN FLEX AND WHAT IS NON-NEGOTIABLE. In sustainability, we created a global framework of principles, objectives, and reporting, while allowing local teams to adapt based on regional priorities, guidelines, and cultural nuances. We also set non-negotiables for messaging, ethics, and performance, with guardrails to establish consistency and empower autonomy. Remembering the gap between 'corporate' and 'local' is key to finding balance. – Jeffrey Whitford MilliporeSigma 13. ADOPT THE HUB AND SPOKE MODEL. The hub and spoke model works the best. The global team defines the key priorities and goals based on what the leadership wants. The power to execute on those priorities and goals should be with the regional teams, and they are in the best situation to understand the complexities on the ground. – Ruchir Nath, Dell Technologies 14. ATTEND REGULAR CROSS-CULTURAL DIALOGUE SESSIONS. Implement a framework of 'core and flex' where core values and strategic goals are standardized globally, while empowering local teams to customize implementation methods. Regular cross-cultural dialogue sessions help leaders understand regional nuances while maintaining organizational alignment, ensuring both global consistency and cultural adaptability. – Chongwei Chen, DataNumen Inc. 15. MANAGE COMPLEXITY BY STRENGTHENING LOCAL PROFIT DESIGN. The issue here is not just primarily balancing global consistency with local autonomy. It's managing complexity. The suggested strategy here is to strengthen profit design at local levels. Focusing on this approach has two direct benefits. First, it improves cash flow. Second, it prevents distraction that restrains profitable growth. – Jay Steven Levin, WinThinking 16. BUILD BUSINESS PLANS FROM THE BOTTOM UP. Build your business plans bottom-up, not top-down, then find the connective tissue between markets, cultures, and priorities. Carve your brand values in stone so you can offer a consistent customer experience globally, but tailor your messaging and delivery to the customs and customers of each country. – Tim Maleeny, Quad
