Latest news with #HebrewUniversity
Yahoo
14 hours ago
- Health
- Yahoo
Tylenol doesn't work the way we thought it does
When you buy through links on our articles, Future and its syndication partners may earn a commission. Acetaminophen is widely used to relieve pain, but exactly how it works has long been a mystery. Now, a new study suggests that a key byproduct of acetaminophen may block pain signals at the nerves — before they can reach the brain. Acetaminophen, also called paracetamol or Tylenol, is broken down by the liver into a compound called 4-aminophenol, which travels through the bloodstream to different organs. There, an enzyme links it with a fatty acid to produce AM404. Previous research found that AM404 can act in the central nervous system — the brain and spinal cord. But the new study, published June 4 in the journal PNAS, reveals that AM404 also affects the peripheral nervous system, where pain signals originate. "These results fundamentally change our understanding of paracetamol's mode of action," study co-authors Alexander Binshtok, a professor in pain research, and Avi Priel, a professor of pharmacy, both at the Hebrew University of Jerusalem, told Live Science in an email. Nial Wheate, a professor of pharmaceutical chemistry at Macquarie University in Australia, who wasn't involved in the study, agreed. "Even though we have been using paracetamol for the management of pain for more than 130 years, we still don't fully understand how the drug works," Wheate told Live Science. One widely held theory was that acetaminophen stopped the body from making. prostaglandins, which can trigger pain and inflammation, he said."If the results of this study are confirmed, then it significantly changes our understanding of the drug." However, the new study was in rats, so the findings may not apply in humans, he added. To test the effects of AM404, the scientists applied the compound to sensory neurons taken from newborn rats. They found that it blocks sodium channels — proteins that normally allow charged sodium particles to pass in and out of cells, which are essential for generating and transmitting pain signals. By blocking these channels, AM404 keeps the neurons from sending pain messages to the brain. Other byproducts of acetaminophen had no such effect. The researchers also injected AM404 into the paws of rats and tested their responses to painful stimuli. The treated paws became less sensitive to heat and pressure, with the strongest effect appearing about an hour after the injection. Importantly, the pain relief was limited to the site of the injection, leaving the other paw unaffected. While the findings may not change how acetaminophen is currently used to treat pain, they could influence the development of next-generation painkillers that are potentially safer, Wheate said. Acetaminophen overdoses can damage the liver and are responsible for 56,000 emergency visits a year in the U.S. RELATED STORIES —FDA approves 1st new class of opioid-free painkillers in over 20 years —Ozempic in a pill? New oral drug may work as well as Ozempic-style injectables —Acne vaccine: Experimental shot for common skin condition reaches clinical trials. Here's what you need to know. "Whole families of new drugs could be designed based around blocking sodium channels. These new drugs could be both more effective and safer than not just paracetamol, but other painkillers like ibuprofen or the opioids," Wheate said. Looking ahead, Binshtok and Priel hope to design improved versions of AM404 that are more chemically stable and optimized to work in the peripheral nervous system, they added. They also plan to test whether these compounds can help with chronic or nerve-related pain, where standard treatments often fall short. Another important next step is to assess the safety and therapeutic potential of AM404 in greater detail. This involves understanding how it is broken down and distributed in the body and whether it might affect any other organs.
UPI
18 hours ago
- Health
- UPI
Study: Wars with Hamas and Iran pose health risks for all Israelis
1 of 7 | Israelis gather in a public bomb shelter in Jerusalem after air raid sirens warned of Iranian ballistic missiles that struck seven cities and a hospital compound early Thursday morning. Photo by Debbie Hill/UPI | License Photo June 19 (UPI) -- Israelis lack sleep and experience high anxiety amid the wars with Hamas and Iran as the two Middle East nations exchange deadly aerial blows. Rocket fire, missile strikes and sirens sounding every night have caused a "severe decline in sleep quality" since the Oct. 7, 2023, attack on Israeli civilians by Iran-supported Hamas, according to a new study published in the International Journal of Clinical and Health Psychology. The study by researchers at the Hebrew University and Hadassah Medical Center doesn't include the recent weeklong war between Israel and Iran. Researchers say the study is the first of its kind to document the effects of warfare on civilian sleep patterns, which could have "serious consequences." "Worldwide, much research focuses on the war's impact on soldiers," lead researcher Shoham Choshen-Hillel of Hebrew University's Business School said. "Until now, no systematic study examined sleep quality for civilians on the home front under daily threat," Choshen-Hillel said. "Israel's situation is unique, demanding a different perspective." Data analyzed from 9,000 participants The study collected and analyzed data from about 9,000 participants who participated in three researcher-led surveys from January 2023 to January 2024. Analysis shows the number of Israeli citizens sleeping less than six hours nightly rose from 13% before Oct. 7, 2023, to 31% during the survey period. Poor sleep health reports likewise increased from 15% to 38%, and clinical insomnia cases increased from 4% to 20%. Nearly half of those surveyed - 48% -- reported sleep problems after the war with Hamas began, which is up from 18% prior to the conflict. "The shocking picture for us is that sleep hasn't improved for a year and a half," Choshen-Hillel said. "Symptoms lasting over six months are significant," she added. "This isn't temporary. It's a long period health-wise with major implications." Among those most affected are women and those who have had friends or relatives killed, injured or abducted by on and after Oct. 7, 2023. Iran war makes matters much worse Choshen-Hillel said the war with Iran and its potential escalation are making the problem worse. "It's clear the situation regarding sleep and other aspects is the worst since the war began," she said. "People now wake for shelters multiple times a night and anxiety has understandably intensified," Choshen-Hillel explained. "I have no doubt that the situation is worse than we previously documented," she added. "We find even those not in direct danger experience deep, lasting psychological impacts from the war, manifesting in sleepless nights." The study was published at the same time that Iranian strikes killed eight Israeli civilians during the overnight hours from Sunday into Monday. The strikes raised the civilian death toll in Israel to 24 and likely 25 due to one person missing but expected to be declared dead, The Jerusalem Post reported on Monday. The Iranian Health Ministry says at least 639 Iranians have died in the Israeli strikes there. Iranian strike on Israeli hospital compound An Iranian missile hit a hospital compound in Beer Sheva in southern Israel, where 400 patients were receiving medical treatment on Thursday. Dozens suffered injuries, but none were killed at the Soroka Medical Center, which still has about 300 patients. "Approximately 80 people were injured in the incident, about half are hospital staff," a hospital spokesperson said in a prepared statement. "All injuries were classified as mild or stress-related," the statement said, adding that the strike was the "most severe incident of its kind in the history of Israel's healthcare system." Iranian officials said they targeted a military installation located near the hospital, but Israeli officials said there is no such installation. "We are hitting with precision the targets of the nuclear and missile programs, and they're hitting the children's ward of a hospital," Israeli Prime Minister Benjamin Netanyahu said in a prepared statement on Thursday. "That's the whole difference between a democracy taking lawful action to save itself from these murderers and these murderers whose aim is to destroy every one of us," Netanyahu added.
