
This Female Scientist Brought The Dire Wolf Back From Extinction
© John Davidson
Women make up 43.1% of scientists in the U.S. workforce, yet they account for just 34% of the broader STEM fields, according to the National Science Foundation. Within these industries, many have faced sexual harassment or undue criticism throughout their careers, especially as their work garners public attention. The numbers—and the stories—are sobering.
Enter Dr. Beth Shapiro, a powerhouse in genomic science. She has directed her own lab at the University of California, Berkeley, authored critically acclaimed books and holds the prestigious title of HHMI Investigator. Now, as the Chief Science Officer at Colossal Biosciences, a groundbreaking company leading the charge in de-extinction, Shapiro is guiding a predominantly female team to reshape the future of conservation and genomics.
While leaving academia wasn't an easy decision for Shapiro, she has gone on to work on some of the most exciting projects in her career. Last year, she made history when she brought the dire wolf back from extinction. On October 1, 2024, the first two dire wolf pups, Romulus and Remus, were born; on January 31, 2025, a third dire wolf named Khaleesi was welcomed into the world.
'What conservation needs is bold ideas and bold action. This breakthrough showcases that humans are capable of both. We can use biotechnologies to speed up the processes of selection and adaptation,' she said in a statement on the Colossal website. 'With the successful birth of Colossal's dire wolf, we are one step closer to a world in which these tools are among those at our disposal to help species thrive in their rapidly changing habitats.'
She has faced some level of criticism for the project, and the harshest are often less qualified males in the STEM field. However, Shapiro is more concerned about the next generation.
'We get letters from kids inspired by our work — our science, conservation efforts, and commitment to bettering the planet,' she explained in an interview. 'I worry about them losing hope when they see how women in science are often treated.'
© John Davidson
This isn't just about Shapiro; it's about the culture of tearing down women in fields where they're already underrepresented. The stakes are high—not just for the scientists, but for the future of innovation itself. What Can We Do To Change The Narrative? Look Beyond The Headlines
Not all scientists are created equal. Before buying into criticism, dig deeper into the credentials of those doing the critiquing. Are their accomplishments anywhere near the level of those they're disparaging? Call Out Inequality
When you see women's work unfairly diminished, speak up. The more we normalize respect and fairness, the better the culture becomes. Support Girls In STEM
Programs that encourage young women to pursue careers in science, technology, engineering and math. Donate, mentor or simply share resources that highlight their importance. Challenge The Status Quo
Question why women face disproportionate scrutiny. Is it jealousy, insecurity, or outdated biases? Sometimes, the problem isn't the science. It's the ego of the critic. Celebrate Women's Wins
Share their successes, amplify their voices, and ensure their stories reach the audiences they deserve. MORE FROM FORBES Forbes The Science Of De-Extinction Is Providing Hope For Nature's Future By Emma Kershaw Forbes Billionaire Eugene Shvidler Revealed As The Artist Behind ES23 By Emma Kershaw Forbes Inside A $22 Million Mediterranean-Style Villa Overlooking San Francisco By Emma Kershaw
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles


Forbes
2 hours ago
- Forbes
White House Aims To Halt Fantastical NASA Missions Across Solar System
The New Horizons spacecraft sends back its sensational snapshots of Jupiter, and its volcanic moon ... More Io, before the mission's close encounter with Pluto (Photo by: Photo12/Universal Images Group via Getty Images) Universal Images Group via Getty Images The White House bid to terminate NASA's leading-edge flights of exploration 'across the solar system' threatens to explode American leadership in discoveries that have reshaped civilization since the rise of the first Space Age, says one of the world's top planetary scientists. As space powers across the continents vie to map and image planets and moons, comets and ice-worlds circling the sun, slashes to NASA's funding would represent a great leap backward, crippling it even as rivals race ahead, says Alan Stern, a one-time leader at NASA and a globally acclaimed space scientist. The president's new proposed budget