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Time of India
09-06-2025
- Health
- Time of India
Certain people are mosquito magnets, and turns out THIS is the reason why
A recent study reveals that some individuals are more attractive to mosquitoes due to high levels of specific fatty acids on their skin. These carboxylic acids, produced by skin bacteria, create a unique body odor that mosquitoes find irresistible. Researchers identified 'mosquito magnets' who consistently attracted more mosquitoes, highlighting the complexity and redundancy of the mosquito's scent-detection system. Ever wondered why the mosquitoes always seem to find you, even in a room full of people? When a female mosquito is on the hunt for some fresh blood, she has certain preferences, just like you ask the barista for a slim oat milk latte with a shot of vanilla. Yes, mosquitoes are picky. Female mosquitoes pick the human species by tracking our CO2 exhalations, body heat, and body odor. But some people seem to be mosquito magnets than others. Many believe this is due to things like blood type, blood sugar, eating garlic or bananas, or being a woman or child. However, most of these ideas lack strong scientific proof, says Leslie Vosshall, a scientist at Rockefeller Laboratory of Neurogenetics and Behavior. Vosshall and Maria Elena De Obaldia, a former postdoc in her lab, looked at the popular theory to explain varying mosquito appeal: individual odor variations connected to skin microbiota. They found that certain fatty acids emanating from the skin may create a heady perfume that mosquitoes can't resist. The findings are published in the Cell journal. 'There's a very, very strong association between having large quantities of these fatty acids on your skin and being a mosquito magnet,' Vosshall, the Robin Chemers Neustein Professor at The Rockefeller University and Chief Scientific Officer of the Howard Hughes Medical Institute, said in a statement. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Trade Bitcoin & Ethereum – No Wallet Needed! IC Markets Start Now Undo A tournament no one wants to win To understand the mechanism of this selection, the researchers conducted a three-year study. The eight participants were asked to wear nylon stockings on their forearms for six hours daily, over several days. The worn nylons were then tested against one another in a round-robin style 'tournament' using a custom-built plexiglass olfactometer. In each round, mosquitoes were given a choice between two nylons, and researchers observed which one they preferred. They placed Aedes Aegypti mosquitoes, the primary vector species for Zika, dengue, yellow fever, and chikungunya, in the main chamber and observed as the insects flew down the tubes towards one nylon or the other. For Aedes aegypti mosquitoes, the most compelling was Subject 33, who was four times more attractive to the mosquitoes than the next most-attractive study participant, and an astonishing 100 times more appealing than the least attractive, Subject 19. The samples in the trials were anonymous, so researchers didn't know which participant wore which nylon. Yet, they noticed that something was unusual about Subject 33, because insects would swarm towards that sample. 'It would be obvious within a few seconds of starting the assay. It's the type of thing that gets me really excited as a scientist. This is something real. This is not splitting hairs. This is a huge effect,' De Obaldia said. The researchers grouped participants into high and low mosquito attractors and looked for what set them apart. Chemical tests revealed 50 compounds that were more common in the skin oil (sebum) of those who attracted more mosquitoes. They also found that these people produced much higher levels of carboxylic acids, substances that skin bacteria use to create unique body odour in humans. To double-check their results, the team ran a second study with 56 new participants. Once again, Subject 33 attracted the most mosquitoes, and continued to do so over time. 'Some subjects were in the study for several years, and we saw that if they were a mosquito magnet, they remained a mosquito magnet. Many things could have changed about the subject or their behaviors over that time, but this was a very stable property of the person,' De Obaldia added. What's the science behind Humans produce two classes of odors that mosquitoes detect with two different sets of odor receptors: Orco and IR receptors. To test whether they could make mosquitoes that couldn't detect humans, researchers created genetically modified mosquitoes missing one or both key scent receptors. The orco mutants remained attracted to humans and were able to distinguish between mosquito magnets and low attractors, while IR mutants lost their attraction to humans to a varying degree, but still retained the ability to find humans. 