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What's your ‘biological age'? And here's how to lower it…
What's your ‘biological age'? And here's how to lower it…

BreakingNews.ie

time20 hours ago

  • Health
  • BreakingNews.ie

What's your ‘biological age'? And here's how to lower it…

It's no secret that wellness fads come as quickly as they go. From the low-fat diets of the Noughties to the UPF-free food of today – society loves indulging in the newest health hack. The newest wellness trend to step onto the scene is 'biohacking'. You may have heard of it via Bryan Johnson's infamous anti-ageing quest, or simply by the numerous podcasts that now discuss cell health and biological age. Advertisement View this post on Instagram A post shared by Bryan Johnson (@bryanjohnson_) But what really is biohacking? How do you find out your biological age? And does it really determine how long you'll live for? Doctors specialising in stem cell and longevity research explain what biological age really means, how to lower it and why it's fast becoming the ultimate wellness metric in modern medicine. What is biological age? Biological age – a measurement of how well your body is functioning based on factors like lifestyle, stress and cellular health – is different to chronological age, as it isn't fixed, and (perhaps thankfully) you can reverse it. According to longevity experts, biological age provides a more accurate picture of health span than the candles on our birthday cake. And increasingly, it's being treated as something we can influence. Advertisement Chief executive of Cellcolabs, Dr Mattias Bernow, who provided the stem cells for biohacker Bryan Johnson, explains that this measurement is, 'a marker of how old your body seems based on your health, lifestyle and cellular function.' In other words, you might be 50 on paper, but living like someone 35 – or 65. 'Two people who are both 40 years old chronologically might have very different biological ages depending on how they live, their stress levels, their metabolic health and more,' says GP and founder of London's longevity clinic, HUM2N, Dr Mohammed Enayat. What accelerates biological ageing? The good news is that many of the biggest culprits behind accelerated ageing are changeable. Both Enayat and Bernow point to chronic stress, poor sleep, lack of exercise, ultra-processed foods and environmental toxins as major accelerants. Parenting itself doesn't inherently age the body, but, as Enayat points out, the chronic sleep deprivation and stress associated with caregiving certainly can. Advertisement Lack of sleep caused by parenting can increase your biological age Inflammation is another central player. 'These factors contribute to increasing low-grade inflammation,' Bernow explains, 'which plays a key role in age-related decline and the development of chronic disease.' But this process, he says, is not set in stone. 'While we can't control everything, small, consistent changes to reduce these stressors can make a meaningful difference in how we age.' Which lifestyle changes have the biggest scientific backing when it comes to reversing it? When it comes to slowing the clock, it turns out the best advice isn't ground-breaking – it's just often overlooked. Quality sleep, regular movement, a balanced whole-food diet, meaningful relationships and avoiding harmful substances all rank highly on the evidence-based list. Advertisement Enayat also points to practices like caloric moderation, intermittent fasting and resistance training for their 'strong results in slowing biological ageing at a cellular level.' However, these diets impact each sex differently, with intermittent fasting in particular causing more stress on women's bodies while being effective for men, meaning they will affect biological age differently. How big a part do genetics play? Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. 'Genes load the gun, but lifestyle pulls the trigger,' Enayat says, noting that genetics may only account for 20 to 30 per cent of ageing outcomes. Bernow says that emerging research suggests as much as 80 per cent of ageing is governed by one's environment and behaviour. Advertisement Do supplements actually make a difference? Supplements claim everything from healthier skin to better energy to thicker hair – but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. However, there are some supplements that have been proven to be helpful if taken correctly and absorbed properly. 'Protein is essential for preserving muscle mass,' says Enayat, while collagen 'may help with skin and joint health,' though its systemic anti-ageing benefits are modest. Some supplements can make a difference if taken and absorbed correctly Fish oil, magnesium, creatine and polyphenols all show promise too, but Enayat is keen to emphasise that supplement should support – not replace – healthy habits. Bernow cautions that while some supplements, like vitamin D, are well-supported (especially in sun-deprived regions), many products on the market are poorly regulated. 'Supplements are not a substitute for healthy habits,' he says, 'but in some cases, they can play a supportive role if used thoughtfully.' How to find out your biological age and what healthy habits the experts incorporate If this has sparked a curiosity to find out your own biological age, figuring it out requires a blood test. 'The most validated tests look at DNA methylation patterns,' says Enayat, and suggests well-known tests like the Horvath Clock, GlycanAge and TruAge. Bernow says that Bryan Johnson uses the DunedinPACE test, which claims to show he's ageing at just 0.66 years per year (66% of his chronological age). As for how these experts practise what they preach – they say it's all about balance and consistency. Moderate, low impact exercise can actually lower biological age Enayat's daily habits include either walking, strength training or stretching, prioritising plants and healthy fats, regular fasting, cold exposure and supplementing with omega-3, vitamin D, magnesium and creatine. 'The goal is consistency, not perfection,' he says. Lifestyle Paul Hollywood's sausage plait recipe Read More Bernow takes a similar approach, but with less exercise and more socialising, explaining he takes a short morning workout, has plenty of family time, eats balanced meals and drinks minimal alcohol. 'More than anything, I believe in consistency,' he says. 'Longevity isn't about extremes but about the things you do every day, for years.' So, while biohacking might conjure visions of futuristic and expensive tech, the real secret to ageing well is actually much simpler – by prioritising balance and relaxation – not difficult at all in today's world!

