Latest news with #CTC
Yahoo
5 days ago
- Business
- Yahoo
Angle PLC - EACR 2025: Innovation in AR Expression Profiling
ANGLE presents new data at EACR 2025 Highlighting Innovation in Androgen Receptor EXPRESSION profiling Poster presentation highlights development of a novel CTC-based assay GUILDFORD, SURREY / / June 17, 2025 / ANGLE plc (AIM:AGL)(OTCQX:ANPCY), a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology, is pleased to announce the presentation of a poster at the European Association for Cancer Research (EACR) Congress, taking place in Lisbon, Portugal from 16-19 June 2025. The poster entitled 'Combined microfluidic isolation and immunofluorescence staining of circulating tumour cells for the assessment of Androgen Receptor expression in metastatic prostate cancer blood samples', is being presented during the Biomarkers in Tissue and Blood session on Tuesday 17 June 2025. This assay addresses a significant unmet need in prostate cancer. The androgen receptor (AR) plays a central role in driving disease growth and progression, and changes in AR can lead to resistance to current treatments and the development of advanced incurable disease known as metastatic castration-resistant prostate cancer (mCRPC). With at least 130 ongoing clinical studies and a projected AR inhibitor market value of US $9.8 billion by 2032, there is growing demand for assays that can monitor AR activity1. ANGLE has developed a new approach for repeatable assessment of AR expression in prostate cancer patients using the Parsortix system and ANGLE's AR immunofluorescence assay. The assay was tested on blood spiked with prostate cancer cells exposed to increasing AR drug concentrations. The results showed a clear, statistically significant reduction in AR expression as AR-drug concentration increased, from over 80% AR-positive cells in untreated samples to under 20% at the highest drug level. This demonstrates the assay's high sensitivity and highlights its potential utility for pharmacodynamic assessment, enabling customers to monitor treatment response in real-time. The assay was then validated in blood samples from 20 patients with mCRPC. 50% of patients were CTC-positive and all CTC-positive patients had AR-positive CTCs enabling the assessment of AR expression levels. CTC clusters, which are known to be up to 100 times more metastatic, were observed in 80% of CTC-positive patients. All CTCs detected were mesenchymal or undergoing EMT, highlighting the importance of using the marker-independent Parsortix system in this patient cohort. This work demonstrates how ANGLE's Portrait AR workflow enables sensitive, real-time monitoring of AR expression from a simple blood draw. The assay is now available as part of ANGLE's assay menu to support pharma customers with longitudinal biomarker assessment in AR-targeted clinical trials. The poster will be available on ANGLE's website from 20:00 on Tuesday 17 June: ANGLE Chief Scientific Officer, Karen Miller, commented:"This work underscores the value of ANGLE's Parsortix system for enabling detailed protein analysis directly in intact CTCs. The androgen receptor assay development programme has successfully been completed, and we are excited by its potential to repeatably monitor drug response and resistance in prostate cancer trials. Sharing this data at EACR reflects our ongoing commitment to advancing precision oncology with innovative, real-world solutions." 1. For further information: ANGLE plc +44 (0) 1483 343434 Andrew Newland, Chief Executive Ian Griffiths, Finance Director Berenberg (NOMAD and Broker) Toby Flaux, Ciaran Walsh, Milo Bonser +44 (0) 20 3207 7800 FTI Consulting Simon Conway, Ciara Martin Matthew Ventimiglia (US) +44 (0) 203 727 1000 +1 (212) 850 5624 For Research Use Only. Not for use in diagnostic procedures. For Frequently Used Terms, please see the Company's website on Notes for editors About ANGLE plc ANGLE is a world-leading liquid biopsy company with innovative circulating tumour cell (CTC) solutions for use in research, drug development and clinical oncology using a simple blood sample. ANGLE's FDA cleared and patent protected CTC harvesting technology known as the Parsortix® PC1 System enables complete downstream analysis of the sample including whole cell imaging and proteomic analysis and full genomic and transcriptomic molecular analysis. ANGLE's commercial businesses are focusing on clinical services and diagnostic products. The clinical services business is offered through ANGLE's GCLP-compliant laboratories. Services include custom made assay development and clinical trial testing for pharma. Products include the Parsortix system, associated consumables and assays. Over 100 peer-reviewed publications have demonstrated the performance of the Parsortix system. For more information, visit Any reference to regulatory authorisations such as FDA clearance, CE marking or UK MHRA registration shall be read in conjunction with the full intended use of the product: The Parsortix® PC1 system is an in vitro diagnostic device intended to enrich circulating tumor cells (CTCs) from peripheral blood collected in K2EDTA tubes from patients diagnosed with metastatic breast cancer. The system employs a microfluidic chamber (a