Latest news with #CMC
Business Wire
9 hours ago
- Business
- Business Wire
Candid Therapeutics Advances Portfolio of Novel T-Cell Engagers into Five Autoimmune Diseases for Clinical Evaluation
SAN DIEGO--(BUSINESS WIRE)--Candid Therapeutics, Inc. ('Candid'), a clinical-stage biotechnology company redefining the treatment of autoimmune and inflammatory diseases through novel T-cell engagers (TCEs), today announced key operational and clinical milestones for its two lead clinical stage programs, cizutamig (BCMA TCE) and CND261 (CD20 TCE). Candid launched in the second half of 2024 with $370 million in financing and two in-licensed TCEs that had completed full Phase 1 dose escalation studies in oncology patients. Emerging clinical data with TCEs have solidified our confidence that TCEs can become the most compelling modality across a range of diseases. Share 'We founded Candid on the conviction that T-cell engagers would become the largest therapeutic class in autoimmune diseases, surpassing the commercial success of TNF inhibitors such as Humira,' said Dr. Ken Song, Chairman, President, and Chief Executive Officer of Candid. 'We are hyperfocused on execution to generate clinical data. Over the past few quarters, we have prioritized disease indications and built a foundation of key CMC and clinical operational activities to set a new benchmark for innovation, scale, and speed. Emerging clinical data with TCEs have solidified our confidence that TCEs can become the most compelling modality across a range of diseases.' Key Highlights Reinforcing Candid's Leadership Position: First patients dosed with cizutamig and CND261: Patients with refractory rheumatoid arthritis and systemic sclerosis have been dosed at therapeutically active doses. Both TCEs have been well tolerated and patients have shown early signs of promising clinical response and disease improvement. Industry-leading clinical study pipeline in motion: Clinical studies are now in progress for IgA Nephropathy, Myasthenia Gravis, Rheumatoid Arthritis, Systemic Lupus Erythematosus and Systemic Sclerosis. Additional clinical studies in high-value disease indications slated to launch in the 2H 2025. Studies are designed to evaluate safety, pharmacokinetics, pharmacodynamic effects, and early signs of efficacy in patients with immunology and inflammatory diseases. CMC activities completed to enable global clinical trials: Candid has invested significant resources to build an integrated Chemistry, Manufacturing, and Controls (CMC) infrastructure to support global development with the completion of several new drug product manufacturing runs. Subcutaneous dosing formulations for both cizutamig and CND261 have been established. Strategic establishment of China operations: To support clinical execution across multiple geographies, Candid has established a fully staffed legal entity in China. The China based team includes professionals with deep expertise in regulatory, clinical development, and clinical operations. With unmatched executional momentum and differentiated programs, Candid Therapeutics is defining a new future in immunology through its commitment to TCEs in autoimmune diseases. Additional trial initiations and clinical data disclosures are anticipated in the coming quarters. About Candid Therapeutics Candid Therapeutics is a clinical-stage biotechnology company focused on transforming the treatment of autoimmune and inflammatory diseases through novel T-cell engager (TCE) platforms. Candid is advancing two lead B-cell depleting TCE antibody drug candidates, with a goal to broadly explore the potential of TCEs across multiple autoimmune diseases by targeting different B-cell protein targets, as well as evaluating different depths of B-cell depletion. Established in 2024 and headquartered in San Diego, CA, Candid is led by a team of entrepreneurial executives who have a track record of advancing programs into and through development and is supported by a distinguished syndicate of premier life science investors. About Cizutamig Cizutamig is a bispecific antibody designed to simultaneously bind B-cell maturation antigen (BCMA) on B-cells and CD3 on T-cells, enabling T-cell–mediated cytotoxicity against BCMA-expressing B-cells. Originally developed and clinically evaluated in multiple myeloma, cizutamig has demonstrated patient experience in oncology settings and is now being investigated in autoimmune diseases where pathogenic B-cells play a critical role in disease progression. Cizutamig has the potential to deliver deep and selective B-cell depletion through its dual-targeting mechanism, offering a novel approach for treating a broad spectrum of immune-mediated disorders. About CND261 CND261 is a bispecific antibody designed to target CD20 on B-cells and CD3 on T-cells, enabling T-cell mediated cytotoxicity against CD20-expressing B-cells. Engineered with low CD3 affinity, CND261 is optimized to reduce the risk of excessive T-cell activation while maintaining potent and selective B-cell depletion. The molecule has demonstrated patient experience in B-cell malignancies and is now being investigated in autoimmune diseases where pathogenic B-cells contribute to disease progression. CND261 represents a promising therapeutic candidate for immune-mediated disorders with the potential for improved safety and efficacy through its targeted mechanism of action.
