Latest news with #CKD
Economic Times
2 days ago
- Health
- Economic Times
Link between restless leg syndrome and kidney disease found in new research. Who are at risk? Check symptoms
A recent study highlights that individuals with chronic kidney disease (CKD), especially those undergoing dialysis, face a significantly higher risk of developing Restless Legs Syndrome (RLS). The condition, marked by an uncontrollable urge to move the legs during rest, is strongly linked to iron deficiency—common in CKD patients due to inflammation, poor iron absorption, and blood loss. Symptoms often worsen at night and disrupt sleep. Tired of too many ads? Remove Ads What Is Restless Legs Syndrome? Why CKD Patients Are More at Risk Tired of too many ads? Remove Ads Recognising the Symptoms Discomfort after sitting or lying down for long periods Temporary relief through leg movement or stretching Trouble falling or staying asleep due to nighttime symptoms Involuntary leg movements during sleep Difficulty focusing and low mood due to sleep disruption Causes Beyond Kidney Disease Managing RLS: Treatment and Lifestyle Support Establishing a consistent and calming bedtime routine Taking warm baths or using heating pads and ice packs Trying leg massages or gentle stretching before bed Using devices such as vibration pads or pressure wraps for temporary relief ( Originally published on Jun 20, 2025 ) A growing body of research has highlighted a strong association between chronic kidney disease (CKD) and Restless Legs Syndrome (RLS), a neurological condition that significantly affects sleep and quality of life. Individuals undergoing dialysis are particularly vulnerable, as their risk of developing RLS is much higher due to complications like iron Legs Syndrome, also known as Willis-Ekbom Disease, is a neurological condition that creates an uncontrollable urge to move the legs, particularly during periods of rest or inactivity. The discomfort is often described as crawling, itching, aching, or pulling sensations. These symptoms tend to worsen in the evening or at night and are usually relieved by the legs are primarily affected, in some cases, the arms may also experience similar sensations. RLS can disrupt sleep and, over time, lead to mood disturbances, chronic fatigue, and impaired shows that nearly one in four people with chronic kidney disease suffer from RLS, with higher prevalence among those on hemodialysis. This increased risk is largely tied to iron deficiency, which is common in CKD patients due to factors like blood loss during dialysis, poor iron absorption, and ongoing imaging and spinal fluid analysis in people with RLS reveal low iron concentrations, particularly in areas that regulate dopamine—a chemical essential for muscle control. In kidney disease, both absolute and functional iron deficiencies are often seen. Patients tend to have reduced levels of ferritin and transferrin saturation, along with elevated total iron-binding capacity (TIBC), indicating iron imbalance that may directly contribute to RLS symptoms of RLS vary in intensity but commonly include:In severe cases, these symptoms can appear more than twice a week, significantly affecting daily life and mental many RLS cases are linked to CKD and iron deficiency, other health conditions also contribute. These include diabetes, peripheral neuropathy, and neurological disorders involving dopamine pathways, such as Parkinson's disease. Genetics also play a role, as the condition is known to run in families. In some individuals, no specific cause can be there is currently no cure for RLS, various treatments can help manage symptoms. Addressing iron deficiency through supplementation, where appropriate, is often a primary focus in CKD patients. Limiting stimulants like caffeine, alcohol, and tobacco—especially in the evening—can also reduce symptom helpful strategies include:For patients with CKD, early identification and management of RLS can significantly improve sleep and overall well-being. Monitoring iron levels and treating deficiencies proactively is key in reducing symptom burden and improving quality of life.