Parsortix cell separation cassette) to capture cells of a certain size and deformability from the population of cells present in blood. The cells retained in the cassette are harvested by the Parsortix PC1 system for use in subsequent downstream assays. The end user is responsible for the validation of any downstream assay. The standalone device, as indicated, does not identify, enumerate or characterize CTCs and cannot be used to make any diagnostic/prognostic claims for CTCs, including monitoring indications or as an aid in any disease management and/or treatment decisions. This information is provided by Reach, the non-regulatory press release distribution service of RNS, part of the London Stock Exchange. Terms and conditions relating to the use and distribution of this information may apply. For further information, please contact rns@ or visit SOURCE: ANGLE plc View the original press release on ACCESS Newswire Sign in to access your portfolio
The Hill
5 days ago
- Business
- The Hill
Senate scales back additional Trump tax cuts in its version of ‘big, beautiful bill'
Senate Republicans' tax and spending cut bill makes many of the core elements of their 2017 tax cuts permanent but scales back additional cuts from what the House passed. The Senate Finance Committee unveiled its version of the central piece of President Trump's 'big, beautiful bill' on Monday. The Senate bill locks in existing federal tax brackets, boosts the standard deduction and maintains the termination of personal exemptions — all without sunsets. Different from the House version, the bill sets a lower increase for the child tax credit (CTC), raising it to $2,200 per child as opposed to the House's $2,500. The bill creates new deductions for taxes on tips, overtime pay and car loan interest but doesn't make them fully deductible. Tips are deductible up to $25,000 through 2028. Overtime pay is deductible up to $12,500, or $25,000 for joint filers, through 2028. Auto loan interest is deductible up to $10,000, also through 2028. Notably, the legislation re-establishes the state and local tax (SALT) deduction cap at $10,000. The House had agreed after intense debate to raise it to $40,000. The reversion is sure to incense members of the SALT Caucus in the House who had threatened to vote against the measure absent the deal — and maybe President Trump as well, who promised to 'get SALT back' while campaigning. Senate Majority Leader John Thune (R-S.D.) told reporters on Monday that SALT would continue to be 'a negotiation' but the total reversion nullifies the tenuous deal struck in the lower chamber. Additionally, the bill sets up savings accounts for children. Parents and relatives can contribute up to an inflation-indexed $5,000 annually of after-tax dollars into the accounts. For U.S. children born between 2024, and 2028, the government will contribute $1,000 per child into the accounts. In addition to a smaller boost in the child tax credit, the bill adds restrictions to the earned income tax credit, another tax break geared to help low-income workers. The new certification program for the credit will require taxpayers to provide information and documentation 'as the Secretary by regulation requires.' Critics of the provision were quick to point out that it will likely result in many new audits of lower income taxpayers, which studies have shown can be biased against Black American taxpayers in particular. 'The EITC pre-certification requirement would lead to an unprecedented number of audits, overwhelmingly focused on low- and moderate-income workers,' NYU tax law center senior fellow Greg Leiserson wrote on Monday. Stanford University researchers found in 2023 that the IRS 'disproportionately audits Black taxpayers' due in part to the way the earned income tax credit is administered. The legislation extends the increased inheritance and gift tax exemption cap of $15-million for single filers and $30 million for married couples in 2026, indexing the amount for inflation. The passthrough entity deduction – cherished by many businesses and always top of mind for Republicans – is kept at 20 percent and made permanent. This is another difference from the House version, which increased it to 23 percent. This passthrough deduction's phase-in range is increased to $75,000 and $150,000 for joint filers. Changes are made for businesses designated as a 'specialized service trade or business,' which covers some professional service industries. Other business tax breaks are in there as well, including a trifecta of changes from 2017 that had already expired and were the subject of tax legislation that was voted down last year. Research and development costs are made immediately deductible and will be retroactive to 2024. Bonus depreciation, allowing companies to immediately deduct depreciation costs, is made permanent. The allowance is increased to 100 percent for equipment bought and used after January 19, 2025. Business interest expenses will get an increased cap of deductibility corresponding to the EBITDA accounting standard, as opposed to EBIT, which excludes depreciation and amortization costs. This is a tax break especially valued by leveraged buyout firms who finance investments with borrowed money.
