Latest news with #CART
Hans India
2 days ago
- Health
- Hans India
Hospital marks milestone in cell therapy treatment
Bengaluru: In a landmark development for cancer care in India and for Chimeric Antigen Receptor T-cell (CAR T) therapy, two patients in Bengaluru have completed three years of successful follow-up, one of the longest documented survivals in South India. The patients were treated with CAR T therapy for relapsed follicular lymphoma. In a press conference organised by Narayana Health on Wednesday, Dr Sharat Damodar, Chairman of the Oncology Collegium at Narayana Health, said these cases reflect the transformative potential of CAR T therapy for patients who have exhausted all other options. Narayana Health had treated the two patients – a woman aged 66 and a man aged 43.
The Journal
3 days ago
- Business
- The Journal
CART Bai: Ireland's second city is getting its own electrified rail line
IRISH RAIL HAS announced plans to build eight new stations and electrify the commuter line in Co Cork to build the county's equivalent to the capital's DART network. Eight new stations will be added at Blarney/Stoneview, Monard, Blackpool/Kilbarry, Tivoli, Dunkettle, Ballynoe, Carrigtwohill West and Water-Rock. The introduction of an electric fleet hopes to reduce current congestion levels and cut carbon emissions from the line. A new depot at Ballyrichard More will be required for these new carriages. 'CART' services or, as Irish Rail calls it, the 'Cork Area Commuter Rail Programme' will operate every ten miinutes across three commuter lines to Mallow, Midleton and Cobh. Advertisement Those three stops are now set to get a facelift to cater for future increases capacity. All stations will also receive upgrades to their accessibility obligations, to make sure passengers gain unassisted access to services. Two of the new stations, Blarney/Stoneview and Dunkettle, have also been identified as stops best-suitable for park and ride services. It is hope that the upgrades will lead to better connections between rail, bus, cycleways and Cork's future Luas line . Members of the public are asked to come forward during one of its seven upcoming consultation events placed around the Rebel county and online . Transport minister Darragh O'Brien has asked the public in Cork to come forward and read Irish Rail's proposals. Junior transport ministers Seán Canney and Jerry Buttimer have welcomed the second phase of Iarnród Éireann's Cork upgrades. Irish Rail boss Jim Meade and the National Transport Authority's investment manager Marcello Corsi have both encouraged the public to engage with the consultation events. Readers like you are keeping these stories free for everyone... A mix of advertising and supporting contributions helps keep paywalls away from valuable information like this article. Over 5,000 readers like you have already stepped up and support us with a monthly payment or a once-off donation. Learn More Support The Journal
Yahoo
4 days ago
- Yahoo
Tacoma police release details on how toddler subject to AMBER Alert was found
Tacoma police released additional details Monday about the search that unfolded after a 2-year-old girl went missing Saturday, leading to her safe return hours later. Authorities activated an AMBER Alert across the state a little over two hours after a woman called to report her daughter, Delilah Everett, couldn't be found in or around a residence in the 4200 block of South Prospect Street, according to a police news release Monday. The alert was canceled that afternoon. Police announced that Delilah had been returned to her family unharmed and they were questioning a man in custody, The News Tribune reported. The Tacoma Police Department initially posted on Facebook that a man was suspected of taking the girl in his car after entering a fast-food restaurant at 4112 S. Steele St. at 9:10 a.m. Saturday. A man who wrote that he is Everett's father posted a reply to the Police Department's post Saturday afternoon, saying that he is grateful for the man who took the girl and that the man saved his daughter. The father declined to comment when The News Tribune reached him via direct message Monday, saying he had already talked to several other news teams, but said he would inform The News Tribune if he has a statement in the future. Here's how police found the toddler, according to the news release: ▪ 9:30 a.m: A call came in from a mother who said her child was missing from a residence in the 4200 block of South Prospect Street. An employee at a nearby business called to report that a man recently entered the business, saying he found the child alone outside and was looking for her parents. When the employee told him that police would be called to help, the man left with the child in his silver sedan. Police began searching for the child and the man based on surveillance footage from the business. Officers checked nearby police stations and the Tacoma Mall, contacted local hospitals and Tacoma Fire stations and ran searches through Flock Safety systems and Automated License Plate Reader technology for the man's vehicle. The search was unsuccessful. ▪ 9:52 a.m.: Suspecting a child abduction, the police patrol shift commander activated the department's Child Abduction Response Team (CART), which includes criminal investigators and personnel from various agencies trained to 'quickly and effectively recover a child who has been abducted, or who is missing under suspicious circumstances by utilizing a team of trained personnel.' ▪ 10:30 a.m.: CART members began arriving on scene and were briefed on the situation as patrol officers continued the search. ▪ 11:42 a.m.: In the absence of new information about the child's location or why she was taken, the Washington State Patrol issued an AMBER Alert across the state notifying the public of the missing child. The alert said the girl was last seen walking on South Steele Street before a man drove away with her toward 38th Street, The News Tribune reported. 'Within minutes, dozens of calls came in from community members,' the news release said. ▪ 11:50 a.m.: A caller provided authorities with 'key identifying information' about the man seen with the missing child. ▪ 12:06 p.m.: Based on the caller's information, police located the man's address, where they found the missing child. Police took the man into custody and interviewed him at police headquarters. Police also interviewed the man's friends and family. Police booked the man into the Pierce County Jail on an outstanding warrant and forwarded their investigation to prosecutors for a charging decision. The investigation is still active, and police might share further updates after a charging decision. 'The Tacoma Police Department would like to thank the community and our agency partners for their swift assistance during this incident,' the release says.