drastically cuts appropriations for NASA, with outlays for its planetary science missions—the exploration of Pluto and other celestial worlds by space-borne rockets and robots, cameras and telescopes—axed almost in half. Now facing the guillotine—inexplicably—are constellations of technologically advanced space probes developed by NASA and spearheading scientists across America, including the Juno imager now orbiting Jupiter, the Mars Odyssey and Maven spacecraft gliding above Mars and the asteroid hunter OSIRIS-Apophis. NASA's Mars Odyssey spacecraft, in orbit around Mars, is one of the leading-edge explorers slated to ... More be terminated by the White House. Shown here is an artist's impression of the orbiter. (Photo) Getty Images 'Incredibly, this budget proposes to turn off 55 perfectly working, productive spacecraft across the solar system,' Dr. Stern, who once headed NASA's Science Mission Directorate, tells me in an interview. Stern took up that post after conceiving and designing one of the American space agency's most sensational missions ever - the New Horizons spacecraft that aced a close approach with Pluto while sending back fantastical images of the otherworldly orb and its moons - a miniature planetary system that generated billions of hits when it began beaming down across NASA's website. While New Horizons continues its super-speed flight through the outer solar system, charting the mysterious frozen reaches of the Kuiper belt, the president's plan calls for the spacecraft to be cast away. Abandoning the $900-million mission in order to recoup the minimal costs of its ongoing operation makes no sense economically or scientifically, Stern says. The robotic photographer New Horizons images Pluto as it speeds through the outer solar system ... More (Photo by NASA/APL/SwRI via Getty Images) Getty Images 'With New Horizons,' he says, 'there are a lot of important scientific objectives still ahead, things no other spacecraft can do.' 'Terminating this mission would also represent a tragic loss of soft power projection for the U.S.' The Horizons craft, and its array of next-generation cameras and spectrometers, is exploring a region beyond Pluto that no other human-created probe has ever entered, with a treasure trove of potential discoveries waiting. 'This would be like sending a message to [Christopher] Columbus to sink his ships while they were in North America,' Stern tells me, upending a new age of discovery. 'With New Horizons, we have the power and the fuel to run this mission for another 20 years … and we have more Kuiper belt objects to explore.' The White House, in issuing its slashed budget plan for NASA, never provided a logical rationale for torpedoing some of the agency's world-leading missions to survey and image the solar system. Its inscrutable sinking of some of these vanguard voyages was unveiled with the terseness of a telegram: 'Operating missions that have completed their prime missions (New Horizons and Juno) and the follow-on mission to OSIRIX-REx, OSIRIS-Apophis Explorer, are eliminated.' The asteroid-hunter OSIRIS spacecraft, shown here at the Kennedy Space Center in Florida, is one of ... More the trailblazers set to be terminated by the White House. (Photo by Bruce Weaver / AFP) (Photo by BRUCE WEAVER/AFP via Getty Images) AFP via Getty Images The OSIRIS spacecraft, which had been slated to rendezvous with the closely approaching Apophis asteroid ahead, is a precursor mission to defending the Earth's eight billion citizens against doomsday cosmic strikes by colossal comets or asteroids of the future. The robotic photographer Juno has snapped an endless kaleidoscope of imagery as it floats around Jupiter. Scientists at NASA's Jet Propulsion Lab have posted raw impressions of the orb and its moons and invited 'citizen scientists' to Photoshop and launch them across the cybersphere. In the process, they are becoming part of the spacefaring civilization that is spreading out across the globe. Model of the $1-billion Juno spacecraft, which is now orbiting and photographing Jupiter (Photo by ... More) Getty Images During its own space odyssey, New Horizons has astounded stargazers, students and scholars worldwide with its technicolor panoramas of Pluto, covered in surreal ice-fields and cryo-volcanoes, and its age-old companion Charon. The twin netherworlds—named after the mythical Greek god of the underworld and the pilot who shuttled souls across the river Styx—circle more than five billion kilometers distant from the sun, along an orbit that Stern's Pluto expedition took nine years to reach. Now, even as it whizzes beyond all