Latest news with #IGF-1
New York Post
4 days ago
- Health
- New York Post
New longevity drug for dogs could extend your pet's life — and pave the way for humans to live longer too
Sit, stay… live longer? Research shows that owning a dog can help humans live longer, healthier lives. Now, a US biotech company wants to return the favor with anti-aging drugs designed to extend the lifespan of your canine companion. 'The longevity space is crowded right now, and for good reason,' Celine Halioua, founder and CEO of Loyal, told The Post. 'We all want to figure out how to get more happy, healthy years for our loved ones —especially the furry ones.' 6 Celine Halioua is leading the push to develop drugs that extend the lives of dogs. X/@loyalfordogs Before launching Loyal in 2019, Halioua worked on treatments for neurodegenerative diseases in humans — conditions that, much like aging in dogs, have no true preventive medicine. 'This combination of experience sparked my mission to develop the first drug approved for healthy lifespan extension,' she said. Good boys, great science Loyal has three longevity drugs in the pipeline, including two that specifically target bigger breeds, which typically have much shorter lifespans. While small dogs like Chihuahuas can live for 18 years or longer, giant breeds such as Great Danes would be lucky to make it to ten. That's where LOY-001 and LOY-003 come in. These drugs target dogs age seven and older that weigh at least 40 pounds. 6 Loyal's drugs aim to increase and quality of life for senior dogs. X/Celine Halioua They work by reducing levels of insulin-like growth factor 1 (IGF-1), a hormone that fuels cell growth. Scientists believe that high levels of IGF-1 shorten the lifespan of large dogs, which can have up to 28 times more of the hormone than smaller breeds. One version, LOY-001, is an injectable given a few times a year at the vet. The other, LOY-003, is a daily chewable pill. Both drugs are currently in pilot studies, and Loyal is eyeing conditional FDA approval by 2027. Loyal's third longevity drug, LOY-002, is even further along in development. The treatment targets senior dogs age 10 and up that weigh at least 14 pounds. It's currently being tested in a large-scale clinical trial involving more than 1,200 dogs across 70 clinics, making it one of the biggest studies in veterinary history, according to Halioua. 6 Small dogs tend to have a longer lifespan than larger breeds. X/Celine Halioua The drug works by targeting metabolism — the complex system of chemical reactions that powers essential functions like breaking down food, producing energy and repairing cells. As metabolism slows with age, it can lead to insulin resistance and trigger a range of health issues in both humans and dogs, including cognitive decline, osteoarthritis and cancer. 'Improving metabolic health is one of the most well-validated pathways for extending both lifespan and healthspan,' Halioua said. 'Research [shows] it can improve health and reduce the risk of age-related diseases across species — from mice to humans,' she added. So far, things are looking paws-itive. A pilot study of 48 dogs showed no adverse effects after three months of LOY‑002. 6 Both LOY-002 and LOY-003 are administered via a daily pill. X/Celine Halioua Loyal previously told The Guardian it's hoping the drug could add at least one extra year to a dog's life — and they'll be healthier during that time, too. Once it's approved, Halioua hopes LOY‑002 will become a common preventive tool, like flea and tick medication. 'We expect all dogs to benefit from its ability to protect against, and even reverse, some of the harmful effects of metabolic dysfunction,' she said. Loyal anticipates that the drug will receive conditional approval by the FDA in 2026. 6 Loyal is aiming to enroll 1,300 dogs in it's LOY-002 study. X/Celine Halioua But the dogs aren't the only ones who could benefit. 'We're on track to develop the first-ever FDA-approved drug for longevity — for any species,' Halioua said. 'Dogs share our environments and develop remarkably similar age-related diseases at similar stages of life, making them valuable models for human health and scientific research,' she added. Dogs make us healthier, too Halioua's lifelong love of animals runs deep. 'I've always been surrounded by animals — growing up, my family had 15 pets and rehabilitated wild animals,' she said. 'My Rottweiler, Della, is always by my side and is a major influence on the work I do.' It turns out dogs don't just bring love — they could bring health benefits as well. Studies show that dogs can ease loneliness, stress and anxiety. One even found that just 10 minutes of petting a pooch can significantly reduce levels of cortisol, the body's main stress hormone. 6 Dogs are known for their unconditional love and companionship. yurakrasil – Even locking eyes with your dog gives your brain a boost. A 2009 Japanese study found that staring into their eyes raises oxytocin — the 'love hormone' linked to bonding and happiness. Dogs might even help you live longer. A sweeping review of research from 1950 to 2019 found that dog owners consistently have a lower risk of death compared to those without pets. It's no accident. Research shows that dog owners tend to have lower blood pressure, cholesterol and a reduced risk of heart disease. Plus, they get more exercise, which builds muscle, strengthen bones and joints and keeps weight in check. That's no coincidence. Dog owners tend to have lower blood pressure, cholesterol, and less risk of heart disease. Plus, they're more active — walking their dogs regularly strengthens muscles, bones and joints, and helps keep weight in check. Some research even links dog ownership to bigger brains and sharper thinking, with faster processing speed and better memory. And here's the kicker: a major study found owning a dog lowers dementia risk — a benefit not shared by cat owners.