Our bodies' biological age: No simple ‘hack' to change how lifestyle and time treat us
Our bodies' biological age: No simple ‘hack' to change how lifestyle and time treat us

Irish Examiner

time13-06-2025

  • Health
  • Irish Examiner

Our bodies' biological age: No simple ‘hack' to change how lifestyle and time treat us

IT'S no secret that wellness fads come as quickly as they go. From the low-fat diets of the noughties to the UPF-free food of today, society loves indulging in the newest health hack. The newest wellness trend to emerge is 'biohacking'. You may have heard of it via American entrepreneur Bryan Johnson's infamous anti-ageing quest, or simply by the numerous podcasts that now discuss cell health and biological age. But what really is biohacking? How do you find out your biological age? And does it really determine how long you'll live for? Doctors specialising in stem cell and longevity research explain what biological age really means, how to lower it, and why it's fast becoming the ultimate wellness metric in modern medicine. What is biological age? Biological age — a measurement of how well your body is functioning based on factors like lifestyle, stress, and cellular health — is different to chronological age, as it isn't fixed and you can reverse it. According to longevity experts, biological age provides a more accurate picture of health span than the candles on our birthday cake. And increasingly, it's being treated as something we can influence. The CEO of Cellcolabs, Dr Mattias Bernow, who provided the stem cells for biohacker Bryan Johnson, explains that this measurement is 'a marker of how old your body seems based on your health, lifestyle, and cellular function.' In other words, you might be 50 on paper, but living like someone 35 — or 65. 'Two people who are both 40 years old chronologically might have very different biological ages depending on how they live, their stress levels, their metabolic health and more,' says GP and the founder of longevity clinic HUM2N, Dr Mohammed Enayat. The biggest culprits behind accelerated ageing are changeable: chronic stress, poor sleep, lack of exercise, ultra-processed foods, and environmental toxins are major accelerants. What accelerates biological ageing? The good news is that many of the biggest culprits behind accelerated ageing are changeable. Both Enayat and Bernow point to chronic stress, poor sleep, lack of exercise, ultra-processed foods, and environmental toxins as major accelerants. Parenting itself doesn't inherently age the body but, as Enayat points out, the chronic sleep deprivation and stress associated with caregiving certainly can. Inflammation is another central player. 'These factors contribute to increasing low-grade inflammation,' Bernow explains, 'which plays a key role in age-related decline and the development of chronic disease.' However, he says, this process is not set in stone. 'While we can't control everything, small, consistent changes to reduce these stressors can make a meaningful difference in how we age.' Which lifestyle changes have the strongest scientific backing? When it comes to slowing the clock, it turns out the best advice isn't ground-breaking – it's just often overlooked. Quality sleep, regular physical activity, a balanced whole-food diet, meaningful relationships, and avoiding harmful substances all rank highly on the evidence-based list. Enayat also points to practices such as caloric moderation, intermittent fasting, and resistance training for their 'strong results in slowing biological ageing at a cellular level'. However, these diets impact each sex differently, with intermittent fasting in particular causing more stress on women's bodies while being effective for men, meaning they will affect biological age differently. Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. How big a part do genetics play? Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. 'Genes load the gun, but lifestyle pulls the trigger,' Enayat says, noting that genetics may only account for 20 to 30% of ageing outcomes. Bernow says that emerging research suggests as much as 80% of ageing is governed by one's environment and behaviour. Supplements can claim everything from healthier skin to better energy to thicker hair — but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. Do supplements make a difference? Supplements can claim everything from healthier skin to better energy to thicker hair — but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. However, there are some supplements that have been proven to be helpful if taken correctly and absorbed properly. 'Protein is essential for preserving muscle mass,' says Enayat, while collagen 'may help with skin and joint health,' though its systemic anti-ageing benefits are modest. Fish oil, magnesium, creatine, and polyphenols all show promise too, but Enayat is keen to emphasise that supplements should support — not replace — healthy habits. Bernow cautions that while some supplements, like vitamin D, are well-supported (especially in sun-deprived regions), many products on the market are poorly regulated. 'Supplements are not a substitute for healthy habits,' he says, 'but in some cases, they can play a supportive role if used thoughtfully.' How to find out your biological age? If you're curious to find out your own biological age, figuring it out requires a blood test. 'The most validated tests look at DNA methylation patterns,' says Enayat, and suggests well-known tests like the Horvath Clock, GlycanAge, and TruAge. Bernow says that Bryan Johnson uses the DunedinPace test, which claims to show he's ageing at just 0.66 years per calendar year (66% of his chronological age). As for how these experts practise what they preach, they say it's all about balance and consistency. Enayat's daily habits include walking, strength training, or stretching, prioritising plants and healthy fats, regular fasting, cold exposure, and supplementing with omega-3, vitamin D, magnesium, and creatine. 'The goal is consistency, not perfection,' he says. Bernow takes a similar approach, but with less exercise and more socialising — explaining he takes a short morning workout, has plenty of family time, eats balanced meals and drinks minimal alcohol. 'More than anything, I believe in consistency,' he says. 'Longevity isn't about extremes but about the things you do every day, for years.' So, while biohacking might conjure visions of futuristic and expensive tech, the real secret to ageing well is actually much simpler: Prioritise balance and relaxation. Read More Fast-track your fitness with five minutes of exercise each day