Times
2 days ago
- Politics
- Times
Israel-Iran latest: Trump says ‘nobody knows what I'm going to do'
António Guterres, the UN's secretary-general, has warned against any 'additional military interventions' in the Middle East, where Israel and Iran have continued to exchange fire for a sixth day. 'Any additional military interventions could have enormous consequences, not only for those involved, but for the whole region and for international peace and security at large,' Guterres said in a statement. The Iranian Communications Ministry has announced restrictions on internet access due to Israel's 'misuse of [the] communication network for military purposes', according to the local news outlet Mehr News. Iranian state TV has reported an evacuation warning for residents of Israel's Haifa. The port city was attacked by Iranian missiles over the weekend, and three people were killed. Israel's assault on Iran has united much of the nation after a period of bitter divisions over the war in Gaza. Most Israelis support using force to destroy Iran's nuclear programme, polling shows, despite retaliatory Iranian missile strikes that have killed 24 civilians and put normal life on hold. On Iran, 83 per cent of Jewish Israelis support his decision to attack, according to a poll by the Hebrew University of Jerusalem conducted on Sunday and Monday. 'In contrast to the ongoing war in Gaza, which is perceived by many of us as a cynical move designed to serve political purposes, the Iranian story is far above any dispute,' wrote the columnist Ben Caspit, a fierce critic of Binyamin Netanyahu, in the newspaper Ma'ariv. In further remarks outside the White House, Trump said Binyamin Netanyahu was a 'good man' who has been 'doing a good job'. 'He's a wartime president. Going through this nonsense, ridiculous,' said Trump, who said he spoke to the Israeli prime minister on Tuesday. Trump added that he told Netanyahu to 'keep going'. The US is working to evacuate its citizens from Israel by arranging flights and cruise ship departures, the US ambassador Mike Huckabee said in a post on X on Wednesday. The US embassy in Jerusalem was working on the evacuation arrangements, he said, urging Americans in the country to sign up for updates through the State Department's Smart Traveler Enrollment Program. Gaza's civil defence agency now says that 33 people were killed by Israeli fire in the Palestinian territory today, including 11 who were seeking aid. Mahmud Bassal, spokesman for the civil service' told AFP that 11 people were killed and more than 100 wounded 'after the occupation forces opened fire and launched several shells … at thousands of citizens' who had gathered to queue for food in central Gaza. The military told AFP that its forces operating in central Gaza identified 'a group of suspicious individuals' approaching 'in a manner that posed a potential threat to the forces'. It said its troops then fired 'warning shots', but that it was 'unaware of injuries'. Earlier, Hamas-run health authorities said 30 people had been killed. President Herzog of Israel has told Times Radio that President Trump has 'a brilliant strategic view' of the conflict between Israel and Iran. 'He's been negotiating with the Iranian leaders. He had a negotiator on a meeting with the Iranian leadership and then they discovered they've been goofed,' said Herzog. 'So I think that I trust Donald Trump in knowing what he wants to achieve.' He added: 'In the end, I believe what he wants to achieve is peace and quiet and well-being for Israel, for the Middle East and for the world at large.' By Larisa Brown Admiral Sir Tony Radakin, the chief of the defence staff, is believed to be at the Cobra meeting to discuss the unfolding situation in the Middle East. He will be speaking at the Royal United Services Institute on Wednesday evening but his speech will not be made public. Downing Street has gagged British military officers from speaking 'on the record' at the land warfare conference in Westminster. Those close to the conference said that they had not seen this amount of 'control' from No 10 in more than two decades of the conference running. Iran's mission to the United Nations has issued a strongly worded response to President Trump, saying Tehran would not 'grovel'. 'No Iranian official has ever asked to grovel at the gates of the White House,' the mission wrote on X. 'The only thing more despicable than his lies is his cowardly threat to 'take out' Iran's supreme leader.' The post continued: 'Iran does NOT negotiate under duress, shall NOT accept peace under duress, and certainly NOT with a has-been warmonger clinging to relevance. Iran shall respond to any threat with a counter-threat, and to any action with reciprocal measures.' The US military is 'prepared to execute' any decision President Trump might make on matters of war and peace, the defence secretary, Pete Hegseth, said, even as he declined to confirm preparations of strike options on Iran. 'If and when those decisions are made, the Department [of Defence] is prepared to execute them,' Hegseth told the Senate Armed Services Committee. President Trump said he may or may not strike Iran as he addressed reporters for the first time on Wednesday. Trump spoke at an event to mark two new flagpoles outside the White House, which he said would be 'beautiful' in a post on Tuesday evening. Asked about the possibility of a US strike on Iran, Trump said: 'You don't know that I'm going to even do it. You know, I may do it, I may not do it. I mean, nobody knows what I'm going to do. I can tell you this: Iran has got a lot of trouble, and they want to negotiate.' He also said it was 'very sad' to watch the conflict and suggested it could have been avoided. 'Why didn't you negotiate with me two weeks ago?' he asked of Iran. 'You could have done fine. You would have had a country. It's very sad to watch this. I mean, I've never, I've never seen anything like it'. Trump also said Iranian officials had expressed a desire to meet with him. 'They've suggested that they come to the White House. That's, you know, courageous, but you know it's like not easy for them to do,' Trump said. Asked if he had given Iran an ultimatum, he said: 'You could say so. Maybe you could call it the ultimate ultimatum.' Gideon Saar, Israel's foreign minister, has responded to President Erdogan of Turkey, who earlier accused Israel of 'state terrorism'. Saar said the Turkish leader had no right to speak, pointing to Ankara's presence in Syria and in the divided island of Cyprus, where it controls the northern part. 