Time of India
14-06-2025
- Health
- Time of India
Longevity expert shares the healthiest diet formula for long life
News Longevity expert shares the healthiest diet formula for long life Share AA + Text Size Small Medium Large Longevity expert Dr. Joseph Antoun suggests that excessive protein intake, especially from animal sources, might shorten lifespan by stimulating IGF-1 secretion. He recommends a balanced approach, incorporating some meat in plant-based diets before 30 and after 65 to maintain muscle mass. Between 30 and 65, prioritizing plant-based proteins like beans and legumes is advised for optimal health and longevity. Read more below. Aging does you less good and more harm. Unless you focus on healthy aging with beneficial diets and exercising, then you could age healthily and happily with no worries in sight. In the world of social media, most people turn to trends to figure out a good diet that will keep them healthy or just continue with their existing one as it isn't particularly unhealthy. Now, a longevity expert has revealed the best diets for healthy aging and his suggestions might shock you to change your current diet completely. Dr Joseph Antoun, a longevity expert, revealed to The Post that too much protein is actually not good for the body. While the nutrient is essential for muscle maintenance and overall health, excess consumption of it could actually be reducing years of your life. 'Animal proteins are rich in arginine, and leucine and contain specific sequences of amino acids that stimulate IGF-1 secretion, whereas an equivalent quantity of plant-based proteins are less likely to trigger the same amount of IGF-1,' he said. Image credits: Getty Images IGF-1, a hormone produced in the liver plays a vital role in promoting growth and regulating metabolism. It's crucial for building muscle when you are young and especially when you are older when the muscle loss accelerates. Since the levels of the hormone reduce over time, it's important to maintain it to support well-being. Antoun thus advises including a certain amount of meat in a plant-based diet before the age of 30 and after the age of 65. "When the body's food absorption capability begins to decrease and the muscle becomes an essential organ for longevity.' Image credits: Getty Images Between the ages of 30 and 65, the doctor advises visiting the salad bar more than the steak table. In this age frame, consuming mainly plant-based proteins is advised. Thus, add in foods like beans, legumes, nuts and seeds. 'The Longevity Diet emphasizes plant-based protein consumption to support lean muscle mass and reduce inflammation, which are important for both heart and metabolic health,' he said. Plant-based diets such as pescatarian, Mediterranean, flexitarian and vegan are linked to healthy aging. However, not all animal proteins are the same, According to Antoun, Red meat, chicken and fish contain various percentages of leucine and arginine- two amino acids that play vital roles in muscle growth. 'Red meat is also high in saturated fats, while fish contains healthier, unsaturated fats.' One step to a healthier you—join Times Health+ Yoga and feel the change TOI Lifestyle Desk The TOI Lifestyle Desk is a dynamic team of dedicated journalists who, with unwavering passion and commitment, sift through the pulse of the nation to curate a vibrant tapestry of lifestyle news for The Times of India readers. At the TOI Lifestyle Desk, we go beyond the obvious, delving into the extraordinary. Consider us your lifestyle companion, providing a daily dose of inspiration and information. Whether you're seeking the latest fashion trends, travel escapades, culinary delights, or wellness tips, the TOI Lifestyle Desk is your one-stop destination for an enriching lifestyle experience. Read More End of Article Follow Us On Social Media Previous How linen is the quiet luxury hero of summer 2025 Lifestyle Helly Shah Serves Ethereal Glamour & Bold Beauty Entertainment From Labrador to Beagles: 10 puppy pictures that are too cute to handle Lifestyle 8 magical tips and tricks to boost your English grammar skills Lifestyle From Gaokao to UPSC: 9 toughest exams around the world in 2025 education Celebrities who stunned the internet with their pink-colored outfits Entertainment 9 low-maintenance Perennial flowers that will fill the balcony with colour and fragrance Lifestyle Hostel life and campus facilities at 10 leading Indian MBBS colleges education 10 activities to do right now that are much better than scrolling through social media Lifestyle Zodiac signs who make the best dads astrology Next 1 2 3 10 rare animals that survive without sleep and how they do it From celebrating their first Eid Al Adha to Joy's Annaprashan ceremony; Devoleena Bhattacharjee shares a glimpse of their multi-cultural celebrations 5 silent ways anger is ruining your life without you realizing it 5 (worrying) things that can happen if the body is dehydrated Did you know "Ek Chatur Naar" was originally sung by Ashok Kumar in a 1941 classic? 