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Private Donors Give $350,000 To Precision Medicine Study for Colorectal Cancer Patients
Private Donors Give $350,000 To Precision Medicine Study for Colorectal Cancer Patients

Yahoo

time12-06-2025

  • Business
  • Yahoo

Private Donors Give $350,000 To Precision Medicine Study for Colorectal Cancer Patients

Ron and Martha Doornink have partnered with Fight CRC to support innovative research focused on tumor profiling metastatic colorectal cancer. Ron and Martha Doornink Quote Springfield, Mo., June 12, 2025 (GLOBE NEWSWIRE) -- Philanthropic support from private donors is what's helping fund a new study focused on advancing precision medicine for metastatic colorectal cancer patients. The Ron and Martha Doornink Foundation is giving $350,000 to help support a feasibility study led by the national nonprofit Fight Colorectal Cancer (Fight CRC) in partnership with biotech company First Ascent Biomedical. The study will utilize First Ascent's xDRIVE tumor profiling platform, which integrates functional drug testing, genetic analysis, and artificial intelligence to deliver rapid, personalized treatment insights. First Ascent's xDRIVE platform enables clinicians to understand tumor biology in real time, providing a clearer path to treatment personalization. Outcomes of the study will lead to increasing understanding and access to a patient's biomarkers, which are unique markers inside a tumor that are essential to identify when it comes to personalizing treatment options. 'Ron and Martha have both been personally impacted by colorectal cancer, which fuels their deep passion for advancing research and improving outcomes for patients facing this disease,' said Anjee Davis, CEO of Fight Colorectal Cancer. 'Their advocacy and support have been instrumental in making this project possible, and we are grateful for their generosity and trust as they team up with Fight CRC to make this happen.' 'We believe in the power of innovation to change lives,' said Ron Doornink, a Fight CRC emeritus board member. 'Supporting this study gives us hope that patients will benefit from more effective, personalized treatment approaches.' The study began enrolling patients in 2025 and will include 25 individuals with metastatic colorectal cancer seen in Rochester, Minnesota. The study is expected to complete enrollment within nine months. Leading the clinical efforts are Hao Xie, MD, PhD, gastrointestinal cancer specialist and precision medicine expert; and Dr. Boardman, a nationally recognized researcher in colorectal cancer. Dr. Boardman previously received a $200,000 research grant from Fight CRC, also supported by the Ron and Martha Doornink Foundation. Noah Berlow, PhD, Chief Technology Officer at First Ascent Biomedical, serves as the study's principal investigator. Additional details will be available on as the study progresses. 'This collaboration with Fight Colorectal Cancer represents an important step toward more precise, timely interventions for patients with advanced disease,' said Jim Foote, founder and CEO of First Ascent Biomedical. This is the 16th research grant Fight CRC has awarded to cutting-edge colorectal cancer research in its 20-year history; several of the awards were privately funded by philanthropists like the Doorninks. To learn more about how to partner with Fight CRC in funding research, contact Michell Baker at PhilTeam@ Attachment Ron and Martha Doornink Quote CONTACT: Savanna Doud Fight Colorectal Cancer 703.548.1225 savanna@ in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data

Why disaffected actors often make excellent playwrights
Why disaffected actors often make excellent playwrights