'It is particularly ironic that someone who does not hide his imperialist ambitions, who invaded northern Syria and illegally holds northern Cyprus, claims to speak in the name of morality and international law,' Saar wrote on X. 'A little self-awareness could be helpful.' Trump declined to answer reporters' questions on whether the US was planning to strike Iran or its nuclear facilities, and said the Iranians had reached out but he felt 'it's very late to be talking'. 'There's a big difference between now and a week ago,' Trump told reporters outside the White House. 'Nobody knows what I'm going to do.' Trump said that Iran had proposed to come for talks at the White House. He did not provide details. He described Iran as totally defenseless, with no air defence whatsoever. President Trump has said that Iran has 'got a lot of trouble' and repeated he wanted Tehran's 'unconditional surrender'. Speaking on the lawns of the White House, where two flagpoles are being put up, Trump said Iran wants 'to make a deal' but said he did not think it was going to happen. 'Unconditional surrender, that means I've had it, that means no more,' he said. 'That means we go blow all the nuclear stuff.' He added: 'The next week is going to be big, very big, maybe less than a week.' By Larisa Brown American and British military sources say that if the US wants to use Diego Garcia as a staging post for an attack on Iran then President Trump would need permission from Sir Keir Starmer. If the UK agrees, there is a risk that Iran would view Britain as a party to the conflict. There will be fears that British assets or people in the region could be attacked as a result. RAF Akrotiri in Cyprus, where the UK has Typhoon fighter jets, could become a target. British military personnel based in Iraq could be exposed to attack — so too could shipping sailing through the Strait of Hormuz. There are also concerns for British diplomats in Tehran: the UK, unlike America, has an embassy there. Maria Zakharova, spokeswoman for Russia's foreign ministry, has warned of nuclear disaster as the crisis escalates in the Middle East. 'Nuclear facilities are being struck,' she said. 'Where is the (concern from the) entire world community? Where are all the environmentalists? I don't know if they think they are far away and that this (radiation) wave won't reach them. Well, let them read what happened at Fukushima. ' A major nuclear accident took place at the Fukushima Daiichi plant in Japan in 2011 when the earthquake and tsunami damaged its backup power sources. The reactors could not be cooled, resulting in a release of radioactive contaminants. By Steven Swinford, Political Editor, and Larisa Brown, Defence Editor Britain is weighing up whether to provide military support to the US in the event that President Trump decides to bomb Iran. Sir Keir Starmer will chair a Cobra meeting with senior officials and ministers this afternoon to discuss a series of potential scenarios. Ministers are expected to discuss what the UK should do in the event that Trump asks for the country's support in conducting military operations. British military sources believe the US may want to use Diego Garcia — the joint UK-US base in the Indian Ocean — as a staging post for any US operation on Iran. B-2 Spirit stealth bombers, the only aircraft certified to carry the bunker-buster bomb capable of destroying Iran's Fordow nuclear site, are often stationed at the base in the Indian Ocean. By Katy Balls in Washington Tucker Carlson, the influential Maga figure, has clashed with Republican senator Ted Cruz in an interview that highlights the growing conservative rift over Iran. Carlson has warned against US involvement but Cruz has said that regime change would be in America's interest. The full episode is yet to air but two clips have been published. First, Cruz struggles to answer Carlson's questions on Iran's population, leading to an accusation from Carlson that he is ill-equipped to speak on the question. 'You don't know the population of the country you seek to topple?' asks Carlson, before adding: 'How could you not know that?' Cruz responds that he 'doesn't sit around memorising population tables'. Second, Cruz appears to suggest that the US is already involved, saying: 'We're carrying out military strikes today'. After Carlson points out the official line is that the strikes were carried out by Israel, Cruz tries to backtrack, suggesting that the US is merely 'supporting' Israel. The clips are being shared online by members of the Maga movement as evidence that President Trump should think twice before getting further involved. Israel has many supporters in the Republican Party — but according to one of Trump's most ardent loyalists, the president would be wrong to embroil the US in another conflict in the Middle East. 'For decades, we've watched our men and women in uniform go all over the world and fight in wars that most Americans don't think that our country should have been in,' Marjorie Taylor Greene told The Times from her Capitol Hill office last week, before the Israeli attack on Iran. 'Americans are very sick and tired of that.' Read in full: Marjorie Taylor Greene: Why Trump should not go to war with Iran A fresh series of strong blasts in east Tehran have been reported. Multiple explosions were heard and images show rising smoke. Two large billboards calling on President Trump 'to finish the job' have appeared on they Ayalon Highway in central Tel Aviv. By Larisa Brown Experts say there is no evidence for Iran's claims that it has fired hypersonic missiles at Israel. The Revolutionary Guards said today that they had launched hypersonic Fattah-1 missiles at Tel Aviv, but Matthew Savill, director of military sciences at the Royal United Services Institute, raised doubts. He said: 'The Iranians have a track record of claiming that they are using new and novel missiles which they call hypersonics. I don't think there is any evidence they have.' Hypersonic missiles travel at more than five times the speed of sound and can manoeuvre mid-flight, making them harder to track and intercept. Savill said that although the missiles were able to travel at high speeds and could alter their trajectories, they did not make significant manoeuvres while powered — so were still ballistic missiles. Binyamin Netanyahu, the Israeli prime minister, is to hold a cabinet meeting at 10pm (8pm UK time), The Times of Israel is reporting. The government is advising British citizens in Israel not to attempt to leave, even though it is helping the families of embassy staff to get out. The prime minister's official spokesman said that Britons should follow the advice of local authorities, which is to 'stay close to shelter'. He also said, however, that they could take taxis or buses to the Jordanian border, despite the potential risk. 