Latest news with #ZhejiangUniversity
Metro
8 hours ago
- Health
- Metro
Your earwax might be able to predict if you have Parkinson's disease
Chemical differences in people' earwax may be a telltale sign of Parkinson's that could revolutionise the fight against the disease, new research suggests. Parkinson's disease, which affects physical movement by damaging the brain, is very hard to diagnose early on. The high cost of brain scans means the only widely viable method is a specialist's evaluation of physical symptoms, which develop only after significant damage to the brain has happened. Since early treatment makes a huge difference in later quality of life, experts are keen to find other ways to detect it. The idea that people with Parkinson's give off different chemicals gained traction after credible evidence emerged that they smell noticeably different. Joy Milne, a retired Scottish nurse in her 70s with a rare condition giving her heightened smell, came forward in 2016 after noticing a distinct change in the smell of her late husband when he began to develop the disease. She was able to guess 100% correctly whether randomly picked items of clothing had belonged to someone with Parkinson's. Since then, early research proved promising for a skin swab test that involves running a cotton bud along the back of the neck. Scientists believe people with Parkinson's have different levels of certain compounds in their sebum, an oily substance produced by glands in the skin. Now another potential method building on this may have been discovered by scientists from Zhejiang University in China. Since earwax is made mostly of sebum, they decided to analyse samples from around 200 people who were known to be living with or without Parkinson's. Data on the chemical make-up of their earwax was into an algorithm that correctly guessed whether an individual had Parkinson's or not 94% of the time. This was based on the levels of four specific types of compounds, which were significant regardless of each person's age and lifestyle. Two of them, ethylbenzene & 4-ethyltoluene, are known to be signs of inflammation in the brain previously linked to Parkinson's. More Trending Another was pentanal, which has been linked to accumulations of protein clumps in patients' brains that are a telltale sign of Parkinson's. The study's authors said 'early diagnosis and treatment are crucial' for treatment. It's hoped their model could lead to a chemical testing device that could be easily distributed to clinics. 'Further enhancements to the diagnostic model could pave the way for a promising new PD diagnostic solution and the clinical use of a bedside PD diagnostic device.' Get in touch with our news team by emailing us at webnews@ For more stories like this, check our news page.
Newsweek
14 hours ago
- Health
- Newsweek
China's Fungus—A Biological Weapons Attack on America's Food Supply?
Advocates for ideas and draws conclusions based on the interpretation of facts and data. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. This month, three Chinese nationals were charged with smuggling biological agents into the United States. The attempts could be part of a biological weapons attack on America's farms and ranches. On June 3, the U.S. Attorney's Office for the Eastern District of Michigan announced that Yunqing Jian, 33, and Zunyong Liu, 34, had been charged with conspiracy, smuggling, false statements, and visa fraud. Jian was arrested for smuggling Fusarium graminearum, a "potential agroterrorism weapon" that causes "head blight." The fungal disease hits wheat, barley, maize, and rice and "is responsible for billions of dollars in economic losses worldwide each year." In humans and livestock, head blight causes vomiting, liver damage, and reproductive defects. A tractor and planting implement creates a dust cloud while planting a wheat field in the fertile farm fields of Idaho. A tractor and planting implement creates a dust cloud while planting a wheat field in the fertile farm fields of Idaho. Getty Images Their actions, according to U.S. Attorney Jerome Gorgon, Jr., represented "the gravest national security concerns." Cheyvoryea Gibson, special agent in charge of the FBI's Detroit Field Office, said the pathogens "posed an imminent threat to public safety." Then on June 9, Michigan's Eastern District announced that it had charged Chinese citizen Chengxuan Han with smuggling "biological materials" and making false statements. The materials, it appears, related to round worms. So why were Jian, Liu, and Han importing pathogens? "Fusarium graminearum is a common pathogen affecting crops in China, and numerous Chinese research institutes, including the Institute of Rice Biology at Zhejiang University, have been actively studying it," Xiaoxu Sean Lin, a former lab director of the viral disease branch of the Walter Reed Army Institute of Research, told Newsweek. "The FBI confiscated samples labeled 'ARP9,' an actin-related gene known to influence chromatin remodeling and gene transcription. This suggests the samples were genetically modified strains of Fusarium graminearum." "This raises a critical biosafety question," Lin noted. "Were these modified strains designed to enhance infectivity or pesticide resistance?" The pair may have intended, Lin said, "to perform field testing with these modified fungal strains on university-owned agricultural land." And perhaps they were intending to develop one or more modified strains of head blight to be introduced on farmland or ranchland elsewhere. Zunyong Liu was affiliated with Zhejiang University, where he conducted research on Fusarium graminearum. That institution, Lin said, has a well-documented collaboration with the People's Liberation Army. As he pointed out, "China's