'The goal was a mosquito that would lose all attraction to people, or a mosquito that had a weakened attraction to everybody and couldn't discriminate Subject 19 from Subject 33. That would be tremendous. And yet that was not what we saw. It was frustrating,' Vosshall added. These findings support another study by Vosshall, which showed how complex and reliable the mosquito's sense of smell is. Female Aedes aegypti mosquitoes depend on blood to survive and reproduce, so their scent-detection system has multiple backups to make sure they can always find a human host. 'Without blood, she can't do either. That's why she has a backup plan and a backup plan and a backup plan and is tuned to these differences in the skin chemistry of the people she goes after,' Vosshall says. Mosquitoes have such a strong sense of smell that it's hard to imagine they'll ever stop targeting humans. However, one possible solution is to change the bacteria on our skin. For example, covering the skin of someone who attracts lots of mosquitoes (like Subject 33) with skin oils and bacteria from someone who doesn't (like Subject 19) might help hide them from mosquitoes. Trump's Health Secrets EXPOSED? Nearly HALF of America Thinks Prez is HIDING Medical Truths | WATCH 'We haven't done that experiment. That's a hard experiment. But if that were to work, then you could imagine that by having a dietary or microbiome intervention where you put bacteria on the skin that are able to somehow change how they interact with the sebum, then you could convert someone like Subject 33 into a Subject 19. But that's all very speculative,' Vosshall added. One step to a healthier you—join Times Health+ Yoga and feel the change
Economic Times
24-05-2025
- Health
- Economic Times
Why do mosquitoes bite you more than your friends? Science reveals the surprising skin chemistry behind it
iStock Some people attract mosquitoes far more than others, and a 2022 study by Rockefeller University explains why. Individuals who emit higher levels of carboxylic acids through their skin are significantly more appealing to Aedes aegypti mosquitoes. Ever wondered why, during a summer evening outdoors, you're being relentlessly attacked by mosquitoes while your friends sip their drinks in peace? If you've blamed your blood type or bad luck, science has a more intriguing answer. A groundbreaking study has revealed that your body scent—specifically, the acids your skin emits—might be what's turning you into a mosquito's favourite meal. In a 2022 study conducted by researchers at The Rockefeller University and published in the prestigious journal Cell , scientists uncovered that certain individuals produce significantly higher levels of carboxylic acids on their skin. These acids, a component of natural body odor, seem to act as a siren song to Aedes aegypti , the mosquito species infamous for spreading diseases like dengue, Zika, chikungunya, and yellow fever. The research involved an unusual but telling experiment. Volunteers wore nylon stockings on their arms to collect their body scent. These were then cut into small pieces and placed in chambers with mosquitoes. What followed was a surprising and consistent pattern: the insects flocked to certain samples again and again, completely ignoring others. One particular participant, known only as 'Subject 33,' was an irresistible hit. 'They won a hundred games,' said lead researcher Leslie Vosshall. 'They were totally undefeated.' In every round, the mosquitoes were drawn to this subject's scent more than anyone else's. The secret? An unusually high presence of carboxylic acids on their skin. This isn't just a fluke. These scent-based preferences remained stable over time, suggesting that mosquito attraction isn't just about what you eat or what you wear—it's rooted in your body chemistry. Although the study doesn't confirm why mosquitoes are obsessed with carboxylic acids, it strongly suggests that an individual's unique 'skin climate'—the natural cocktail of chemicals we exude—is what seals the deal for mosquitoes. And while the researchers couldn't strip these acids from the high-attraction subjects to prove their exact role, they did note that human skin odor is a complex blend of many compounds. This study, however, focused exclusively on those with carboxylic acid groups, providing a promising lead in the quest to understand mosquito preferences. This isn't just about annoyance. Mosquitoes aren't merely buzzing pests—they are deadly vectors that contribute to over 700 million infections globally each year. Understanding why some people are more prone to bites could change the game in mosquito control and repellent design. Future repellents might target the specific chemical signatures mosquitoes crave, offering more personalized protection—especially crucial for vulnerable populations in disease-prone regions. If you've ever joked that you're a 'mosquito magnet,' it might be more scientific than you think. Your skin may be giving off signals that these insects find impossible to ignore. Until science finds a way to mask or neutralize those signals, your best defense might still be the classic combo of repellents, covered clothing, and clever timing. But at least now, you can say: it's not you. It's your chemistry.