Want to lower your biological age? Doctors reveal key lifestyle changes
Want to lower your biological age? Doctors reveal key lifestyle changes

The Independent

time12-06-2025

  • Health
  • The Independent

Want to lower your biological age? Doctors reveal key lifestyle changes

Wellness trends are known for their fleeting popularity, from the low-fat diets of the early 2000s to today's focus on ultra-processed foods. Now, a new trend called " biohacking" has emerged, fuelled by figures like Bryan Johnson and numerous podcasts discussing cell health and biological age. But what exactly is biohacking? How can you determine your biological age, and does it truly predict your lifespan? Experts in stem cell and longevity research are beginning to clarify the meaning of biological age, methods to reduce it, and why it's rapidly becoming a key metric in modern medicine. What is biological age? Biological age – a measurement of how well your body is functioning based on factors like lifestyle, stress and cellular health – is different to chronological age, as it isn't fixed, and (perhaps thankfully) you can reverse it. According to longevity experts, biological age provides a more accurate picture of health span than the candles on our birthday cake. And increasingly, it's being treated as something we can influence. CEO of Cellcolabs, Dr Mattias Bernow, who provided the stem cells for biohacker Bryan Johnson, explains that this measurement is, 'a marker of how old your body seems based on your health, lifestyle and cellular function.' In other words, you might be 50 on paper, but living like someone 35 – or 65. 'Two people who are both 40 years old chronologically might have very different biological ages depending on how they live, their stress levels, their metabolic health and more,' says GP and founder of London's longevity clinic, HUM2N Dr Mohammed Enayat. The good news is that many of the biggest culprits behind accelerated ageing are changeable. Both Enayat and Bernow point to chronic stress, poor sleep, lack of exercise, ultra-processed foods and environmental toxins as major accelerants. Parenting itself doesn't inherently age the body, but, as Enayat points out, the chronic sleep deprivation and stress associated with caregiving certainly can. Inflammation is another central player. 'These factors contribute to increasing low-grade inflammation,' Bernow explains, 'which plays a key role in age-related decline and the development of chronic disease.' But this process, he says, is not set in stone. 'While we can't control everything, small, consistent changes to reduce these stressors can make a meaningful difference in how we age.' When it comes to slowing the clock, it turns out the best advice isn't ground-breaking – it's just often overlooked. Quality sleep, regular movement, a balanced whole-food diet, meaningful relationships and avoiding harmful substances all rank highly on the evidence-based list. Enayat also points to practices like caloric moderation, intermittent fasting and resistance training for their 'strong results in slowing biological ageing at a cellular level.' However, these diets impact each sex differently, with intermittent fasting in particular causing more stress on women's bodies while being effective for men, meaning they will affect biological age differently. How big a part do genetics play? Though it's tempting to think of ageing as a genetic lottery, our DNA doesn't write the full script. 'Genes load the gun, but lifestyle pulls the trigger,' Enayat says, noting that genetics may only account for 20 to 30% of ageing outcomes. Bernow says that emerging research suggests as much as 80% of ageing is governed by one's environment and behaviour. Supplements claim everything from healthier skin to better energy to thicker hair – but it's fair to be sceptical of whether they really make a difference, or if it's all marketing. However, there are some supplements that have been proven to be helpful if taken correctly and absorbed properly. ' Protein is essential for preserving muscle mass,' says Enayat, while collagen 'may help with skin and joint health,' though its systemic anti-ageing benefits are modest. Fish oil, magnesium, creatine and polyphenols all show promise too, but Enayat is keen to emphasise that supplement should support – not replace – healthy habits. Bernow cautions that while some supplements, like vitamin D, are well-supported (especially in sun-deprived regions), many products on the market are poorly regulated. 'Supplements are not a substitute for healthy habits,' he says, 'but in some cases, they can play a supportive role if used thoughtfully.' How to find out your biological age and what healthy habits the experts incorporate If this has sparked a curiosity to find out your own biological age, figuring it out requires a blood test. 'The most validated tests look at DNA methylation patterns,' says Enayat, and suggests well-known tests like the Horvath Clock, GlycanAge and TruAge. Bernow says that Bryan Johnson uses the DunedinPACE test, which claims to show he's ageing at just 0.66 years per year (66% of his chronological age). As for how these experts practise what they preach – they say it's all about balance and consistency. Enayat's daily habits include either walking, strength training or stretching, prioritising plants and healthy fats, regular fasting, cold exposure and supplementing with omega-3, vitamin D, magnesium and creatine. 'The goal is consistency, not perfection,' he says. Bernow takes a similar approach, but with less exercise and more socialising, explaining he takes a short morning workout, has plenty of family time, eats balanced meals and drinks minimal alcohol. 'More than anything, I believe in consistency,' he says. 'Longevity isn't about extremes but about the things you do every day, for years.' So, while biohacking might conjure visions of futuristic and expensive tech, the real secret to ageing well is actually much simpler – by prioritising balance and relaxation – not difficult at all in today's world!

Jesper Parnevik, Stem Cells And The Swede Who Might Make Major History
Jesper Parnevik, Stem Cells And The Swede Who Might Make Major History