'Routes via land currently remain open,' the spokesman said, pointing out that some buses are not full. The spokesman did not comment on the contradictory nature of the advice. Keir Starmer will hold a meeting of the Cobra emergency committee with senior ministers and officials this afternoon to discuss the 'fast moving' situation in Israel. The prime minister will return from the G7 summit to chair the meeting amid suggestions that the US could become involved in the conflict with Iran. Britain has so far refrained from offering Israel military support in an attempt to de-escalate the conflict. Starmer said yesterday that he was confident that Trump would not get involved in the conflict. His official spokesman declined to repeat the suggestion today. Khamenei has also taken to Twitter again to issue further warnings, accusing President Trump of using 'absurd rhetoric'. Please enable cookies and other technologies to view this content. You can update your cookies preferences any time using privacy manager. Khamenei also claimed that the Israeli attacks began while Iran was in talks with Washington. 'The Zionist regime's malicious attack on our country took place at a time when Iranian officials were indirectly engaged in negotiations with the US side.' Iranian state TV has shown Ayatollah Khamenei, reading his message personally. Earlier, the statement was read by a television presenter. They were Khamenei's first remarks since Israel began airstrikes on Iran. President Putin and President Sheikh Mohammed bin Zayed Al Nahyan of the UAE have spoken by phone and agreed that there needed to be an immediate end to the conflict between Israel and Iran, the Kremlin said. Putin reiterated Russia's readiness to serve as a mediator to help find a diplomatic solution to Israeli and Western concerns about Iran's nuclear programme, the Kremlin added. Russia's deputy foreign minister, Sergei Ryabkov, has warned that direct American military assistance to Israel could 'radically destabilise' the situation in the Middle East. Ryabkov warned the US against direct military assistance to Israel or even considering 'speculative options', according to Russia's Interfax news agency. 'This would be a step that would radically destabilise the entire situation,' he said. Meanwhile, the Russian foreign ministry spokeswoman Maria Zakharova said the world was 'millimetres away from catastrophe' because of the daily Israeli strikes on Iran's nuclear infrastructure. Overnight the United States moved air force refuelling tankers and C-17 aircraft to European bases including Prestwick, as well as Aviano in Italy, according to Aurora Intel, a group that reviews open-source information in real time. Washington is shifting military aircraft and warships into and around the Middle East to protect Israel from Iranian attacks as President Trump has warned Tehran to step back from the conflict. On Tuesday the US relocated a dozen F-16s from the Italian base to Prince Sultan Air Base in Saudi Arabia, reported the Associated Press. Israeli troops have raided two Palestinian refugee camps in the occupied West Bank. The IDF told the AFP news agency that Israeli forces had entered Balata camp at about 4am, near the northern city of Nablus, for 'a routine counter-terrorism operation'. It added that the troops had been deployed to the nearby Askar camp prior to the operation in Balata. Imad Zaki, head of the popular services committee of Balata camp, said: 'They closed all entrances to the camp, seized several homes after evicting their residents, and ordered the homeowners not to return for 72 hours. These homes were turned into military outposts and interrogation centres.' Throughout the war in Gaza, violence in the West Bank, a separate Palestinian territory, has soared. Since October 2023, Israeli troops or settlers have killed at least 939 Palestinians, according to the Palestinian health ministry. Over the same period, at least 35 Israelis have been killed . A YouGov poll found that 49 per cent of Britons were against 'helping to defend Israel by assisting in the shooting down of missiles and drones from Iran'. Twenty-five per cent of people surveyed supported the idea. Germany's foreign minister has appealed to Iran's leaders to make credible assurances it is not seeking a nuclear weapon and to show it is willing to find a negotiated solution as fears mount of further military escalation. 'We are still ready to negotiate a solution. However, Iran must act urgently … it is never too late to come to the negotiating table if one comes with sincere intentions,' Johann Wadephul Germany's chancellor, Friedrich Merz, expressed strong support for Israel and its strikes against Iran, saying: 'This is the dirty work Israel is doing for all of us.' Khamenei's statement was read by a television presenter and not made in person. These were the supreme leader's first remarks since Friday, when Israel launched its strikes on Iran. President Trump had said: 'We know exactly where the so-called 'supreme leader' is hiding. He is an easy target, but is safe there — we are not going to take him out (kill!) at least not for now.' In further remarks, Ayatollah Khamenei responded directly to President Trump's call for Iran's 'unconditional surrender' warning that a US strike would have 'serious irreparable consequences'. Khamenei said: 'Wise people who know Iran, its people, and its history never speak to this nation in the language of threats, because Iranians are not those who surrender.' Israel claims to have struck more than 40 missile infrastructure components directed towards it, and, in a tweet, posted video of a strike on an Iranian missile launcher. Please enable cookies and other technologies to view this content. You can update your cookies preferences any time using privacy manager. President Erdogan of Turkey has said that Iran has the 'legitimate' right to defend itself in the face of Israel's ongoing bombing campaign. 