military-civil fusion strategy makes it reasonable to speculate about military interest in these genetically modified pathogens, which are potentially related to biological warfare or agroterrorism." Lin said research on such organisms would require special permits from both the University of Michigan and the U.S. Department of Agriculture. Jian and Liu, as experienced researchers, would have known that. "If the intent was purely academic," Lin asked, "why did the researchers not pursue the legal, regulated channels for pathogen transfer?" The fact that Yunqing Jian and Zunyong Liu would risk their careers by smuggling a known pathogen is a factor suggesting malign intent, especially given their relations with the Communist Party—Jian is a member—and their probable connections with military research at their home institutions in China. U.S. Attorney Gorgon said Chengxuan Han's smuggling was part of "an alarming pattern." Brandon Weichert, author of Biohacked: China's Race to Control Life, agreed, telling Newsweek, "The twin incidents are unlikely to be coincidental and certainly part of a troubling series of pathogen transfers to and from Chinese research institutions in recent years." Lin believed Han's affiliation with Huazhong University of Science and Technology is a warning sign because that institution is also involved in military-civil fusion programs. "Questions about PLA involvement are warranted," Lin said. "Biological warfare is a strategic 'commanding height' in Chinese military doctrine." As Weichert told this publication, "These agents can be weapons of mass destruction and their introduction into the United States could very well have been preparation for a biological weapons attack." The Chinese attempts this year to smuggle pathogens may be only the latest incidents in a Chinese campaign to bring down American agriculture. China, I believe, has been trying to plant invasive species in America since at least 2020. That year, Americans in all 50 states received seeds unsolicited from China. Early this year, Temu, the online Chinese retailer, was caught sending seeds to the U.S. unsolicited. In one case, a Chinese party sent unsolicited both seeds and an unidentified liquid. "We can expect many more attempts at sabotaging our food supply both to damage our economy and cause chaos," Weichert said. Gordon G. Chang is the author of Plan Red: China's Project to Destroy America and The Coming Collapse of China. Follow him on X @GordonGChang. The views expressed in this article are the writer's own.
Scottish Sun
15 hours ago
- Health
- Scottish Sun
The strange sign in your EARWAX that can predict if you'll develop devastating brain disorder
Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) YOUR earwax could be used to predict whether you'll develop Parkinson's, scientists say, About 153,000 people in the UK live with the devastating neurological disorder, caused by a loss of nerve cells in the brain. Sign up for Scottish Sun newsletter Sign up 2 Earwax could be used to predict whether someone will get Parkinson's or catch the disease in its early stages Credit: Getty The progressive disease is characterised by symptoms such as tremors, slow movement and muscle stiffness, which slowly get worse. According to researchers Zhejiang University in China, most Parkinson's treatments only slow the disease's progression, so early diagnosis is important for managing symptoms. But current tests for spotting the disease - such as brain scans or rating scales - can be expensive or subjective, they said. Now, a study published to Analytical Chemistry suggests that earwax could be used as a cost effective way to screen people for Parkinson's. Researchers claimed they'd developed a new AI system that could help catch the disease at an early stage, using earwax samples. Previous studies have shown that changes in sebum - an oily substance secreted by the skin - could help identify people with Parkinson's. Sebum from people with the disease may have a characteristic, musky smell because volatile organic compounds released by sebum are altered by disease progression. But sebum on the surface of the skin isn't a reliable substance for testing as it's exposed to pollution or humidity, which can change its composition. However, sebum in ear canals is sheltered from the elements. Seeing as the oily substance is the main component of earwax and it's easy to sample, researchers decided to use it for their screening tool. Good Morning Britain star reveals Parkinson's diagnosis after tragic death of his wife To identify the compounds released by sebum in people with Parkinson's, the researchers swabbed the ear canals of 209 participants, more than half of which were diagnosed with the condition. They then analysed wax samples, identifying four volatile organic compounds specific to people with Parkinson's. Those include ethylbenzene, 4-ethyltoluene, pentanal, and 2-pentadecyl-1,3-dioxolane. Researchers said these could serve as potential biomarkers for Parkinson's. Using these findings, they were able to develop a system that inexpensively screens for Parkinson's. Everything you need to know about Parkinson's Parkinson's is a progressive neurological condition, meaning that it causes problems in the brain and gets worse over time. It affects around 153,000 people in the UK. People with Parkinson's don't have enough of the chemical dopamine because some of the nerve cells that make it have stopped working. This can cause a range of more than 40 symptoms, but the three main ones are: Tremor (shaking) Slow movement Rigidity (muscle stiffness) Other common signs include: Mild memory and thinking problems Trouble sleeping Issues with balance Pain Anxiety and depression Shuffling walk with very small steps Difficulty making facial expressions Loss of sense of smell Problems peeing Constipation The four main ways of managing Parkinson's include medication, staying active, exploring occupational therapy, physical therapy and speech and language therapy, and monitoring symptoms. Source: Parkinson's UK and NHS They trained an artificial intelligence olfactory system - a robotic model that can mimic how we smell - with their ear wax compound data. They found it was able to categorise samples with and without Parkinson's with 94 percent accuracy. Researchers suggested their system could be used to a first-line screening tool for early Parkinson's detection and could help improve care for condition by making it possible to administer treatments earlier. Author Hao Dong said: 'This method is a small-scale single-center experiment in China." 