Forbes

time24-04-2025

  • Health
  • Forbes

Jesper Parnevik, Stem Cells And The Swede Who Might Make Major History

NAPLES, FLORIDA - FEBRUARY 15: Jesper Parnevik of Sweden looks on from the eighth hole during the ... More second round of the Chubb Classic 2025 at Tiburon Golf Club on February 15, 2025 in Naples, Florida. (Photo by) Jesper Parnevik, 60, currently competing on the PGA Tour Champions circuit, spent 38 weeks ranked among the world's top 10 golfers around the turn of the century. During his heyday, he became as well known for his flamboyant fashion—an upturned baseball cap that unintentionally succeeded in turning the underside of the brim into fresh new real estate for sponsor branding—as for his play. The late, great sportswriter Dan Jenkins once described the Swedish fashionista who amassed 5 PGA Tour and 4 European tour victories, as 'the last guy to climb out of the clown car' but the down-to-clown ballstriker's unorthodox style statements belied a game that was all business underneath. His commitment to flair, fitness and fearless shot-making made him one of the most memorable—and effective—players of his generation. Parnevik's trailblazing tendency has not faded with age. While on a flight to Miami, he struck up a conversation with a group of friends who were enroute to Albany, Bahamas to participate in a clinical trial led by Cellcolabs—a Solna based biotech focused on stem cell therapies. The mention of a clinic run by a company from his home country piqued the golfer's interest. 'I was impressed that first of all, it was a Swedish clinic and I was impressed with what they showed me and the talks I had with their doctors and scientists. That was the reason I went with Cellcolabs,' Parnevik, a self-described 'research nerd,' who as part of his due diligence met with doctors at a lab in the Karolinska Institute in Stockholm where the research behind the treatment was developed. The clinical trial Parnevik participated in is aimed at preventing cardiovascular disease and treating musculoskeletal injuries and involves injecting mesenchymal stem cells (MSCs) in hopes of reducing inflammation and improving longevity biomarkers. Stem cell injections into joints— which are still considered experimental—start at $16,500, while an intravenous (IV) treatment is $25,000. Parnevik has had the IV treatment twice while his wife has had both the IV and a targeted injection in her hip. These treatments, which utilize stem cells from donors, are not FDA approved. Currently, the only approved stem cell therapies in the United States involve hematopoietic progenitor cells derived from umbilical cord blood. In certain cases, a patient's own stem cells may also be used in procedures that meet specific regulatory criteria. While most MSC therapies remain unproven and unapproved in the U.S., particularly for anti-aging or orthopedic use, they have shown promise in regenerative medicine. Mesoblast's Ryoncil recently became the first of its kind to receive FDA approval to treat a rare pediatric condition. Athletes seeking non-FDA approved stem cell therapies is hardly novel. Peyton Manning reportedly traveled to Europe in 2011 to undergo such a procedure for a neck injury. That treatment involved harvesting stem cells from his own fat cells and injecting them into his neck in hopes of regenerating damaged tissue. Five years later, Manning led the Denver Broncos to Super Bowl glory—though there's no way of knowing whether the therapy played any role in his recovery. Today, the price of treatments like this is currently prohibitive. Even Parnevik had some sticker shock before he committed to the Cellcolabs trial and concurred that affordability is a major barrier. The company believes that as production scales up, costs could come down. Its goal is to reduce the price of stem cells by 90% over the next decade. 'Not everyone can pay the 16 or 20 grand to do an injection. If you have some severe injuries, you are ready to try anything. But yes, it is pricy,' Parnevik noted, adding that he believes stem cells will help a lot of people in the future as the treatments become more affordable. BOCA RATON, FLORIDA - FEBRUARY 08: Jesper Parnevik of Sweden reacts after a putt on the ninth green ... More during the first round of the Oasis Championship at The Old Course at Broken Sound on February 08, 2019 in Boca Raton, Florida. (Photo by) Golf is a lifetime sport that rewards both commitment and creativity. The game's resident health guru Gary Player —who, at 89, can still launch into his signature karate kick with the flair of Ralph Macchio—recently told reporters at the Masters that he hopes to live to 100. While Parnevik may not have a number in mind, extending his own longevity has been a focus for years. 