Time of India
24-05-2025
- Health
- Time of India
Why do mosquitoes bite you more than your friends? Science reveals the surprising skin chemistry behind it
Ever wondered why, during a summer evening outdoors, you're being relentlessly attacked by mosquitoes while your friends sip their drinks in peace? If you've blamed your blood type or bad luck, science has a more intriguing answer. A groundbreaking study has revealed that your body scent—specifically, the acids your skin emits—might be what's turning you into a mosquito's favourite meal. A Scent Too Strong to Resist In a 2022 study conducted by researchers at The Rockefeller University and published in the prestigious journal Cell , scientists uncovered that certain individuals produce significantly higher levels of carboxylic acids on their skin. These acids, a component of natural body odor , seem to act as a siren song to Aedes aegypti , the mosquito species infamous for spreading diseases like dengue, Zika, chikungunya, and yellow fever. The research involved an unusual but telling experiment. Volunteers wore nylon stockings on their arms to collect their body scent. These were then cut into small pieces and placed in chambers with mosquitoes. What followed was a surprising and consistent pattern: the insects flocked to certain samples again and again, completely ignoring others. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Access all TV channels anywhere, anytime Techno Mag Learn More Undo Meet 'Subject 33': The Mosquito World's Celebrity One particular participant, known only as 'Subject 33,' was an irresistible hit. 'They won a hundred games,' said lead researcher Leslie Vosshall. 'They were totally undefeated.' In every round, the mosquitoes were drawn to this subject's scent more than anyone else's. The secret? An unusually high presence of carboxylic acids on their skin. This isn't just a fluke. These scent-based preferences remained stable over time, suggesting that mosquito attraction isn't just about what you eat or what you wear—it's rooted in your body chemistry. You Might Also Like: Why is it always the 'Orange Cat'? Scientists uncover the genetic secret that could prove they are freaks of nature Your Skin's Chemical Climate Matters Although the study doesn't confirm why mosquitoes are obsessed with carboxylic acids, it strongly suggests that an individual's unique 'skin climate'—the natural cocktail of chemicals we exude—is what seals the deal for mosquitoes. And while the researchers couldn't strip these acids from the high-attraction subjects to prove their exact role, they did note that human skin odor is a complex blend of many compounds. This study, however, focused exclusively on those with carboxylic acid groups, providing a promising lead in the quest to understand mosquito preferences. iStock This scent-based preference, which remains consistent over time, could pave the way for more effective mosquito repellents and disease prevention. The Bigger Picture: More Than Just Itchy Bites This isn't just about annoyance. Mosquitoes aren't merely buzzing pests—they are deadly vectors that contribute to over 700 million infections globally each year. Understanding why some people are more prone to bites could change the game in mosquito control and repellent design. Future repellents might target the specific chemical signatures mosquitoes crave, offering more personalized protection—especially crucial for vulnerable populations in disease-prone regions. You Might Also Like: What is your favourite colour? Does it really matter, psychologist reveals So, Why You? If you've ever joked that you're a 'mosquito magnet,' it might be more scientific than you think. Your skin may be giving off signals that these insects find impossible to ignore. Until science finds a way to mask or neutralize those signals, your best defense might still be the classic combo of repellents, covered clothing, and clever timing. But at least now, you can say: it's not you. It's your chemistry.
Telegraph
01-04-2025
- Health
- Telegraph
The good body fat that holds the key to keeping weight off (and how to activate yours)
It is the 'good' fat which can help us lose weight rather than gain it. Now new research has found that the brown adipose tissue (BAT) which is rich in mitochondria, could promote longevity and help keep us healthy as we age. The Rutgers New Jersey Medical School study found that mice lacking a specific gene developed an unusually potent form of BAT that expanded lifespan and increased exercise capacity by 30 per cent. The genetically modified mice, which lack a protein called RGS14, lived around 20 per cent longer than normal mice and avoided typical signs of ageing including hair-loss and greying. Their BAT also protected them from obesity, glucose intolerance, cardiovascular disorders, cancer and Alzheimer's disease. The team is now working on a drug that could mimic these effects in humans. 'Exercise capacity diminishes as you get older, and to have a technique that could enhance exercise performance would be very beneficial for healthful ageing,' said Prof Stephen Vatner, the study's senior author. What role does brown fat play? Most of the fat in our bodies is white tissue, distributed around our waist, hips and thighs. But most adults have around 100g of brown fat, too, according to Prof Michael Symonds, the deputy head of the University of Nottingham School of Medicine, mainly stored around our necks and also found in the collarbone and spine. Studies suggest it is only detectable in a minority of people – possibly as few as 10 per cent – but currently, the only way to know how we compare is via a positron emission tomography (PET) scan, which involves injecting radioactive material into the body and is usually used to diagnose cancer. The primary function of brown fat is to provide warmth: it produces 300 times more heat than any other tissue in the body. It is first activated in newborn babies to protect them from the shock of exposure to the cold after birth. As we age, the amount of brown fat in our bodies declines. But it would be helpful if we could hang onto it or increase the levels we have. Research has shown it has numerous health benefits, including better blood sugar control – decreasing the risk of Type 2 diabetes – higher levels of 'good' cholesterol and a decreased risk of fatty liver. A study of over 52,000 participants by The Rockefeller University in New York also found a strong link between having detectable brown fat and a reduction in coronary heart disease, heart failure and high blood pressure. Brown fat has a unique protein – the uncoupling protein 1 (UCP1) – which makes it different from white fat. This protein is present on the inner mitochondria, and when it's stimulated, it produces heat. 