2 'The next step is to conduct further research at different stages of the disease, in multiple research centres and among multiple ethnic groups, in order to determine whether this method has greater practical application value.' Earlier this year, scientists warned of a surge in cases of Parkinson's. They said 25 million people across the world will be living with the debilitating brain condition by 2050. Researchers from Capital Medical University in Beijing, China, estimated that an ageing population would drive the surge in cases of Parkinson's disease over the next 25 years. According to Parkinson's UK, the condition is the fastest growing neurological condition in the world.
The Sun
16 hours ago
- Health
- The Sun
The strange sign in your EARWAX that can predict if you'll develop devastating brain disorder
Eliza Loukou, Health Reporter Published: Invalid Date, YOUR earwax could be used to predict whether you'll develop Parkinson's, scientists say, About 153,000 people in the UK live with the devastating neurological disorder, caused by a loss of nerve cells in the brain. The progressive disease is characterised by symptoms such as tremors, slow movement and muscle stiffness, which slowly get worse. According to researchers Zhejiang University in China, most Parkinson's treatments only slow the disease's progression, so early diagnosis is important for managing symptoms. But current tests for spotting the disease - such as brain scans or rating scales - can be expensive or subjective, they said. Now, a study published to Analytical Chemistry suggests that earwax could be used as a cost effective way to screen people for Parkinson's. Researchers claimed they'd developed a new AI system that could help catch the disease at an early stage, using earwax samples. Previous studies have shown that changes in sebum - an oily substance secreted by the skin - could help identify people with Parkinson's. Sebum from people with the disease may have a characteristic, musky smell because volatile organic compounds released by sebum are altered by disease progression. But sebum on the surface of the skin isn't a reliable substance for testing as it's exposed to pollution or humidity, which can change its composition. However, sebum in ear canals is sheltered from the elements. Seeing as the oily substance is the main component of earwax and it's easy to sample, researchers decided to use it for their screening tool. Good Morning Britain star reveals Parkinson's diagnosis after tragic death of his wife To identify the compounds released by sebum in people with Parkinson's, the researchers swabbed the ear canals of 209 participants, more than half of which were diagnosed with the condition. They then analysed wax samples, identifying four volatile organic compounds specific to people with Parkinson's. Those include ethylbenzene, 4-ethyltoluene, pentanal, and 2-pentadecyl-1,3-dioxolane. Researchers said these could serve as potential biomarkers for Parkinson's. Using these findings, they were able to develop a system that inexpensively screens for Parkinson's. Everything you need to know about Parkinson's Parkinson's is a progressive neurological condition, meaning that it causes problems in the brain and gets worse over time. It affects around 153,000 people in the UK. People with Parkinson's don't have enough of the chemical dopamine because some of the nerve cells that make it have stopped working. This can cause a range of more than 40 symptoms, but the three main ones are: Tremor (shaking) Slow movement Rigidity (muscle stiffness) Other common signs include: Mild memory and thinking problems Trouble sleeping Issues with balance Pain Anxiety and depression Shuffling walk with very small steps Difficulty making facial expressions Loss of sense of smell Problems peeing Constipation The four main ways of managing Parkinson's include medication, staying active, exploring occupational therapy, physical therapy and speech and language therapy, and monitoring symptoms. They trained an artificial intelligence olfactory system - a robotic model that can mimic how we smell - with their ear wax compound data. They found it was able to categorise samples with and without Parkinson's with 94 percent accuracy. Researchers suggested their system could be used to a first-line screening tool for early Parkinson's detection and could help improve care for condition by making it possible to administer treatments earlier. Author Hao Dong said: 'This method is a small-scale single-center experiment in China." 2 'The next step is to conduct further research at different stages of the disease, in multiple research centres and among multiple ethnic groups, in order to determine whether this method has greater practical application value.' Earlier this year, scientists warned of a surge in cases of Parkinson's. They said 25 million people across the world will be living with the debilitating brain condition by 2050.