'Throughout my career. I have always been very curious and tried a lot of different ways to improve my health and my golf game,' Parnevik said. 'I've tried most things in the past. I tried not only to be a vegetarian, I tried to be a fruitarian for a while—it was very convincing that that was the way to go.' That particular vitamin-c heavy phase also included ingesting volcanic sand, which he'd read could help flush heavy metals from the body. 'But for me, to eat fruit like I did for a few months, I didn't have the energy to practice or play golf at the level I wanted,' he said, admitting it was more of an experiment—one that allowed him to speak knowledgeably when other players asked what he was doing and why. Today, he laughs when recalling just how deep into that wellness experimentation he once ventured. 'When you go into that world and meet the people who are part of it—now we're getting really funky—they were talking about how, in the future, there are going to be 'airtarians,'' Parnevik said. 'All you're going to do is breathe, and the atoms are going to change into whatever you need. And I thought, 'Alright, now it's gone a little too far for me.'' Nowadays, Parnevik is off the strict diet kicks and just simply tries to eat well. Some may view Parnevik—once one of the most unconventional and entertaining golfers, an open book who wore his heart on his sleeve—as a dying breed. But the charming and eccentric Swede still sees a few big personalities on tour that could rival his own swagger. He name-checks seven-time PGA Tour winner Viktor Hovland, the black metal devotee with the ear-to-ear grin as a 'pretty funny guy.' Still, he admits such throwbacks are rare, as ballooning purses have made players more corporate. 'When I started, most of the guys who played on the European Tour weren't really doing it to make big money,' he said. 'They could barely make ends meet from week to week. It was more of a lifestyle—it felt a bit like a traveling circus.' Back then, Parnevik said, players didn't return home between tournaments. Instead, they picked up a little money playing extra pro-ams—$500 here or there—which helped them pay for travel and hotels. By the early 2000s, Tiger Woods domination transformed the economics of the sport. As interest and television ratings soared in tandem, sponsorship dollars piled up, fundamentally shifting professional golf's financial landscape. 'Most players started thinking of golf like any business venture—they hired trainers, swing coaches, mental coaches,' Parnevik said. 'Maybe some part of golf got a little more serious.' These days, with constant social media scrutiny, he believes players are more guarded—which can make them appear 'boring.' 'It's a double-edged sword,' he said. 'I love characters and so on but I also see guys get hammered if they say what they think.' THE WOODLANDS, TX - MAY 08: Jesper Parnevik of Sweden watches his tee shot on the 16th hole as Jeff ... More Maggert looks on during the final round of the Insperity Invitational at The Woodlands Country Club on May 8, 2016 in The Woodlands, Texas. (Photo by) Parnevik was never one to play it safe—on the mic or in the mirror. When he showed up to a senior circuit event in Texas in 2016 wearing bright pink pants, it raised eyebrows and helped flip the script on golf fashion, foreshadowing a pastel wave that would come into vogue. 'Luckily I played well, because it could have been a completely different situation if I had a terrible day,' Parnevik remembered. His flipped-brim look—the whole point was just to get a little suntan—might have presaged golf's future cultural pervasiveness, but it was his early commitment to fitness that truly forecast where the game was headed. 'People were laughing back in the 1990s when we went to the gym rather than the bar after a round. They thought 'you are going to workout now? We are going to go have a pint.' But now, if you are not fit and don't take care of yourself, you have no chance today.' Even now, on the Champions Tour, Parnevik still crosses paths with fellow fitness pioneer Bernhard Langer—the original ageless wonder—who reminds him that longevity is earned. And while Parnevik once pushed golf forward in his own unique way, he's now keeping close tabs on another Swede doing the same. Ludvig Åberg, one of the most exciting young players in the game today, has his elder countryman's attention and admiration. 'His technique is pretty much flawless,' Parnevik said. 'He looks like he can't miss a golf shot. Ludvig has a very sound golf swing and he seems like his mental side is very good. Any situation he's put in, he's doing really well. I think we are going to see him win a lot of majors in the future.'