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Here's everything about the viral Kick streamer who was seen crying outside the TikTok HQ 'Counting the many blessings'- Stephen Curry's sister Sydel Curry celebrates motherhood with gratitude and hope 'Counting the many blessings'- Stephen Curry's sister Sydel Curry celebrates motherhood with gratitude and hope "Attempted manslaughter": Gisele Bündchen slammed for risking baby's life on reckless dog walk, as fans blame her for Tom Brady's divorce decision "Attempted manslaughter": Gisele Bündchen slammed for risking baby's life on reckless dog walk, as fans blame her for Tom Brady's divorce decision Paulina Gretzky set to inherit incredible fortune and stunning luxury boat from hockey icon Wayne Gretzky 'Historic blunder': Himanta says India missed chance to stop Pakistan from becoming nuclear state; claims Israel offered help 'Historic blunder': Himanta says India missed chance to stop Pakistan from becoming nuclear state; claims Israel offered help India distances itself from SCO statement condemning Israeli strikes on Iran; 'We did not participate in the discussions,' says MEA India distances itself from SCO statement condemning Israeli strikes on Iran; 'We did not participate in the discussions,' says MEA Mets star Francisco Alvarez becomes a dad for the first time and shares sweet photo with baby girl Mets star Francisco Alvarez becomes a dad for the first time and shares sweet photo with baby girl Travis Kelce stuns fans with Taylor Swift-inspired makeover ahead of possible last NFL season Travis Kelce stuns fans with Taylor Swift-inspired makeover ahead of possible last NFL season 'Until we got married': Kansas City Chiefs star Patrick Mahomes opens up about how Brittany supported him since high school 'Until we got married': Kansas City Chiefs star Patrick Mahomes opens up about how Brittany supported him since high school 'It's Our Hope': Former YouTuber MatPat Launches Creator Economy Caucus 'It's Our Hope': Former YouTuber MatPat Launches Creator Economy Caucus Who is Natalie Reynolds? Here's everything about the viral Kick streamer who was seen crying outside the TikTok HQ Who is Natalie Reynolds? Here's everything about the viral Kick streamer who was seen crying outside the TikTok HQ 'Counting the many blessings'- Stephen Curry's sister Sydel Curry celebrates motherhood with gratitude and hope 'Counting the many blessings'- Stephen Curry's sister Sydel Curry celebrates motherhood with gratitude and hope "Attempted manslaughter": Gisele Bündchen slammed for risking baby's life on reckless dog walk, as fans blame her for Tom Brady's divorce decision "Attempted manslaughter": Gisele Bündchen slammed for risking baby's life on reckless dog walk, as fans blame her for Tom Brady's divorce decision Paulina Gretzky set to inherit incredible fortune and stunning luxury boat from hockey icon Wayne Gretzky Tired of too many ads? go ad free now
Yahoo
13-06-2025
- Health
- Yahoo
Longevity doctor reveals the best diets for healthy aging — and the change to make at 65
Your love of steak could make you prematurely meat your maker. While protein is essential for muscle maintenance and overall health, eating too much protein — especially at a certain age — could be shaving years off your life. 'Animal proteins are rich in arginine, leucine and contain specific sequences of amino acids that stimulate IGF-1 secretion, whereas an equivalent quantity of plant-based proteins are less likely to trigger the same amount of IGF-1,' Dr. Joseph Antoun, CEO of the longevity company L-Nutra, told The Post. IGF-1 is a hormone, primarily produced in the liver, that plays a crucial role in promoting growth and regulating metabolism. It's essential for building muscle when you're young and especially when you're older, as muscle loss often accelerates over 60. Because IGF-1 levels tend to decline in adulthood, it's important to maintain a healthy range to support well-being. 'Before age 30, it is considered healthy to consume certain amounts of meat in a plant-based diet,' Antoun said. 'The same applies after the age of 65, when the body's food absorption capability begins to decrease and muscle becomes an essential organ for longevity.' If you're between those two numbers — you should be eyeballing the salad bar more than the steak buffet. 'Between the ages of 30-65, consumption of mainly plant-based sources of protein is recommended,' he said. 'The mid-life period is the age of disease formation and is when the speed and quality of aging mostly determines our lifespan.' If you're looking to live to 100, Antoun is a proponent of the Longevity Diet, which leans heavily on plant-based proteins like beans, legumes, nuts and seeds. 