Time of India
2 days ago
- Health
- Time of India
CMC cracks down on illegal water bottling units amid diarrhoea outbreak
Cuttack: The Cuttack Municipal Corporation (CMC) sealed two illegal water bottling units in Shankarpur's Das Sahi area on Wednesday, amid rising concerns over a diarrhoea outbreak in Odisha linked to contaminated water consumption. The raid, conducted by the municipal health wing following specific complaints, revealed serious violations of hygiene and licensing norms at both facilities. "These units were operating without any safety standards or proper documentation," CMC mayor Subhash Singh said, adding, "Such negligence during a diarrhoeal outbreak is unacceptable." The mayor confirmed that both units have been sealed until further notice. Officials found the facilities lacking basic filtration systems and disinfection mechanisms. A local resident, speaking on condition of anonymity, revealed that the units had been operating for years while flouting safety guidelines. "Large quantities of untreated water were being bottled and distributed in the local market, posing a serious health threat to consumers," the resident added. The enforcement action was carried out jointly by the municipal health team and CMC enforcement squad. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like USDJPY đang đi lên không? IC Markets Đăng ký Undo Authorities are now investigating the distribution network to identify and take action against involved retailers. Singh announced that city-wide inspections would be intensified and urged citizens to verify the certification of packaged drinking water before consumption. The crackdown comes as part of CMC's broader efforts to control the spread of water-borne diseases in the region. Health officials have warned residents against consuming unverified packaged drinking water and emphasized the importance of ensuring water sources are certified and hygienic. Cuttack: The Cuttack Municipal Corporation (CMC) sealed two illegal water bottling units in Shankarpur's Das Sahi area on Wednesday, amid rising concerns over a diarrhoea outbreak in Odisha linked to contaminated water consumption. The raid, conducted by the municipal health wing following specific complaints, revealed serious violations of hygiene and licensing norms at both facilities. "These units were operating without any safety standards or proper documentation," CMC mayor Subhash Singh said, adding, "Such negligence during a diarrhoeal outbreak is unacceptable." The mayor confirmed that both units have been sealed until further notice. Officials found the facilities lacking basic filtration systems and disinfection mechanisms. A local resident, speaking on condition of anonymity, revealed that the units had been operating for years while flouting safety guidelines. "Large quantities of untreated water were being bottled and distributed in the local market, posing a serious health threat to consumers," the resident added. The enforcement action was carried out jointly by the municipal health team and CMC enforcement squad. Authorities are now investigating the distribution network to identify and take action against involved retailers. Singh announced that city-wide inspections would be intensified and urged citizens to verify the certification of packaged drinking water before consumption. The crackdown comes as part of CMC's broader efforts to control the spread of water-borne diseases in the region. Health officials have warned residents against consuming unverified packaged drinking water and emphasized the importance of ensuring water sources are certified and hygienic.