Daily Mail
a day ago
- Health
- Daily Mail
Strange sign in earwax may predict if you'll get brain disorder that affects 10million
That gross, waxy stuff in your ears could actually say a lot about your health. Researchers in China have identified key differences in the makeup of earwax in people with Parkinson's disease compared to people without the condition, suggesting the sticky stuff holds secrets that could flag a person's risk of eventually developing the condition. Scientists at Zhejiang University took earwax samples from 100 people with Parkinson's and 79 without. They chose earwax because much of it is made up of sebum, an oily substance that undergoes chemical changes in cases of Parkinson's, and releases distinct volatile organic compounds (VOCs). Parkinson's triggers neurodegeneration, inflammation, and oxidative stress, altering sebum's composition and creating a distinct odor. It also progressively damages the brain, causing tremors, stiffness, and slow movement. Over time, symptoms worsen to include sudden freezing, speech loss, swallowing problems — often leading to pneumonia — and falls, both common causes of death among people with Parkinson's. Four specific types of VOCs stood out among people with the condition, suggesting that earwax could potentially be an accessible indicator of Parkinson's, which would allow patients to avoid invasive diagnostic tests and spinal taps. Around 1million Americans and 10million people globally currently have the disease, with nearly 90,000 new cases diagnosed each year. As that number is projected to climb, early diagnosis is more important than ever. While there is no cure, medication regimens can be started early to treat symptoms and slow down the progression of the disease. Researchers fed the VOC data from the samples of earwax into an algorithm that categorized subjects' Parkinson's status accurately 94 percent of the time, demonstrating the potential for a fast, reliable diagnostic tool. The VOCs that stood out to researchers were all significant in differentiating between people with the condition and those without it, even after accounting for age and lifestyle factors. Two of the VOCS, Ethylbenzene & 4-Ethyltoluene, are compounds commonly found in plastics and petroleum products. Their presence suggests inflammation in the brain, which is a key driver of the breakdown of dopamine in the brain. Dopamine, while often thought of as a 'feel good' neurotransmitter, is a key chemical messenger that regulates movement control. As dopamine levels plummet while Parkinson's progresses, people become steadily more immobile. Another significant VOC was Pentanal, which is produced when fats break down. Elevated levels suggest cell damage, a hallmark of Parkinson's. The compound has been linked to an accumulation of protein clumps in patients' brains. And the VOC 2-Pentadecyl-1,3-dioxolane likely reflects issues with the metabolism of fats, which could have originated from microbiome changes in the skin of patients. It's unclear whether this VOC has any direct links to PD, but there is an expanding body of research pointing to a connection between PD and an imbalance in the gut microbiome. Research suggests that VOCs are produced by the balance of good bacteria in the gut, which have also been associated with brain health. An imbalance that allows harmful bacteria to flourish, leading to a proliferation of toxins that can cause inflammation in the brain. VOCs come from a wide array of toxic sources in the environment, from pesticides used to grow food, industrial chemicals in gasoline, and solvents in everyday items like dry cleaning chemicals and adhesives, to cleaning products, car emissions, and contaminated groundwater. Parkinson's is believed to be caused by a confluence of genetic and environmental factors. It is the world's fastest-growing brain disorder, and, according to NIH research, 'exposure to environmental toxicants is the principal reason.' In the US, deaths from Parkinson's disease have more than doubled in the past 20 years, with about 35,000 deaths in 2019 compared to 14,500 in 1999. Parkinson's death rates rose from 42 to 65 deaths per 100,000 from 1999–2017 While considering the clues that earwax can provide about Parkinson's development is new, investigating the role that VOCs play is not. A sweeping 2023 meta-analysis identified distinct VOCs present in the breath and skin oil in people with the disease compared to those without it. These compounds are specifically linked with oxidative stress, or a barrage of damage that cells endure before dying. Dr Hao Dong, a co-researcher on the recent study, said: 'This method is a small-scale single-center experiment in China. 'The next step is to conduct further research at different stages of the disease, in multiple research centers and among multiple ethnic groups, in order to determine whether this method has greater practical application value.'