'It is a very natural, legitimate and legal right for Iran to defend itself against Israel's thuggery and state terrorism,' he said, a day after referring to Benjamin Netanyahu, the Israeli prime minister, as 'the biggest threat to the security of the region'. He also claimed Israel's attacks began before nuclear talks had finished. 'These attacks were organised while the Iranian nuclear negotiations were taking place,' Erdogan said. 'Israel, which possesses nuclear weapons and does not recognise any international rules.. did not wait for the negotiations to end, but carried out a terrorist act without waiting for the result.' Ayatollah Ali Khamenei, Iran's supreme leader, has warned that Israel has made 'a huge mistake and will be punished' in a televised message to the Iranian people. IRIB, an Iranian state broadcaster, has urged the public to delete WhatsApp, claiming it was sharing users' 'last known locations and communications' with Israel. WhatsApp dismissed the claims and said that all messages sent on the platform were 'end-to-end encrypted' and the only people with access were the sender and recipient. 'We're concerned these false reports will be an excuse for our services to be blocked at a time when people need them the most,' a spokesman said, adding that the company, owned by Meta, did not track users' precise location or messaging logs. On Friday, Tehran placed temporary restrictions on the internet for the duration of the has since banned civil servants and their security teams from using any connected devices and appealed to the public to 'minimise their use of equipment connected to the internet and to take appropriate precautions' online. President Trump will have one mission on his mind if he decides to join the war against Iran — destroying Fordow, its most heavily fortified nuclear site. Only the Americans have the weapon capable of annihilating it. The 13.6-tonne class GBU-57/B, otherwise known as the Massive Ordnance Penetrator bomb (Mop), has a thick steel outer casing that can penetrate fortifications up to 60m below ground — and Fordow is buried beneath a mountain. • Read in full: How US military could destroy Fordow Israeli gunfire and airstrikes have killed at least 30 people across the Gaza Strip today, according to local health authorities. Some Palestinians say their plight is being forgotten as attention shifts to the air war between Israel and Iran. Medics said separate airstrikes on the Maghazi refugee camp in central Gaza and the Zeitoun area of the north had killed at least 14 people. Another five died in an airstrike on an encampment in Khan Yunis. They also said that eleven others were killed when Israeli forces fired at crowds of displaced Palestinians awaiting aid UN aid lorries on the Salahuddin road in central Gaza. The Israel Defence Forces said they were investigating the reported deaths. On Tuesday, Gaza's Hamas-run health ministry said that 397 Palestinians trying to get food had been killed and more than 3,000 had been wounded since aid deliveries restarted in late May. Israeli strikes have hit two facilities in Iran that made parts for centrifuges, says the International Atomic Energy Agency, the UN's nuclear watchdog. It identified the facilities as the TESA Karaj workshop and the Tehran Research Centre. 'At the Tehran site, one building was hit where advanced centrifuge rotors were manufactured and tested. At Karaj, two buildings were destroyed where different centrifuge components were manufactured,' the IAEA said. 'Both sites were previously under IAEA monitoring and verification as part of the JCPOA.' Please enable cookies and other technologies to view this content. You can update your cookies preferences any time using privacy manager. The JCPOA was the international agreement signed in 2015 to limit Iran's nuclear programme in exchange for sanctions relief. The US, under Trump in his first term as president, pulled out of the 'horrible' deal, claiming 'it didn't bring peace, and it never will'. A televised message from Ayatollah Ali Khamenei, Iran's supreme leader, will be aired shortly, state media reports. Khamenei's last appearance was on Friday shortly after Israel attacked Iran. • Profile: Who is Ayatollah Ali Khamenei, Iran's ruthless supreme leader? Britain is temporarily withdrawing the families of staff at its embassy and consulate in Israel. 'Family members of staff at the British embassy in Tel Aviv and the British consulate in Jerusalem have been temporarily withdrawn as a precautionary measure,' the Foreign Office said on its travel advice page for Israel. 'The embassy and consulate continues with essential work including services to British nationals.' Thousands of people are fleeing Tehran and other major Iranian cities. Heavy traffic was reported on roads heading from the capital towards northern provinces. Limits have been placed on fuel purchases. Mohsen Paknejad, the oil minister, told state TV that restrictions were to prevent shortages but there would be no problems with supply. Ali Bahreini, Iran's ambassador to the UN in Geneva, went on to accuse Israel of a 'war against humanity'. He said: 'The deliberate targeting of Iran's nuclear facilities not only constitutes a grave violation of international law and UN charter but also risks exposition of all people in our neighbourhood to possible hazardous leak. This is not an act of war against our country, it is war against humanity'. He also criticised the failure of states to condemn Israel's attacks. 'We are hearing almost nothing from those self-proclaimed champions of human rights.' Iran says it has conveyed to Washington that it will respond firmly to the United States if it becomes directly involved in Israel's military campaign. Ali Bahreini, Tehran's ambassador to the UN in Geneva, said that he saw America as 'complicit in what Israel is doing'. So far, the US has taken only indirect action such as helping to shoot down missiles fired toward Israel. It is also deploying more fighter aircraft to the Middle East and extending the deployment of other warplanes. Bahreini said Iran would also respond strongly to Israeli strikes. 'We will not show any reluctance in defending our people, security and land — we will respond seriously and strongly, without restraint.' The FTSE 100 defied the conflict in the Middle East to start the session in positive territory, as defence-facing stocks sustained gains and anxiety eased over international travel. London's blue chip index was up 0.25 per cent, or 21 points, to 8,855 as trading got underway. Aerospace engineers Melrose (up 3.6 per cent), Babcock (up 1.2 per cent) and Rolls-Royce (up 0.99 per cent) led the way, with British Airways owner IAG reversing several days of decline to add 1 per cent. Almost 800 Chinese citizens have been evacuated from Iran since Israel launched military strikes against the country last week. 