of the classical planets, New Horizons, and its future, has entered the purgatory of potential excommunication by mission controllers—and their masters—six worlds away. The New Horizons spacecraft, now speeding through the outer solar system, could be jettisoned under ... More a White House plan that would destroy American leadership in planetary science missions. (Photo by Heritage Art/Heritage Images via Getty Images) Heritage Images via Getty Images 'This is a vast and tragic mistake,' Stern says, 'because the issue is larger than just NASA, it also affects U.S. world leadership [and] responsible government that protects taxpayers from waste like this.' The administration's crash-and-burn dismissal of the solar system's trailblazing robotic discoverers has triggered trepidation across NASA, whose ranks of pioneering scientists are likewise set to be culled. Within NASA, Alan Stern is a pole star of cutting-edge exploration, helping guide more than two dozen missions. After his New Horizons spacecraft rendezvoused with Pluto, the agency bestowed its highest honor on him - the NASA Distinguished Public Service Medal. 'Stern led the team that returned remarkable imagery and other data from the Pluto system last summer, generating headlines worldwide and setting a record for the farthest world ever explored,' NASA's leaders said. "New Horizons represents the best of humanity and reminds us of why we explore,' added Jim Green, NASA's director of planetary science. "The first flyby of Pluto is a remarkable achievement.' Being given the chance to lead the close encounter with Pluto, Stern said on accepting the award, 'has been the greatest honor of my lifetime.' Around the same time, NASA film-makers paid tribute to Stern, his 2000+ Pluto mission colleagues, and the target of their interplanetary expedition in the captivating documentary ' The Year of Pluto .' Stern has himself chronicled his trek across the twilight reaches of the star system in a stream of fascinating books, including Pluto and Charon: Ice Worlds on the Ragged Edge of the Solar System and Chasing New Horizons, and in a torrent of acclaimed papers . Scholar Stern predicts that if the White House's proposed death sentence for flotillas of pathfinding space missions is actually carried out, that would mark the decline and fall of NASA's planetary science breakthroughs, and the comparative rise of its competitors in the renewed space race of the 2020s. If NASA's funding and inter-planet journeys are decimated, he tells me, 'These cuts will absolutely destroy U.S. leadership in all the space sciences.' 'This is tragically misguided.' The potential death knell for an armada of space discovery missions has been reverberating not just across NASA, but also throughout the U.S. universities that help conceive or design these flights. 'Certainly termination of the New Horizons mission would be terrible,' says Kip Hodges , who as founding director of Arizona State University's School of Earth and Space Exploration helped transform the university into one of the top American space studies centers. 'This a real frontier mission at this point,' he tells me in an interview, 'delivering important new information about distant parts of our Sun's heliosphere.' Congress has the power to save NASA and its leading-edge robotic explorers across the solar system ... More (Illustration by Tobias Roetsch/Future Publishing via Getty Images) Future Publishing via Getty Images Professor Hodges , one of the top space scholars in the U.S., predicts that the Swords of Damocles now hanging above New Horizons and other new-frontier flights could still be lifted. If the White House plan to cut away at NASA and its revolutionary planetary scouting missions were enacted as is, he predicts, 'a great many folks in industry, the NASA labs, and academia will be disappointed.' Yet he adds that 'the budget for NASA evolves over several stages,' with the president's initial proposal just one of competing models—one that could be rejected as the Senate and House of Representatives look afresh at NASA's missions, goals and funding. After the twin chambers reach a consensus on reshaping NASA for the next phase of its evolution, Professor Hodges adds, 'Quite often, the appropriated budget is not the president's budget.' That means space aficionados across America who seek to overturn the president's capital sentence on NASA's boundary-breaking missions have a clear channel of recourse, Stern says. Would-be petitioners for a reprieve, he advises, 'should contact their elected representatives in Congress and tell them this is a huge mistake.'
