Latest news with #Seyfried
Time of India
5 days ago
- Health
- Time of India
Leading biologist exposes what fuels cancer, and, no, it's not what most people think
credit: Instagram/@thomasseyfriedbc credit: Instagram/@thomasseyfriedbc 1 2 Cancer continues to be one of the most difficult diseases to treat, with ongoing research uncovering new dimensions of its biology. One such voice advocating a different lens to understanding cancer is Dr. Thomas N. Seyfried, a professor of biology at Boston College and a recognized authority in the field of cancer metabolism. ( source: Boston College, National Institute of Health) In a recent viral video, Dr. Seyfried deconstructs two biological compounds that, in his research, supply the growth of cancer: glucose and glutamine. His perspective conforms to the metabolic theory of cancer, which holds that cancer is derived more from aberrant cellular metabolism than from mutations in genes alone. A renowned researcher in cancer metabolism Dr. Seyfried received his Ph.D. in genetics and biochemistry from the University of Illinois and finished postdoctoral fellowships in the Department of Neurology at the Yale University School of Medicine. He is now a professor at Boston College, where he studies the ways in which cellular energy metabolism can drive cancer, epilepsy, and neurodegenerative disease development. His pioneering book, "Cancer as a Metabolic Disease," released in 2012, offers scientific proof that mitochondrial breakdown—not genetic mutation—is the underlying cause of most cancers. What does his expertise say? Glucose: It nourishes your tumor Dr. Seyfried maintains that glucose is the major fuel for cancer cells. In contrast to healthy cells, which have the flexibility to cycle between burning sugar and fat, cancer cells depend nearly completely on sugar. This characteristic makes them susceptible to interventions that lower blood glucose, including ketogenic diets or fasting. This concept is derived from the Warburg Effect, a discovery made by Nobel Prize Winner Otto Warburg, where cancer cells have abnormally high glucose metabolism even when oxygen is present. Glutamine: The secret fuel The second fuel is glutamine, an amino acid that tumors use to keep growing even during glucose starvation. Glutamine sustains key processes that fuel cancer cell growth and evade immune responses. Dr. Seyfried contends that the combination of therapies that limit both glucose and glutamine may be a promising approach to inhibiting tumor growth, although he emphatically warns that such treatment should be undertaken only by experienced professionals. Are the paradigms shifting or are we clinging to some new hope? By pinpointing cancer as fundamentally a metabolic disorder, Thomas Seyfried reframes the prevailing genetic-focused paradigm in oncology. Although not yet mainstream, his research has generated excitement in the realm of metabolic therapies, such as nutritional treatments and non-toxic, metabolism-targeting medications. As a seasoned scientist of many decades, Dr. Seyfried stresses evidence-based, holistic strategies over band-aid remedies. While increased attention is being paid to metabolic strategies for treating cancer, these strategies should not displace mainstream therapy until they are tested in the clinic. Cancer is exceedingly personalized, and any dietary or supplement modification must be done at the direction of oncologists and medical doctors. Dr. Thomas Seyfried's research keeps challenging the traditional thinking in cancer understanding and treatment. Whether or not this approach will open new paradigms in oncology is an intriguing question for the future of medical research. One step to a healthier you—join Times Health+ Yoga and feel the change
Time of India
6 days ago
- Entertainment
- Time of India
"I think it's really scary...": Amanda Seyfried slams Hollywood's sequel obsession
Amanda Seyfried has voiced her frustration with Hollywood's reliance on sequels, sharing that they are often driven by profit rather than creative vision. As quoted by Variety, in a recent interview, Seyfried expressed her desire for original content, and said, "I think it's really scary and brave to do it. It's not scary and not very brave to do sequels. It's just for money and it's frustrating." Seyfried's comments come amid a summer blockbuster season filled with sequels, including James Gunn 's 'Superman' and 'Jurassic World Rebirth.' Brosnahan, who stars as Lois Lane in the new 'Superman' film, jokingly asked, "What's our Barbenheimer between 'Fantastic Four,' 'Jurassic Park,' and 'Superman'?" Seyfried responded with humour, "It's Fantastic Super-park. It's Four Superparks. Four Dinosaurs. Four Super Dinosaurs. I don't know!" as quoted by Variety. Despite her criticism of sequels, Seyfried has starred in several herself, including 'Mamma Mia! Here We Go Again' and 'Ted 2.' However, she clarified that she would eagerly participate in 'Mamma Mia 3' if given the chance. Seyfried is also working on a potential 'Jennifer's Body' sequel with Megan Fox , but emphasised that she won't do it without her co-star. Brosnahan shared her thoughts on sequels, and said that she would return for a 'Superman' sequel. "Yeah, I'd come back. We had a great time. There's also so many people in this cast who I didn't get to work with," she said. She also commented on the trend of actors complaining about superhero movies after joining them, and said, "Do it or don't do it, and then stand by it." Meanwhile, 'Superman' is set to open on July 11.
