Latest news with #Moderna
Globe and Mail
4 hours ago
- Business
- Globe and Mail
VOO ETF News, 6/16/2025
How is VOO stock faring? The Vanguard S&P 500 ETF is down 1.03% in the past five days and 9.11% over the past year. Confident Investing Starts Here: According to TipRanks' unique ETF analyst consensus, determined based on a weighted average of its holdings' analyst ratings, VOO is a Moderate Buy. The Street's average price target of $611.49 implies an upside of 11.43%. Currently, VOO's five holdings with the highest upside potential are Caesars Entertainment (CZR), Interpublic Group of Companies (IPG), Moderna (MRNA), LKQ Corp. (LKQ), and PG&E Corp. (PCG). Meanwhile, its five holdings with the greatest downside potential are Palantir Technologies (PLTR), Franklin Resources (BEN), Cf Industries Holdings (CF), Tesla (TSLA), and Garmin (GRMN). Revealingly, VOO ETF's Smart Score is a seven, implying that this ETF will likely perform in line with the market. Power up your ETF investing with TipRanks. Discover the Top Equity ETFs with High Upside Potential, carefully curated based on TipRanks' analysis.
Medscape
a day ago
- Health
- Medscape
Vaccination Tied to Better Survival in COVID-Linked AKI
Among patients hospitalized with COVID and acute kidney injury (AKI), unvaccinated individuals had longer hospital stays, more frequent need for continuous renal replacement therapy, higher dependence on dialysis at discharge, and substantially higher rates of in-hospital and long-term mortality than their vaccinated peers. METHODOLOGY: AKI affects up to 28%-46% of patients hospitalized with COVID, with effects ranging from mild decline in renal function to dependency on dialysis; however, long-term renal and survival outcomes of these patients remain poorly understood. Researchers conducted a single-center cohort study to evaluate renal outcomes in 972 vaccinated and unvaccinated patients with COVID and AKI admitted to a large urban academic quaternary care hospital from March 1, 2020, to March 30, 2022. Among the included patients, 411 (median age at COVID diagnosis, 67 years; 37% women) were unvaccinated, whereas 467 (median age at COVID diagnosis, 67.4 years; 38.5% women) had received at least two primary-series doses of the Pfizer-BioNTech or Moderna mRNA COVID vaccine or a single dose of the Johnson & Johnson Janssen COVID vaccine prior to hospitalization. The primary outcome was in-hospital mortality, whereas secondary outcomes included long-term mortality, length of hospital stay, and need for renal replacement therapy at discharge. The median follow-up duration was 232 days. TAKEAWAY: Unvaccinated patients had significantly higher rates of in-hospital mortality (adjusted hazard ratio [HR], 5.54; 95% CI, 3.36-9.13) and long-term follow-up mortality (adjusted HR, 4.78; 95% CI, 3.39-6.73) than vaccinated patients. They were also more likely to require continuous renal replacement therapy during hospitalization than vaccinated patients (15.8% vs 10.9%; P = .03); the need for this therapy was associated with increased risks for in-hospital death (adjusted HR, 2.82; 95% CI, 1.88-4.25) and long-term mortality (adjusted HR, 2.44; 95% CI, 1.73-3.42). = .03); the need for this therapy was associated with increased risks for in-hospital death (adjusted HR, 2.82; 95% CI, 1.88-4.25) and long-term mortality (adjusted HR, 2.44; 95% CI, 1.73-3.42). Unvaccinated patients had higher odds of being discharged on renal replacement therapy (odds ratio, 2.56; 95% CI, 1.52-4.30) and had a significantly longer median length of hospital stay (12 days vs 8 days) than vaccinated patients. IN PRACTICE: 'Patients who completed the primary vaccine series with COVID-19 infection and AKI had a lower mortality rate and were less likely to remain on renal replacement therapy at the time of discharge,' the authors wrote. SOURCE: This study was led by Niloofar Nobakht, MD, Division of Nephrology, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles. It was published online on June 17, 2025, in Kidney Medicine . LIMITATIONS: Missing baseline creatinine data limited the ability to stage AKI and likely contributed to the significant differences in AKI staging observed between the vaccinated and unvaccinated cohorts. This study lacked data on ventilation status and other indicators of infection severity in patients admitted to ICUs who received continuous renal replacement therapy. Information regarding COVID booster vaccinations was not available. DISCLOSURES: One author received support from the National Institutes of Health, the Smidt Family Foundation, the Factor Family Foundation, the Davita Allen Nissenson Research Fund, and the Ralph Block Family Foundation.