Hindustan Times
6 days ago
- Politics
- Hindustan Times
An arena for Islamabad to do grandstanding
Pakistan will assume the presidency of the UN Security Council (UNSC) in July, for one month. However, in the run-up to the presidency, there has been much consternation in the Indian media about Pakistan becoming one of the three vice-chairs of UNSC's Committee on Counter-Terrorism (CTC). Algeria will remain the CTC chair till the end of 2025, and Pakistan wants to become the chair in 2026. Even though Pakistan unwisely held up the work of other UNSC Committees for a full five months just to get this express commitment for 2026 — similar to the dispensation India got in 2021 — the P-5 (permanent five members of UNSC) still would not agree to give Pakistan any such commitment. When India wanted to be the CTC chair during its term at UNSC between 2021-2022, there was no vacancy in 2021 since the chair, Tunisia, still had one year to go. Normally, the chair would then have gone to those members elected for 2022-2023, and India would have missed the chance. However, the UNSC, and more importantly, the P-5 (which included China), gave an express commitment to India in 2021 that it would be the CTC chair for 2022. Needless to add, India made an impact by bringing the entire CTC Committee in 2022 to visit the venue of the 2008 Mumbai attacks and chairing a special CTC session in New Delhi. Pakistan wanted a similar express commitment for the CTC chair in 2026, which was refused by the Council. This is not to say that it won't get the chair in 2026, but it will have five other newly elected member-States competing for the post. The P-5 also rightly, and outrightly, rejected Pakistan's demand to chair the 1267 sanctions committee dealing with al-Qaeda and ISIL (Da'esh), since the 1267 sanctions list is peppered with the names of Pakistani terrorists and terror groups, including Lashkar-e-Taiba and Jaish-e-Mohammed and the masterminds of the Pahalgam terror attack. Pakistan had to settle for the 1988 Taliban sanctions committee which has now become a mere shell of its former self after the Taliban takeover in Afghanistan in August 2021. Though some Taliban ministers are still on the sanctions list, they have been continuously given waivers from sanctions to perform their functions. If Pakistan thinks that it can arm-twist the Taliban as the chair, it is sadly mistaken. That said, the focus is on Pakistan's UNSC presidency in July. Its presidency comes in the aftermath of Operation Sindoor, with a civilian government fattened by the International Monetary Fund (IMF) and other loans and a military establishment receiving arms from China and Turkey. Since it is Islamabad's only presidency, during its term, it will go for the 'jugular vein' — borrowing a phrase from its much-decorated army chief. During its presidency, Pakistan can be expected to do all it can to have an open debate on Jammu and Kashmir to do some grandstanding on the world stage. It would ideally prefer this under an anachronistically titled agenda item, 'The India-Pakistan question'. However, the P-5 nations have allowed only closed consultations under this agenda item in the recent past. Since Pakistan is adamant about an open discussion, it may settle for another agenda item 'peaceful resolution of conflicts' which would, however, dilute the focus given there are enough conflicts around the world. Of course, technically any decision for an open or closed session can be challenged and voted on, for which nine affirmative votes out of 15 members are required (since vetoes do not apply to procedural votes). But Pakistan is mindful of the fact that contrary to what it is trying to project, there is really no appetite in the international community to internationalise the Kashmir issue. Moreover, while Indians like to portray any call for de-escalation as a hyphenation of India and Pakistan, this hyphenation is more in our minds and not in those who call for de-escalation. The world knows better. On the Indus Water Treaty, even before India held it in abeyance after the Pahalgam attacks, Pakistan had declared its intention to make it an issue during its presidency. After consistently thwarting India's attempt to renegotiate this lopsided treaty, it will take the matter to the UNSC citing breach of security. There is a precedence of UNSC presidential statements being adopted earlier, on the construction of the Grand Ethiopian Renaissance Dam that was contested by Egypt fearing decreased flow of Nile waters from Ethiopia. Any UNSC statement will require the concurrence of all 15 member-States. Further, a Pakistani focus on combatting terrorism and Islamophobia is inevitable, in the country's attempt to wipe away the stains of being a State sponsor of terrorism. A session on the Organisation of Islamic Cooperation is on the cards to burnish Pakistan's Islamic credentials. The Gaza war and Israeli-Iran conflict will receive attention. So will UN peacekeeping, since Pakistan is a major troop-contributing country. While our multiparty delegations have visited UNSC countries, multilateral issues have dynamics of their own. Close bilateral friendship with a country does not necessarily translate into greater multilateral cooperation at the UN. India will no doubt keep a close eye on what the US and the UK do in July, given recent American flip-flops on Pakistan and the UK's ambivalent postures in UNSC. Further, given India's geopolitical distancing from recent conflicts around the world — in its national interest — we should be prepared for similar reactions towards India when we need them. Given our standing, the world now expects us to get geopolitically involved in their problems as well. As I have argued before, it is time for India to take its right geopolitical place — regionally and globally. Pakistan's presidency also comes during the monsoon session of our Parliament. One hopes that we in India treat Pakistan's grandstanding with a sense of perspective and equanimity. No UNSC document can threaten the national interests of India. TS Tirumurti is a former ambassador and Permanent Representative of India to the United Nations, New York. The views expressed are personal