'The Longevity Diet emphasizes plant-based protein consumption to support lean muscle mass and reduce inflammation, which are important for both heart and metabolic health,' he said. Plant-based diets such as the pescatarian, Mediterranean and flexatarian plans are also linked to healthy aging, as is the vegan diet, although some adjustments should be made. 'A pure vegan diet is also correlated with longevity, but it needs to be supplemented with protein — especially at early and late stages of life,' he said. And if you've ever wondered why bodybuilders look amazing when they're young, only to seem as if they stepped into a time machine once they reach their twilight years — it's because getting ripped has ripped them of their ageless appearance. 'Animal-based diets stimulate IGF-1 and therefore help a consumer look good and muscular in the short term, which many food companies market as a sign of health and strength — when in fact, the body is in 'accelerated bio-age mode,' which leads to a shorter lifespan,' he said. 'Bodybuilders, for example, look great in the short term, but end up looking far older than their real age in their 50s and 60s.' Finally, when it comes to longevity, Orwell had it right. All animals are equal, but some are more equal than others. 'Not all animal proteins are the same,' Antoun said. 'Red meat, chicken and fish contain different percentages of leucine and arginine,' he added, referencing two amino acids that play vital roles in muscle growth. 'Red meat is also high in saturated fats, while fish contains healthier, unsaturated fats.' In short: sticking to chickpeas while you're middle-aged means you'll be able to really enjoy that nice, juicy burger once you're in retirement. Eat to live — don't lift to eat.
Time of India
13-06-2025
- Health
- Time of India
Want to live to 100? Skip these foods in your 30s and enjoy them later. Longevity doctor shares surprising diet secret
If you're counting on steak to fuel you through the years, it might be time to rethink your plate. According to Dr. Joseph Antoun, longevity physician and CEO of the health-focused company L-Nutra, your love for animal protein could be accelerating your biological clock — especially if you're between 30 and 65. In a recent interview with the New York Post , Dr. Antoun detailed how different kinds of protein affect aging, and why your diet should shift as you grow older. 'Animal-based diets stimulate IGF-1 and therefore help a consumer look good and muscular in the short term… but the body is in 'accelerated bio-age mode,' which leads to a shorter lifespan,' he explained. IGF-1 (Insulin-like Growth Factor 1), a hormone key to cell growth and metabolism, can be a double-edged sword. While it supports muscle development, elevated levels—particularly triggered by animal proteins rich in arginine and leucine—can also speed up aging and disease formation in midlife. Play Video Pause Skip Backward Skip Forward Unmute Current Time 0:00 / Duration 0:00 Loaded : 0% 0:00 Stream Type LIVE Seek to live, currently behind live LIVE Remaining Time - 0:00 1x Playback Rate Chapters Chapters Descriptions descriptions off , selected Captions captions settings , opens captions settings dialog captions off , selected Audio Track default , selected Picture-in-Picture Fullscreen This is a modal window. Beginning of dialog window. Escape will cancel and close the window. Text Color White Black Red Green Blue Yellow Magenta Cyan Opacity Opaque Semi-Transparent Text Background Color Black White Red Green Blue Yellow Magenta Cyan Opacity Opaque Semi-Transparent Transparent Caption Area Background Color Black White Red Green Blue Yellow Magenta Cyan Opacity Transparent Semi-Transparent Opaque Font Size 50% 75% 100% 125% 150% 175% 200% 300% 400% Text Edge Style None Raised Depressed Uniform Drop shadow Font Family Proportional Sans-Serif Monospace Sans-Serif Proportional Serif Monospace Serif Casual Script Small Caps Reset restore all settings to the default values Done Close Modal Dialog End of dialog window. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like The Top 25 Most Beautiful Women In The World Articles Vally Undo A Diet Timeline: What to Eat, When to Eat It Dr. Antoun recommends tailoring your protein intake based on age. Before 30, meat can be part of a healthy, mixed diet as the body is still developing muscle and bone mass. After 65, it becomes essential again due to declining absorption and rapid muscle loss. But between those two milestones — from age 30 to 65 — the stakes change. 