Gulf Insider
2 days ago
- Politics
- Gulf Insider
Purging Of Top Chinese Generals Shows Central Military Commission In "Disarray"
General He Weidong, once the second-highest-ranking officer in China's military and a close ally of President Xi Jinping, has been purged—three months after vanishing from public view. His removal is now clear, following his absence from a high-profile funeral and other political signals, according to Nikkei. He was vice chairman of the Central Military Commission (CMC), the top body overseeing the People's Liberation Army (PLA), and a Politburo member. His sudden downfall marks the first time a sitting CMC vice chairman has been purged since the Cultural Revolution in the 1960s. Nikkei writes that the clearest sign of He's fall came during the funeral of former CMC vice chairman Xu Qiliang. Footage from the event showed floral tributes from top leaders—but none from He. His absence, unedited by state media, underscored his political erasure. This continues a broader purge within the PLA under Xi. Since the early 2010s, multiple high-ranking generals—including Guo Boxiong, Xu Caihou, and Fang Fenghui—have been arrested, imprisoned, or died under investigation. Another, Zhang Yang, committed suicide in 2017 while facing charges. While such purges have become more common, He's case is notable because he was an active member of Xi's inner circle. He was promoted under Xi, seen as trusted, and attended the final session of China's parliament just in March—his last public appearance. The PLA has seen significant internal turmoil, especially since the Communist Party's 20th Congress in late 2022. Several top military figures—including Defense Ministers Li Shangfu and Wei Fenghe, and CMC Political Work Department head Miao Hua—have also disappeared or been removed. These purges have left the CMC in disarray. Its membership has dropped from seven to just four, including Xi himself. Nearly half of the leadership selected in 2022 is now gone, signaling instability at the military's highest levels, the article details. In China, the military is controlled by the Communist Party, not the state, and survival at the top depends on absolute loyalty. He Weidong's fall suggests that even the most senior and trusted officers are not safe in today's political climate.
Yahoo
2 days ago
- Business
- Yahoo
CMC Announces Quarterly Dividend of $0.18 Per Share
IRVING, Texas, June 18, 2025 /PRNewswire/ -- Today, June 18, 2025, the board of directors of Commercial Metals Company ("CMC" or the "Company") (NYSE: CMC) declared a regular quarterly cash dividend of $0.18 per share of CMC common stock. CMC's 243rd consecutive quarterly dividend will be paid on July 9, 2025, to stockholders of record as of the close of business on June 30, 2025. About CMC CMC is an innovative solutions provider helping build a stronger, safer and more sustainable world. Through an extensive manufacturing network principally located in the United States and Central Europe, CMC offers products and technologies to meet the critical reinforcement needs of the global construction sector. CMC's solutions support early-stage construction across a wide variety of applications, including infrastructure, non-residential, residential, industrial and energy generation and transmission. View original content: SOURCE Commercial Metals Company Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
Hans India
3 days ago
- Health
- Hans India
Raids at eateries to curb diarrhoea
Bhubaneswar: Raids were conducted on Tuesday at several restaurants in Bhubaneswar, Jajpur and Cuttack to assess the standard of hygiene amid the diarrhoea outbreak in parts of the State, officials said. Diarrhoea was first detected in Jajpur on June 9. Over 200 patients are still under treatment in different healthcare facilities in the district. A team, led by Darpan's tehsildar Manas Tripathy, conducted raids at eateries, sweet shops and hotels in Barchana town in Jajpur. 'We are checking the hygiene and quality of food served in eateries. If stale food was found, we issued a warning to the owner. If they continue to serve unhygienic or stale food, we will seal their shop,' he said. The local administration in Bari, Dharmasala, Vyasanagar and Binjharpur blocks has already shut down hotels, eateries, fast-food stalls, meat shops and water packaging units for a temporary period. Municipal authorities in Cuttack and Bhubaneswar have also started conducting raids after diarrhoea cases were detected in some pockets of the twin cities. Bhubaneswar Municipal Corporation teams conducted raids at eateries in Kalinga Vihar and Delta Square areas. They collected food samples for testing and also fined some restaurant owners for not maintaining the quality, an official said. The Cuttack Municipal Corporation (CMC) sealed two hotels in Station Bazar after finding low-quality water and food served there, he said. Capital Hospital's Director, Rupabhanu Mishra, said a separate ward has been set up to treat diarrhoea patients. Meanhile, Odisha Housing and Urban Development Minister Krushna Chandra Mahapatra said the State government is fully alert and taking all precautionary arrangements to avoid spread of diarrhoea during the Rath Yatra, which is scheduled to commence from June 27. While speaking to mediapersons, Mahapatra said the Urban Development department is fully alert in view of the rising cases of diarrhoea in the State. 'Particular attention is being given to the town areas where Rath Yatra celebrations will take place. The department is on high alert to avoid any outbreak during the festival. Intensive surveillance and monitoring are being carried out to ensure that the public remains safe, and the festival is conducted smoothly,' said Mahapatra. 'Although no concrete evidence of contaminated water has been found so far, we are taking every precaution to avoid any health crisis,' added Mahapatra.