'Currently … 791 Chinese nationals have been relocated from Iran to safe areas,' Guo Jiakun, the foreign ministry spokesman, said. 'More than 1,000 other people are in the process of relocating and withdrawing.' Some Chinese citizens had also left Israel, he said. 'China expresses its thanks to the relevant countries for providing full support and assistance,' he said. By Liz Cookman Russia believes Israel's strikes on Iran's nuclear facilities are pushing the world toward a 'nuclear catastrophe'. Moscow's foreign ministry called the strikes 'illegal from the point of view of international law' and said they would 'create unacceptable threats to international security and push the world towards a nuclear catastrophe, the consequences of which will be felt everywhere, including in Israel itself'. Maria Zakharova, the ministry's spokeswoman, said that Iran 'had, has and will have the right' to 'peaceful' nuclear facilities. She told Sputnik radio: 'This all leads not just to escalation, but to a direct threat to the region and the world due to the fact that strikes are being carried out on peaceful atomic or nuclear facilities. The nuclear threat has a practical, not a hypothetical dimension.' Russia has repeatedly made veiled threats concerning the use of its own nuclear weapons in relation to the war in Ukraine. By Gabrielle Weiniger in Tel Aviv British Jews stranded in Tel Aviv after five days of Iranian missile bombardment are wondering how to return to the UK. Karen Tuhrim said: 'Having driven myself mad, I'm going to book the Sharm el-Sheikh flight because we've got very good friends here from London and … they're on that flight on the first of July. Even though things might change, I have to have something concrete booked. I can't stay in a hotel indefinitely.' The Barzilay family arrived in Israel to surprise their father on his 60th birthday and were supposed to leave today. Simon Barzilay said: 'It looks as though we'll be staying a lot longer. Initially, having to get up two or three times during the night to go to the bomb shelter was a scary experience, but we quickly got used to it.' The British authorities have advised those stranded to follow guidelines on the Foreign Office website. At least 2,800 stranded Israelis are expected to be repatriated today. The first two flights bringing Israeli citizens home from Larnaca, Cyprus, have landed at Ben Gurion airport. Between 100,000 and 150,000 Israelis have been unable to return since the air war led to the closure of Israeli Kedmi, chief executive of Israel Airports Authority, said: 'Our aim is to bring back as many people as possible, but it is more important that they are safe. We are carrying out assessments on an hourly basis.' Matthew Pennycook has told Times Radio that Britain is 'sending military assets to the region to support regional security in general terms — contingency support throughout the Middle East should the escalation of the conflict continue'. Pennycook, the housing minister, said he would not comment on future operational decisions or specific decisions. 'We obviously already have RAF jets in the region as part of our operation against Daesh. So it's right that they are protected. So we have already sent military assets to the region,' he said. Israel's foreign minister Israel Katz has alluded to the collapse of the Iranian government in a post on X. 'A tornado passes over Tehran,' he wrote. 'Symbols of government are being bombed and destroyed — from the Broadcasting Authority and soon other target — and crowds of residents are fleeing. This is how dictatorships collapse.' Katz, speaking to senior military officials yestereday, said that Ayatollah Ali Khamenei could suffer the same end as Saddam Hussein of Iraq. Iran has arrested five suspected agents of Mossad, Israel's intelligence agency, on charges of 'tarnishing' the country's image, Iranian news agencies have reported. 'These mercenaries sought to sow fear among the public and tarnish the image of the sacred system of the Islamic Republic of Iran through their calculated activities online,' the Tasnim and ISNA news agencies said, quoting a statement from the Revolutionary Guards. The arrests were made in western Iran. Ayatollah Ali Khamenei, Iran's supreme leader, has made his first public comments since President Trump made a veiled threat on his life, saying that he was an 'easy target'. Khamenei wrote two messages on X. In Farsi, one said: 'In the name of the noble Haidar, the battle begins,' referring to Ali, considered by Shia Muslims to be the rightful successor to the prophet Mohammed. It was accompanied with an image of fireballs falling on what appeared to be an ancient city or castle. Please enable cookies and other technologies to view this content. You can update your cookies preferences any time using privacy manager. In a second post, in English, he wrote: 'We must give a strong response to the terrorist Zionist regime. We will show the Zionists no mercy.' Israel has launched a strike on Imam Hussein University in Tehran, which is affiliated with Iran's Islamic Revolutionary Guard Corps. Following the attack, smoke was seen rising from the area. Israeli authorities said that at least 24 people had been killed and hundreds injured in Iranian missile attacks. Iran said that at least 224 people had been killed and more than 1,000 wounded in Israeli attacks. More than 700 foreigners living in Iran have crossed into neighbouring Azerbaijan and Armenia since Israel launched its campaign on Friday, according to Tehran government figures. Among those fleeing were citizens of Russia, Belarus, Kazakhstan, Germany, Spain, Italy, and the United States. Israel is running low on defensive Arrow interceptors, which are designed to destroy ballistic missiles. The shortage introduces concerns about Israel's ability to counter long-range ballistic missiles from Iran in a drawn-out conflict. A US official told The Wall Street Journal that Washington had been aware of the capacity problems for months. Since the onset of the recent conflict, the Pentagon has sent additional missile-defence assets to the region, raising concerns about its supplies. 