'This mid-life period is the age of disease formation and is when the speed and quality of aging mostly determines our lifespan,' Antoun warned. You Might Also Like: What is the 'Planetary Health Diet'? New study reveals the foods that could help you live to 100 That's why he champions the Longevity Diet , a mostly plant-based approach that prioritizes legumes, beans, nuts, and seeds over animal products. Diets like the Mediterranean, pescatarian, and flexitarian models also score high for promoting longer, healthier lives — thanks to their balance of plant-rich nutrition and heart-friendly fats. Why Ripped Isn't Always Right Antoun also pointed to a surprising observation: bodybuilders often look youthful in their prime but age dramatically later. 'They look great in the short term but end up looking far older than their real age in their 50s and 60s,' he said, noting that constant stimulation of IGF-1 can fast-track aging, even if it builds impressive muscle along the way. He warns that commercial food industries tend to glamorize muscular physiques as the ultimate health goal — when in fact, they may reflect an accelerated internal aging process. Meat Isn't All Equal, Either Dr. Antoun isn't suggesting you abandon all animal protein, especially not after 65. But he does urge caution — and selection. 'Red meat is high in saturated fats, while fish contains healthier, unsaturated fats,' he noted. Even among meats, different amino acid profiles can affect IGF-1 stimulation differently. You Might Also Like: What is the 'Kilimanjaro Diet'? Is the new secret to long life emerging from Tanzania? The bottom line? Eat plant-based when it counts the most — in your middle years — so that by the time you're in retirement, you can enjoy the occasional burger without guilt or risk.
Economic Times
13-06-2025
- Health
- Economic Times
Want to live to 100? Skip these foods in your 30s and enjoy them later. Longevity doctor shares surprising diet secret
iStock Longevity expert Dr. Joseph Antoun advises shifting to a plant-based diet between ages 30 and 65 to slow aging and prevent disease. While animal protein helps build muscle, it also raises IGF-1 hormone levels that accelerate biological aging. (Representational image: iStock) If you're counting on steak to fuel you through the years, it might be time to rethink your plate. According to Dr. Joseph Antoun, longevity physician and CEO of the health-focused company L-Nutra, your love for animal protein could be accelerating your biological clock — especially if you're between 30 and 65. In a recent interview with the New York Post , Dr. Antoun detailed how different kinds of protein affect aging, and why your diet should shift as you grow older. 'Animal-based diets stimulate IGF-1 and therefore help a consumer look good and muscular in the short term… but the body is in 'accelerated bio-age mode,' which leads to a shorter lifespan,' he explained. IGF-1 (Insulin-like Growth Factor 1), a hormone key to cell growth and metabolism, can be a double-edged sword. While it supports muscle development, elevated levels—particularly triggered by animal proteins rich in arginine and leucine—can also speed up aging and disease formation in midlife. Dr. Antoun recommends tailoring your protein intake based on age. Before 30, meat can be part of a healthy, mixed diet as the body is still developing muscle and bone mass. After 65, it becomes essential again due to declining absorption and rapid muscle loss. But between those two milestones — from age 30 to 65 — the stakes change. 'This mid-life period is the age of disease formation and is when the speed and quality of aging mostly determines our lifespan,' Antoun warned. That's why he champions the Longevity Diet , a mostly plant-based approach that prioritizes legumes, beans, nuts, and seeds over animal products. Diets like the Mediterranean, pescatarian, and flexitarian models also score high for promoting longer, healthier lives — thanks to their balance of plant-rich nutrition and heart-friendly fats. Antoun also pointed to a surprising observation: bodybuilders often look youthful in their prime but age dramatically later. 'They look great in the short term but end up looking far older than their real age in their 50s and 60s,' he said, noting that constant stimulation of IGF-1 can fast-track aging, even if it builds impressive muscle along the way. He warns that commercial food industries tend to glamorize muscular physiques as the ultimate health goal — when in fact, they may reflect an accelerated internal aging process. Dr. Antoun isn't suggesting you abandon all animal protein, especially not after 65. But he does urge caution — and selection. 'Red meat is high in saturated fats, while fish contains healthier, unsaturated fats,' he noted. Even among meats, different amino acid profiles can affect IGF-1 stimulation differently. The bottom line? Eat plant-based when it counts the most — in your middle years — so that by the time you're in retirement, you can enjoy the occasional burger without guilt or risk.