Groundbreaking stem cell trial for knee osteoarthritis
Groundbreaking stem cell trial for knee osteoarthritis

Gulf Today

time13-04-2025

  • Health
  • Gulf Today

Groundbreaking stem cell trial for knee osteoarthritis

The Department of Health - Abu Dhabi (DoH), has successfully completed a groundbreaking clinical trial in Abu Dhabi, in collaboration with Cellcolabs and Burjeel Holdings. Developed by Swedish biotech company Cellcolabs, StromaForte has shown a favourable safety profile and significant therapeutic potential for knee osteoarthritis, marking a significant step in evaluating cell-based therapies for degenerative joint diseases. The study evaluated the regenerative properties of Mesenchymal Stem Cells (MSCs), a type of stem cell known for its ability to reduce inflammation and repair and regenerate damaged tissues. Found naturally in the body, MSCs function as biological mediators by detecting areas of stress or injury and signalling the body to initiate its own healing process, rather than simply replacing damaged cells. In this clinical trial, patients received MSC injections derived from carefully screened healthy donors aged 18-30, directly into their affected knee joints. The goal was to confirm safety, ease pain, reduce inflammation and potentially repair cartilage damage, offering a potential alternative to surgery for those suffering from knee osteoarthritis. The clinical trial was led by Dr. Oussama Chaar, consultant Orthopaedic Surgeon and Dr. Veerabahu Muthusamy, specialist Orthopaedic Surgeon, and conducted at Burjeel Medical City and Burjeel Hospital from November 2023 to October 2024, where patients received a single dose of 50 million MSCs via ultrasound-guided injections. The results of the first phase (Phase I/II) of the trial have been encouraging, meeting its primary endpoint of safety confirmed by an independent safety monitoring board. Patients reported a significant reduction in pain levels, as measured by the Visual Analogue Scale (VAS), and an overall improvement in their quality of life, enabling them to move more comfortably and engage in daily activities with greater ease. Importantly, the treatment was well tolerated, with no serious adverse events reported. To further evaluate the therapy's efficacy, provide deeper insights into the therapy's impact, MRI scans have been conducted with detailed findings set to be presented at Abu Dhabi Global Health Week in April 2025. Dr. Asma Al Mannaei, Executive Director of the Health Life Sciences Sector at the Department of Health - Abu Dhabi, highlighted, 'The successful completion of this clinical trial is a testament to Abu Dhabi's robust regulatory oversight and its growing appeal as a hub for cutting-edge medical research. WAM

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