Health Line
a day ago
- Health
- Health Line
What Are the Side Effects of the COVID-19 Vaccine?
According to the World Health Organization (WHO), healthcare professionals have given more than 13 billion COVID-19 vaccine doses since 2021, saving an estimated 14.4 million lives. These vaccines can also help prevent hospitalizations and serious illness caused by COVID-19. Researchers carefully track the side effects of the COVID-19 vaccine. Side effect considerations were an important part of clinical trials before the Food and Drug Administration (FDA) approved the vaccines, and will remain in consideration as people continue to get the vaccines. Here's what you should know about COVID-19 vaccine side effects. What are the common side effects of the COVID-19 vaccine? As with all vaccines, side effects may occur after getting the COVID-19 vaccine. Currently, two types of COVID-19 vaccines are available: mRNA vaccines from Pfizer-BioNTech and Moderna and protein subunit vaccines from Novavax. Each type of vaccine has the potential for side effects. Here are the more commonly reported side effects for each type of COVID-19 vaccine: Side effects mRNA vaccines subunit vaccines pain, soreness, redness at injection site √ √ fatigue √ √ headache √ √ muscle pain √ √ joint pain √ √ chills √ √ fever √ √ nausea and vomiting √ √ in infants: irritability or crying, decreased appetite, and sleepiness √ According to the Centers for Disease Control and Prevention (CDC), even if you've had side effects from a COVID-19 vaccine, you can likely still have that vaccine at the next recommended vaccination dosage. However, if your healthcare professional suspects your reaction was an allergic reaction, you may need to see a doctor who specializes in treating allergies (allergist or immunologist) for a consultation before having another COVID-19 vaccination of that type. What are the chances of getting serious side effects from the COVID-19 vaccine? Serious COVID-19 vaccine side effects are very rare. According to the CDC, researchers have identified four adverse event types that have occurred. These include: Anaphylaxis: This is a severe and potentially life threatening allergic reaction that can cause breathing problems, hives, and low blood pressure. The CDC reports that Anaphylaxis affects approximately 5 individuals per one million people who receive a dose of the COVID-19 vaccine. Guillain-Barré syndrome (GBS): GBS is a rare side effect that can cause the immune system to attack healthy nerve cells. Symptoms include muscle weakness and sometimes paralysis. Myocarditis and pericarditis: These heart conditions are rare COVID-19 vaccine side effects. Myocarditis occurs when the heart muscle becomes inflamed, and pericarditis occurs when the tissue surrounding the heart swells and becomes inflamed. According to the CDC, though rare, these side effects most often affect young adult males within 7 days of their second mRNA COVID-19 vaccine dose. Currently approved mRNA vaccines include Moderna and Pfizer-BioNTech. Thrombosis with thrombocytopenia syndrome (TTS): TTS is a very rare side effect, affecting approximately 4 individuals per 1 million Johnson & Johnson Janssen COVID-19 vaccines given. It's associated with the now-discontinued Johnson & Johnson's Janssen COVID-19 vaccine. TTS can cause blood clots or increased blood clotting, which can potentially be life threatening. Once reports of individuals with TTS following the Johnson & Johnson's Janssen COVID-19 vaccine were studied, this vaccine was removed from the market in the United States. As of June 1, 2023, the FDA changed the Emergency Use Authorization (EUA) granted to the Johnson & Johnson vaccine, limiting authorization. This decision follows an analysis of the safety concerns regarding thrombosis with thrombocytopenia syndrome (TTS). The (Johnson & Johnson) Janssen COVID-19 Vaccine is no longer given in the United States. Federal agencies continue to track and investigate both mild and severe side effects of COVID-19 vaccines. Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission. Learn more. Do the side effects vary by age? COVID-19 vaccines are now FDA-approved for people ages 5 and up. Here are some of the side effects reported by age. Children Research suggests that children who receive the Pfizer-BioNTech (BNT162b2) have mainly mild and self-limiting side effects, such as discomfort at the injection site. Clinical trials in which researchers tested the vaccines in children also revealed no serious side effects, according to 2021 research. The most common side effects from the study were similar to those of adults. These included pain at the injection site, fatigue, chills, and headache. The most common symptom in children was a mild to moderate fever. Young adults A 2021 study of vaccine side effects published in JAMA found that younger adults were more likely to have adverse side effects than older adults. Another 2021 study found young adults and adolescent males were the most likely to experience myocarditis as a vaccine side effect. The study found that 79% of reported myocarditis events were in men. Older adults A 2024 survey of over 200,000 older adults who had between one and three COVID-19 vaccinations and boosters found that older adults who had COVID-19 vaccination had no increased risk of emergency hospital visits or hospitalization when compared to unvaccinated older adults. The participants reported common symptoms that rarely required medical assessment and resolved. Do the side effects vary by vaccine brand? The FDA has approved two COVID-19 vaccine brands in the United States: Pfizer-BioNTech and Moderna for mRNA vaccines and Novavax for protein subunit vaccines. The side effects of the two different types of vaccines are very similar. However, if you have a severe allergic reaction after getting a COVID-19 vaccine, the CDC recommends that you avoid getting another dose of the same vaccine type. For example, if you have an allergic reaction to the Pfizer-BioNTech vaccine, avoid the Moderna vaccine (and vice versa) since they work in the same way. Individuals are seven times more likely to experience myocarditis after infection with the virus that causes COVID-19 than after a COVID-19 vaccination. The CDC reports 80% of patients who were diagnosed with myocarditis at least three months before participating in a survey study had fully recovered or likely fully recovered as determined by their cardiologists. What does a lack of side effects from the COVID-19 vaccine mean? Some people will experience mild side effects from the COVID-19 vaccine, while others may have none. Your side effects (or lack thereof) don't mean the vaccine will work better for you than another person. The vaccine can help protect you regardless of your body's response. How to cope with the side effects of the COVID-19 vaccine If you experience side effects from the COVID-19 vaccine, here are some measures that may help: Apply cold compresses to the injection site. Drink plenty of fluids. Perform light stretches to relax your arm muscles. Take over-the-counter pain relievers like acetaminophen, ibuprofen, or aspirin (but only for those older than age 18). Rest and give your body time to recover. Side effects are generally mild and usually resolve within a few hours to a few days – less than a week. If you experience a significant side effect of the COVID-19 vaccine, report it to the Vaccine Adverse Event Reporting System (VAERS). This resource can also be used to report any new side effects you haven't heard mentioned before. How effective is the COVID-19 vaccine? At the start of the COVID-19 pandemic, there were no readily available protections or treatments for the coronavirus. Since then, researchers have found that the COVID-19 vaccinations have been highly effective at reducing the death rate from COVID-19 while finding no indication of increased risk of non-COVID mortality after vaccination. The COVID-19 vaccine has helped protect people against the coronavirus. According to the CDC, people who are unvaccinated have higher diagnosis and death rates than people who are vaccinated. People who are vaccinated, especially those ages 65 and older, can further reduce their risk by receiving a booster dose. Takeaway All vaccines have the potential for side effects. However, very few adverse events have been reported for the COVID-19 vaccine, and many worldwide health groups are monitoring side effects closely. Given the recommendations for COVID-19 vaccinations for people at increased risk, you may want to speak with your doctor or a healthcare professional to see if you have any health conditions that put you in the high risk category and if you are recommended to get a COVID-19 vaccination.