'Neither the US nor the Israelis can continue to sit and intercept missiles all day,' Tom Karako, director of the Missile Defense Project at the Center for Strategic and International Studies, a think tank, said. 'The Israelis and their friends need to move with all deliberate haste to do whatever needs to be done because we cannot afford to sit and play catch.' The first aircraft bringing home Israelis stranded abroad landed at Ben Gurion Airport on Wednesday. Flights had been cancelled and Israeli airspace closed because of the conflict. 'Just a short while ago, the first flight of Operation Safe Return landed at Ben Gurion Airport,' the airport's authority said in a statement. It added that the flight had been operated by the national carrier El Al and brought Israelis home from Larnaca in Cyprus. Israel's new bombing campaign against Iran began with strikes on nuclear facilities and military commanders on Friday and has continued with daily attacks on missile launchers, air-defence systems and even a state television channel. Iran has responded by firing salvoes of ballistic missiles at Israel, including some that have penetrated the Iron Dome missile-defence system, sending the population hurrying for shelter at the sound of air-raid alerts. • How the conflict unfolded The Israeli army said it had struck Iran's centrifuge-production and weapons-manufacturing sites in overnight strikes. 'More than 50 air force fighter jets, guided by precise intelligence from the intelligence directorate, completed a series of strikes on military targets in the Tehran area in recent hours,' the Israel Defence Forces (IDF) said. The army said a centrifuge-production site in Tehran used by Iran to expand the scope of its uranium enrichment was attacked. 'As part of the broad effort to disrupt Iran's nuclear weapons development programme, a centrifuge-production facility in Tehran was targeted.' In what it described as a 'wave of attacks', Israel struck several arms factories it claims were producing raw materials and components for assembling ground-to-ground missiles. 'Additionally, sites producing systems and components for ground-to-air missiles designed to target aircraft were attacked. These targets were struck as part of the IDF's effort to disrupt the Iranian regime's nuclear-weapons programme and its missile-production industry,' the IDF wrote on X. Please enable cookies and other technologies to view this content. You can update your cookies preferences any time using privacy manager. Israeli strikes have killed at least 585 people across Iran and wounded 1,326 others, according to a human rights group. The Human Rights Activists, based in Washington, said it had identified 239 of the dead as civilians and 126 as security personnel. Iran has not published regular death tolls during the conflict. Its last update, issued on Monday, put the death toll at 224 people killed and 1,277 wounded — however, the regime has minimised casualties in the past. Human Rights Activists provided detailed casualty figures during the 2022 protests over the death of Mahsa Amini, who was arrested for allegedly violating rules requiring women to wear the headscarf. The group cross-checks local reports in Iran against a network of sources it has developed in the country. The US embassy in Jerusalem said it will close until Friday. It directed government employees to shelter in place as the air war between Israel and Iran continued. In a statement posted to its website, the embassy said on Tuesday evening that the closure was 'a result of the current security situation and ongoing conflict between Israel and Iran'. It added: 'Given the security situation and in compliance with Israel Home Front Command guidance, the US embassy in Jerusalem will be closed tomorrow (Wednesday, June 18) through Friday (June 20).' Iran claims to have fired hypersonic missiles at the Israeli city in the latest round of overnight strikes. In retaliation for attacks on Tehran overnight Wednesday, Iran told residents of Tel Aviv to prepare for an attack, with the Islamic Revolutionary Guard Corps claiming its hypersonic Fattah-1 missiles were 'repeatedly shaking the shelters' in the city. 'The 11th wave of the proud Operation Honest Promise 3 using Fattah-1 missiles' was carried out, the Guards said in a statement broadcast on state television early Wednesday. Hypersonic missiles travel at more than five times the speed of sound and can manoeuvre mid-flight, making them harder to track and intercept. Iran also sent a 'swarm of drones' towards Israel, according to the army. Israeli warplanes targeted Tehran in a predawn raid on Wednesday as the air war entered its sixth day. The Israeli military issued a warning on social media for civilians in an area of the Iranian capital known as District 18, near the city's international airport, to evacuate. Iranian state media reported explosions ricocheting in the Piroozi, Sabalan and Sayyad areas of Tehran. Overnight, at least 60 Israeli air force jets carried out 'an extensive wave of strikes in the heart of Iran', targeting ballistic missile launchers that were aimed at Israel, according to the country's military. President Trump demanded an unconditional surrender from Iran and warned its supreme leader that he was an 'easy target' who would not be killed 'at least for now'. Increasing pressure on Ayatollah Ali Khamenei, while weighing up bombing raids on Iran's nuclear facilities, Trump said America's patience with the regime was running out. He aligned the US with Israel, boasting that 'we' have 'total control of the skies over Iran'. Trump posted: 'We know exactly where the so-called 'Supreme Leader' is hiding. He is an easy target, but is safe there — We are not going to take him out (kill!), at least not for now. But we don't want missiles shot at civilians, or American soldiers. Our patience is wearing thin.' Gideon Saar, Israel's foreign minister, has responded to President Erdogan of Turkey, who earlier accused Israel of 'state terrorism'. Saar said the Turkish leader had no right to speak, pointing to Ankara's presence in Syria and in the divided island of Cyprus, where it controls the northern part. 'It is particularly ironic that someone who does not hide his imperialist ambitions, who invaded northern Syria and illegally holds northern Cyprus, claims to speak in the name of morality and international law,' Saar wrote on X. 