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The Hindu
4 hours ago
- Health
- The Hindu
What you need to know about the ‘razor blade' Covid variant
Covid-19, it seems, can never stay out of the news for very long. One variant of the virus has been making headlines recently for being behind a spike in cases, particularly in China and the United States, and for causing 'razor blade' throats, or a severely painful sore throat. What do you need to know about this? Read on, to find out. The 'razor blade' throat, reports indicate, is being caused by the NB.1.8.1 variant of the virus, an Omicron-descendent variant dubbed as 'Nimbus' and currently accounting for a large number of cases worldwide. On May 23, 2025, the World Health Organization classified this variant as a 'SARS-CoV-2 variant under monitoring (VUM) with increasing proportions globally, while LP.8.1 is starting to decline.' A technical document by the WHO states: 'Considering the available evidence, the additional public health risk posed by NB.1.8.1 is evaluated as low at the global level. Currently approved COVID-19 vaccines are expected to remain effective to this variant against symptomatic and severe disease. Despite a concurrent increase in cases and hospitalizations in some countries where NB.1.8.1 is widespread, current data do not indicate that this variant leads to more severe illness than other variants in circulation.' Symptoms remain similar to those caused by other Covid-19 strains and include fever, a sore throat, cough, runny nose and tiredness. Media reports indicate some patients complaining of a sharp, stabbing pain while swallowing, often at the back of the throat, akin to 'swallowing a razor blade'. However, it is unclear if this is a distinctive symptom of this variant The WHO, in its technical document, had said spike mutations in this variant could increase its transmissibility. In India, according to data from the Indian SARS-CoV-2 Genomics Consortium (INSACOG), one case of NB.1.8.1 was identified in April in Tamil Nadu and four cases of LF.7 were detected in Gujarat in May. As of May, the most common variant remained JN.1, comprising 53 % of samples tested, followed by BA.2 (26 %) and other Omicron sublineages (20 %). In June, a media report stated about 163 cases of the COVID-19 variant XFG, had been detected, according to INSACOG data. Earlier this week, Naveen Kumar, Director, National Institute of Virology (NIV), Pune, said surveillance and genome sequencing have been scaled up. He said genomic analysis had revealed the surge was due to the JN.1.16 sub-lineage of the Omicron variant, and that since May 2025, it had been replaced by the XFG (LF.7 and LP.81.2) recombinant variant. Doctors in India have reiterated that Covid-19 is now co-circulating with other seasonal infections and that they do not expect any major waves of the kind seen in 2021 and 2021. Spikes and dips however, may continue. Personal protection and hygiene measures such as hand washing, avoiding crowded places when possible or masking up, and protecting vulnerable segments of the population must continue, they have said. As of Friday, June 20, 2025, India's tally of active Covid-19 cases dipped to 5,608 from the 7,000 plus mark last week, and four new deaths were reported, taking the total toll this year to 120.
The Hindu
a day ago
- Health
- The Hindu
ICMR sets up high performing computing facility to boost genomic surveillance and pandemic preparedness
Working to address limitations faced during the COVID-19 pandemic due to conventional computing infrastructure, the Indian Council of Medical Research (ICMR) has now introduced its first high-performance computing facility at its National Institute of Virology (NIV) facility in Pune. The acquisition of the state-of-the-art computing cluster, named NAKSHATRA, comes soon after India reported a surge in COVID-19 cases, though the number of active cases have dipped marginally over the last two days. ICMR-NIV Pune director Naveen Kumar noted that several new pathogens and COVID variants are being reported. 'It's essential that we upgrade to stay ahead in enhancing public health research capacity,' he said. Genomic research upgrade Attributing the emergence of novel pathogens to increased globalisation, global warming, and deforestation, Dr. Kumar said that his centre has been doing extensive sequence analysis using multiple strains, which used to take weeks. 'Now with the upgrade we can do the same work in 24 to 48 hours. It has increased the capability of our country for genomic surveillance, which will help us in pandemic preparedness,' he said. The NAKSHATRA facility enables enhanced storage and optimises the pipeline for genomic research, which ensures better viral genomic surveillance capacity and national preparedness for any future pandemic. The facility supports faster analysis of complex genomic data, allowing scientists to detect new disease threats sooner, respond to outbreaks more efficiently, and accelerate AI-driven vaccine and drug development. Central data repository Developed under the Pradhan Mantri Ayushman Bharat Health Infrastructure Mission (PMABHIM), the facility forms the cornerstone of a new project, called the High Performance Computing Next Generation Sequencing Hub. The Pune facility will initially serve five ICMR institutes across the country, acting as a central repository for sequencing data. Sarah Cherian, group leader of the Bioinformatics and Data Management Group and principal investigator of the project, provided a comprehensive overview of the cluster's capabilities and its role in genomic research. She said that the computing cluster is tailored to support complex bioinformatics workflows, including next-generation sequencing, transcriptomics, phylogenetics, metagenomics, and structural bioinformatics. Genomic monitoring impact Already, NIV Pune has played a key role in the management of the COVID-19 pandemic. Previously significant genetic alterations in the virus had triggered the second and third wave and ongoing genomic monitoring and analysis helped in early detection of variants of interest and concern. 'This in turn had helped in paving the way for implementing the booster dose of vaccination for COVID,' the institute noted.