Time of India
2 days ago
- Health
- Time of India
Link between restless leg syndrome and kidney disease found in new research. Who are at risk? Check symptoms
A growing body of research has highlighted a strong association between chronic kidney disease (CKD) and Restless Legs Syndrome (RLS), a neurological condition that significantly affects sleep and quality of life. Individuals undergoing dialysis are particularly vulnerable, as their risk of developing RLS is much higher due to complications like iron deficiency. What Is Restless Legs Syndrome? Restless Legs Syndrome, also known as Willis-Ekbom Disease, is a neurological condition that creates an uncontrollable urge to move the legs, particularly during periods of rest or inactivity. The discomfort is often described as crawling, itching, aching, or pulling sensations. These symptoms tend to worsen in the evening or at night and are usually relieved by movement. While the legs are primarily affected, in some cases, the arms may also experience similar sensations. RLS can disrupt sleep and, over time, lead to mood disturbances, chronic fatigue, and impaired focus. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Top 5 Dividend Stocks for May 2025 Seeking Alpha Read Now Undo Why CKD Patients Are More at Risk Research shows that nearly one in four people with chronic kidney disease suffer from RLS, with higher prevalence among those on hemodialysis. This increased risk is largely tied to iron deficiency, which is common in CKD patients due to factors like blood loss during dialysis, poor iron absorption, and ongoing inflammation. Brain imaging and spinal fluid analysis in people with RLS reveal low iron concentrations, particularly in areas that regulate dopamine—a chemical essential for muscle control. In kidney disease, both absolute and functional iron deficiencies are often seen. Patients tend to have reduced levels of ferritin and transferrin saturation, along with elevated total iron-binding capacity (TIBC), indicating iron imbalance that may directly contribute to RLS symptoms. Recognising the Symptoms The symptoms of RLS vary in intensity but commonly include: Discomfort after sitting or lying down for long periods Temporary relief through leg movement or stretching Trouble falling or staying asleep due to nighttime symptoms Involuntary leg movements during sleep Difficulty focusing and low mood due to sleep disruption In severe cases, these symptoms can appear more than twice a week, significantly affecting daily life and mental well-being. Causes Beyond Kidney Disease While many RLS cases are linked to CKD and iron deficiency, other health conditions also contribute. These include diabetes, peripheral neuropathy, and neurological disorders involving dopamine pathways, such as Parkinson's disease. Genetics also play a role, as the condition is known to run in families. In some individuals, no specific cause can be identified. Managing RLS: Treatment and Lifestyle Support Though there is currently no cure for RLS, various treatments can help manage symptoms. Addressing iron deficiency through supplementation, where appropriate, is often a primary focus in CKD patients. Limiting stimulants like caffeine, alcohol, and tobacco—especially in the evening—can also reduce symptom flare-ups. Other helpful strategies include: Establishing a consistent and calming bedtime routine Taking warm baths or using heating pads and ice packs Trying leg massages or gentle stretching before bed Using devices such as vibration pads or pressure wraps for temporary relief For patients with CKD, early identification and management of RLS can significantly improve sleep and overall well-being. Monitoring iron levels and treating deficiencies proactively is key in reducing symptom burden and improving quality of life.
Time of India
3 days ago
- Health
- Time of India
Kidney health and Restless Legs Syndrome explained: Symptoms, causes, and cure
A recent study has identified chronic kidney disease (CKD) patients—especially those undergoing dialysis—as a group at significantly higher risk of developing Restless Legs Syndrome (RLS). The research highlights that RLS symptoms are highly prevalent in this population and are closely associated with iron deficiency, a condition frequently seen in CKD due to chronic inflammation, poor dietary intake, and blood loss. A 2016 meta-analysis found that nearly one in four CKD patients experiences RLS, with higher rates among those on hemodialysis. Further, brain imaging and cerebrospinal fluid studies have shown lower iron concentrations in certain areas in RLS patients, suggesting that central, rather than peripheral, iron deficiency is more relevant to symptom development. In CKD, this imbalance is often worsened by dialysis-related blood loss and systemic inflammation. The study further noted that CKD patients with RLS had lower levels of serum ferritin, transferrin saturation, and serum iron, along with elevated TIBC, pointing to both absolute and functional iron deficiency. These findings underscore the importance of early detection and iron-targeted therapy in managing RLS symptoms and improving overall quality of life in CKD patients. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Giao dịch CFD với công nghệ và tốc độ tốt hơn IC Markets Đăng ký Undo What is Restless Legs Syndrome (RLS)? Restless Legs Syndrome—also called Willis-Ekbom Disease—is a neurological and sensory condition characterized by an uncontrollable urge to move the legs. It typically occurs during periods of rest or inactivity, especially in the evening or at night, making it a sleep-disrupting disorder. The condition tends to worsen in the evening and improves with movement. People often describe the sensations as aching, itching, throbbing, crawling, or pulling in the legs. Though it mostly affects the legs, it can occasionally impact the arms too. Signs and symptoms of RLS RLS symptoms can range from mild to severe and vary from person to person. Some of its key features include: Discomfort after resting: Symptoms typically start when you're sitting or lying down for long periods, for example during a long drive, or while watching a move in a theatre. Relief with movement: Stretching, pacing, or leg simple movement helps temporarily improve the symptoms. Worse at night: Many experience trouble falling or staying asleep. Night time twitching: RLS may be associated with another, more common condition called periodic limb movement of sleep, wherein the legs twitch and kick during sleep, possibly throughout the night. Impact on mood and focus: Chronic fatigue, depression, and difficulty concentrating are common. In severe cases, RLS symptoms occur more than twice a week and can interfere with work, social life, and mental health. What causes RLS? Often, there's no known cause for restless legs syndrome. However several contributing factors have been identified. Genetics appear to play a role, as RLS often runs in families. One of the most significant medical links is iron deficiency, especially low levels of iron in the brain, which interferes with dopamine production—an essential chemical for smooth muscle control. RLS is also frequently seen in people with chronic illnesses such as diabetes, kidney disease, and peripheral neuropathy. Additionally, problems in the brain's dopamine pathways, similar to those seen in Parkinson's disease, have been associated with RLS. Managing RLS: What helps? Currently there is no cure for RLS but its symptoms can often be managed with the right combination of treatment and lifestyle adjustments. The first step towards tackling the issue is to address and acknowledge underlying conditions like iron deficiency, diabetes, or sleep apnea. People with RLS are often advised to avoid or limit their intake of caffeine, alcohol, and nicotine, especially in the evening. In order to reduce the nighttime symptoms, it has been observed that Creating a regular sleep routine and maintaining a calming bedtime environment has a positive effect on the body. Further, warm baths, leg massages, or the use of heating pads and ice packs also give relief. Some devices like vibration pads or specially designed foot wraps that apply gentle pressure have also proved to provide temporary relief. One step to a healthier you—join Times Health+ Yoga and feel the change
Medscape
4 days ago
- Health
- Medscape
CKD Tied to Depression Risk, More So in Young Patients
Patients with chronic kidney disease (CKD) showed a 2.6-fold higher risk for depression requiring antidepressant treatment than those without CKD. The greatest risk was observed in those younger than 60 years. METHODOLOGY: Depression is one of the most common psychiatric conditions in patients with CKD. However, evidence from large population-based studies on whether CKD increases the risk for depression requiring treatment is limited. Researchers conducted a retrospective cohort study using data from primary care practices in Germany between 2005 and 2022 to examine the association between CKD and the risk of developing depression requiring treatment. They included 165,787 patients (mean age, 71.6 years; 48.3% women) with CKD and matched them to control individuals without CKD using propensity score matching. Patients with schizophrenia, mood disorders, and neurotic disorders documented within 12 months prior to or on the date of the CKD diagnosis were excluded. The outcome was the diagnosis of depression within up to 10 years following the diagnosis of CKD; antidepressant prescriptions were evaluated in participants with a diagnosis of depression. TAKEAWAY: The 10-year cumulative incidence of depression and depression followed by an antidepressant prescription was significantly higher in patients with CKD than in those without ( P < .001 for both). < .001 for both). Patients with CKD had a 2.6-fold higher risk for depression requiring antidepressant treatment than those without CKD (hazard ratio [HR], 2.63; P < .001), with the strongest effect found in those younger than 60 years (HR, 6.03; P < .001). < .001), with the strongest effect found in those younger than 60 years (HR, 6.03; < .001). Mirtazapine was the most commonly prescribed antidepressant in both CKD and non-CKD groups, followed by citalopram, opipramol, amitriptyline, and escitalopram. IN PRACTICE: "Our findings argue against strict screening protocols for the detection of depression in all patients with CKD. Though, some awareness should be raised for younger patients, given that depression risk was highest in this subgroup," the authors wrote. SOURCE: This study was led by Andreas Kommer, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. It was published online on June 12, 2025, in Clinical Kidney Journal . LIMITATIONS: This study relied on diagnostic codes, which could have led to miscoding or undercoding. The database lacked information on how depression was diagnosed. Additionally, laboratory values were not available for every patient, making it impossible to track the progression of CKD and the initiation of renal replacement therapy. DISCLOSURES: This study did not receive any grant or funding. Two authors reported receiving support through the Clinician Scientist Fellowship, Else Kröner Research College . One author reported being an employee of IQVIA.