Spectator

time11-06-2025

  • Entertainment
  • Spectator

Why disaffected actors often make excellent playwrights

Actors are easily bored on long runs. Phoebe Waller-Bridge once revealed that she staged distractions in the wings to amuse her colleagues. On the last night of Hay Fever, egged on by another actor, she bent over 'and showed [her] arsehole' to the on-stage actors. Nabokov's plays are seldom performed. But he was alive to middling, mediocre dramatic clichés, fashions long-forgotten, but invaluably preserved in his 1941 lecture 'The Tragedy of Tragedy': 'The next trick, to take the most obvious ones, is the promise of somebody's arrival. So-and-so is expected. We know that so-and-so will unavoidably come…' This is the lost convention, the stand-by that Beckett was frustrating in Waiting for Godot – with its tedious announcements and its adamantine disappointment. John Osborne was a jobbing actor and therefore intimately irritated by the conventions of repertory drama. In Epitaph for George Dillon, co-written with another actor, Anthony Creighton, Osborne super-sizes the Act One curtain line. It is announced that George Dillon will be arriving as a temporary lodger. He arrives. It is intimated that he will replace Raymond, a son who has been killed in the war. He is exceedingly polite. But his curtain line, as he contemplates a framed photograph of Raymond, is 'You stupid-looking bastard'. As David Baron (his stage name), Harold Pinter was another disaffected thesp. Hence his brusque impatience with dramatic convention. The Caretaker begins by violating convention: MICK is alone in the room, sitting on the bed. He wears a leather jacket. Silence. He slowly looks about the room, looking at each object in turn. He looks up at the ceiling, and stares at the bucket. Ceasing, he sits quite still, expressionless, looking out front. Silence for thirty seconds. Thirty seconds of silence in the theatre is an eternity. And this second silence follows on the initial silence. Then Mick exits. Without saying a word. An unusual, irregular opening. When Act One ends, we expect the act-division to cover an omitted passage of time. But Act Two begins 'A few seconds later'. The Room begins as a two-hander – a bizarre one-handed two-hander, in which the wife drivels on, unstoppably. The husband, Bert, says nothing until the very end of the play – an extreme version perhaps of the radio comedy Take it from Here, where the young couple, Ron and Ethel, displayed the same imbalance, Ron's dialogue being restricted to 'Yes, Eth'. Ron being short for Moron. The Homecoming has an important stage direction describing the set. The wall between the sitting room and the staircase isn't there. The audience assumes this is an exploded view, a stage convention, so we can see what would otherwise be hidden. However, as Lenny tells us later, the wall has actually been knocked through. The imaginary and the real are confused, as they are for most of the play, until it becomes clear that the men in the play are acting out a communal fantasy – a sexual fantasy trailed by Max, the patriarch, when he is guying his homosexual brother, Sam: 'When you find the right girl, Sam, let your family know, don't forget, we'll give you a number one send-off, I promise you. You can bring her to live here, she can keep us all happy. We'd take it in turns to give her a walk round the park.' This prolepsis is long before the arrival of Ruth and Teddy, long enough for the audience to forget it. Ruth is a prostitute. But for most of the play we aren't certain. The confusion over the wall is emblematic of this overall instability. The Dumb Waiter – two killers waiting for their victim – derives from Hemingway's story 'The Killers'. The hyper-banal is invested with menace. Hemingway's title makes even the diner menu toxic: 'chicken croquettes with green peas and cream sauce and mashed potatoes.' Banal, except that the men eat with their gloves on. 'In their tight overcoats and derby hats they looked like a vaudeville team' – if they didn't look so much like gangsters, George Raft or Jimmy Cagney. Food and fear, a telling zeugma. In Pinter, orders for scampi, for soup of the day, liver and onions, jam tart, arrive via the dumb waiter, defunct but still active – like a moribund stage convention. Here we have the classical convention of the deus ex machina, the god lowered in some sort of box who intervenes at a play's end to resolve all difficulties and provide solutions. But instead of instructions, there are customer 'orders'. It is significant that the stage directions refer to the 'box': 'The box descends with a clatter and bang.' Not 'compartment' or 'shelf'. Pinter's play knows it is a play. Just before the dénouement, Gus and Ben rehearse: BEN: When we get the call, you go over and stand behind the door. GUS: Stand behind the door. BEN: If there's a knock on the door you don't answer it… What transpires, however, is nothing like the rehearsal. Gus stumbles in looking more like a victim than an executioner: 'He is stripped of his jacket, waistcoat, tie, holster and revolver.' A reversal of the rehearsal. Nothing is resolved. Anyone for menace?

Evolve Sparkling House Crowned Canada's Top Sparkling Producer at 2025 All Canadian Wine Championships
Evolve Sparkling House Crowned Canada's Top Sparkling Producer at 2025 All Canadian Wine Championships

Cision Canada

time11-06-2025

  • Business
  • Cision Canada

Evolve Sparkling House Crowned Canada's Top Sparkling Producer at 2025 All Canadian Wine Championships

Penticton's Sparkling Winery Takes Home Coveted National and International Titles Ahead of its Official Grand Opening PENTICTON, BC, June 11, 2025 /CNW/ - Evolve Sparkling House is proudly popping corks after sweeping the sparkling wine category at this year's All Canadian Wine Championships (ACWC), earning the prestigious trophy of 'Best in Category' for its 2018 Brut Nature officially making it Canada's Best Sparkling Wine of the Year. The soon-to-open Sparkling House, located on the iconic Naramata Bench, also captured Gold for its 2018 Brut Rosé and Silver for the 2020 Brut Premiere, reaffirming its dedication to crafting exceptional sparkling wines in British Columbia. And it's not just national recognition. Earlier this year, the 2020 Brut Premiere earned a Silver Medal and 90 points at the International Wine & Spirits Competition (IWSC) in London, U.K.—one of the world's most respected global benchmarks for quality. "We're absolutely thrilled by this recognition," said Ron and Shelley Mayert, owners of Evolve Sparkling House. "These wins validate our vision of dedicating an entire winery to bubbles—and prove what we've believed all along: that BC is producing sparkling wines that deserve the spotlight." Crafted using the traditional method, all three award-winning wines reflect the unique terroir of the Okanagan Valley—an emerging region for premium sparkling thanks to its Champagne-aligned latitude and growing conditions. Each cuvée showcases the craftsmanship of winemaker Lynzee Schatz, who brings global perspective and local roots to every bottle. "It's incredibly special to see our 2018 Brut Nature named Canada's top sparkling wine," said Schatz. "This wine is pure expression—zero dosage, zero compromise—and to see it stand out on a national stage is a moment of pride for our entire team." Evolve Sparkling House is set to officially welcome guests later this June, offering tasting experiences and unforgettable lake views from its contemporary new home on the Naramata Bench. While a full grand opening announcement is coming soon, today's news serves as a toast-worthy teaser—and a reminder that life's too short not to sparkle. Stay tuned for the grand reveal. In the meantime, buy the award-winning bubbles here. About Evolve Sparkling House Evolve Sparkling House is a family-owned winery located in the heart of British Columbia's stunning Okanagan Valley. Specializing in sparkling wines, the winery focuses mainly on traditional method expressions, complemented by a couple crafted in the Charmat method. In addition to its sparkling portfolio, Evolve also produces a still rosé, white, and red, thoughtfully made to reflect the character and vibrancy of the region. Blending time-honored techniques with a fresh perspective, Evolve Sparkling House is driven by the idea of pushing boundaries. Every bottle tells a story—of place, passion, and the belief that life's too short not to sparkle.