Yahoo
2 hours ago
- Yahoo
This Poop 'Cure' May Have Unintended Long-Term Effects, Study Finds
Faecal microbial transplants (FMT), which involve transferring stool samples from a healthy gut to someone else's colon, have yielded some impressive medical results in the past. Researchers have seen promising signs of its ability to address irritable bowel syndrome, Crohn's disease, and even early Parkinson's (though this benefit only seemed to be short-lived) and other neurological issues. It has a 90% success rate for treating a bacterium related to diarrhoea, the BBC reported. But a new study published in the journal Cells has raised questions about the long-term safety of FMT treatments, suggesting that a bacterial 'mismatch' may cause problems with the patient's immune system and metabolism down the line. The scientists only found the link in mice and were not able to say how the changes they witnessed in the animals might manifest in people. They gave antibiotics to mice to interrupt their gut's normal microbiome, and then treated them with FMT and monitored them for one to three months. Often, the researchers discovered, the gut bacteria ended up in the wrong part of the gut – 'regional mismatches' – that seemed to disrupt the gut. After taking biopsies of the liver and gut, the scientists found that some genes, especially those related to the immune system and metabolism, had changed. Speaking to the University of Chicago, the study's lead author, researcher Orlando 'Landon' DeLeon said: 'I think it's a bit of a wake-up call to the field that maybe we shouldn't willy-nilly put large bowel microbes into different parts of the intestine that shouldn't be there. 'There are microbes along the entire intestinal tract, and we just study predominantly the last third of it (the colon),' he added. 'So how can you expect an FMT, with microbes from a third of the intestinal tract at the end of it, to fix the rest of the intestine?' No. This study was done on mice, which have different anatomies from us; even though the scientists found genetic changes in the liver and gut, they are not sure yet how those changes might affect even the mouse, never mind us. The study's researchers, however, still think it's a good idea to pursue 'omni-microbial transplants,' or OMT, writing in their paper: 'regional microbial mismatches after FMTs can lead to unintended consequences and require rethinking of microbiome-based interventions.' OMTs would include more bacteria from a greater area of the gut, theoretically increasing the likelihood that the correct ones will go to the right spot. Gut Health Discovery Could Help Future Parkinson's Diagnoses Let's Settle This – Is The Viral 'Puff Vs Pit' Armpit Health Check Actually Helpful? New Study Finds The Exact Age Bad Health Habits Catch Up To You


Medscape
2 hours ago
- Medscape
Can Behavioral Support Enhance CGM Use in T1D?
TOPLINE: Behavioral support for first-time users of a continuous glucose monitoring (CGM) device showed no significant difference in reduction of A1c levels compared with CGM alone in the management of type 1 diabetes (T1D). Adults in both groups reported reduced diabetes distress. METHODOLOGY: Automated insulin delivery systems are the standard of care for adults with T1D, and using them requires both an insulin pump and a CGM device. A randomized controlled trial was conducted to assess the use of CGM among 134 adults with T1D who had not previously used CGM (mean age, 35 years; 77% women; 55% not using an insulin pump) who were recruited from clinics and T1D organizations across the United States. Participants were randomly assigned to one of two groups: one received CGM alone and the other received CGM plus the ONBOARD behavioral intervention, both for 3 months. The ONBOARD intervention included four 60-minute virtual, 1:1 biweekly sessions to address barriers related to wearing the device, data management, social concerns, and trust. Changes in A1c levels and diabetes distress scores were evaluated using t-tests and linear mixed-effect models over 12 months. TAKEAWAY: At 12 months after initiating CGM, 80% of participants in the ONBOARD group and 71% in the CGM-only group reported using CGM. Both the CGM-only and ONBOARD groups showed significant reductions in A1c levels (P < .05), with no significant difference between the groups. Participants in both groups experienced significant and clinically meaningful decreases in diabetes distress (P < .001). The CGM-only group showed greater reductions in diabetes distress than the ONBOARD group at 3 months; reductions were similar between groups at 6 and 12 months. IN PRACTICE: "Findings highlight benefits of introducing CGM on diabetes management and diabetes distress for adults with T1D. Most participants were still using CGM 12 months after initiating use through the study, indicating durable uptake," the authors write. SOURCE: The study was led by Molly L. Tanenbaum, PhD, Stanford University School of Medicine, California. The poster will be presented on June 23 at the American Diabetes Association (ADA) 85th Scientific Sessions, being held June 20-23 at the McCormick Place Convention Center, Chicago, Illinois. LIMITATIONS: No study limitations were discussed in the abstract. DISCLOSURES: One author disclosed consulting roles with Sanofi and Havas Health, an advisory role with MannKind Corporation, and receiving research support from embecta. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.