New York Post
10-06-2025
- Entertainment
- New York Post
Why Amanda Seyfried is ‘resentful' toward ‘Mean Girls'
Amanda Seyfried doesn't think 'Mean Girls' merch is that fetch. The Oscar-nominated star, 39, shared that while she doesn't mind fans wearing clothing with her face on it, she's 'resentful' that her likeness is used for merchandise since she doesn't get paid for it. Seyfried opened up about the 2004 iconic movie while reuniting with her 'Jennifer's Body' co-star Adam Brody for Variety's Actors on Actors published on Monday, June 9. Advertisement 8 Amanda Seyfried as Karen Smith in 'Mean Girls.' CBS via Getty Images During their chat, Brody, 45, asked Seyfried if she's 'rewatched Mean Girls' in the past two decades since the timeless movie's release. 'I haven't. It's on often enough, though. I love it,' the actress, who played ditzy Karen Smith in the teen comedy, replied before sharing her thoughts on the 'Mean Girls' merch. Advertisement 'I really love seeing my face on people's T-shirts. I'm a little resentful because Paramount still owes me some money,' Seyfried alleged. 'Every store sells 'Mean Girls' T-shirts with our faces, photographs!' she explained, noting that her likeness is used on each item. 'Don't I [get something from that]?' The 'Long Bright River' actress went even further, wondering out loud if she allowed it to happen 'because I was 17 and dumb?' 8 'I'm a little resentful because Paramount still owes me some money,' she told Adam Brody. Getty Images Advertisement 8 She contemplated if she allowed it to happen 'because I was 17 and dumb?' Photo Image Press via ZUMA Press Wire / As Brody listened, Seyfried continued, 'Ugh. I love it. Even the girl at TSA tells me it's her favorite movie. And I'm like, 'Great, I was 17. I had nothing to do with it.'' The Post reached out to Paramount for comment. 'Mean Girls' followed a group of cool high school students, dubbed 'The Plastics,' and the influence their tight-knit clique had on the entire school body. Advertisement 8 'Mean Girls' followed a group of teen cool girls known as 'The Plastics.' CBS via Getty Images 8 The 2004 movie was an instant hit. CBS via Getty Images 8 'The Plastics' included Seyfried, Rachel McAdams, Lacey Chabert, and Lindsay Lohan. ©Paramount/Courtesy Everett Collection Seyfried's cast included Lindsey Lohan as the new girl (Cady Heron), Lacey Chabert as the rich, Toasters Strudel heir (Gretchen Wieners) and Rachel McAdams as the queen bee (Regina George). Tina Fey wrote the screenplay and starred in the film as Ms. Norbury. Three of the four 'Plastics' reunited in 2023 for a Walmart Black Friday ad. 8 Three out of four of the girls reunited for a Walmart Black Friday ad in 2023. CBS via Getty Images 8 Rachel McAdams was absent from the ad, later revealing she 'wasn't that excited about doing a commercial.' ©Paramount/Courtesy Everett Collection Advertisement The commercial saw Lohan, Chabert and Seyfried channel their legendary characters as adults who are parents to a new group of cool kids at North Shore High School. The reunion caused millennials to go into a tailspin while speculating why McAdams was nowhere to be found. 'Rachel McAdams didn't want to do it,' an insider told Page Six at the time. 'They were all offered it. But the three of them loved being together for their reunion.' Advertisement The source added, 'They had a great time talking about being moms, and it was definitely a loss not having Rachel there.' McAdams later addressed her absence, telling Variety, 'I don't know; I guess I wasn't that excited about doing a commercial if I'm being totally honest.'