'World-first' Abbey Road proposal inspires new song
'World-first' Abbey Road proposal inspires new song

Perth Now

time11-06-2025

  • Entertainment
  • Perth Now

'World-first' Abbey Road proposal inspires new song

A couple's proposal has inspired a new record. Christina Teenz Tan and Ron Danziger got engaged inside London's Abbey Road's Studio One in November 2021, while they were recording their co-written track Pie-in-the-Sky - will have their new song Timeless be performed by 2022 Britain's Got Talent star Tom Ball. Like Pie-in-the-Sky, the Royal Philharmonic Orchestra and London Voices Choir, conducted by Robert Zeigler, recorded with Tom for the single - which will be released on June 27. The song - which has won 40 international awards for excellence in music and artistic direction - celebrates the preciousness of a bond that transcends time, culture, and the human experience. It was composed by Danziger with lyrics by Tan, arranged by Manu Martin, directed by Susan Lim and co-produced by Lim and Martin. The track was mastered by Greg Calbi and Steve Fallone - two of the industry's most respected engineers with a combined 12 Grammy Awards, having worked with Tony Bennett, Lady Gaga, Taylor Swift, and more. Ron and Christina will walk down the aisle to 'Timeless' when they marry at the Hotel Bel-Air in Los Angeles on June 14. It will then be performed in St Giles Church, London on June 19 as part of the Summer Music in City Churches Festival. Ron, the composer, said: 'Timeless captures the essence of our story—one of deep connection across worlds of science and music. To celebrate our wedding with this piece feels like coming full circle.' Christina, the songwriter, added: 'Writing the lyrics to Timeless was a way of capturing how I saw our journey then. Hearing it now—fully realised with an orchestra, and sung on stage—it feels like our love set to music.' Hear 'Timeless' live in London on June 19, by booking tickets through Pre-order the single by visiting

HBO's ‘Harry Potter' series reportedly casts Harry, Ron, Hermione
HBO's ‘Harry Potter' series reportedly casts Harry, Ron, Hermione

American Military News

time10-06-2025

  • Entertainment
  • American Military News

HBO's ‘Harry Potter' series reportedly casts Harry, Ron, Hermione

The spell has been cast, and so too have Harry, Ron and Hermione in HBO's new 'Harry Potter' series. Dominic McLaughlin will sport the lightning bolt scar as the titular chosen wizard, while Arabella Stanton — who recently starred as Matilda in the West End's production of 'Matilda: The Musical' — and Alastair Stout will round out the trio as Hermione Granger and Ron Weasley, respectively, Variety reports. Daniel Radcliffe, Emma Watson and Rupert Grint were the first actors to play the magical roles, across eight films from 2001 to 2011. 'The talent of these three unique actors is wonderful to behold, and we cannot wait for the world to witness their magic together onscreen,' showrunner Francesca Gardiner and director-executive producer Mark Mylod said in a statement to the outlet. 'We would like to thank all the tens of thousands of children who auditioned.' Variety reports that over 30,000 hopefuls tossed their sorting hats in the ring since the fall. Also recently announced were the castings of John Lithgow as Headmaster Albus Dumbledore, Janet McTeer as Minerva McGonagall, Paapa Essiedu as Severus Snape and Nick Frost as Rubeus Hagrid. The Hollywood Reporter first broke news of the show, based on J.K. Rowling's hit children's fantasy books, in early 2021. The show is expected to debut next year, with filming slated for this summer. The network has already promised 'a faithful adaptation of the beloved 'Harry Potter' books.' In April 2023, Bloomberg reported that Warner Bros. Discovery was 'close to a deal' enabling them to adapt each of the seven books for the small screen. Rowling's name in recent years has been perhaps more entwined with her anti-transgender political views than the Hogwarts-set tale. ___ © 2025 New York Daily News. Distributed by Tribune Content Agency, LLC.

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