'To make heat, brown fat requires a lot of energy in the form of lipids [fats] and sugar,' says Toni Vidal-Puig, a professor of molecular nutrition and metabolism at the University of Cambridge. 'It burns this excess fuel – meaning that the more brown fat you have, the higher your capacity to remain lean. Intriguingly, the Rockefeller University study also suggested that if obese people have detectable brown fat, it can protect them from the harmful effects of their white fat. 'It acts like a vacuum cleaner preventing the nutrients [from the fats and sugar] going to the liver, the arteries and muscles,' says Prof Vidal-Puig. As a result, researchers are working to find a way to harness brown fat to 'prevent the complications associated with obesity', he says. The drug Mirabegron, used to treat an overactive bladder, has been shown to activate brown fat, but it also raises blood pressure. Researchers are exploring whether smaller doses of the drug taken over long periods will be enough to stimulate brown fat without significant cardiovascular risks. In the meantime, there are ways to safely activate brown fat through lifestyle changes. Spend two hours a day in the cold The brown fat protein, UCP1, 'isn't innately active; it has to be activated,' says Roland Stimson, professor of endocrinology at the University of Edinburgh. Perhaps the most efficient way to do this is through cold exposure. One study in Maryland involved five healthy 21-year-old men spending 10 hours per night in a room with the temperature set to 19C. After a month of this exposure to mild cold, they had a 42 per cent increase in brown fat volume and a 10 per cent increase in fat metabolic activity. Turning the thermostat down at night, then, could be a simple way to activate brown fat. And if that sounds too punishing, according to Prof Stimson: 'We've seen from the controlled studies that even mild cold exposure of 17C for two hours a day is sufficient to expand the function of your brown fat.' Take a cold shower Immersion in cold water is also beneficial. ''Three or four minutes in a cold shower every morning, or a cold water swim a few times a week will activate brown fat and may be helpful in keeping excess weight off,' says Prof Symonds. In 2008, researchers at Maastricht University found that Wim Hof, the Dutch extreme athlete known for his ability to withstand freezing temperatures, had built up so much brown fat he could produce five times more heat energy than the typical 20-year-old. Cold water also helps boost your immune system, increases endorphins and improves circulation, making it a particularly positive habit to adopt. Drink a daily cup of coffee A first-of-its-kind 2019 study by Prof Symonds and his Nottingham University team suggested that drinking a cup of coffee can stimulate brown fat. The team used a thermal imaging technique they pioneered to trace the body's brown fat reserves, then used it again immediately after participants had drunk the coffee to see if the brown fat became hotter. 'The results were positive,' says Prof Symonds. The team are conducting further research to ascertain if caffeine supplements have a similar effect. In the meantime, he says: 'Drinking 10 cups of coffee a day won't prevent you from having a weight problem, sadly, but as part of a bigger picture, it's certainly worth adding a coffee into your daily routine.' Eat spicy food and drink green tea Research by Japanese scientists has shown that capsinoids, the compounds found in chilli peppers and some types of red peppers, activate brown fat – so adding spice to your meals may help you stave off excess pounds. Other foods which have been shown to stimulate brown fat include green tea, which is rich in catechins, a type of flavonoid and polyphenol known for its strong antioxidant properties. Another Japanese study looked at participants who had ingested catechins and caffeine in the same drink and found it 'acutely increases EE [whole body energy expenditure] associated with increased BAT [brown adipose tissue] activity'. Eat more mackerel Omega fatty acids have also been shown to positively impact brown fat, particularly docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are primarily found in oily fish such as salmon, tuna, mackerel and sardines. Fish oil supplements are a good idea for those who don't eat seafood. Ursolic acid, an anti-inflammatory, antioxidant compound found in plants including apples, rosemary and thyme, has been shown in mice studies to increase brown fat and energy expenditure. Other studies involving mice suggest ginger can also induce browning in white fat – in other words, turn unhealthy white fat into beneficial brown fat. Don't starve yourself – or binge Researchers at the Yale School of Medicine found that in mice, the neurons in the brain which regulate hunger can encourage fat to turn brown. The study found that eating too few calories prevented white fat from turning brown, while eating just enough to satisfy hunger stimulated the neurons and turned the fat brown. Conversely, eating too much can also cause harm, not only because it increases white fat, but because it could interfere with brown fat's ability to burn calories.