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Business Standard
7 days ago
- Business
- Business Standard
Tripura eyeing tea boom as govt support, unused land fuel expansion plans
Tripura is witnessing a big transformation in its tea sector, with large tracts of unused government-allotted land and rising production figures setting the stage for what officials are calling a tea uprising in the northeastern state. Tripura Tea Development Corporation (TTDC) Chairman Samir Ghosh said the state's tea industry holds immense potential due to underutilised land and favourable policies. Altogether 12,832 hectares were allotted by the government for tea cultivation, but only 6,000 hectares are currently being utilised. The remaining 6,832 hectares are lying vacant, Ghosh told PTI, emphasising the untapped potential for expanding cultivation. Unlike several other states that cap tea garden land at 4.2 hectares, Tripura imposes no ceiling, allowing both large-scale and small-scale growers to flourish. That gives Tripura a clear competitive edge. Plus, Tripura tea has a very strong liquor it's one of our biggest strengths, Ghosh said. Currently, Tripura has 54 tea gardens, including five run directly by the government, 11 managed by cooperative societies, and the remaining under private ownership. Additionally, around 2,800 small tea growers, each cultivating on 12 hectares, contribute nearly 30 per cent to the state's total tea production. To support these growers, TTDC is ramping up local infrastructure. We are setting up a modern tea processing centre in Machhmara in Dhalai district, and a tea auction centre is coming up at Brahmakunda in West Tripura district, Ghosh said. The auction centre, being developed with financial support from the North Eastern Council (NEC) at a cost of Rs 2.2 crore, is expected to help local growers secure better prices and reduce dependence on auction houses in Assam. Our teas are currently sold under the Assam label. With this auction centre, we aim to build a distinct identity for Tripura tea, asserted Ghosh. Production has seen a dramatic upswing in recent years. According to State Cabinet Minister Ratan Lal Nath, Tripura's tea production has grown from 2 lakh kg in 2017-18 to 7.55 lakh kg in 2024-25. This jump in production is the result of the state government's strong political will to revive and promote the sector, Nath told PTI. Since 2018, the state government has launched multiple initiatives to give Tripura tea a national and international presence. A unique Tripura Tea' logo was unveiled in 2018, and TTDC has also introduced its own branded offerings. Further efforts are underway to establish more processing units for green tea, orthodox tea, and CTC (Crush, Tear, Curl) variants, officials said. In an innovative distribution strategy, TTDC has also started selling Tripureswari Packet Tea' through Public Distribution System (PDS) outlets, bringing locally-produced tea directly into ration shops. Beyond industry-focused steps, the state government has undertaken measures to improve the lives of tea workers, too. Under the Pradhan Mantri Awas Yojana (PMAY), housing has been provided to 3,339 tea labourer families, reinforcing the administration's focus on inclusive rural development, they said.
News18
11-06-2025
- Business
- News18
Bengaluru Techie Feels ‘50 LPA Is The New 25 LPA' In The City
Last Updated: According to a report by on average, a person in Bengaluru earns around Rs 27.2 Lakh per year. Bengaluru, the IT Capital of India, has long been regarded as one of the most expensive cities in India for middle-class families, with studies indicating a monthly cost of living of around Rs 36,000 for a comfortable lifestyle. This rising cost of living significantly impacts individuals' financial stability and well-being, affecting their ability to afford essential needs and plan for the future. Amid this, a post from a techie has gained traction on social media, highlighting whether the Rs 50 lakh per annum (LPA) package has become the new Rs 25 LPA in the IT hub. Taking to X, a user wrote, 'I hear so many people earning 50LPA in the Bangalore IT sector. Either they're stating inflated CTC or 50LPA is the new 25LPA. Can some techies confirm?" I hear so many people earning 50LPA in Bangalore IT they're stating inflated CTC or 50LPA is the new 25LPA. Can some techies confirm? — Sourav Dutta (@Dutta_Souravd) June 10, 2025 The post instantly grabbed the attention of the audience, prompting many to share their reactions. Some users claimed that even Rs 50 LPA doesn't mean much anymore in the city's high-cost tech ecosystem. An X user commented, 'It is the new 25 LPA. At 40, it will be strange if you are not earning 50." Another one wrote, '50L is the new 10L. Most earn 1Crs+++." One of them shared, 'It depends, Bengaluru has 10L+ IT employees, 90 per cent of them are on 2-3X of their years of experience, while 5-10 per cent employees are getting 4-6X I know guys who have 10-12 years of experience and earning 20-25L and on other hand 5-year experience guys earning 60-70L also." 'In a way, yes, but only for top-tier tech professionals," a comment read. Another one reads, '50L is 5LPA of 2015, 10LPA of 2020." A person wrote, 'Generally, people with over 5 years of experience can land it, but it heavily depends on negotiation skills, experience, and the college they graduated from." According to a report by on average, a person in Bengaluru earns around Rs 27.2 Lakh per year.