New York Times
2 days ago
- Health
- New York Times
Kennedy's Purge Is a ‘Code Red' for Vaccines in America
'Some people believe that the term anti-vaxxer is a pejorative,' the physician Robert Malone wrote on June 9. 'I do not — I view it as high praise.' Early in the pandemic, Malone campaigned for treatment with ivermectin and hydroxychloroquine and against mRNA vaccines, which he described as 'causing a form of' AIDS, though he later admitted he received the Moderna vaccine to treat his own long Covid. In 2021, Malone circulated a 2013 video of a high school athlete collapsing on the football field, blaming coronavirus vaccination for the death before he was served with a cease-and-desist letter from the family. More recently, he dismissed as 'misinformation' news reports attributing the deaths of two girls in Texas to measles, blaming not vaccine refusal but 'medical errors,' and last fall published a book, 'PsyWar,' claiming that between the C.I.A. and Department of Defense, the United States maintains 'reality-bending information control capabilities' and that much of federal government's business is conducted via sexual favor. 'The term 'anti-vaxxer,'' he repeated June 9, 'it is not a slur, but a compliment.' Two days later, he was appointed to the advisory board that steers America's vaccine policy. Richard Nixon conducted his 'Saturday night massacre,' back in 1973, when one after another federal prosecutor refused to withdraw a subpoena of the White House tapes. Robert F. Kennedy Jr., the health and human services secretary, staged his night of the long knives a week ago Monday, firing all 17 members of the vaccine advisory board, called the A.C.I.P., in one fell swoop — a historically unprecedented action and one that broke an explicit promise he made to Senator Bill Cassidy, Republican of Louisiana and a physician, as a condition of his confirmation as secretary. The epidemiologist and immunologist Michael Mina called Kennedy's move a 'code red' for vaccines in America. None of the A.C.I.P. advisers were warned or had their firings explained; they had to read the news in a Wall Street Journal op-ed that accused them of 'malevolent malpractice.' Cassidy, who dodged questions from reporters on the subject, was left sputtering on X: 'Of course, now the fear is that the A.C.I.P. will be filled up with people who know nothing about vaccines except suspicion.' Malone, whose appointment to the board hadn't yet been announced, posted proudly, 'Promises made, promises kept.' The new appointees are not all fully committed skeptics — though, beyond Malone, they include several people who have testified in lawsuits against vaccine manufacturers, as well as a longstanding board member for an anti-vaccine nonprofit and an M.I.T. business-school professor who has been publicly describing mRNA vaccines as mass killers since 2023. (The choices also include a nutritional scientist focused on fatty acids in the brain and a founder of a biotech company without a single piece of published research to his name.) The new group fails to include experts on any diseases that vaccines prevent. Or experts on vaccines themselves. Or experts on infectious-disease epidemiology. Or experts on clinical trials. 'We've taken people who had expertise and fired them for a bogus reason,' says the University of Pennsylvania vaccinologist Paul Offit, a former member of the A.C.I.P. and the creator of the rotavirus vaccine. In their place have been installed what the bioethicist Ezekiel Emanuel, also of the University of Pennsylvania, described to me as 'vaccine skeptics.' Offit calls them, more pointedly, 'purveyors of disinformation.' Want all of The Times? Subscribe.
Reuters
2 days ago
- Health
- Reuters
US Senate Democrats demand Kennedy explain canceling bird flu vaccine contract
WASHINGTON, June 18 (Reuters) - U.S. Senate Democrats demanded on Wednesday Health Secretary Robert F. Kennedy Jr. make public the reviews on which his department said it based its decision to cancel a contract for developing a bird flu vaccine. President Donald Trump's administration last month canceled a $590-million contract awarded to Moderna (MRNA.O), opens new tab in January by outgoing President Joe Biden's administration for the late-stage development of its bird flu vaccine for humans, as well as the right to purchase shots. "This is a grievous mistake that threatens to leave the country unprepared for what experts fear might be the next pandemic – and there appears to be no rationale for this decision other than your ill-informed and dangerous war on vaccines," Senators Elizabeth Warren and Tammy Duckworth wrote in a letter seen by Reuters. The cancellation endangers American lives and will likely contribute to a 20% rise in the price of eggs this year, they wrote to Kennedy, who has a long history of questioning the safety of vaccines contrary to scientific evidence. A spokesperson for the Department of Health and Human Services at the time said the contract was canceled after a comprehensive internal review determined the project did not meet the scientific standards or safety expectations required for continued federal investment. Warren and Duckworth demanded Kennedy make the review public, alongside a similar review the department cited when it cut funding of a $258-million program researching an HIV vaccine. They also asked for a detailed description of how the department decided to end the contracts, and a staff briefing. "You have failed to justify either of these moves to cripple vaccine research," Warren and Duckworth wrote. "Furthermore, these decisions appear to be part of your larger, unfounded vendetta against mRNA technology." Kennedy named eight members last week to serve on a panel of vaccine advisers to the U.S. Centers for Disease Control and Prevention, including some who have advocated against vaccines, days after abruptly firing all 17 members who had been serving on the independent committee of experts. Several of his appointees specifically oppose the mRNA vaccine technology used in some of the newest immunizations such as the COVID-19 vaccine, including by Moderna.
