Latest news with #Breakthrough
Fox News
2 days ago
- Health
- Fox News
FDA approves first twice-yearly injection that prevents HIV infection
The U.S. Food and Drug Administration (FDA) approved a new, twice-yearly shot — the first and only of its kind — to prevent HIV, the creator of the drug, Gilead Sciences, announced on Wednesday. Sold under the name Yeztugo, the company's injectable HIV-1 capsid inhibitor (lenacapavir) reduces the risk of sexually acquired HIV in adults and adolescents. "This is a historic day in the decades-long fight against HIV," said Daniel O'Day, chairman and CEO of California-based Gilead Sciences, in a press release. The medicine, which only needs to be administered twice a year, has shown "remarkable outcomes in clinical studies," as Gilead claims it could transform HIV prevention. The drug is given as an injectable under the skin that the body then slowly absorbs. Individuals must have a negative HIV-1 test prior to starting the treatment. In large trials last year, the drug was not only nearly 100% effective in its prevention of HIV, but proved superior to once-daily oral medication like Truvada, another drug by Gilead. The journal Science named lenacapavir its 2024 "Breakthrough of the Year." Lenacapavir uses a multi-stage approach that distinguishes it from other approved antiviral medications. "While most antivirals act on just one stage of viral replication, lenacapavir is designed to inhibit HIV at multiple stages of its lifecycle," states the press release from Gilead. For more Health articles, visit "Yeztugo is one of the most important scientific breakthroughs of our time and offers a very real opportunity to help end the HIV epidemic," O'Day said in the press release. The most commonly reported adverse reactions during clinical trials included injection site reactions, headache and nausea, according to the company.
Geek Tyrant
5 days ago
- Entertainment
- Geek Tyrant
Darren Aronofsky in Talks to Direct A24's BREAKTHROUGH with Dwayne Johnson Playing a Dark Guru — GeekTyrant
Darren Aronofsky is in early talks to direct Breakthrough , a new A24 project that already has Dwayne Johnson attached in a rare supporting role. While nothing is locked in just yet, sources say the conversations are serious, and if a deal comes through, it'll mark Aronofsky's first film with A24 since The Whale , which earned Brendan Fraser his Oscar. The story is set in early 2000s Southern California and centers on an alienated young man who falls under the influence of a motivational guru. The twist? That guru's magnetic charm masks manipulation and something much darker brewing beneath the surface. Johnson is set to play the enigmatic guru, in what sounds like one of his more unexpected roles to date. The lead role, presumably the young man being pulled into the guru's orbit, has yet to be cast, and A24 isn't offering any additional comments at the moment. The screenplay is being written by Zeke Goodman, and If Aronofsky signs on, Breakthrough will come right on the heels of Caught Stealing , his upcoming thriller with Sony starring Austin Butler and Zoë Kravitz, which hits theaters this August. Source: Deadline
Yahoo
5 days ago
- Entertainment
- Yahoo
Darren Aronofsky Circling A24 Film ‘Breakthrough' Co-Starring Dwayne Johnson–The Dish
EXCLUSIVE: Darren Aronofsky is in early conversations to direct the A24 pic Breakthrough that has Dwayne Johnson on board. Sources stress it is still very early, but if a deal closes this would mark his return to A24 after helming The Whale, which won Brendan Fraser an Oscar. Zeke Goodman penned the script. A24 had no comment. More from Deadline Bill Pullman & Rick Moranis Returning For New 'Spaceballs'; Keke Palmer, Lewis Pullman Also Set - The Dish 'Texas Chainsaw Massacre' Bidding War Talks Heat Up; Taylor Sheridan Among New Names In The Mix - The Dish 'The Hunger Games' Intrigue: Studios, Streamers & Indies In The Mix To Buy 'Sunrise On The Reaping' - The Dish Set in turn-of-the-millennium Southern California, the story follows an alienated young man who comes under the influence of a motivational guru, whose intoxicating charm masks his morally questionable methods of manipulation and his own concealed darkness. We're told Johnson will play the supporting role of the guru, with casting still underway for the lead role and other supporting parts. The pic will be produced and financed by A24. Stacey Sher's Shiny Penny Productions will produce alongside Johnson and Dany Garcia's Seven Bucks Productions, with Jacob Epstein and Justin Wolf to exec produce via Lighthouse Management and Media. Next up for Aronofsky is the Sony thriller Caught Stealing, starring Austin Butler and Zoe Kravitz. That pic will bow this August. He is repped by CAA. Best of Deadline 2025 TV Series Renewals: Photo Gallery 2025 TV Cancellations: Photo Gallery 2025-26 Awards Season Calendar: Dates For Tonys, Emmys, Oscars & More
New Indian Express
5 days ago
- Entertainment
- New Indian Express
A24 in talks with Darren Aronofsky to direct Dwayne Johnson-starrer Breakthrough
This marks Johnson's second collaboration with A24. He is set to appear in Benny Safdie's The Smashing Machine, slated for an October release. Best known for his blockbuster and family-friendly roles in films like Jungle Cruise and Red One, Johnson has recently been aligning with more auteur-driven ventures. He's also attached to a Hawaii-set mob drama directed by Martin Scorsese, starring alongside Emily Blunt and Leonardo DiCaprio. As for Aronofsky, Breakthrough would come on the heels of his upcoming crime thriller Caught Stealing.
Time of India
14-06-2025
- Entertainment
- Time of India
Darren Aronofsky eyes next film: Enters talks for 'Breakthrough'; Dwayne Johnson set for dark supporting role
Darren Aronofsky Academy-nominated director Darren Aronofsky is said to be in early talks to helm a new psychological drama called 'Breakthrough'. Deadline reports that Dwayne Johnson will be seen breaking away from his action-hero role to play a more complex and demanding part. The actor is not the lead but will reportedly play a central supporting character that is a new trajectory consistent with his increased desire to perform more complicated, character-oriented parts. The film follows an intriguing tale of Southern California in the early 2000s about a lonely young guy who is swept under the wing by a charismatic self-help guru. Under the surface of this inspiring figure, there is a master manipulator with a dark, hidden agenda. Fans of Johnson will next catch him in 'The Smashing Machine,' opening in theatres on October 3. The film represents a significant departure from Johnson's career, signaling a move toward more dramatic, independent fare. His production firm, Seven Bucks Productions, co-founded with longtime collaborator Dany Garcia is also behind Breakthrough in association with Stacey Sher's Shiny Penny Productions. While negotiations are on, Aronofsky is keeping pace. His next film, 'Caught Stealing', which features Austin Butler and Zoe Kravitz will open in theatres this August. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Switch to UnionBank Rewards Card UnionBank Credit Card Apply Now Undo On the Personal front Dwayne Johnson's career shift comes after he spoke publicly about a dramatic personal transformation. In an insightful interview with Cageside Seats, he discussed a health issue that involved digestive issues, heart valve problems and a clogged artery. These developments led the actor to re-evaluate not only his physical health but his life priorities.
