Latest news with #UPB
Business Insider
7 days ago
- Health
- Business Insider
Upstream Bio announces presentation of data on verekitug's TSLP receptor
Upstream Bio (UPB) announced the presentation of translational pharmacology modeling data supporting verekitug's Thymic Stromal Lymphopoietin, TSLP, receptor targeting as a mechanism for greater potency when compared to treatments targeting the TSLP ligand. Data were presented at the European Academy of Allergy & Clinical Immunology, EAACI, Congress taking place June 13-16, 2025, in Glasgow, United Kingdom. Data presented used an in silico system pharmacology modeling approach to provide a mechanism-based understanding for the observed potency of verekitug and are summarized as follows: Semi-mechanistic pharmacokinetic/pharmacodynamic models were built using the same biological and drug-specific parameters for verekitug and tezepelumab and populated with observed clinical data for verekitug and published clinical data for tezepelumab. Across a range of doses, PK/PD model simulations predict complete and sustained inhibition of the TSLP/TSLPR complex with verekitug compared to tezepelumab. Dose-response model simulations predict that potent inhibition of the TSLP/TSLPR complex would result in a greater reduction in fractional exhaled nitric oxide, a biomarker of lung inflammation. Modeling data indicated that the greater predicted reduction of FeNO observed with verekitug, compared with published data for tezepelumab, is potentially driven by lower expression levels of the TSLP receptor over time versus the ligand, as well as slower protein turnover time for the TSLP receptor versus the ligand.
Reuters
11-06-2025
- Business
- Reuters
Climate change could cost Italy over 5% of GDP in 2050, budget watchdog says
ROME, June 11 (Reuters) - Extreme weather due to climate change may cost Italy more than 5% of GDP in 2050, the country's budget watchdog said on Wednesday, adding that global action to reduce carbon emissions could significantly reduce the impact. In recent years, floods have devastated cities across Italy killing dozens of people and causing billions of euros in damage, as severe droughts damaged crops and livestock particularly in the less developed southern regions. Italy has also recorded the European heat record of 48.8 degrees, registered in Sicily in 2021. "The impact on public finances of extreme events in Italy would increase from an estimated annual value of 0.2% of GDP in 2024 to 5.1% in 2050 in the unchanged policy scenario," the UPB watchdog said in its annual report. It added that this would decrease to 0.9% if global carbon-neutrality targets were met. Achieving carbon neutrality means reaching a zero balance between CO2 emissions and CO2 absorbed from the atmosphere. Under a plan agreed in 2019, the European Union aims to become carbon neutral by 2050. "The projections assume that the number of extreme events in 2050 will be six times greater than in 2024 in an unchanged policy scenario and two times greater in the carbon-neutral scenario," the UPB said. The independent watchdog said climate-related burdens on state finances included subsidies for the transition to less polluting energy sources. Presenting the document, UPB President Lilia Cavallari said the "fragile international environment" makes it more difficult to find shared solutions on major issues, including climate change. "The urgency of coordinating climate change mitigation actions by involving as many actors as possible remains pressing. In this field, isolated measures risk being ineffective as well as more costly," Cavallari said. Since returning to power in January, U.S. President Donald Trump has led a pushback against largely Democratic-led policies to curb carbon emissions.
The Sun
20-05-2025
- General
- The Sun
Bomb found at construction site in Tanjung Tokong
GEORGE TOWN: An old bomb, believed to be a still-active relic from the Second World War, was discovered at a construction site on Jalan Seri Tanjung Pinang, Tanjung Tokong. Timur Laut police chief ACP Abdul Rozak Muhammad said police received a report from the public about the bomb's discovery at 9.42 pm. 'The Bomb Disposal Unit (UPB) of the Penang contingent police headquarters (IPK) inspected the object and confirmed that it was an unexploded ordnance (UXO) bomb dating back to the Second World War. 'No casualties or property damage were reported in this incident,' he said in a statement. Abdul Rozak said that the UPB's inspection confirmed the area is safe, and the bomb is scheduled for disposal today.
The Sun
20-05-2025
- General
- The Sun
Bomb found at construction site in Tg Tokong
GEORGE TOWN: An old bomb, believed to be a still-active relic from the Second World War, was discovered at a construction site on Jalan Seri Tanjung Pinang, Tanjung Tokong. Timur Laut police chief ACP Abdul Rozak Muhammad said police received a report from the public about the bomb's discovery at 9.42 pm. 'The Bomb Disposal Unit (UPB) of the Penang contingent police headquarters (IPK) inspected the object and confirmed that it was an unexploded ordnance (UXO) bomb dating back to the Second World War. 'No casualties or property damage were reported in this incident,' he said in a statement. Abdul Rozak said that the UPB's inspection confirmed the area is safe, and the bomb is scheduled for disposal today.
Barnama
20-05-2025
- Barnama
Bomb Found At Construction Site In Tanjung Tokong
GEORGE TOWN, May 20 (Bernama) -- An old bomb, believed to be a still-active relic from the Second World War, was discovered at a construction site on Jalan Seri Tanjung Pinang, Tanjung Tokong. Timur Laut police chief ACP Abdul Rozak Muhammad said police received a report from the public about the bomb's discovery at 9.42 pm. 'The Bomb Disposal Unit (UPB) of the Penang contingent police headquarters (IPK) inspected the object and confirmed that it was an unexploded ordnance (UXO) bomb dating back to the Second World War.