Time of India
a day ago
- Health
- Time of India
ICMR-NIV Pune inaugurates High Performance Computing facility to boost genomic research and pandemic preparedness
Pune: The Indian Council of Medical Research (ICMR) on Wednesday marked a significant milestone in advancing India's public health research capabilities with the inauguration of its first High Performance Computing (HPC) facility at the ICMR-National Institute of Virology (NIV), Pune. The computing cluster named 'Nakshatra' was officially inaugurated by Dr Rajiv Bahl, Secretary of the Department of Health Research (DHR) and Director General of ICMR, according to an official statement from ICMR. "Developed under the Pradhan Mantri Ayushman Bharat Health Infrastructure Mission (PM ABHIM), the HPC facility forms the cornerstone of a new project titled "High Performance Computing Next Generation Sequencing (NGS) Hub". The initiative aims to revolutionize how genomic and bioinformatics data are processed, addressing limitations faced during the COVID-19 pandemic due to conventional computing infrastructure," the statement added. Addressing a gathering regarding the inauguration of the computing facility, the Director General of ICMR commended the institute for its timely and strategic step towards ' Viksit Bharat 2047 ' vision by strengthening the country's genomic surveillance and data analysis capacity. He highlighted how enhanced computing resources are crucial in preparing for technology-driven pandemic preparedness and future public health emergencies. Meanwhile, Director of ICMR-NIV, Dr Naveen Kumar, emphasised the critical role the HPC cluster will play in supporting rapid, data-driven responses to outbreaks. Dr Sarah Cherian, Group Leader of the Bioinformatics and Data Management Group and Principal Investigator of the project, provided a comprehensive overview of the cluster's capabilities and its role in genomic research . According to the official statement, the newly commissioned HPC cluster features twelve compute nodes offering a total of 700 cores and 1 petabyte of storage. "The infrastructure is tailored to support complex bioinformatics workflows, including next-generation sequencing (NGS), transcriptomics, phylogenetics, metagenomics, and structural bioinformatics. Initially, the facility will serve five ICMR institutes across the country, acting as a central repository for sequencing data and extending support to Viral Research and Diagnostic Laboratories (VRDLs) soon, making the institute as a critical hub for outbreak investigations and pandemic preparedness, with the potential to accelerate AI-driven drug and vaccine discovery," the statement added. Highlighting the advantages of the HPC facility, ICMR highlighted how it is a "national investment in speed, precision, and preparedness." The statement mentioned, "By enabling faster analysis of complex genomic data, the facility positions India to detect new disease threats sooner, respond to outbreaks more efficiently, and accelerate AI-driven vaccine and drug development."
Hindustan Times
a day ago
- Hindustan Times
20-year-old man shot dead in Punjab's Hoshiarpur, search on for three accused
A 20-year-old man was shot dead by three unidentified motorcycle-borne assailants near Shahpur Ghata village on the Garhshankar-Nangal road in Hoshiarpur district, police said on Thursday. Aryan, a resident of Seehwan village, was returning from Ludhiana with his relative, Naveen Kumar, 27, in his Maruti Swift car on Wednesday night, Hoshiarpur superintendent of police (investigation) Mukesh Kumar said. Both were returning after buying garments for their shop. They halted near Shahpur Ghata village as Naveen felt unwell. Soon after he stepped out of the car, three masked men on a motorcycle opened fire at Aryan, who was sitting inside the car, hitting him in the head and chest. He died on the spot, the officer said, adding the assailants fled immediately after the attack. The police came to know of the incident on receiving a call from the Garhshankar civil hospital, where the body had been brought. Deputy superintendent of police Gurpreet Singh said a murder case has been registered and investigation is underway.
Time of India
a day ago
- Health
- Time of India
NIV Pune isolating 4 Omicron sub-variants responsible for recent rise in Covid cases: Director
Pune: The National Institute of Virology (NIV) Wednesday said it is genome sequencing and isolating four new sub-variants of Omicron which are believed to be responsible for the recent rise in Covid cases across India. This effort will help in assessing vaccine effectiveness , Dr Naveen Kumar, director of Pune-based NIV under the ICMR, said. An upsurge of Covid cases was noticed since the second week of April. Kumar said that after genome sequencing of samples across India, four sub- variants of Omicron -- LF.7, XFG, JN.1. 16 and NB. 1.8.1 -- have been found. Genomic analysis revealed that the surge was due to JN.1.16 sub lineage of Omicron variant and since May, it was replaced by the XFG (LF.7 and LP.81.2) recombinant variant. Whole genome sequences have been submitted to Indian Biological Data Centre and Global Initiative On Sharing All Influenza Data, Kumar said. "Scientists at NIV are doing monitoring, genome sequencing and isolating the new variants. The strain, which was circulating in Singapore, was also found in India five-six weeks ago. "Isolation is important to replace the existing vaccine strain if at all it is required. Whether or not this needs to be replaced is something which is to be critically analysed based on the severity of the disease. So far it appears that the strains are not much severe. However, the decision of making a new vaccine using the currently circulating strains is taken by policy makers after extensive discussion," Kumar said. Currently, two monovalent Omicron-based vaccines are available - Biological E Limited's Corbivax and Serum Institute of India's COVOVAX. The situation is being continuously monitored by the health ministry. Meanwhile, the active Covid caseload in the country has marginally dropped. As of June 18, there are 6,483 active cases as compared to 6,837 cases on Tuesday. Official sources have maintained that severity of infections has been low and most of the patients are being managed under home care. Since January 1, 113 deaths have been reported, primarily among individuals with pre-existing illnesses. Kerala continues to be the most-affected state, followed by Gujarat, Karnataka and Delhi, according to the health ministry's data released on Sunday. Meanwhile, all states have been instructed to ensure availability of oxygen, isolation beds, ventilators, and essential medicines to deal with Covid cases, official sources said on Wednesday.