Free Malaysia Today
14-06-2025
- Health
- Free Malaysia Today
Foundation applauds World Health Assembly's landmark resolution on kidney disease
The World Health Assembly's recent adoption of a groundbreaking resolution is aimed at reducing the global burden of kidney disease. (Envato Elements pic) PETALING JAYA : With prevalence among adults increasing from 9.07% in 2011 to 15.48% in 2018, chronic kidney disease (CKD) is a significant public health concern in Malaysia. Alarmingly, only 5% of individuals with CKD are aware of their condition. Cases of end-stage renal disease are also on the rise: annually, more than 10,000 people are newly diagnosed as requiring renal replacement therapy or dialysis. Indeed, over 50,000 Malaysians currently require dialysis treatments. If trends persist, it is projected this number could exceed 106,000 by 2040. In light of this, the National Kidney Foundation Malaysia commends the World Health Assembly's (WHA) recent adoption of a groundbreaking resolution aimed at reducing the global burden of kidney disease. The WHA is the top decision-making body of the World Health Organization. This pivotal move underscores the urgent need for comprehensive strategies to combat kidney-related ailments, which have reached alarming levels in Malaysia. Notably, this marks the first time kidney health has been formally prioritised within WHO's non-communicable disease (NCD) agenda. It also aligns with the United Nations' Sustainable Development Goal Target 3.4, which aims to reduce premature mortality from NCDs by one-third through prevention and treatment, while promoting mental health and well-being by 2030; and Target 3.8, which aims to achieve universal health coverage by that year. Over 50,000 Malaysians currently require dialysis treatments – a number that could exceed 106,000 by 2040. (Bernama pic) The adoption of the resolution represents a historic commitment by the global community to prioritise kidney health. With full implementation in Malaysia, it aims to achieve the following: strengthen national kidney-disease prevention programmes, encouraging early screening and intervention to reduce new cases of CKD; improve access to affordable, quality kidney care including dialysis and transplantation, especially for vulnerable groups such as the B40 community; enhance health workforce capacity by training more nephrologists, dialysis nurses, and community health workers; foster multisectoral collaboration involving health authorities, NGOs, the private sector, and community stakeholders to implement effective policies; increase funding and resource allocation towards kidney health, supporting sustainable dialysis services and infrastructure expansion; promote patient-centred care and equity, ensuring no Malaysian is denied access to life-saving treatment due to financial hardship or geographic barriers; support data collection and research, enabling better understanding of the burden of kidney disease in Malaysia and guiding evidence-based interventions. National Kidney Foundation chairman Dr Zaki Morad Zaher said the resolution's call for equitable and sustainable financing underscores the urgent need for universal access to kidney care, particularly for underserved communities such as those in rural Sabah and Sarawak, and among B40 groups. 'We hope this global commitment will inspire the government to enhance support through increased funding, expanded insurance coverage, and improved infrastructure,' he added. 'This includes greater investment in peritoneal dialysis, kidney transplantation, and early-stage interventions to slow the progression of kidney disease in Malaysia.'