Yahoo
03-06-2025
- Automotive
- Yahoo
Detroit Grand Prix: A quick history from F1 to Belle Isle to downtown
Downtown racing may feel like a new phenomenon for many Detroiters, but the history of the Detroit Grand Prix actually stretches back decades. If you want to get really historical, open-wheel racing in metro Detroit actually stretches back a century, back when Grosse Pointe hosted a non-championship event on Aug. 8, 1905. The winner of that race, by the way, was Jay Webb, who was born (1870) when there were only 37 states in the United States. Advertisement But that's ancient history — let's fast-forward a bit. GET READY TO RACE: 5 narratives to watch during 2025 Grand Prix downtown The modern edition of the Detroit Grand Prix started in 1982 and has had a bit of a bumpy existence (almost as bumpy as the downtown track itself). With a handful of starts and stops, open-wheel racing in Detroit could have ended as the result of many different events in the city's history. But 43 years after the first downtown race, the Grand Prix is back as a fixture on the IndyCar calendar. Here's a quick history of the many faces of the Detroit Grand Prix: 1982-88: The Formula 1 era Believe it or not, the Detroit Grand Prix started out as an Formula 1 race, not an IndyCar race, in downtown Detroit. Advertisement It was also arguably the least popular race on the F1 schedule at the time. The 1982 Detroit Grand Prix, on a course that included Beaubien, Congress and Larned streets in addition to Jefferson and Atwater along the river, was marred by scheduling issues, rain during the qualifiers and crashes during the main event, partially caused by a bumpy track (a recurring theme for the downtown course). The bumpy track, June heat and safety issues caused F1's governing body (FISA) to bow out of Detroit after the 1988 race, leaving the U.S. without an F1 race for the first time in 30 years. It wouldn't take long for open-wheel racing to return to the city, however. 1989-2001: CART and move to Belle Isle Walker Racing Team's driver Gil De Ferran, signs Wayne Ramocan's, 13, of Detroit, shirt of the Detroit Area Pre-college Engineering Programs summer PVP program, at the Grand Prix on Belle Isle, on August 5, 1999. The Paper Vehicle Program, is geared at introducing kids to the field of engineering. Championship Auto Racing Teams (CART), a predecessor (and eventual competitor) to IndyCar founded in 1979, brought a race back to downtown Detroit in 1989 and moved it to Belle Isle in 1992. Belle Isle hosted the race under CART until 2001, two years before the circuit folded. Advertisement The Belle Isle race provided some advantages to drivers (like a less bumpy ride) and some disadvantages for organizers and fans, who now had to make their way to an island to watch the event instead of landing downtown. The Belle Isle track lay dormant to open-wheel's biggest circuit as the sport reorganized itself in the early 2000s, but the Grand Prix returned to the island a few years later. 2007-19: Return to Belle Isle and doubleheader era IMSA Sports Car Classic competitors drive by James Scott fountain during the Detroit Grand Prix on Saturday June 1, 2019, on Belle Isle. IndyCar, the biggest current American open-wheel circuit, came back to Belle Isle in 2007 to a big crowd but shut down from 2009-2011 due to the recession and its economic impacts on Detroit. Advertisement When the race returned to Belle Isle in 2012, IndyCar turned the Detroit Grand Prix into a doubleheader, for a while the only doubleheader on the circuit's schedule. That meant drivers had back-to-back races during race weekend, often driving in three races during a seven-day span with the Indianapolis 500 usually scheduled for the weekend before the Detroit Grand Prix. The Grand Prix on Belle Isle had another pause in 2020 due to the coronavirus pandemic but returned to its doubleheader schedule in 2021. IndyCar returned in 2022 but dialed it back, turning the Grand Prix into a single race for its final event on Belle Isle. 2023-present: Return downtown Alex Palou (10) drives on the Detroit Grand Prix race track during the NTT IndyCar Series qualifying in downtown Detroit on Saturday, June 