'A little self-awareness could be helpful.' Donald Trump has said Iran has 'got a lot of trouble' and repeated he wanted Tehran's 'unconditional surrender'. Speaking on the lawns of the White House, where two flagpoles are being put up, Trump said Iran wants 'to make a deal' but said he did not think it was going to happen. 'Unconditional surrender. That means I've had it, that means no more,' he said. 'That means we go blow all the nuclear stuff.' He added: 'The next week is going to be big, very big, maybe less than a week.' Israeli troops have raided two Palestinian refugee camps in the occupied West Bank. The IDF told the AFP news agency that at 'around 4am Israeli forces entered Balata camp', near the northern city of Nablus, for 'a routine counterterrorism operation'. It added that the troops had been deployed to the nearby Askar camp prior to the operation in Zaki, head of the services committee of Balata camp, said: 'They closed all entrances to the camp, seized several homes after evicting their residents, and ordered the homeowners not to return for 72 hours. These homes were turned into military outposts and interrogation centres.' Germany's foreign minister has appealed to Iran's leaders to make credible assurances it is not seeking a nuclear weapon and to show it is willing to find a negotiated solution as fears mount of further military escalation. 'We are still ready to negotiate a solution. However, Iran must act urgently … it is never too late to come to the negotiating table if one comes with sincere intentions,' Johann Wadephul Germany's chancellor, Friedrich Merz, expressed strong support for Israel and its strikes against Iran, saying: 'This is the dirty work Israel is doing for all of us.' Germany's foreign minister has appealed to Iran's leaders to make credible assurances it is not seeking a nuclear weapon and to show it is willing to find a negotiated solution as fears mount of further military escalation. 'We are still ready to negotiate a solution. However, Iran must act urgently … it is never too late to come to the negotiating table if one comes with sincere intentions,' Johann Wadephul Germany's chancellor, Friedrich Merz, expressed strong support for Israel and its strikes against Iran, saying: 'This is the dirty work Israel is doing for all of us.'
Time of India
2 days ago
- Politics
- Time of India
Iran-Israel war: A lifeline for Netanyahu?
Israeli Prime Minister Benjamin Netanyahu As Israeli warplanes continue to hammer Iranian targets, Prime Minister Benjamin Netanyahu has emerged politically reinvigorated, both domestically and on the world stage. Just days before Israel's offensive began, Netanyahu's coalition government was teetering on collapse over internal tensions, particularly over plans to conscript ultra-Orthodox Jews. Facing mounting criticism for his handling of the prolonged Gaza war and a hostage crisis dating back to Hamas's October 2023 attack, Netanyahu's leadership seemed on the brink. Now, with the war against Iran reshaping Israel's political mood, Netanyahu's approval ratings are rebounding. A new poll published by a conservative Israeli broadcaster shows 54% of respondents support the prime minister, up significantly from earlier weeks. 'Netanyahu is greatly strengthened,' said Yonatan Freeman, a geopolitics expert at Hebrew University. 'There's broad public support for his argument that striking Iran preemptively was necessary.' Even opposition leader Yair Lapid backed the decision, calling the strike 'the right one' in a Jerusalem Post op-ed. For Netanyahu, who has long warned of Iran's nuclear ambitions, this war appears to be a defining moment. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like When Knee Pain Hits, Start Eating These Foods, and Feel Your Pain Go Away (It's Genius) Read More Undo 'Israel is fighting for its survival and has a chance to reshape the Middle East,' he said before the strikes began. The Israeli leader's international standing, badly damaged by the humanitarian crisis in Gaza and an ICC arrest warrant for alleged war crimes, has seen a shift. Since the Iran offensive began, European leaders have rallied behind him. German Chancellor Friedrich Merz even said Israel was doing 'the dirty work… for all of us.' Yet analysts warn the support may be fleeting. 'If the war drags on, public sentiment could turn again,' said Denis Charbit of Israel's Open University. 'Netanyahu is asserting his Churchillian image, but the final act is still unwritten.'
Time of India
3 days ago
- Politics
- Time of India
Post-doc fellow spends sleepless nights
Rourkela: A post-doctoral fellow at a university in Israel is in the grip of fear amid the ongoing Israel-Iran conflict. Taranga Dehury (29) from Maranda, a small village in Angul district, is hopeful that the Indian govt will evacuate him and other students, if required. Tired of too many ads? go ad free now Dehury joined the Institute of chemistry, Hebrew University of Jerusalem in March 2025. He completed his PhD from IIT-BHU, Varanasi, in 2024 after completing MSc from Utkal University in 2018. "The recent escalation in the Israel-Iran conflict has disrupted daily life. The Hebrew University, along with several other institutions, has temporarily closed. Siren's warning of incoming missiles, drone, or rockets have become routine," said Dehury to TOI over phone from Israel. The prestigious Weizmann Institute being struck by Iranian missiles also has had its impact. "Despite Israel's advanced missile defence systems like the iron dome, arrow, and THAAD, no technology can offer complete protection. Several missiles have impacted different areas, and there have been civilian casualties. Every time the sirens sound, we must take shelter, often spending 30 minutes to an hour in underground safe rooms," he added. Dehury said super markets are open and Jerusalem is relatively safer but the fear is real. "Nights are particularly unsettling, as missile alerts often interrupt sleep. I consider myself fortunate that my accommodation is on the ground floor and close to a shelter making access easier during emergencies," said Dehury. His family is very worried. "We are praying for the safety of my son," said Sriram Dehury, his father. Tired of too many ads? go ad free now Around 500 Indian students are studying at the Hebrew University with many more Indian nationals in other universities and workplaces in Israel. The Indian Embassy in Tel Aviv has issued advisories urging all citizens to strictly follow safety protocols issued by Israel's Home Front Command.