Yahoo
10-06-2025
- Entertainment
- Yahoo
Amanda Seyfried and Adam Brody on Making ‘Jennifer's Body,' Surviving ‘O.C.' Fame and ‘Mean Girls': ‘Paramount Still Owes Me Money for the Likeness'
It's funny how the memory of a demonic teenage girl who feasts on human flesh can spark nostalgia. But that's how it works with Amanda Seyfried and Adam Brody. The stars of two of this season's buzziest shows — the harrowing cop drama 'Long Bright River' for Seyfried and the hit romantic comedy 'Nobody Wants This' for Brody — met almost 20 years ago on the set of Karyn Kusama's cult horror classic 'Jennifer's Body.' Seyfried played the nerdy and devout best friend of Jennifer, the aforementioned demon, played by Megan Fox, while Brody was cast as a douchey aspiring rock star who performs a satanic ritual meant to bring fame, and winds up creating a monster. More from Variety Natasha Rothwell and Sterling K. Brown Get Honest About 'White Lotus' Rewrites, Doomsday and Being No. 1 on the Call Sheet: 'For the Longest Time I Thought It Meant Something' Sam Nivola and Cooper Koch Confront Nepo Baby Criticism and Being Accused of Playing Sexual Deviant Brothers: 'You Still Have to Love Your Character' Parker Posey Tells Lisa Kudrow to Star in 'The White Lotus' Season 4 as They Bond Over Sitcom Struggles and Why Phoebe on 'Friends' Was 'A Lot of Work' Considered a flop at the time, the film found new life and cross-generational fans in subsequent years. It also provided the perfect occasion for a reunion for the actors, who have even more in common than 'Jennifer's Body.' Seyfried bought Brody's Hollywood home, and the two also shared a bedroom in 'Lovelace,' the 2013 film about the trailblazing '70s porn star Linda Lovelace. Here they reminisce about trying to get Harvey Weinstein's attention for their early indies, parenting in show business and the overwhelming fame they gained as teens with 'Mean Girls' and 'The O.C.' Amanda Seyfried: Did you play that video game 'Guitar Hero' with us on [the set of 'Jennifer's Body']? Adam Brody: No. But I think you had a rental car, and we drove to a beach. Seyfried: Yep. We got high. Brody: I don't remember that. I was too high to remember that. Seyfried: I don't know if I could do pot again. I think I'm allergic to it. I had some bad experiences. But I remember that being the most peaceful. That was probably the last time. I might have also gotten stoned with you at your house that I now own. Brody: What a host. Seyfried: You have an effect on people. Look at what's happening: You're in a hit show, and people are gasping, 'Adam Brody.' Brody: I don't think it's pot-related. Seyfried: It's just that you make people feel at ease. Brody: I really appreciate that. I'm pretty attuned to people's discomfort. Seyfried: Everybody watched 'Nobody Wants This.' But with our shows, we're talking about opposites when it comes to genre and tone. Brody: Yours is sad and dreary. And you're in almost every frame. Was it a lot of heavy lifting? Seyfried: It was the first time I had been away from my kids five days a week. Our days were so long, I'd stay in the city and then I'd go home on the weekends. That was a lot of 'I'm here for you, kids. If I end up taking a nap accidentally, you can cuddle with me.' Brody: You were a producer on this as well. What did that mean? Seyfried: I was the kind of producer whose agent just negotiated a credit. But I did have the leadership role on set. I was No. 1 on the call sheet, which was nice because you set the tone. If you're a No. 2 or 3 and you have an asshole No. 1? The show can just be [awful]. Brody: I haven't been a lead on a series in a while, and I enjoy saying, 'OK, we're all going to be here for a minute. This is the family; let's get into a groove.' Seyfried: My friend Katherine Pope, who works with Liz Meriwether and produced 'The Dropout,' sent me this beautiful book, 'Long Bright River.' I thought, 'OK, I'm ready for this.' The strike had just ended. What about you? Brody: Kristen Bell and I are connected in a few ways. I heard through the grapevine she was doing this and was really recommending me for it. I knew I had a job at the other end of the strikes, and it did afford me some time do research. Seyfried: The show was originally called 'Shiksa.' Brody: It was. Seyfried: That's a genius title. We need romance. Brody: That's something that I love doing. It doesn't come your way that often, and if it does, it's not good. They make [fewer romances] now. Romance and comedy are a pure dopamine hit and were sorely needed in 2024. They're going to be sorely needed in '25. In terms of the interfaith relationship, I think it's been relatable. So many people have come up to me and said, 'My wife is a shiksa.' We're a great stand-in for any differences between two people, philosophical or cultural. When you merge two individuals, growth and compromise is what you have to navigate. Seyfried: And it's about what your families want. It's 'Romeo and Juliet.' Brody: On 'Long Bright River,' the kid who plays your son is so good. We're parents of similar-age kids, and I haven't portrayed a parent yet. Had you done that before? Seyfried: As soon as the people of Hollywood understood that I popped something out of my body, they're like, 'You're a mom now.' And it comes with a lot of benefits. The roles are richer. Are you more collaborative now that you're in the second season of 'Nobody Wants This'? Are you bringing your own ideas? Brody: It's a very collaborative set, but I would say the first season was so in flux that we were finding the show together. Now we know what we're doing, so the die is cast and there's a little less to discuss. Seyfried: Remember when you played an iconic teenage character on 'The O.C.'