3, 2023. Palou won his second consecutive NTT P1 Award. After 32 years of pauses and Belle Isle races, the Grand Prix returned downtown with mixed results in 2023. Heat and a modest turnout for the refreshed event gave it a slightly muted feel for some, but organizers have been building up the event over the past two years to turn it into a staple of the IndyCar season. Advertisement Though the downtown course retains its trademark bumpiness (making it once again one of the most challenging races for many IndyCar drivers), the race weekend has turned into one of Detroit's can't-miss annual sporting events and (for many) the unofficial start to summer in the city. You can reach Christian at cromo@ This article originally appeared on Detroit Free Press: Detroit Grand Prix: Quick history from F1 to Belle Isle to Downtown
Mint
02-06-2025
- Business
- Mint
Glenmark-Ichnos cancer drug shows 74% response in phase-1 trial
Mumbai: Ichnos Glenmark Innovation (IGI), a joint venture between Glenmark Pharmaceuticals and Ichnos Sciences, on Monday shared promising results from an ongoing phase-1 trial of ISB 2001, a novel drug targeting relapsed or refractory multiple myeloma. The data, presented at the 2025 Annual Meeting of the American Society of Clinical Oncology (ASCO), showed an overall response rate (ORR) of 74% in heavily pre-treated patients. Refractory multiple myeloma refers to cases where the cancer does not respond or stops responding to treatment. Multiple myeloma is a rare, incurable blood cancer affecting plasma cells. While several therapies have been approved in recent years, most patients eventually relapse or become resistant, leaving limited treatment options. ISB 2001 is being developed by IGI to address this unmet need, particularly in patients who have previously received T-cell–based therapies such as CAR T-cells or bispecific antibodies. It is a first-in-class tri-specific antibody designed to simultaneously target BCMA, CD38, and CD3—three proteins associated with multiple myeloma. The drug aims to overcome resistance mechanisms seen with earlier-generation immunotherapies, while minimizing off-tumour toxicity. The phase-1 trial, known as TRIgnite-1, is evaluating the drug's safety and efficacy in patients who have exhausted standard treatment options. The latest data, from the full dose-escalation phase, covered 35 patients with a median of six prior lines of therapy. The overall response rate was 74%. 'The high response rates and low safety concerns demonstrated in the dose-escalation portion of the TRIgnite-1 study, conducted in a heavily pre-treated population across multiple types of therapies, reinforce the promise of ISB 2001 as a potential new treatment for patients,' said Lida Pacaud, M.D., chief medical officer at IGI. 'As we advance to the second part of the TRIgnite-1 study, our focus is now on defining the recommended dosing schedule and evaluating ISB 2001 in a larger population of heavily pre-treated RRMM patients, where we hope to observe similarly impressive treatment responses and tolerability,' Pacaud said. Among patients receiving higher, active dose levels (≥50 µg/kg), the ORR rose to 79%, with 30% achieving complete or stringent complete responses. Patients who had not previously received T-cell–based treatments saw an ORR of 84%. Even among those with prior exposure to CAR T or CD38-targeted therapies, response rates remained strong, ranging from 71% to 73%. The safety profile of ISB 2001 was favourable, with no dose-limiting toxicities reported. The most common side effect was cytokine release syndrome (CRS), seen in 69% of patients—mostly mild (Grade 1), with only four cases classified as moderate (Grade 2). There were no severe neurological adverse events. The market for multiple myeloma is projected to grow to about $33 billion by 2030, according to estimates by Bloomberg Intelligence. The trial has now entered its dose-expansion phase, which will determine the recommended Phase 2 dose and optimal dosing schedule. ISB 2001 was granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) in 2023 and recently received Fast Track status, underscoring the agency's recognition of its potential.