? Brody: In my 20s. You were younger when you did 'Mean Girls,' right? Seyfried: I was 17, the perfect age for that. Except my mom had to live with me. Brody: I was that Steve Buscemi meme of the old man saying, 'Hello, fellow kids.' Seyfried: You weren't that old. Are you kidding? The people from '90210' were in their 30s. Brody: Have you rewatched 'Mean Girls'? Seyfried: No. It's on often enough though. I love it. I really love seeing my face on people's T-shirts. I'm a little resentful because Paramount still owes me some money for the likeness. Every store sells 'Mean Girls' T-shirts with our faces. Don't I [get something from that]? Even the girl at TSA tells me it's her favorite movie. Oh my God, remember when we did 'Lovelace,' and I gave you a blow job? Brody: An iconic blow job. The deep throat — the titular deep throat. How do you feel about that movie now? Seyfried: I had a great experience. It was a move towards attracting a level of respect for skill as opposed to … I didn't care about the reception as much as just changing the idea people had of me in the business. It's just so easy to get pigeonholed. Brody: I remember Harvey Weinstein bought it. Seyfried: I had heard a few rumors about him, but not to the extent that it became. I invited him to the screening [at Sundance]. He showed up and said, 'I bought it,' and I gave him the biggest hug. The whole room was buzzing. He was the big papa of the room — we all needed him to want our project if it was an indie, because that meant it was going to go somewhere. So 2003 was the year I graduated and did 'Mean Girls,' and the year you started 'The O.C.' We both had these pivotal career moments, and you became a pop star overnight. I can't imagine that was easy. Brody: It was. We were in a bubble. It was pre-social media. I can't imagine it now. Now it seems like an incredible responsibility, where you could fuck your whole life up in one second. I'm really impressed with some of these kids who have this awesome responsibility of huge platforms, and some of them are brave and do what's right. Seyfried: I think doing what's right is just hiding in a bunker. We're making another ['Jennifer's Body']. Are you going to do it? Brody: I heard. I wasn't contacted. I died [in the first one]. Seyfried: So did Megan Fox, and I'm not doing it without her. Best of Variety 25 Hollywood Legends Who Deserve an Honorary Oscar New Movies Out Now in Theaters: What to See This Week Emmy Predictions: Animated Program — Can Netflix Score Big With 'Arcane,' 'Devil May Cry' and the Final Season of 'Big Mouth?'
Business Insider
10-06-2025
- Entertainment
- Business Insider
Amanda Seyfried says Paramount still owes her money for using her face on 'Mean Girls' merch
Amanda Seyfried still loves seeing her face on "Mean Girls" T-shirts — but she's also wondering why she never saw any cut of the merchandise profits. Seyfried, who played the ditzy "Plastics" clique member Karen Smith in the 2004 teen comedy, recently sat down with her "Jennifer's Body" costar Adam Brody for Variety's "Actors on Actors" video series. When asked about her iconic role, she said "Mean Girls" is still a big part of her life more than two decades after its release. "I'm a little resentful because Paramount still owes me some money [for] the likeness," Seyfried told Brody. "Every store sells 'Mean Girls' T-shirts with our faces, photographs. And I'm like, don't I [get something from that]?" "Is it 'cause I was 17 and dumb?" Seyfried added, referring to her age when she was signed on for the role. It's not uncommon for actors to receive royalties if their name or likeness is used in merchandising, although deals vary and tend to be negotiated by lawyers and agents ahead of filming. It's also not unheard of for studios to be stingy with payments. For example, James Best, who played Sheriff Rosco P. Coltrane in the '80s film "The Dukes of Hazzard," reportedly signed a contract with Warner Bros. Entertainment that guaranteed him "5% of merchandising revenue from products that featured his identity," per The Hollywood Reporter. However, in 2011, he sued the studio for withholding millions in compensation. (The parties reached an undisclosed settlement two years later.) The question of actors controlling their own images became a central issue during the 2023 SAG-AFTRA strike in Hollywood, when the union fought to require "informed consent" for an actor's likeness to be replicated with AI.
